阅读说明：本技术 一种改善人体尿酸代谢的果味压片及其制备方法 (Fruity tablet for improving uric acid metabolism of human body and preparation method thereof ) 是由 苏华山 赵文栋 牛克平 苏同兴 张桂琴 于 2021-07-20 设计创作，主要内容包括：本发明属于生物医药技术领域,特别涉及一种改善人体尿酸代谢的果味压片及其制备方法。该改善人体尿酸代谢的果味压片,主要由以下重量份数的原料制成：决明子6-10份、苦瓜3-5份、车前子5-9份、薏苡仁6-8份、蒲公英3-7份、紫苏籽2-4份、玉米须6-8份、金银花5-7份、芦根4-8份、郁李仁3-5份、荜茇5-6份、寡糖6-9份、甲壳素4-6份、果粉3-5份、食品粘合剂2-4份。本发明原料易得,制备工艺稳定,制得的改善人体尿酸代谢的果味压片可有效降低痛风及其并发症的发生几率,且无明显副作用,适合长期服用。(The invention belongs to the technical field of biological medicines, and particularly relates to a fruity tablet for improving the uric acid metabolism of a human body and a preparation method thereof. The fruity tablet for improving the uric acid metabolism of the human body is mainly prepared from the following raw materials in parts by weight: 6-10 parts of cassia seed, 3-5 parts of bitter gourd, 5-9 parts of plantain seed, 6-8 parts of coix seed, 3-7 parts of dandelion, 2-4 parts of perilla seed, 6-8 parts of corn stigma, 5-7 parts of honeysuckle, 4-8 parts of reed rhizome, 3-5 parts of bunge cherry seed, 5-6 parts of long pepper, 6-9 parts of oligosaccharide, 4-6 parts of chitin, 3-5 parts of fruit powder and 2-4 parts of food adhesive. The raw materials are easy to obtain, the preparation process is stable, and the prepared fruity tablet for improving the uric acid metabolism of the human body can effectively reduce the occurrence probability of gout and complications thereof, has no obvious side effect, and is suitable for long-term administration.)

1. A fruity tabletting for improving the uric acid metabolism of a human body is characterized by being mainly prepared from the following raw materials in parts by weight: 6-10 parts of cassia seed, 3-5 parts of bitter gourd, 5-9 parts of plantain seed, 6-8 parts of coix seed, 3-7 parts of dandelion, 2-4 parts of perilla seed, 6-8 parts of corn stigma, 5-7 parts of honeysuckle, 4-8 parts of reed rhizome, 3-5 parts of bunge cherry seed, 5-6 parts of long pepper, 6-9 parts of oligosaccharide, 4-6 parts of chitin, 3-5 parts of fruit powder and 2-4 parts of food adhesive.

2. The fruity tabletting for improving uric acid metabolism of human body according to claim 1, which is prepared from the following raw materials in parts by weight: 8 parts of cassia seed, 4 parts of balsam pear, 7 parts of plantain seed, 7 parts of coix seed, 5 parts of dandelion, 3 parts of perilla seed, 7 parts of corn stigma, 6 parts of honeysuckle, 6 parts of reed rhizome, 4 parts of bunge cherry seed, 5.5 parts of long pepper, 7.5 parts of oligosaccharide, 5 parts of chitin, 4 parts of fruit powder and 3 parts of food adhesive.

3. The fruity pressed tablet for improving the uric acid metabolism of the human body according to claim 1 or 2, which is characterized in that: the oligosaccharide is one or two of isomaltooligosaccharide and chitosan oligosaccharide.

4. The fruity pressed tablet for improving the uric acid metabolism of the human body according to claim 1 or 2, which is characterized in that: the food adhesive is one of edible gelatin and glycerol.

5. The method of claim 1, wherein the method comprises the steps of: (1) cleaning each plant raw material which meets the requirements, and then dehydrating and drying each plant raw material; (2) baking each plant raw material obtained in the step (1), and then crushing each plant raw material; (3) mixing the plant raw materials obtained in the step (2), breaking the wall and making powder to obtain wall-broken powder; (4) adding oligosaccharide, chitin, fruit powder and food adhesive into the wall-broken powder obtained in the step (3), and uniformly mixing to obtain a mixed material; (5) and (4) tabletting, packaging and sterilizing the mixed material obtained in the step (4).

6. The method for preparing a fruity pressed tablet for improving uric acid metabolism of human bodies according to claim 5, which comprises the following steps: in the step (1), each plant material is washed for 2-3 times.

7. The method for preparing a fruity pressed tablet for improving uric acid metabolism of human bodies according to claim 5, which comprises the following steps: in the step (3), the fineness of the wall-broken powder is 200 meshes.

8. The method for preparing a fruity pressed tablet for improving uric acid metabolism of human bodies according to claim 5, which comprises the following steps: in the step (5), the sterilization mode is irradiation sterilization.

Technical Field

The invention belongs to the technical field of biological medicines, and particularly relates to a fruity tablet for improving the uric acid metabolism of a human body and a preparation method thereof.

Background

Gout is a disease directly related to hyperuricemia caused by purine metabolic disorder and/or reduction of uric acid excretion, and belongs to the category of metabolic rheumatism. Gout can be complicated with kidney disease, and severe cases can cause joint destruction and renal function damage, often accompanied by hyperlipidemia, hypertension, diabetes, arteriosclerosis, coronary heart disease and the like. Hyperuricemia is the basis for the development of gout.

The current drugs for treating hyperuricemia are divided into two main categories: one is a drug that inhibits uric acid production, and the other is a drug that promotes uric acid excretion; however, both of these drugs have significant side effects. The traditional Chinese medicine preparation is increasingly becoming the research and development direction of the medicine for treating hyperuricemia due to mild curative effect and relatively small side effect.

Disclosure of Invention

The invention provides a fruity tablet for improving the uric acid metabolism of a human body and a preparation method thereof, aiming at solving the problem of great side effect of a drug for treating hyperuricemia in the prior art.

The invention is realized by the following technical scheme:

a fruity tablet for improving uric acid metabolism of a human body is mainly prepared from the following raw materials in parts by weight: 6-10 parts of cassia seed, 3-5 parts of bitter gourd, 5-9 parts of plantain seed, 6-8 parts of coix seed, 3-7 parts of dandelion, 2-4 parts of perilla seed, 6-8 parts of corn stigma, 5-7 parts of honeysuckle, 4-8 parts of reed rhizome, 3-5 parts of bunge cherry seed, 5-6 parts of long pepper, 6-9 parts of oligosaccharide, 4-6 parts of chitin, 3-5 parts of fruit powder and 2-4 parts of food adhesive.

The preferable weight ratio of the raw materials is as follows:

8 parts of cassia seed, 4 parts of balsam pear, 7 parts of plantain seed, 7 parts of coix seed, 5 parts of dandelion, 3 parts of perilla seed, 7 parts of corn stigma, 6 parts of honeysuckle, 6 parts of reed rhizome, 4 parts of bunge cherry seed, 5.5 parts of long pepper, 7.5 parts of oligosaccharide, 5 parts of chitin, 4 parts of fruit powder and 3 parts of food adhesive.

Preferably, the oligosaccharide is one or two of isomaltooligosaccharide and chitosan oligosaccharide.

Preferably, the food adhesive is one of edible gelatin and glycerol.

The invention takes the traditional Chinese medicine for promoting urination and discharging as the main part and is also assisted with the medicine for harmonizing the spleen, and is used for preparing the fruity tabletting for improving the uric acid metabolism of the human body; the fruity tablet for improving the uric acid metabolism of the human body can not only promote the uric acid metabolism of the human body, but also effectively inhibit gout complications.

In the invention, the cassia seed is dry mature seed of cassia tora or cassia tora of leguminous plants, has sweet, bitter, cold and slightly salty taste, and has the functions of clearing liver, improving eyesight, promoting diuresis and relaxing bowels; can be used for treating conjunctival congestion, photophobia, lacrimation, headache, vertigo, dim eyesight, and constipation.

The fructus Momordicae Charantiae is bitter and cold in taste, and has effects of clearing away heat and toxic materials and improving eyesight; can be used for treating heatstroke, fever, toothache, diarrhea, dysentery, and hematochezia.

Semen plantaginis is dry mature seed of Plantago asiatica or Plantago depressa of Plantaginaceae, has sweet taste and cold property, and has effects of clearing heat, promoting diuresis, treating stranguria, eliminating dampness, relieving diarrhea, improving eyesight, and eliminating phlegm; can be used for treating pyretic stranguria, pain, edema, swelling, summer-heat dampness, diarrhea, conjunctival congestion, swelling and pain, and cough due to phlegm heat.

Coicis semen is dry mature seed of Gramineae plant Coicis semen, has sweet and light taste and cool property, and has effects of promoting diuresis, moistening moisture, invigorating spleen, relieving diarrhea, eliminating arthralgia, expelling pus, removing toxic substance and resolving hard mass; can be used for treating edema, tinea pedis, dysuria, spleen deficiency, diarrhea, damp arthralgia, spasm, pulmonary abscess, intestinal abscess, wart, and cancer.

The herba Taraxaci is root-carrying whole plant of herba Taraxaci of Compositae, is bitter, sweet and cold in nature, and has effects of clearing away heat and toxic materials, promoting urination and resolving hard mass; can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.

Fructus Perillae is dried fruit of Perilla frutescens or Perilla frutescens of Labiatae, is pungent in taste and warm in nature, and has effects of lowering qi, eliminating phlegm, relieving asthma, and moistening intestine; can be used for treating phlegm stagnation, adverse flow of qi, cough, asthma, and constipation due to intestinal dryness.

Stigma Maydis is stigma Maydis of Gramineae, has sweet and light taste, and mild nature, and has effects of inducing diuresis, relieving swelling, clearing liver-fire and promoting bile flow; can be used for treating edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, and galactostasis.

The flos Lonicerae is dried flower bud or flower with initial bloom of Lonicera japonica of Lonicera of Caprifoliaceae, has sweet taste and cold property, and has effects of clearing away heat and toxic materials, relieving inflammation and subsiding swelling; can be used for treating wind-heat common cold, epidemic febrile disease, fever, heatstroke, toxic heat, dysentery, carbuncle, furuncle, pharyngitis, and various infectious diseases.

Rhizoma Phragmitis contains abundant vitamin B1, vitamin B2, vitamin C, protein, fat, carbohydrate, asparagine, etc., and also contains amino acids, fatty acids, sterols, tocopherol, polyalcohol such as caffeic acid and gentisic acid, etc.; has the effects of clearing heat, promoting fluid production, relieving restlessness, relieving vomit and promoting urination when being used as a medicine.

The semen Pruni is seed of Prunus humilis Bunge, Prunus ulmaria, Prunus pedunculata pall, etc. of Rosaceae, has pungent, bitter, sweet, neutral nature, and has effects of moistening dryness, smoothing intestine, promoting qi circulation, and inducing diuresis to alleviate edema; can be used for treating intestinal dryness, dyspepsia, abdominal distention, constipation, edema, loempe, and dysuria.

The long pepper is named as long pepper, bibo and long pepper sargent, is pungent in taste and hot in nature, and has the effects of warming spleen and stomach for dispelling cold, and descending qi for relieving pain; can be used for treating abdominal psychroalgia, emesis, diarrhea, cold accumulation, qi stagnation, thoracic obstruction, cardialgia, headache, and toothache.

Oligosaccharides, i.e., oligosaccharides, are low-degree polymeric saccharides having a branched or linear chain formed by dehydration of 2 to 10 monosaccharide molecules and linkage thereof via a glycosidic bond of α, β type, etc., and include isomaltooligosaccharides, chitooligosaccharides, etc. At present, a plurality of oligosaccharides have the function of regulating the intestinal flora structure, wherein isomaltooligosaccharide can promote the proliferation of bifidobacteria in the intestinal tract, inhibit the formation of harmful bacteria and putrefactive substances in the intestinal tract, increase the vitamin content and improve the immunity of the organism; isomaltose hypgather can not be absorbed by stomach and small intestine, but directly enters large intestine, is preferentially utilized by bifidobacterium, helps the bifidobacterium to breed in a large scale, and is a bifidobacterium proliferation factor; other harmful bacteria in the intestines can not utilize the isomaltooligosaccharide, so that the growth of the harmful bacteria is inhibited, and the microecology in the intestines is promoted to be adjusted to a benign cycle. The chitosan oligosaccharide can regulate the metabolic activity of microorganisms in the intestinal tract, improve the distribution of intestinal microflora, and promote the growth and reproduction of bifidobacterium, thereby improving the immunity of the organism, reducing the pH value in the intestinal tract, inhibiting the growth of harmful bacteria in the intestinal tract, generating B vitamins, decomposing carcinogenic substances, promoting the intestinal peristalsis and enhancing the protein absorption; the chitosan oligosaccharide also has the functions of improving the intestinal tissue morphology and enhancing the immune function.

Chitin is a polysaccharide substance extracted from the shell of marine crustaceans, and has inhibitory effect on various harmful microorganisms, thereby regulating intestinal flora structure.

The fruit powder is prepared from one or more fruits by processing raw materials, squeezing to obtain juice, filtering, clarifying, concentrating, spray drying, cooling, and packaging; fruit powder is commonly used for flavoring.

The food adhesive is a substance which plays a role in thickening and viscosity increasing in food processing, and the common food adhesive comprises edible gelatin, glycerin and the like.

The preparation method of the fruity tabletting for improving the uric acid metabolism of the human body comprises the following steps: (1) cleaning each plant raw material which meets the requirements, and then dehydrating and drying each plant raw material; (2) baking each plant raw material obtained in the step (1), and then crushing each plant raw material; (3) mixing the plant raw materials obtained in the step (2), breaking the wall and making powder to obtain wall-broken powder; (4) adding oligosaccharide, chitin, fruit powder and food adhesive into the wall-broken powder obtained in the step (3), and uniformly mixing to obtain a mixed material; (5) and (4) tabletting, packaging and sterilizing the mixed material obtained in the step (4).

The invention adopts the processes of baking and wall breaking and milling to fully release the active ingredients in the plant raw materials, and then adds the fruit powder and other auxiliary agents into the wall breaking powder to prepare the fruity tabletting for improving the uric acid metabolism of the human body, which is used for adjusting the uric acid metabolism level of the human body.

Preferably, in step (1), each plant material is washed 2 to 3 times.

Preferably, in the step (3), the fineness of the wall-broken powder is 200 meshes.

Preferably, in step (5), the sterilization mode is irradiation sterilization.

Compared with the prior art, the invention has the following beneficial effects:

after the plant raw materials in the fruity tabletting for improving the uric acid metabolism of the human body are baked and subjected to wall breaking and powdering, the effective ingredients in the plant raw materials can be fully released, and the fruity tabletting is more beneficial to the absorption of the human body. The semen Cassiae, semen plantaginis, Coicis semen, herba Taraxaci, stigma Maydis, rhizoma Phragmitis, and semen Pruni in the fruit-flavored tablet for improving uric acid metabolism has effects of promoting urination and excretion, promoting blood uric acid discharge through urine, and promoting uric acid metabolism; the balsam pear, the perilla seed, the honeysuckle, the long pepper, the oligosaccharide and the chitin in the fruit-flavored tabletting for improving the uric acid metabolism of the human body can regulate the functions of gastrointestinal tracts and various organs and effectively inhibit gout-related complications; the fruit powder can adjust the taste of the fruit-flavored tabletting for improving the uric acid metabolism of the human body, and the food adhesive can promote the fruit-flavored tabletting for improving the uric acid metabolism of the human body to be formed.

The raw materials are easy to obtain, the preparation process is stable, and the prepared fruity tablet for improving the uric acid metabolism of the human body can effectively reduce the occurrence probability of gout and complications thereof, has no obvious side effect, and is suitable for long-term administration.

Detailed Description

The technical solutions of the present invention are described in detail below with reference to specific examples to facilitate understanding of the present invention, but the present invention is not limited thereto.

Example 1: a fruity tabletting for improving the uric acid metabolism of a human body is mainly prepared from the following raw materials in parts by weight: 6kg of cassia seed, 3kg of balsam pear, 5kg of plantain seed, 6kg of coix seed, 3kg of dandelion, 2kg of perilla seed, 6kg of corn stigma, 5kg of honeysuckle, 4kg of reed rhizome, 3kg of bunge cherry seed, 5kg of long pepper, 6kg of oligosaccharide, 4kg of chitin, 3kg of fruit powder and 2kg of food adhesive; the oligosaccharide is isomaltooligosaccharide; the food adhesive is edible gelatin.

The preparation method comprises the following steps:

(1) cleaning each plant raw material meeting the requirements for 2 times, and then dehydrating and drying each plant raw material;

(2) baking each plant raw material obtained in the step (1), and then crushing each plant raw material;

(3) mixing the plant raw materials obtained in the step (2), breaking the walls and preparing powder to obtain wall-broken powder with the fineness of 200 meshes;

(4) adding oligosaccharide, chitin, fruit powder and food adhesive into the wall-broken powder obtained in the step (3), and uniformly mixing to obtain a mixed material;

(5) and (4) tabletting, packaging and irradiating for sterilization of the mixed material obtained in the step (4).

Application test: (1) patient screening: screening to obtain three patients with hyperuricemia of male and female with age of 35-45 years; (2) the taking method comprises the following steps: randomly selecting two men and two women from the screened patients as test groups, taking the fruity tablet for improving the uric acid metabolism of the human body at 0.5g/kg, taking the fruity tablet twice a day half an hour after meals, and continuously taking the tablet for 60 days; the other screened patients served as a control group and were administered 0.5g/kg placebo tablets having the same appearance and taste as the fruit-flavored tablets for improving uric acid metabolism of the human body described in this example twice a day and half an hour after meals for 60 days continuously, and the placebo tablets were prepared by mixing, toning, seasoning and compressing starch, fruit powder and a food binder.

And (3) test results: respectively detecting the blood uric acid value, urine pH value and urine uric acid quantitative value of 24h 1 day before the patient takes the tablet, 15 days after the patient takes the tablet continuously, 30 days after the patient takes the tablet continuously and 60 days after the patient takes the tablet continuously; the specific detection results are as follows:

and (4) analyzing results: the blood uric acid value of a hyperuricemia patient continuously taking the fruity tabletting for improving the uric acid metabolism of the human body is continuously reduced, the pH value of urine is gradually increased, and the excretion of uric acid in the urine is obviously increased; while the indexes of the hyperuricemia patients of the control group do not have obvious change; after taking the tablet, no obvious side effect appears in each patient. The above results show that the fruity tablets for improving the uric acid metabolism of the human body can promote the uric acid metabolism of the human body, and the occurrence probability of gout and complications thereof can be effectively reduced after long-term administration.

Example 2: a fruity tabletting for improving the uric acid metabolism of a human body is mainly prepared from the following raw materials in parts by weight: 10kg of cassia seed, 5kg of balsam pear, 9kg of plantain seed, 8kg of coix seed, 7kg of dandelion, 4kg of perilla seed, 8kg of corn stigma, 7kg of honeysuckle, 8kg of reed rhizome, 5kg of bunge cherry seed, 6kg of long pepper, 9kg of oligosaccharide, 6kg of chitin, 5kg of fruit powder and 4kg of food adhesive; the specific weight ratio of the oligosaccharide is 4.5kg of isomaltooligosaccharide and 4.5kg of chitosan oligosaccharide; the food adhesive is glycerol.

The preparation method comprises the following steps:

(1) cleaning each plant raw material meeting the requirements for 3 times, and then dehydrating and drying each plant raw material;

(2) baking each plant raw material obtained in the step (1), and then crushing each plant raw material;

(3) mixing the plant raw materials obtained in the step (2), breaking the walls and preparing powder to obtain wall-broken powder with the fineness of 200 meshes;

(4) adding oligosaccharide, chitin, fruit powder and food adhesive into the wall-broken powder obtained in the step (3), and uniformly mixing to obtain a mixed material;

(5) and (4) tabletting, packaging and irradiating for sterilization of the mixed material obtained in the step (4).

Application test: (1) patient screening: screening to obtain three patients with hyperuricemia of male and female with age of 35-45 years; (2) the taking method comprises the following steps: randomly selecting two men and two women from the screened patients as test groups, taking the fruity tablet for improving the uric acid metabolism of the human body at 0.5g/kg, taking the fruity tablet twice a day half an hour after meals, and continuously taking the tablet for 60 days; the other screened patients served as a control group and were administered 0.5g/kg placebo tablets having the same appearance and taste as the fruit-flavored tablets for improving uric acid metabolism of the human body described in this example twice a day and half an hour after meals for 60 days continuously, and the placebo tablets were prepared by mixing, toning, seasoning and compressing starch, fruit powder and a food binder.

And (3) test results: respectively detecting the blood uric acid value, urine pH value and urine uric acid quantitative value of 24h 1 day before the patient takes the tablet, 15 days after the patient takes the tablet continuously, 30 days after the patient takes the tablet continuously and 60 days after the patient takes the tablet continuously; the specific detection results are as follows:

and (4) analyzing results: the blood uric acid value of a hyperuricemia patient continuously taking the fruity tabletting for improving the uric acid metabolism of the human body is continuously reduced, the pH value of urine is gradually increased, and the excretion of uric acid in the urine is obviously increased; while the indexes of the hyperuricemia patients of the control group do not have obvious change; after taking the tablet, no obvious side effect appears in each patient. The above results show that the fruity tablets for improving the uric acid metabolism of the human body can promote the uric acid metabolism of the human body, and the occurrence probability of gout and complications thereof can be effectively reduced after long-term administration.

Example 3: a fruity tabletting for improving the uric acid metabolism of a human body is mainly prepared from the following raw materials in parts by weight: 8kg of cassia seed, 4kg of balsam pear, 7kg of plantain seed, 7kg of coix seed, 5kg of dandelion, 3kg of perilla seed, 7kg of corn stigma, 6kg of honeysuckle, 6kg of reed rhizome, 4kg of bunge cherry seed, 5.5kg of long pepper, 7.5kg of oligosaccharide, 5kg of chitin, 4kg of fruit powder and 3kg of food adhesive; the oligosaccharide is chitosan oligosaccharide; the food adhesive is edible gelatin.

The preparation method comprises the following steps:

(1) cleaning each plant raw material meeting the requirements for 3 times, and then dehydrating and drying each plant raw material;

(2) baking each plant raw material obtained in the step (1), and then crushing each plant raw material;

(3) mixing the plant raw materials obtained in the step (2), breaking the walls and preparing powder to obtain wall-broken powder with the fineness of 200 meshes;

(4) adding oligosaccharide, chitin, fruit powder and food adhesive into the wall-broken powder obtained in the step (3), and uniformly mixing to obtain a mixed material;

(5) and (4) tabletting, packaging and irradiating for sterilization of the mixed material obtained in the step (4).

Application test: (1) patient screening: screening to obtain three patients with hyperuricemia of male and female with age of 35-45 years; (2) the taking method comprises the following steps: randomly selecting two men and two women from the screened patients as test groups, taking the fruity tablet for improving the uric acid metabolism of the human body at 0.5g/kg, taking the fruity tablet twice a day half an hour after meals, and continuously taking the tablet for 60 days; the other screened patients served as a control group and were administered 0.5g/kg placebo tablets having the same appearance and taste as the fruit-flavored tablets for improving uric acid metabolism of the human body described in this example twice a day and half an hour after meals for 60 days continuously, and the placebo tablets were prepared by mixing, toning, seasoning and compressing starch, fruit powder and a food binder.

And (3) test results: respectively detecting the blood uric acid value, urine pH value and urine uric acid quantitative value of 24h 1 day before the patient takes the tablet, 15 days after the patient takes the tablet continuously, 30 days after the patient takes the tablet continuously and 60 days after the patient takes the tablet continuously; the specific detection results are as follows:

and (4) analyzing results: the blood uric acid value of a hyperuricemia patient continuously taking the fruity tabletting for improving the uric acid metabolism of the human body is continuously reduced, the pH value of urine is gradually increased, and the excretion of uric acid in the urine is obviously increased; while the indexes of the hyperuricemia patients of the control group do not have obvious change; after taking the tablet, no obvious side effect appears in each patient. The above results show that the fruity tablets for improving the uric acid metabolism of the human body can promote the uric acid metabolism of the human body, and the occurrence probability of gout and complications thereof can be effectively reduced after long-term administration.

In the above embodiments, the best mode of the present invention has been described, and it is apparent that many changes can be made under the inventive concept of the present invention. It should be noted here that any changes made under the inventive concept of the present invention shall fall within the protective scope of the present invention.