阅读说明：本技术 一种消毒液及其制备方法 (Disinfectant and preparation method thereof ) 是由 何爱民 于利平 于 2020-06-10 设计创作，主要内容包括：本发明涉及一种消毒液及其制备方法,按重量百分比计,消毒液包括5％～25％的季铵盐、0.1％～5％的侧链含有卤胺和季铵盐的聚硅氧烷、1％～10％的助溶增效剂、0.01％～1％的金属螯合剂和余量的水。本发明的消毒液对人体安全、无毒、无害、无刺激、对设备无腐蚀、对环境无污染,且本发明的消毒液杀菌能力好且杀菌效果稳定。(The invention relates to a disinfectant and a preparation method thereof, and the disinfectant comprises, by weight, 5-25% of quaternary ammonium salt, 0.1-5% of polysiloxane containing halamine and quaternary ammonium salt on side chains, 1-10% of a solubilizing synergist, 0.01-1% of a metal chelating agent and the balance of water. The disinfectant disclosed by the invention is safe to a human body, non-toxic, harmless, non-irritant, non-corrosive to equipment and non-pollution to the environment, and has good sterilization capability and stable sterilization effect.)

1. A disinfection solution is characterized in that: the composition comprises, by weight, 5-25% of quaternary ammonium salt, 0.1-5% of polysiloxane with a side chain containing halamine and quaternary ammonium salt, 1-10% of a solubilizing synergist, 0.01-1% of a metal chelating agent and the balance of water, wherein the polysiloxane with a side chain containing halamine and quaternary ammonium salt is one or more of the substances shown in the following structural general formula:

wherein R is₁Is any one of N-halamine, heterocyclic amine or acyclic amine; r₂Is quaternary ammonium salt; r₃Is a single bond or an organic group R, and R is any one of substituted or unsubstituted straight-chain alkyl, branched-chain alkyl, aryl, aralkyl or benzyl; r₄Is any one of substituted or unsubstituted straight-chain C1-C4 alkyl, substituted or unsubstituted branched-chain C1-C4 alkyl or hydroxyl; m and n are both natural numbers larger than 0, and m: n is 1: 20-20: 1.

2. The sterilizing solution of claim 1, wherein: the quaternary ammonium salt is one or more of chlorine type quaternary ammonium salt and/or bromine type quaternary ammonium salt.

3. The sterilizing solution of claim 2, wherein: the chloride type quaternary ammonium salt is one or more of quaternary ammonium chloride salts consisting of single-chain or double-chain fatty chains of C5-C18, methyl or methylbenzyl or ethylbenzyl, and/or one or more of benzalkonium chloride pining consisting of pining, dimethyl and benzyl; the bromine-type quaternary ammonium salt is one or more of single-chain or double-chain fatty chain of C8-C18 and bromide quaternary ammonium salt consisting of methyl or methylbenzyl or ethylbenzyl.

4. The sterilizing solution of claim 1, wherein: the quaternary ammonium salt is one or more of dioctyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, hexadecyl dimethyl benzyl ammonium chloride, benzalkonium chloride and benzalkonium bromide.

5. The sterilizing solution of claim 1, wherein: in the polysiloxane containing the haloamine and the quaternary ammonium salt on the side chain, when R is₁When the halogen amine is N-halogen amine, Y is selected from substituted or unsubstituted straight-chain C1-C4 alkyl and substituted or unsubstituted branched-chain C1-C4.

6. The sterilizing solution of claim 1, wherein: the cosolvent synergist is one or more of ethanol, tween 80, isopropanol, n-butanol, polyethylene glycol, and terpineol.

7. The sterilizing solution of claim 6, wherein: the cosolvent synergist is terpineol.

8. The sterilizing solution of claim 1, wherein: the metal chelating agent is one or more of ethylenediamine tetraacetic acid, citric acid and tartaric acid.

9. The sterilizing solution according to any one of claims 1 to 8, wherein: according to weight percentage, the water-soluble organic silicon fertilizer comprises 7 to 20 percent of quaternary ammonium salt, 0.5 to 2 percent of polysiloxane with a side chain containing halamine and quaternary ammonium salt, 2 to 8 percent of cosolvent synergist, 0.05 to 0.5 percent of metal chelating agent and the balance of water.

10. A method for preparing the disinfecting solution according to any one of claims 1 to 9, characterized in that: weighing the quaternary ammonium salt, the polysiloxane with the side chain containing the halamine and the quaternary ammonium salt and the cosolvent synergist according to the formula ratio, and dissolving in water; then adding the metal chelating agent with the formula amount, uniformly stirring, adding water to the formula amount, stirring, and filtering to obtain the disinfectant.

Technical Field

The invention relates to a disinfectant and a preparation method thereof.

Background

The following common disinfectant liquids are mainly available in the market: the main components are triclosan, chlorhexidine, o-phenylphenol, trichloroisocyanuric acid, sodium hypochlorite and the like, and the main components are chlorine and phenol compounds which have certain harm to human bodies and the environment; the ethanol disinfectant has strong irritation to skin, produces stabbing pain to wounds and is easy to cause fire; aldehyde disinfectant, such as glutaraldehyde disinfectant, has strong pungent smell, has strong irritation to skin and mucous membrane, and can make skin yellow and desquamate; peroxide disinfectant such as peracetic acid and hydrogen peroxide has strong pungent smell and is volatile, and the sterilization effect of the peroxide disinfectant can be reduced due to the existence of organic matters; the iodine-containing disinfectant mainly contains iodine, iodophor and the like, has a wide bactericidal spectrum, has a certain killing effect on spores, needs higher content, has weakened efficacy when organic matters exist, and is easy to decompose by visible light; the quaternary ammonium salt disinfectant belongs to a cationic surfactant disinfectant, has low concentration, no irritation, no color, no odor, no corrosion, no bleaching effect, good solubility, convenient use and stable property, but has poor effect on part of microorganisms, and cannot kill microorganisms such as fungi, tubercle bacillus, viruses, spores and the like; the disinfectant has the advantages of high price, more incompatibility, larger influence of organic matters on the sterilization effect, sensitivity to metal ions such as calcium and magnesium, easy formation of quaternary ammonium salt compounds with lower activity and poorer solubility with quaternary ammonium salt cations, and reduction of the sterilization activity of the quaternary ammonium salt disinfectant.

CN101967351A, American Orimu university and Wansheng light source company, the invention synthesizes a series of siloxane monomers containing N-halamine functional groups and polysiloxanes containing only N-halamine functional groups on side chains. The aim is to functionalize the surface of materials so that they have a germicidal effect when in contact with oxidizing halogen solutions. However, the N-halamine functional group has poor water solubility due to the organic heterocyclic structure, and an organic solvent is required in the use process, so that environmental pollution is easily caused.

Disclosure of Invention

The invention aims to provide a disinfectant with good sterilizing effect and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides a disinfectant, which comprises, by weight, 5-25% of quaternary ammonium salt, 0.1-5% of polysiloxane containing halamine and quaternary ammonium salt in side chains, 1-10% of solubilizing synergist, 0.01-1% of metal chelating agent and the balance of water, wherein the polysiloxane containing halamine and quaternary ammonium salt in side chains is one or more of the substances shown in the following structural general formula:

wherein R is₁Is any one of N-halamine, heterocyclic amine or acyclic amine; r₂Is quaternary ammonium salt; r₃Is a single bond or an organic group R, and R is any one of substituted or unsubstituted straight-chain alkyl, branched-chain alkyl, aryl, aralkyl or benzyl; r₄Is any one of substituted or unsubstituted straight-chain C1-C4 alkyl, substituted or unsubstituted branched-chain C1-C4 alkyl or hydroxyl; m and n are both natural numbers larger than 0, and m: n is 1: 20-20: 1.

According to the invention, the effect of the compound quaternary ammonium salt on sterilization and disinfection is researched, and the novel quaternary ammonium salt disinfectant with the optimal proportion is screened, so that the sterilization effect is better and more stable. The polysiloxane with the side chain containing the halamine and the quaternary ammonium salt is a polymer with the side chain containing halamine functional groups, namely N-X bonds (X can be Cl or Br), N-X in the polymer can be slowly decomposed under the action of water molecules to release halogen positive ions with oxidation, and meanwhile, the N-X bonds in the polymer are reduced into N-H bonds which are unstable and easy to decompose, so that chloramine polymers are commonly used in practical use. The chloride positive ions have an oxidizing effect and can kill germs, and other microorganisms. After killing germs, the N-H bond in the polymer can be oxidized into the N-Cl bond after the polymer is rinsed by chlorine water, and the sterilization function is obtained again. The antibacterial agent containing halamine functional groups has the characteristic of reproducible antibacterial performance, and through practical tests, when the antibacterial agent is compatible with other components in the antibacterial agent, the antibacterial performance is excellent, most of common germs such as staphylococcus, escherichia coli, pseudomonas aeruginosa and the like can be killed in a short time, and even certain viruses can be killed. The disinfectant has stronger sterilizing capability than that of the common quaternary ammonium salt disinfectant, can be used for surface disinfection and fabric disinfection of common objects, and has the advantages of less consumption, longer acting time, no pollution, no corrosion and no irritation.

Preferably, the quaternary ammonium salt is one or more of chlorine type quaternary ammonium salt and/or bromine type quaternary ammonium salt.

Further preferably, the chloride-type quaternary ammonium salt is one or more of a single-chain or double-chain aliphatic chain of C5-C18, a quaternary ammonium chloride salt consisting of methyl or methylbenzyl or ethylbenzyl, and/or one or more of benzalkonium chloride pinine consisting of pinningyl, dimethyl and benzyl; the bromine-type quaternary ammonium salt is one or more of single-chain or double-chain fatty chain of C8-C18 and bromide quaternary ammonium salt consisting of methyl or methylbenzyl or ethylbenzyl.

According to a specific and preferred embodiment, said quaternary ammonium salt is one or more of dioctyldimethylammonium chloride, didecyldimethylammonium bromide, hexadecyldimethylbenzylammonium chloride, benzalkonium bromide.

Preferably, in the polysiloxane containing the haloamine and the quaternary ammonium salt on the side chain, when R is₁When the halogen amine is N-halogen amine, Y is selected from substituted or unsubstituted straight-chain C1-C4 alkyl and substituted or unsubstituted branched-chain C1-C4.

Further preferably, the polysiloxane having a side chain containing a halamine and a quaternary ammonium salt is as disclosed in 201210347627.5.

Preferably, the cosolvent synergist is one or more of ethanol, tween 80, isopropanol, n-butanol, polyethylene glycol and terpineol.

Further preferably, the solubilizing synergist is terpineol.

Preferably, the metal chelating agent is one or more of ethylenediamine tetraacetic acid, citric acid and tartaric acid.

Preferably, the water-soluble polymer comprises 7-20% of quaternary ammonium salt, 0.5-2% of polysiloxane with a side chain containing halamine and quaternary ammonium salt, 2-8% of cosolvent synergist, 0.05-0.5% of metal chelating agent and the balance of water by weight percentage.

The second aspect of the invention provides a preparation method of the disinfectant, the quaternary ammonium salt, the polysiloxane with the side chain containing the halamine and the quaternary ammonium salt and the solubilizing synergist are weighed according to the formula amount and dissolved in water; then adding the metal chelating agent with the formula amount, uniformly stirring, adding water to the formula amount, stirring, and filtering to obtain the disinfectant.

The disinfectant of the invention has simple and convenient production and low cost.

Due to the adoption of the technical scheme, compared with the prior art, the invention has the following advantages:

the disinfectant disclosed by the invention is safe to a human body, non-toxic, harmless, non-irritant, non-corrosive to equipment and non-pollution to the environment, and has good sterilization capability and stable sterilization effect.

The disinfectant of the invention has simple preparation and low cost.

Detailed Description

The technical solution of the present invention is further described below with reference to specific embodiments, but the present invention is not limited to the following embodiments. The implementation conditions used in the examples can be further adjusted according to specific requirements, and the implementation conditions not indicated are generally the conditions in routine experiments. The reagents or starting materials used in this example are either commercially available or prepared according to methods conventional in the art. The N-halamine and quaternary ammonium salt-containing polymethylsiloxanes in the following examples were prepared according to the protocol disclosed in 201210347627.5 example 1. The percentages in the following examples are by mass.