阅读说明：本技术 嵌合抗原和t细胞受体及使用的方法 (Chimeric antigens and T cell receptors and methods of use ) 是由 A.佩雷兹 S.A.西弗斯 R.A.罗德里格斯 J.贝尔克 于 2019-12-11 设计创作，主要内容包括：提供了包含一个或多个本文公开的抗原结合基序的嵌合抗原受体(CAR)或T细胞受体(TCR)。本公开的方面涉及编码包含一个或多个抗原结合基序的嵌合抗原受体(CAR)或T细胞受体(TCR)的多核苷酸。提供了包含结合CD20的结合基序和任选地结合CD19的结合基序的抗体和抗原结合系统,以及生产和使用它们的方法。本公开的抗体和抗原结合系统包括包含抗CD20结合基序和抗CD19结合基序的CAR。提供了组合物,如作为或包含本公开的抗CD20/抗CD19抗原结合系统的抗体和CAR,以及包含它们的细胞疗法,其可用于例如癌症治疗中。(Chimeric Antigen Receptors (CARs) or T Cell Receptors (TCRs) comprising one or more of the antigen binding motifs disclosed herein are provided. Aspects of the present disclosure relate to polynucleotides encoding a Chimeric Antigen Receptor (CAR) or T Cell Receptor (TCR) comprising one or more antigen binding motifs. Antibodies and antigen binding systems comprising a binding motif that binds CD20 and optionally a binding motif that binds CD19 are provided, as well as methods of making and using the same. The antibodies and antigen binding systems of the present disclosure include CARs comprising an anti-CD 20 binding motif and an anti-CD 19 binding motif. Compositions, such as antibodies and CARs that are or comprise the anti-CD 20/anti-CD 19 antigen binding systems of the present disclosure, and cell therapies comprising the same, are provided that are useful, for example, in cancer treatment.)