阅读说明：本技术 一种预防脱发、减少头皮炎症及治疗前列腺炎症的药物 (Medicine for preventing alopecia, reducing scalp inflammation and treating prostatitis ) 是由 蔚晨歌 于 2021-08-27 设计创作，主要内容包括：本发明提供了一种预防脱发、减少头皮炎症及治疗前列腺炎症的药物,属于药物配方技术领域,由以下重量份的原料制备而成：初榨南瓜子油200-2000份,锯棕榈油100-800份,生育三烯酚50-500份,姜黄100-800份,类胡萝卜素维生素0.1-10份,维生素D3 0.005-0.1份,生物素0.1-5份,锌1-100份；本发明的药物,无毒副作用,可以预防脱发症状,减少头皮炎症,并可以治疗哺乳动物的前列腺炎症。(The invention provides a medicine for preventing alopecia, reducing scalp inflammation and treating prostatitis, which belongs to the technical field of medicine formulas and is prepared from the following raw materials in parts by weight: 200-2000 parts of virgin pumpkin seed oil, 800 parts of saw palm oil, 50-500 parts of tocotrienol, 800 parts of turmeric, 0.1-10 parts of carotenoid vitamin, 0.1-0.1 part of vitamin D30.005, 0.1-5 parts of biotin and 1-100 parts of zinc; the medicine of the present invention has no toxic side effect, can prevent alopecia symptoms, reduce scalp inflammation and treat mammal prostatitis.)

1. The medicine for preventing alopecia, reducing scalp inflammation and treating prostatitis is characterized by being prepared from the following raw materials in parts by weight:

200-2000 parts of virgin pumpkin seed oil, 800 parts of saw palm oil, 50-500 parts of tocotrienol, 800 parts of turmeric, 0.1-10 parts of carotenoid vitamin, 0.1-0.1 part of vitamin D30.005, 0.1-5 parts of biotin and 1-100 parts of zinc.

2. A dietary supplement or a medicament for preventing alopecia, reducing scalp inflammation and treating prostatitis is characterized by being prepared from the following raw materials in parts by weight:

1600 portions of virgin pumpkin seed oil, 600 portions of 200 portions of saw palm oil, 400 portions of tocotrienol, 600 portions of turmeric 200, 0.2-5 portions of carotenoid vitamin, 30.01-0.1 portion of vitamin D, 0.2-4 portions of biotin and 2-50 portions of zinc.

3. A dietary supplement or a medicament for preventing alopecia, reducing scalp inflammation and treating prostatitis is characterized by being prepared from the following raw materials in parts by weight:

800 portions of virgin pumpkin seed oil, 500 portions of saw palm oil, 350 portions of tocotrienol, 500 portions of turmeric, 0.5 to 3 portions of carotenoid vitamin, 30.01 to 0.05 portion of vitamin D, 0.4 to 3 portions of biotin and 5 to 20 portions of zinc.

Technical Field

The invention relates to the technical field of medicament formulas, in particular to a dietary supplement or medicament for preventing alopecia, reducing scalp inflammation and treating prostatitis.

Background

At present, the existing medicines have no obvious using effect on preventing alopecia and reducing scalp inflammation.

Disclosure of Invention

In view of the technical defects, the invention aims to provide a medicament for preventing alopecia, reducing scalp inflammation and treating prostatitis, which has no toxic or side effect, can prevent alopecia symptoms, reduce scalp inflammation and treat prostatitis of mammals.

In order to solve the technical problems, the invention adopts the following technical scheme:

the medicine for preventing alopecia, reducing scalp inflammation and treating prostatitis is characterized by being prepared from the following raw materials in parts by weight:

200-2000 parts of virgin pumpkin seed oil, 800 parts of saw palm oil, 50-500 parts of tocotrienol, 800 parts of turmeric, 0.1-10 parts of carotenoid vitamin, 0.1-0.1 part of vitamin D30.005, 0.1-5 parts of biotin and 1-100 parts of zinc.

Preferably, the feed additive is prepared from the following raw materials in parts by weight:

1600 portions of virgin pumpkin seed oil, 600 portions of 200 portions of saw palm oil, 400 portions of tocotrienol, 600 portions of turmeric 200, 0.2-5 portions of carotenoid vitamin, 30.01-0.1 portion of vitamin D, 0.2-4 portions of biotin and 2-50 portions of zinc.

Preferably, the feed additive is prepared from the following raw materials in parts by weight:

800 portions of virgin pumpkin seed oil, 500 portions of saw palm oil, 350 portions of tocotrienol, 500 portions of turmeric, 0.5 to 3 portions of carotenoid vitamin, 30.01 to 0.05 portion of vitamin D, 0.4 to 3 portions of biotin and 5 to 20 portions of zinc.

The invention has the beneficial effects that: the medicine of the present invention has no toxic side effect, can prevent alopecia symptoms, reduce scalp inflammation and treat mammal prostatitis.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

A medicine for preventing alopecia, reducing scalp inflammation and treating prostatitis is prepared from the following raw materials:

200-2000 parts of virgin pumpkin seed oil, 800 parts of saw palm oil, 50-500 parts of tocotrienol, 800 parts of turmeric, 0.1-10 parts of carotenoid vitamin, 0.1-0.1 part of vitamin D30.005, 0.1-5 parts of biotin and 1-100 parts of zinc.

Preferably, the feed additive is prepared from the following raw materials in parts by weight:

1600 portions of virgin pumpkin seed oil, 600 portions of 200 portions of saw palm oil, 400 portions of tocotrienol, 600 portions of turmeric 200, 0.2-5 portions of carotenoid vitamin, 30.01-0.1 portion of vitamin D, 0.2-4 portions of biotin and 2-50 portions of zinc.

Preferably, the feed additive is prepared from the following raw materials in parts by weight:

800 portions of virgin pumpkin seed oil, 500 portions of saw palm oil, 350 portions of tocotrienol, 500 portions of turmeric, 0.5 to 3 portions of carotenoid vitamin, 30.01 to 0.05 portion of vitamin D, 0.4 to 3 portions of biotin and 5 to 20 portions of zinc.

Supplementary explanation:

brief introduction to saw palm

Saw palmetto, a precious medicinal plant of the palmaceae family commonly found in the southeast united states, is saw palmetto (Serenoa repens), also known as lolium and sabal, and is distributed from south carolina, to south mississippi and louisiana, to the tropical and subtropical coastal sandy plains of florida and gulf of mexico.

Efficacy and Effect of saw palms

First, the hormone regulating the hormone change in the body is a very important part of our human body, and regulates the physiological function of the human body.

If the hormone in the body is unstable and becomes disturbed, undesirable phenomena occur.

The sawpalmetto has the effect of regulating the hormone change in vivo, can effectively prevent the hormone disorder phenomenon, can inhibit the hormone secretion for stimulating the prostatic hyperplasia and solves the problem of the prostatic hyperplasia.

And secondly, the Italian scientists research on maintaining the prostate health finds that the saw palmetto also has the effects of helping to maintain the prostate health and keeping the normal volume and function of the prostate, and also has the effects of relieving symptoms such as nocturia, frequent micturition, urgent micturition and the like, so that men are full of spirit and have confidence to burst.

The third effect is that the treatment of alopecia and alopecia is a phenomenon often seen in daily life, which is mostly seen in male friends, and the main reason of alopecia of the male friends is caused by DHT.

The application of saw palms can improve alopecia, because saw palms can prevent androgen and DHT from damaging hair follicle, thereby preventing alopecia.

And fourthly, the traditional Chinese medicine has the effect of treating male diseases, and a plurality of male friends suffer from the male diseases due to poor living habits and other reasons in real life, and the male friends can use the saw palms at this time.

Because saw palmetto has the function of preventing and improving male diseases such as cystitis, urethritis, prostatitis, and the like.

Pumpkin seeds are common, and when the melons are pedicled down in autumn, the pulp is taken out and dried, so that the pumpkin seeds can be eaten or used as medicines. Many people like to eat fried pumpkin seeds, so that the roasted pumpkin seeds are good to eat without excessive internal heat, and are common to eat, and especially the old and children eat the pumpkin seeds well. What are the effects and actions of pumpkin seeds? The bar will be understood from the following.

Efficacy of

Pumpkin is sweet in taste and warm in nature, enters spleen and stomach meridians; has effects in invigorating spleen, replenishing qi, relieving inflammation, relieving pain, removing toxic materials, killing parasite, lowering blood sugar, and quenching thirst; it can be used for treating qi deficiency, spleen and stomach weakness, short breath, listlessness, loose stool, diabetes, and ascariasis.

Function of

1. Detoxification:

contains vitamins and pectin, has good adsorbability, can bind and eliminate in vivo bacterial toxin and other harmful substances, such as lead, mercury and radioactive elements in heavy metal, and has effect of removing toxic substances;

2. protecting gastric mucosa and aiding digestion:

the pectin contained in fructus Cucurbitae Moschatae can protect gastric mucosa from rough food irritation, promote ulcer healing, and is suitable for patients with gastropathy. The pumpkin contains ingredients which can promote bile secretion, strengthen gastrointestinal peristalsis and help food digestion;

3. preventing and treating diabetes and reducing blood sugar:

the pumpkin contains rich cobalt, the cobalt can activate the metabolism of a human body, promote the hematopoietic function, participate in the synthesis of vitamin B12 in the human body, is a necessary microelement for islet cells of the human body, and has special curative effects on preventing and treating diabetes and reducing blood sugar;

4. elimination of carcinogenic substances:

the pumpkin can eliminate the mutation of a carcinogen nitrosamine, has the cancer prevention effect, can help the recovery of the functions of the liver and the kidney, and can enhance the regeneration capacity of liver and kidney cells;

5. promoting growth and development:

the pumpkin contains abundant zinc, participates in the synthesis of nucleic acid and protein in a human body, is an inherent component of adrenocortical hormone, and is an important substance for the growth and development of the human body.

Physiological function of tocotrienols

Despite the great similarity in structure between tocopherols and tocotrienols, there are significant differences in certain biological functions. With the progress of research, it has been found that tocotrienols have superior physiological functions to tocopherols in many reaction systems.

Antioxidant effect in folded living body

As a fat-soluble antioxidant, tocopherol exists mainly in cell membranes, and captures free radicals generated by lipid oxidation to play a certain antioxidation role. Mohd et al (2003) showed in vitro that TRF, a mixed fraction enriched in alpha-tocotrienols extracted from palm oil, is a better antioxidant than alpha-tocopherol and is effective in inhibiting LDL oxidation and endothelial cell lipid peroxidation. Studies by Serbinova et al (1991) showed that alpha-tocotrienol has much greater antioxidant activity than alpha-tocopherol and greater cytochrome P450 protecting activity than alpha-tocopherol during peroxidation of microsomal lipids in rat liver; tocotrienols can also protect rat hearts from oxidative damage. Rat experiments report that in liver microsomes, in lipid peroxidation induced by iron ions/ascorbate and iron ions/NADPH, the antioxidant activity of alpha-tocotrienol is 40-60 times that of alpha-tocopherol. Alpha-tocotrienol is more effective at scavenging free radicals from lipid cell membranes.

Kamat et al (1995) examined the oxidation resistance of TRF and alpha-tocopherol by oxidizing lipids and proteins in mitochondria of rat brain cells respectively using systems such as radical generators (AAPH +), ascorbic acid-Fe, and methylene blue, and the results showed that the oxidation resistance of the former is concentration and time dependent and has more excellent oxidation resistance than the latter. Therefore, TRF can be used as a natural antioxidant to prevent brain tissue from being oxidized. Further studies have found that gamma-tocotrienol may have better antioxidant properties than alpha-tocotrienol, but the exact mechanism is not currently well understood.

Folding cholesterol-lowering synthesis

A number of epidemiological data have suggested that tocotrienols have been effective in reducing cardiovascular disease, and several clinical trials have supported this recognition. Asaf et al (2002) supplemented 90 hypercholesterolemic people with different gradients of TRF25, 25, 50, 100, 200mg/d, respectively, found that supplementation with 100mg/d of TRF25 was most effective in reducing total cholesterol, LDL-cholesterol, apolipoprotein B (apoB) and triglycerides by 20%, 25%, 14% (P <0.05) and 12%, respectively, while HDL-cholesterol and lipoprotein A1 levels were increased by 19% and 14% (P <0.05), respectively, effectively controlling the occurrence of coronary heart disease in these hypercholesterolemic people. Research shows that tocotrienols inhibit the catalytic biosynthesis of cholesterol in the liver through a post-transcriptional regulatory mechanism

The enzyme HMG-CoA reductase (hydroxymethylglutaryl-CoA reductase) effectively reduces LDL-cholesterol and total cholesterol levels in serum while alpha-tocopherol has the opposite effect, which induces the activation of the enzyme. However, in vivo, tocotrienols can be converted to tocopherols, so dosage should be tightly controlled otherwise adverse effects occur.

More researches have recently reported that tocotrienols have a more significant serum cholesterol reducing effect. There is a report of a 13% reduction in total cholesterol after AHA restriction within 8 weeks following 4 weeks of gamma-tocotrienol administration.

Fold-induced gene expression

Tocotrienols enhancing expression of the IKBKAP gene may be an effective way to treat familial autonomic dysfunction (FD). FD is a neurodegenerative genetic disease, mainly caused by mutation of IKBKAP gene, which encodes expression of IKAP (IKB kinase complex-associated protein). The IKBKAP gene mutation results in aberrant splicing of IKAP, such that an IKAP mutant is present in the tissue. Sylvia et al (2003) have found that tocotrienols enhance the correct expression of the IKBKAP gene in FD cells by preregistic regulation, thereby promoting the correct splicing of IKAP and the formation of normal IKAP, whereas tocopherols do not.

Folding nerve protection function

Previous studies have generally accepted that alpha-tocotrienol does not reach the brain. Recent studies have shown that alpha-tocotrienol passes placental barriers more efficiently and alpha-tocotrienol reaches the brain than alpha-tocopherol. Sashwai Roy et al (2002) studied the effect of vitamin E on the development of the brain of a rat fetus using gene chip technology. Experimental results showed that the level of alpha-tocopherol in the brain of the fetus is approximately 1/2 for its mother; in the group with tocotrienols, the level of alpha-tocotrienol in the brain of the fetus was significantly higher than that of the mother (Figure 3). And the gene chip technology is adopted for analysis, and the alpha-tocotrienol mainly regulates and controls the development of the fetal brain relative to the development of the brain of the pregnant rat, so that the normal structure and function of the brain nervous tissue are ensured.

In addition, α -tocotrienols inhibit glutamate-induced signal transduction responses, which can ultimately lead to neurodegeneration in the body, whereas tocopherols do not.

Folded anticancer and antitumor Properties

Numerous studies have shown that tocotrienols inhibit the growth of human, mouse and rat tumor cells. It can inhibit the growth of cancer cells regulated by hormones, such as the proliferation of human breast cancer cells by inhibiting the secretion of estrogen, while the effect of tocopherol in this respect is less pronounced. The role of tocotrienols in cell proliferation suggests that it has important practical significance in the prevention and treatment of cancer. However, the exact mechanism of action of tocotrienols against cell proliferation is not well understood and is currently believed to be likely related to their structure. In the mevalonate biosynthetic pathway, the foreign diene side chain of tocotrienols is involved in the formation of isoprenoid intermediates. These intermediates are involved in some signal transduction such as prenylation of Ras protein, which is essential for normal cell growth, so that tocotrienols competitively inhibit mevalonate biosynthesis and thus have an effect on preventing or treating cancer. However, the prevention or treatment of human tumor formation by tocotrienols is still controversial, and no specific clinical report is found.

Folding editing of the mechanism of action

Mechanism of action of tocotrienols

Folding antioxidant Properties

Vitamin E is an important antioxidant, and this property is mainly directly related to the phenolic group on the benzo-monohydropyran ring. Tocotrienols scavenge free radicals and inhibit the production of hydrogen peroxide and alkoxy groups during lipid peroxidation. Further research shows that the more excellent antioxidant function of alpha-tocotrienol may be related to its structural characteristics. Firstly, under the action of a reducing agent, alpha-tocotrienol molecules can be effectively reduced; secondly, alpha-tocotrienol can be uniformly distributed in the lipid layer of the cell membrane; thirdly, because alpha-tocotrienol can be well dissolved in membrane lipids, the structure of the cell membrane lipids is disordered, and thus the interaction of the alpha-tocotrienol and free radicals in the lipids is more facilitated.

In conclusion, in vitro tests all prove that the tocotrienol has excellent antioxidant property and can effectively inhibit the oxidation of LDL in vivo, which has important significance clinically. Serbinova et al demonstrated that tocotrienols could protect mouse heart from oxidative damage due to ischemia.

Folding cholesterol-lowering

The molecular mechanism of tocotrienols to lower cholesterol is related to their unique side chain structure. The side chains of tocotrienols increase the amount of farnesesol, a metabolic intermediate that promotes the degradation of HMGR (HMG-COA reductase) by proteases (Figure 2). In vitro experiments show that the inhibition of HMGR activity by tocotrienols is not only directly related to its side chain structure, but also to the groups on the ring. Gamma-tocotrienol and delta-tocotrienol lack the 5' -methyl group but also inhibit the activity of HMGR and are superior to alpha-tocotrienol.

Folding-reduced apolipoprotein B

Apolipoprotein b (apob) is a constituent of LDL, which, if present in the plasma, can lead to the development of coronary heart disease and atherosclerosis. Epidemiological studies indicate that tocotrienols can significantly reduce apoB levels in plasma by 10-15%. Tocotrienols may make LDL more susceptible to apoB binding by preregistically regulating the expression of LDL receptors in the liver, while they may also have the effect of accelerating the clearance of LDL-apoB binding in the blood, and ultimately, the reduction of apoB levels in plasma. In addition, it has been reported that tocotrienols can promote intracellular protease degradation of apoB and alter VLDL assembly. In summary, the ability of tocotrienols to reduce apoB is largely dependent on LDL clearance rate and VLDL production rate.

Lipoprotein (a) -lp (a) reduction

The amount of lp (a) is somewhat directly related to cardiovascular disease, and is a lipoprotein present in plasma, formed by the association of apoB and apo (a) by disulfide bonds, and has a structure similar to LDL. An increase in lp (a) in plasma can also lead to atherosclerosis. Lp (a) can inhibit the activation of plasma zymogens, leading to thrombosis. It is difficult to reduce the plasma level of lp (a) by conventional drugs or dietary adjustments, because the expression of lp (a) is mainly genotype-controlled. However, tocotrienols have a unique effect in this respect, reducing lp (a) levels by 17%, but the detailed mechanism of action is not clear.

Anti-fibrous plaque formation

Tocotrienols can reduce the synthesis of eicosanoids such as thromboxane B2, and act by a mechanism similar to that of tocopherol. Phospholipase A2 can promote release of eicosanoids, which can make platelets adhere and aggregate, and tocotrienol can inhibit activity of phospholipase A2 and inhibit vascular occlusion, thereby preventing diseases such as atherosclerosis, but the exact mechanism of the phospholipase A2 is not yet determined.

Folding inhibits monocyte adhesion

Adhesion of monocytes to the vascular endothelium can lead to atherosclerosis. Recent studies have shown that alpha-tocotrienol inhibits the expression of adhesion molecules and that its properties of inhibiting monocyte adhesion are superior to those of tocopherol. Thus, tocotrienols can be used to prevent or treat atherogenesis. The university of wisconsin (usa) has studied the relationship between tocotrienols and cardiovascular disease (CVD) in humans. It was shown that tocotrienol supplementation can lower cholesterol, LDL-cholesterol, apolipoprotein B and lipoproteins (a). At the same time, the plasma levels of thromboxane B2 and platelet factor 4 were also reduced, indicating that tocotrienols have antithrombotic and platelet aggregation-reducing effects.

Folding editing book section bar

In recent years, tocotrienols have become one of the hot spots of foreign research, and more researches show that tocotrienols have unique physiological functions in the aspects of oxidation resistance, cholesterol reduction, cancer inhibition and the like, and have more excellent physiological functions than tocopherols in certain aspects, which shows that tocotrienols have important values in the aspects of medical and health-care food applications such as prevention and treatment of cardiovascular diseases, prevention of cancer and the like, but also have divergence. Since vitamin E has synergistic effect with selenium and vitamin C, when researching action mechanism and physiological effect of different vitamin E in inhibiting cholesterol synthesis and cell proliferation, etc., synergistic effect of other related factors (such as selenium and vitamin C, etc.) should be considered. In addition, it has been found that tocotrienols have these properties limited to certain tissues, but the exact mechanisms associated therewith are currently poorly understood and further studies are needed.

(Curcuma longa)

Rhizoma Curcumae Longae is also named as BAOTANGXIANG and HUANGJIANG, and has bitter taste; pungent taste; warm in nature, entering spleen meridian; the liver meridian. Can break blood and promote qi circulation; induce menstruation to relieve menalgia. In the following, I see the specific effects, actions and contraindications of turmeric. 1 Huang Longjin, having the actions of warming and resolving stagnation, enters blood system and qi system, excels at alleviating pain, and is good at treating qi stagnation and blood stasis, stabbing pain in chest and hypochondrium, obstruction of qi in the chest and heart pain, dysmenorrhea and amenorrhea, abdominal mass and traumatic injury with swelling pain. 2, Curcuma rhizome, rhizoma Curcumae Longae, being pungent and warm in nature and bitter in flavor, can dispel wind-cold-dampness, move qi and blood internally, dredge meridians and alleviate pain. It is especially good at moving limbs and limbs to relieve arthralgia. It is often combined with wind-damp-dispelling and blood-activating herbs, such as Qiang Huo, Fang Feng and Dang Gui, etc. Cholagogic 3 turmeric decoction and infusion can increase bile secretion of dogs, restore bile components to normal, increase gallbladder contraction, have weak and lasting effect and can last for 1-2 hours. Experiment: curcumin or its sodium salt has choleretic effect, and can be administered to dog by intravenous injection to reduce solid content and increase bile secretion, but in terms of total absolute value, the secretion of bile salt, bilirubin and cholesterol is increased, and fatty acid content is kept constant. The antibacterial and anti-inflammatory 4 curcumin and the volatile oil have good antibacterial effect on staphylococcus aureus. The turmeric water infusion has different degrees of inhibition effects on various dermatophytes in test tubes. Experiment: the decoction can prolong the survival time of virus-inoculated mice, but is ineffective to the liver injury caused by adding chemical (carbon tetrachloride) on the basis of viral hepatitis graves. In addition, turmeric preparations are fly-killing. The volatile oil and curcumin have significant anti-inflammatory effect on acute and subacute swelling inflammation of feet of rats and mice. The decoction has analgesic effect.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.