Drug delivery device with locking member and removable cap for preventing accidental activation
阅读说明:本技术 具有用于防止意外启动的锁定构件和可移除盖的药物递送装置 (Drug delivery device with locking member and removable cap for preventing accidental activation ) 是由 阿拉斯泰尔·威洛比 乔治·萨维尔 唐纳德·斯蒂尔 于 2019-01-17 设计创作,主要内容包括:提供了一种药物输送装置,其包括外壳,该外壳用于接收注射器,该外壳具有可分离地附接至彼此的第一壳体部分和第二壳体部分。该装置进一步包括套筒,该套筒可接收在所述外壳内,并且包括具有界定孔的内表面和相对的外表面的管状壁。锁定构件可接收在第二壳体部分内,使得锁定构件可相对于第二壳体部分在第一轴向位置与第二轴向位置之间轴向移动。在第一轴向位置,锁定构件可与外表面接合,以阻止套筒相对于第一壳体部分的轴向移动。在第二轴向位置,锁定构件与外表面脱离。该装置可以具有作为自动注射器的应用。(A drug delivery device is provided comprising a housing for receiving a syringe, the housing having a first housing part and a second housing part detachably attached to each other. The device further includes a sleeve receivable within the housing and including a tubular wall having an inner surface defining a bore and an opposite outer surface. The locking member may be received within the second housing portion such that the locking member is axially movable relative to the second housing portion between a first axial position and a second axial position. In the first axial position, the locking member may engage the outer surface to prevent axial movement of the sleeve relative to the first housing portion. In the second axial position, the locking member is disengaged from the outer surface. The device may have application as an auto-injector.)
1. A drug delivery device comprising:
a housing for receiving a syringe, the housing having a first housing portion and a second housing portion detachably attached to each other;
a sleeve receivable within the housing and including a tubular wall having an inner surface defining a bore and an opposite outer surface; and
a locking member receivable within the second housing portion such that the locking member is axially movable relative to the second housing portion between a first axial position and a second axial position, the locking member including a body portion having one or more radially inward projections extending therefrom such that in the first axial position the one or more radially inward projections are engageable with the outer surface to prevent axial movement of the sleeve relative to the first housing portion and in the second axial position the one or more radially inward projections are disengageable from the outer surface.
2. A drug delivery device as in claim 1, wherein the drug delivery device is actuatable by axial movement of the sleeve.
3. A drug delivery device as in claim 1 or 2, wherein the locking member is movable from the first axial position to the second axial position by separation of the first and second housing portions from each other.
4. A drug delivery device as in claim 1, 2 or 3, wherein the body portion is annular.
5. A drug delivery device as claimed in any preceding claim, wherein the body portion is circumferentially continuous.
6. A drug delivery device as claimed in any preceding claim, wherein the body portion defines an opening through which the sleeve is receivable.
7. A drug delivery device as claimed in any preceding claim, wherein the locking member is engageable with the outer surface, wherein the outer surface has a radially inward groove extending therealong in which the one or more radially inward projections are engageable.
8. The drug delivery device of claim 7, wherein the radially inward groove is circumferentially continuous.
9. A drug delivery device as claimed in any preceding claim, wherein the body portion has one or more first axially extending arms, a respective one of the one or more radially inward projections being integrated or coupled proximate a free end of the first axially extending arms.
10. A drug delivery device as in claim 9, wherein the plurality of first axially extending arms are equally spaced around the body portion.
11. A drug delivery device as in any preceding claim, wherein the locking member is disengageable from the outer surface by radially outward movement of the one or more radially inward protrusions.
12. A drug delivery device as in claim 11, wherein the radially outward movement of the one or more radially inward protrusions is by deformation of the locking member.
13. A drug delivery device as claimed in claim 12 when dependent on claim 8, wherein the radially outward movement of the one or more radially inward projections is by deformation of the one or more first axially extending arms.
14. A drug delivery device as in claim 11, 12 or 13, wherein in the first axial position, radially outward movement of the one or more radially inward protrusions is prevented by abutment of the locking member against the second housing portion.
15. A drug delivery device as in claim 14, wherein radially outward movement of the one or more radially inward protrusions is prevented by the locking member abutting against a first radially inward extending region of the second housing portion.
16. A drug delivery device as in claim 15, wherein the first radially inwardly extending region comprises one or more first ridges, ridges and/or ribs extending over the first portion of the second housing portion.
17. The drug delivery device of claim 15 or 16, wherein in the first axial position the first radially inwardly extending region is radially aligned with the one or more radially inward projections, and in the second axial position the first radially inwardly extending region is not radially aligned with the one or more radially inward projections.
18. A drug delivery device as in any preceding claim, wherein the locking member is disengageable from the outer surface by separation of the first and second housing portions from each other.
19. A drug delivery device as claimed in any preceding claim, wherein the body portion has one or more radially outward projections extending therefrom engageable with the second housing portion to retain the locking member within the second housing portion.
20. A drug delivery device as in claim 19, wherein the body portion has one or more second axially extending arms, a respective one of the one or more radially outward projections being integrated or coupled proximate a free end of the second axially extending arms.
21. A drug delivery device as in claim 19 or 20, wherein the one or more radially outward projections are engageable with the second housing portion by abutment of the one or more radially outward projections against a second radially inward extending region of the second housing portion.
22. A drug delivery device as in claim 21, wherein the second radially inwardly extending region comprises one or more second ridges, ridges and/or ribs extending over the second portion of the second housing portion.
23. A drug delivery device as in any preceding claim, wherein the second housing part comprises a cap detachably attached to the first housing part at an end of the drug delivery device.
24. A drug delivery device as in any preceding claim, wherein the cartridge comprises a needle guard to selectively cover a needle of the drug delivery device.
25. A drug delivery device as in any preceding claim, wherein the second housing portion comprises or is coupled to a needle guard removal portion receivable within the aperture.
26. A drug delivery device as in any preceding claim, wherein the first and second housing portions form one of a push fit, a snap fit and a screw thread fit with each other.
27. A drug delivery device as claimed in any preceding claim, comprising a power source provided as a propellant.
28. The drug delivery device of claim 27, wherein the power source comprises a propellant comprising a hydrofluoroalkane ("HFA").
29. The drug delivery device of claim 27 or 28, wherein the power source comprises a propellant comprising a hydrofluoroolefin ("HFO").
30. A drug delivery device as in any of claims 1 to 26, comprising a power source provided as a compression spring.
Technical Field
The present invention relates to a drug delivery device, and in particular to an automatically actuated injector.
Background
Automatically actuated injectors (sometimes referred to as autoinjectors) are well known. These devices include a power source, such as a compressed spring or a container of propellant, for delivering a dose of medicament to a patient. Additional components may include a needle shield for selectively covering the needle of the device during various stages of storage and delivery. As will be appreciated by those skilled in the art, a needle shield may generally be used to actuate the device by displacing the internal components of the device rearwardly as the user presses the device against an injection site in order to release a compressed spring or open a container of propellant. However, in the event that the device falls onto a hard surface, the internal components may be displaced rearwardly by inertia, causing the device to be inadvertently actuated. Clearly, it is desirable to prevent inadvertent actuation to maintain the efficacy of the device. It is an aim of embodiments of the present invention to at least reduce problems associated with one or more known arrangements.
Disclosure of Invention
According to an aspect of the present invention, there is provided a drug delivery device comprising: a housing for receiving a syringe, the housing having a first housing portion and a second housing portion detachably attached to each other; a sleeve receivable within the housing and including a tubular wall having an inner surface defining a bore and an opposite outer surface; and a locking member receivable within the second housing portion such that the locking member is axially movable relative to the second housing portion between a first axial position in which the locking member is engageable with the outer surface to prevent axial movement of the sleeve relative to the first housing portion and a second axial position in which the locking member is disengageable from the outer surface. In this way, the locking member can selectively maintain the relative position of the housing with respect to the sleeve. Of course, the locking member may be disengaged from the outer surface to allow axial movement of the sleeve. By engaging with the outer surface, the locking member does not obstruct or extend into the bore of the device.
In certain embodiments, the drug delivery device may be actuated by axial movement of the sleeve, i.e. as a direct result of axial movement of the sleeve. In this way, the locking member may reduce the likelihood of accidental actuation of the device. The axial movement may be a rearward movement. The locking member may be movable from a first axial position to a second axial position by separation of the first and second housing portions from each other.
Optionally, the locking member may be engageable with the outer surface, wherein the locking member may comprise a body portion having one or more radially inward projections extending therefrom engageable with the outer surface. The body portion may be an annular body portion. The body portion may be circumferentially continuous or discontinuous. In some embodiments, the body portion may define an opening through which the sleeve may be partially or fully received. In this way, the locking member, or at least a portion thereof, may be concentrically received between the sleeve and the second housing portion.
The locking member may be engaged with the outer surface, wherein the outer surface may have a radially inward groove extending therealong (i.e., around the circumference of the sleeve) in which one or more radially inward protrusions may be engaged. The radially inwardly recessed groove may be circumferentially continuous or discontinuous. The groove may engage the one or more radially inward projections with the outer surface in any rotational orientation of the sleeve relative to the locking member.
In some embodiments, the body portion may have one or more first axially extending arms, and a respective one of the one or more radially inward projections may be integrated or coupled proximate a free end of the first axially extending arms. The plurality of first axially extending arms may be arranged at equal intervals around the body portion.
The locking member may be disengaged from the outer surface by radially outward movement of one or more radially inward protrusions. The radially outward movement of the one or more radially inward protrusions may be by deformation (e.g., elastic deformation) of the locking ring. More specifically, the radially outward movement of the one or more radially inward protrusions may be performed by deformation (e.g., elastic deformation) of the one or more first axially extending arms.
In certain embodiments, in the first axial position, radially outward movement of the one or more radially inward protrusions may be prevented by abutment of the locking member against the second housing portion. More specifically, radially outward movement of the one or more radially inward protrusions may be prevented by abutment of the locking member against a first radially inward extending region of the second housing portion. The first radially inwardly extending region may comprise one or more first ridges, ridges and/or ribs extending over the first portion of the second housing portion.
In a first axial position, the first radially inwardly extending region may be radially aligned with the one or more radially inward projections, and in a second axial position, the first radially inwardly extending region may not be radially aligned with the one or more radially inward projections. In this way, in the second axial position, space may be provided to accommodate the deflection of the locking member. The locking member may be disengaged from the outer surface by separation of the first and second housing portions from each other.
Optionally, the body portion may have one or more radially outward projections extending therefrom which are engageable with the second housing portion to retain the locking member within the second housing portion. The body portion may have one or more second axially extending arms with a respective one of the one or more radially outward projections integrated or coupled proximate a free end of the second axially extending arms. The one or more radially outward projections may engage with the second housing portion by the one or more radially outward projections abutting against a second radially inward extending region of the second housing portion. The second radially inwardly extending region may comprise one or more second ridges, ridges and/or ribs extending over the second portion of the second housing portion.
In certain embodiments, the second housing part may comprise a cover detachably attached to the first housing part at an end of the drug delivery device. Additionally or alternatively, the cartridge may comprise a needle guard to selectively cover a needle of the drug delivery device. The second housing portion may include or be coupled to a needle guard removal portion receivable within the aperture. The first and second housing portions may be detachably attached to each other, wherein the first and second housing portions form one of a push fit, a snap fit, and a threaded fit with each other.
In certain embodiments, the drug delivery device may further comprise a power source provided as a propellant. The propellant may be a liquefied gas propellant. The power source may include a propellant comprising a hydrofluoroalkane ("HFA"). Additionally or alternatively, the power source may include a propellant comprising a hydrofluoroolefin ("HFO"). In certain embodiments, the drug delivery device may comprise a power source provided as a compression spring.
According to another aspect of the present invention, there is provided a drug delivery device comprising: a housing for receiving a syringe, the housing having a first housing portion and a second housing portion detachably attached to each other; an actuator member receivable within the housing and comprising a tubular wall having an inner surface defining an aperture and an opposite outer surface, the drug delivery device being actuatable by an actuating movement of the actuator member relative to the first housing part; and a locking member receivable within the second housing portion such that the locking member is axially movable relative to the second housing portion between a first axial position in which the locking member is engageable with the outer surface to prevent actuation movement and a second axial position in which the locking member is disengageable from the outer surface.
As will be appreciated by those skilled in the art, the features described above with reference to the first aspect of the invention may be combined with features of another aspect of the invention.
Drawings
Embodiments of the invention will now be described, by way of example only, with reference to the accompanying drawings, in which:
fig. 1 is a cross-sectional view of a drug delivery device according to an embodiment of the present invention;
fig. 2 is a perspective cross-sectional view of the proximal end of the drug delivery device of fig. 1;
fig. 3 is a perspective view of a locking member of the drug delivery device of fig. 1;
fig. 4a and 4b are partial cross-sectional views of the proximal end of the drug delivery device of fig. 1, with the locking member in a first axial position;
fig. 5a and 5b are partial cross-sectional views of the proximal end of the drug delivery device of fig. 1, with the locking member in a second axial position;
fig. 6a and 6b are partial cross-sectional views of the proximal end of the drug delivery device of fig. 1, wherein the locking member is in the second axial position and the locking ring is deformed; and
fig. 7 is a partial cross-sectional view of the proximal end of the drug delivery device of fig. 1, wherein the first housing portion and the second housing portion of the drug delivery device are separated from each other.
Detailed Description
Fig. 1 shows a
In certain embodiments, the
The
The locking
The locking
Prior to use of the
In the event that the
To prepare the
Continued axial movement of the locking
Fig. 7 shows the
In certain embodiments, a removable needle cover 62 may cover the needle 22 prior to use of the
As used herein, the terms "axial" and "axially" refer to an axis extending between proximal end 18 and distal end 52 of
All of the features disclosed in this specification (including any accompanying claims and drawings), and/or all of the steps of any method or process so disclosed, may be combined in any combination, except combinations where at least some of such features and/or steps are mutually exclusive.
Each feature disclosed in this specification (including any accompanying claims and drawings) may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise. Thus, unless expressly stated otherwise, each feature disclosed is one example only of a generic series of equivalent or similar features.
The invention is not restricted to the details of any of the foregoing embodiments. The invention extends to any novel one, or any novel combination, of the features disclosed in this specification (including any accompanying claims and drawings), or to any novel one, or any novel combination, of the steps of any method or process so disclosed. The claims are not to be interpreted to cover the aforementioned embodiments only, but also to cover any embodiments falling within the scope of the claims.
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