阅读说明：本技术 一种治疗小叶增生的中药组合物喷剂及制备方法 (Traditional Chinese medicine composition spray for treating lobular hyperplasia and preparation method ) 是由 张天亮 于 2019-02-12 设计创作，主要内容包括：本发明提供一种治疗小叶增生的中药组合物喷剂,其特征在于,包括以下重量的中药原料：牡蛎1-5克、八梭瓜135-165克、猫爪草7-13克、瓜蒌135-165克、马钱子5-11克、僵蚕3-9克、昆布1-5克、夏枯草9-15克、老鲜丝瓜145-175克和白酒500克。其制备方法是将夏枯草在夏单独季放入盛有500克白酒的密闭玻璃容器中,置于阴凉干燥处,泡制40天为宜；将其余中药原料同时放入泡制的药酒中,浸泡40天后方可取出；从上述获得的固液混合物中分离出滤液,并装入带有喷头的喷壶中。本发明的中药组合物喷剂针对小叶增生具有疏通,镇疼,活血化瘀功效；并起到化结,散淤；对皮下结节,脂肪瘤,纤维瘤有效缓解,还有有一定的抗癌疗效。(The invention provides a traditional Chinese medicine composition spray for treating lobular hyperplasia, which is characterized by comprising the following traditional Chinese medicine raw materials by weight: 1-5 g of oyster, 165 g of 135-inch luffa, 7-13 g of ternate buttercup root, 165 g of 135-inch snakegourd fruit, 5-11 g of nux vomica, 3-9 g of stiff silkworm, 1-5 g of kelp, 9-15 g of selfheal, 175 g of 145-inch old and fresh luffa and 500 g of white spirit. The preparation method comprises placing Prunellae Spica in a sealed glass container containing 500 g Chinese liquor in summer, and soaking in cool and dry place for 40 days; simultaneously putting the rest Chinese medicinal materials into the soaked medicated liquor, and taking out after soaking for 40 days; the filtrate was separated from the solid-liquid mixture obtained above and charged into a watering can with a shower head. The traditional Chinese medicine composition spray has the effects of dredging, relieving pain, promoting blood circulation and removing blood stasis aiming at lobular hyperplasia; and has the functions of resolving knots and dispersing silt; can be used for effectively relieving subcutaneous nodule, lipoma, and fibroma, and also has anticancer effect.)

1. A traditional Chinese medicine composition spray for treating lobular hyperplasia is characterized by comprising the following traditional Chinese medicine raw materials by weight: 1-5 g of oyster, 165 g of 135-inch luffa, 7-13 g of ternate buttercup root, 165 g of 135-inch snakegourd fruit, 5-11 g of nux vomica, 3-9 g of stiff silkworm, 1-5 g of kelp, 9-15 g of selfheal, 175 g of 145-inch old and fresh luffa and 500 g of white spirit.

2. The traditional Chinese medicine composition spray for treating lobular hyperplasia according to claim 1, which is characterized by comprising the following traditional Chinese medicine raw materials by weight: 2-4 g of oyster, 160 g of 140-160 g of sarcandra glauca, 8-12 g of radix ranunculi ternati, 160 g of 140-140 g of snakegourd fruit, 6-10 g of nux vomica, 4-8 g of stiff silkworm, 2-4 g of kelp, 10-14 g of selfheal, 150-170 g of old and fresh luffa and 500 g of white spirit.

3. The traditional Chinese medicine composition spray for treating lobular hyperplasia according to claim 1, which is characterized by comprising the following traditional Chinese medicine raw materials by weight: 3 g of oyster, 150 g of sarcandra, 10 g of ternate buttercup root, 150 g of snakegourd fruit, 8 g of nux vomica, 6 g of stiff silkworm, 3 g of kelp, 12 g of selfheal, 160 g of old and fresh towel gourd and 500 g of white spirit.

4. A preparation method of a traditional Chinese medicine composition spray for treating lobular hyperplasia is characterized by comprising the following steps:

(1) putting the selfheal into a closed glass container filled with 500 g of white spirit in a summer single season, and putting the container in a cool and dry place to soak for 40 days;

(2) simultaneously putting the rest Chinese medicinal materials into the soaked medicated liquor, and taking out after soaking for 40 days;

(3) the filtrate was separated from the solid-liquid mixture obtained above and charged into a watering can with a shower head.

5. The preparation method of the Chinese medicinal composition spray for treating lobular hyperplasia according to claim 4, wherein the solid-liquid mixture is separated in the step (3), ultrasonic extraction is adopted, the extraction is performed for 3 times, and the extraction time is set to be 20-25 min each time.

6. The preparation method of the traditional Chinese medicine composition spray for treating lobular hyperplasia according to claim 4, wherein the solid-liquid mixture is separated in the step (3), a centrifuge is adopted, the first centrifugation is carried out for 25-35 min at the rotation speed of 1000-1500 rpm, and supernatant of the first centrifugation is collected; and (4) carrying out secondary sedimentation and centrifugation on the collected supernatant in the same way, and collecting the supernatant obtained by the secondary centrifugation.

7. The method for preparing a Chinese medicinal composition spray for treating lobular hyperplasia according to claim 4, wherein the outer wall of the spray can used in step (3) is provided with scales so as to control the usage amount.

Technical Field

The invention relates to the field of medicine formulas, in particular to a traditional Chinese medicine composition spray for treating lobular hyperplasia and a preparation method thereof.

Background

Lobular hyperplasia belongs to the category of hyperplasia of mammary glands, and is a benign proliferative disease of mammary tissue. Neither inflammation nor tumor, due to hormonal cycling in women. Hyperplasia of mammary duct epithelial cells and fibrous tissue in the breast can be caused by excessive levels of estrogen secreted by the ovaries, insufficient luteal progestagen, or an uncoordinated secretion of both. Normally, the acinus, duct and fibrous tissue of each woman entering the breast of puberty undergoes a process of tissue alteration of proliferation and recovery during each menstrual cycle. Due to the change, before each menstruation, each woman may have a slight or heavy distending pain in one or both breasts, and the distending pain naturally disappears after menstruation, which is a normal physiological phenomenon without hindering life, learning and work. However, when the body is under the action of some stress factors (such as over-tension in work, over-excited mood, old age without marriage, no lactation after delivery and some chronic diseases), the hyperplasia of mammary glands which should be restored by the breasts can not be restored or can not be restored completely, and hyperplasia of mammary glands is formed after a long time, which is manifested as three symptoms and signs of thickened breast lobes and nodular granules, breast distending pain, nipple overflow and the like.

Lobular hyperplasia of mammary gland (stage i hyperplasia of mammary glands): for medical diagnosis, the early hyperplasia of mammary glands mostly occurs in 25-35 years old, the symptoms are mild, and the mammary gland hyperplasia belongs to the stage I of mammary glands. The prevalence rate of hyperplasia of mammary glands is more than 70%, which is not paid attention to and is not treated actively. If the treatment is not carried out in time, the mammary gland is easy to become cancerous, part of mammary gland hyperplasia is lingering for a long time, and benign tumor or malignant lesion of the mammary gland can be generated.

At present, the treatment of the disease is mainly based on drug therapy, western medicines take hormone as a preferred medicine, symptoms are relieved by regulating endocrine, and medicines for symptomatic treatment are supplemented according to the symptoms. According to the traditional Chinese medicine, the Chong and ren meridians are the sea of qi and blood, the ascending meridians are the breast, the descending meridians are the channels, once worry damages the spleen and worry damages the liver, the qi stagnation of the channels and the disorder of the Chong and ren meridians can occur as a result, and the breast diseases can occur.

Chinese patent (No. CN 102225123B) discloses a Chinese medicament for treating hyperplasia of mammary glands, which is prepared by decocting the following raw material medicaments in part by weight in water into decoction: 9-12 parts of muskroot-like semiaquilegia root, 10-20 parts of coltsfoot-flower, 9-12 parts of wild chrysanthemum flower, 10-20 parts of honeysuckle flower, 20-40 parts of dandelion, 9-12 parts of orange leaf and 6-10 parts of green plum blossom. Chinese patent (No. CN 101564483B) discloses a liver soothing granule for treating hyperplasia of mammary glands, which comprises the following raw materials in parts by weight: 200-250 parts of angelica, 133-150 parts of white peony root, 133-150 parts of bighead atractylodes rhizome, 67-100 parts of vinegar-processed rhizoma cyperi, 93-140 parts of radix bupleuri, 133-150 parts of poria cocos, 67-100 parts of mint, 40-60 parts of cape jasmine, 40-60 parts of moutan bark and 94-120 parts of liquorice. Therefore, the traditional Chinese medicine has a good curative effect on treating the lobular hyperplasia of mammary glands, but the existing traditional Chinese medicine is an oral medicine, has a poor effect on treating the lobular hyperplasia of mammary glands as compared with a spray, and causes additional burden on the body of a patient.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the traditional Chinese medicine composition spray for treating the lobular hyperplasia, which is convenient to carry and has an obvious effect. The invention also aims to provide a preparation method of the spray.

In order to achieve the purpose, the technical scheme of the invention is as follows:

a traditional Chinese medicine composition spray for treating lobular hyperplasia comprises the following traditional Chinese medicine raw materials by weight: 1-5 g of oyster, 165 g of 135-inch luffa, 7-13 g of ternate buttercup root, 165 g of 135-inch snakegourd fruit, 5-11 g of nux vomica, 3-9 g of stiff silkworm, 1-5 g of kelp, 9-15 g of selfheal, 175 g of 145-inch old and fresh luffa and 500 g of white spirit.

The preferred scheme of the traditional Chinese medicine composition spray is as follows: comprises the following Chinese medicinal raw materials by weight: 2-4 g of oyster, 160 g of 140-160 g of sarcandra glauca, 8-12 g of radix ranunculi ternati, 160 g of 140-140 g of snakegourd fruit, 6-10 g of nux vomica, 4-8 g of stiff silkworm, 2-4 g of kelp, 10-14 g of selfheal, 150-170 g of old and fresh luffa and 500 g of white spirit.

The better preferable scheme of the traditional Chinese medicine composition spray is as follows: comprises the following Chinese medicinal raw materials by weight: 3 g of oyster, 150 g of sarcandra, 10 g of ternate buttercup root, 150 g of snakegourd fruit, 8 g of nux vomica, 6 g of stiff silkworm, 3 g of kelp, 12 g of selfheal, 160 g of old and fresh towel gourd and 500 g of white spirit.

The preparation method of any traditional Chinese medicine composition spray preferably comprises the following steps:

(1) putting the selfheal into a closed glass container filled with 500 g of white spirit in a summer single season, and putting the container in a cool and dry place to soak for 40 days;

(2) simultaneously putting the rest Chinese medicinal materials into the soaked medicated liquor, and taking out after soaking for 40 days;

(3) the filtrate was separated from the solid-liquid mixture obtained above and charged into a watering can with a shower head.

The preferred scheme is as follows: and (4) separating the solid-liquid mixture in the step (3), extracting for 3 times by adopting ultrasonic extraction, wherein the extraction time is set to be 20-25 min each time.

Another preferred solution is: separating the solid-liquid mixture in the step (3), performing primary centrifugation for 25-35 min by adopting a centrifuge at the rotating speed of 1000-1500 rpm, and collecting supernatant of the primary centrifugation; and (4) carrying out secondary sedimentation and centrifugation on the collected supernatant in the same way, and collecting the supernatant obtained by the secondary centrifugation.

The preferred scheme is as follows: scales are arranged on the outer wall of the sprinkling can used in the step (3), so that the using amount is convenient to control.

The using method comprises the following steps: in order to achieve the best treatment effect, when the traditional Chinese medicine composition spray is used, hands and breasts are cleaned by warm water, and the traditional Chinese medicine composition spray is sprayed on the breasts twice in the morning and evening, and 3-4 g of the traditional Chinese medicine composition spray is sprayed every day.

The pharmacological effects of the raw materials are respectively as follows:

(1) oyster shell: [ PROPERTIES AND FLAVOUR ] slightly cold and salty. [ GUIJING ] enters liver, gallbladder and kidney meridians. [ EFFECT ] calming the liver and suppressing yang hyperactivity; heavy-weight tranquilizing; softening and resolving hard mass; astringe and induce astringency. Dominant vertigo tinnitus; palpitation and insomnia; scrofula and goiter; abdominal mass; spontaneous sweating and night sweat; spermatorrhea; (ii) metrorrhagia and metrostaxis; with leucorrhea.

(2) Eight-shuttle melon (loofah): [ PROPERTIES AND FLAVOUR ] PING, sweet. [ GUIJING ] enters stomach meridian, lung meridian and liver meridian. [ EFFECT ] can dredge collaterals, promote blood circulation, and dispel pathogenic wind. Can be used for treating arthralgia and spasm, distending pain in chest and hypochondrium, and galactostasis.

(3) Radix ranunculi ternati: [ PROPERTIES AND FLAVOUR ] WEN, pungent and sweet. [ GUIJING ] enters lung and liver meridians. [ EFFECT ] detoxication; resolve phlegm and dissipate nodulation. Mainly treats scrofula; tuberculosis; pharyngitis; furuncle; snake bite; malaria; migraine headache; toothache.

(4) And (3) snakegourd fruit: [ PROPERTIES AND WESTERN ] is cold, pungent and bitter. [ GUIJING ] enters stomach meridian, lung meridian, and large intestine meridian. [ EFFECT ] clear heat and remove phlegm, relieve chest stuffiness and dissipate nodulation, moisten intestines. Can be used for treating cough due to lung heat, turbid phlegm, yellow and thick phlegm, thoracic obstruction, cardialgia, acute mastitis, pulmonary abscess, and intestinal abscess with swelling and pain. Effect on the cardiovascular system: dilating coronary artery; anti-myocardial ischemia; dilating the microvasculature and improving microcirculation; inhibiting platelet aggregation; hypoxia tolerance; antiarrhythmic, expectorant, purgative, and anticancer effects.

(5) Nux vomica: [ PROPERTIES AND WESTERN ] is warm and bitter. [ GUIJING ] enters spleen and liver meridians. [ EFFECT ] can dredge collaterals, alleviate pain, dissipate stagnation and relieve swelling. Can be used for treating rheumatism, numbness, paralysis, traumatic injury, carbuncle, cellulitis, and swelling and pain; sequela of poliomyelitis, rheumatoid arthralgia. Can be used for treating numbness of limbs, paralysis, anorexia, lump, carbuncle, sore, toxic swelling, and sore throat.

(6) Stiff silkworm: [ PROPERTIES AND FLAVOUR ] PING, pungent and salty. [ GUIJING ] enters stomach meridian, lung meridian and liver meridian. [ EFFECT ] dispel pathogenic wind, arrest convulsion, resolve phlegm and dissipate nodulation. Used for treating crooked liver wind with phlegm, convulsive epilepsy and convulsion, infantile acute convulsion, tetanus, apoplexy, wind-heat headache, conjunctival congestion and pharyngalgia, rubella pruritus, Yimei mumps, wind extinguishing and spasm relieving, wind dispelling and pain relieving, phlegm eliminating and stagnation resolving; it can also be used for treating skin pruritus, submandibular lymphadenitis, and facial paralysis.

(7) Kelp: [ PROPERTIES AND FLAVOUR ] Cold and salty. [ GUIJING ] enters liver, stomach and kidney meridians. [ EFFECT ] the product has effects of softening hard masses, resolving phlegm, inducing diuresis and clearing heat. Treating goiter, tumor, tuberculosis, hernia, edema and tinea pedis. Resisting oxidation and preventing cancer.

(8) Selfheal: [ PROPERTIES AND WESTERN ] is cold, bitter and pungent. [ GUIJING ] enters gallbladder and liver meridian. [ EFFECT ] removing liver heat and improving eyesight; dispersing accumulation of pathogen and removing toxic substance. Mainly treats photophobia of eyes; pain in the eyeball; headache and dizziness; tinnitus; scrofula; goiter and tumor; acute mastitis; mumps; carbuncle and furuncle; acute and chronic hepatitis; hypertension.

(9) Old and fresh towel gourd: [ PROPERTIES AND FLAVOUR ] Cool and medicinal. [ GUIJING ] enters stomach meridian and liver meridian. [ EFFECTIVE ACTION ] can clear away heat, resolve phlegm, cool blood and remove toxicity. It is indicated for fever with polydipsia, phlegm dyspnea, cough, intestinal wind, hemorrhoid, metrorrhagia, bloody stranguria, furuncle, galactostasis, and carbuncle.

(10) White spirit: [ PROPERTIES AND FLAVOUR ] pungent, sweet and bitter. [ EFFECT ] can promote blood circulation; the efficacy of the medicine is exerted. Is mainly used for treating wind-cold arthralgia; spasm and urgency of tendons and vessels; chest stuffiness; heartburn; abdominal cold pain.

Has the advantages that: the traditional Chinese medicine composition spray has the effects of dredging, relieving pain, promoting blood circulation and removing blood stasis aiming at lobular hyperplasia; and has the functions of resolving knots and dispersing silt; can be used for effectively relieving subcutaneous nodule, lipoma, and fibroma, and also has anticancer effect.

Detailed Description

The invention is illustrated below with reference to specific examples. It will be understood by those skilled in the art that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention in any way.