阅读说明：本技术 具有bet抑制活性的化合物及其制备方法和用途 (Compound with BET inhibition activity, preparation method and application thereof ) 是由 夏林 耿美玉 叶艳 丁健 张琼 沈爱军 黄颖 刘红椿 杨浩然 艾菁 张敏敏 于 2019-02-01 设计创作，主要内容包括：本发明属于药物化学领域。具体地,本发明涉及一系列具有新型结构的BET(bromodomain and extra-terminal domain)抑制剂,尤其是靶向BRD4(Bromodomain-containing protein 4)的抑制剂,及其制备方法和用途。其结构如下列通式(I)所示。这些化合物或其立体异构体、外消旋物、几何异构体、互变异构体、前药、水合物、溶剂化物、晶型或其药学上可接受的盐及药物组合物,可用于治疗或/和预防由溴结构域蛋白介导的相关疾病。(The invention belongs to the field of pharmaceutical chemistry. In particular, the invention relates to a series of BET (branched and extra-tertiary domain) inhibitors with novel structures, in particular to inhibitors targeting BRD4 (Bromodomain-relating protein 4), and a preparation method and application thereof. The structure is shown in the following general formula (I). The compounds or stereoisomers, racemates, geometric isomers, tautomers, prodrugs, hydrates, solvates, crystal forms or pharmaceutically acceptable salts and pharmaceutical compositions thereof can be used for treating or/and preventing related diseases mediated by bromodomain proteins.)