阅读说明：本技术 一种用于改善口罩过敏性的蚕丝蛋白功能层及其制备方法 (Fibroin functional layer for improving mask allergy and preparation method thereof ) 是由 盛卫琴 于 2020-06-03 设计创作，主要内容包括：本发明公开了一种用于改善口罩过敏性的蚕丝蛋白功能层及其制备方法,属于卫生用品材料制备技术领域。制备方法包括：1)通过常规脱胶方法制备蚕丝蛋白溶液；2)将蚕丝蛋白溶液置于一定温度下进行温度处理；3)将温度处理后的蚕丝蛋白溶液和交联剂、醇混匀；4)将步骤3的混合溶液涂布在相应模具上,进行冷冻干燥；5)对干燥后的蚕丝蛋白材料进行处理,得到相应的蚕丝蛋白功能层。该蚕丝蛋白功能层具有良好的生物相容性外,还具有非常好的吸湿、透气性、可降解性,是一种理想的防过敏口罩功能层材料。(The invention discloses a fibroin functional layer for improving the allergy of a mask and a preparation method thereof, and belongs to the technical field of preparation of sanitary product materials. The preparation method comprises the following steps: 1) preparing a fibroin solution by a conventional degumming method; 2) placing the fibroin solution at a certain temperature for temperature treatment; 3) uniformly mixing the fibroin solution subjected to temperature treatment with a cross-linking agent and alcohol; 4) coating the mixed solution obtained in the step (3) on a corresponding mould, and freeze-drying; 5) and processing the dried fibroin material to obtain a corresponding fibroin functional layer. The fibroin functional layer has good biocompatibility, good moisture absorption, air permeability and degradability, and is an ideal allergy-free mask functional layer material.)

1. A preparation method of a fibroin functional layer for improving the allergy of a mask is disclosed, wherein the fibroin functional layer is prepared from fibroin, and is characterized by comprising the following steps:

1) degumming silk by a conventional degumming method to prepare a fibroin solution;

2) placing the fibroin solution at a certain temperature for temperature treatment;

3) uniformly mixing the fibroin solution subjected to temperature treatment with a cross-linking agent and alcohol;

4) coating the mixed solution obtained in the step (3) on a corresponding mould, and freeze-drying;

5) and (3) carrying out curing treatment on the dried fibroin material to obtain a corresponding fibroin functional layer.

2. The silk protein functional layer for improving allergy of a mask and the preparation method thereof according to claim 1, wherein the silk protein solution obtained in the step 1) has a concentration of 0.05-20%.

3. The silk protein functional layer for improving the allergy of the mask and the preparation method thereof according to claim 1, wherein the silk protein solution of step 2) is treated at a temperature of 40-90 ℃.

4. The functional fibroin layer for improving allergy of a mask and the preparation method thereof according to claim 1, wherein the cross-linking agent in step 3) is one or a mixture of alginate and starch.

5. The functional fibroin layer for improving mask allergy according to claim 1, wherein the alcohol in step 3) is one or a mixture of two or more of ethylene glycol, glycerol and tert-butyl alcohol.

6. The fibroin functional layer for improving the allergy of the mask and the preparation method thereof according to claim 1, wherein the mass ratio of the fibroin, the alcohol and the cross-linking agent aqueous solution in the step 3) is 1 (0.2-15): (10-30).

7. The silk protein functional layer for improving allergy of a mask and the preparation method thereof according to claim 1, wherein the freeze-drying time in the step 4) is 40-80 hours.

8. The silk protein functional layer for improving the allergy of the mask and the preparation method thereof according to claim 1, wherein the silk protein curing treatment time in the step 5) is 20-100 hours.

9. The chitosan porous functional layer of the dustproof and bacteriostatic mask prepared according to any of the preparation methods of claims 1 to 8, wherein the thickness of the functional layer material is 0.5 to 5 mm, the pore diameter is 150 to 400 μm, and the porosity is 85% or more.

Technical Field

The invention belongs to the field of preparation of sanitary product materials, and particularly relates to a fibroin functional layer for improving mask allergy and a preparation method thereof.

Background

Coronaviruses are a large family of viruses known to cause the common cold and more serious diseases such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). The novel coronavirus which is outbreak in 2019 is a novel strain of coronavirus which has never been found in human bodies before, and can cause respiratory symptoms, fever, cough, shortness of breath, dyspnea and even death of infected persons. 12/1/2020 was named 2019-nCoV by the world health organization, and 11/2/2020 was named SARS-CoV-2 by the International Committee for Classification of viruses.

For people, when epidemic situation is prevented, it is a basic requirement that protective tools are worn for self protection and trip, and protective articles such as masks and the like are out of stock once. Meanwhile, the epidemic situation improves the hygiene habits of people, and people can keep the habit of wearing the mask in public places for a long time, so that the development of the high-quality protective mask has wide application prospect and has very important significance for the current healthy life of people all over the world and even the future.

Although various different types of protective masks exist in the market, the mainstream products in the market still have the defects of poor air permeability and moisture permeability and the like. In this epidemic situation, a large amount of medical workers are exposed to the shortcomings of the existing protective products due to the fact that protective equipment is worn for a long time: poor air and moisture permeability and no skin affinity. Therefore, in order to better solve the problems, the fibroin which is rich in source and relatively low in price is adopted as a raw material, the fibroin nanofiber is formed by a self-assembly regulation and control technology, and then the anti-allergic fibroin mask functional layer is prepared.

The silk is natural protein fiber, contains 18 amino acids, wherein leucine can accelerate metabolism of cells, serine and threonine can delay skin aging, and tryptophan and tyrosine can absorb ultraviolet rays, so that various excellent functions of silk fibroin are transferred to the fiber for taking in the way of facing to human bodies, the skin of the human bodies is cared, the human bodies have healthy skin, and the concept of green consumption of the human bodies in the new century is met.

Disclosure of Invention

Aiming at the problems in the prior art, the invention aims to provide a fibroin functional layer for improving the allergy of a mask and a preparation method thereof, and the steps are as follows:

1) degumming silk by a conventional degumming method to prepare a fibroin solution;

2) placing the fibroin solution at a certain temperature for temperature treatment;

3) uniformly mixing the fibroin solution subjected to temperature treatment with a cross-linking agent and alcohol;

4) coating the mixed solution obtained in the step (3) on a corresponding mould, and freeze-drying;

5) and (3) carrying out curing treatment on the dried fibroin material to obtain a corresponding fibroin functional layer.

Preferably, the concentration of the silk protein solution obtained in the step 2) is 0.05% -20%.

Preferably, the treatment temperature of the fibroin solution in the step 2) is 40-90 ℃.

Preferably, the cross-linking agent in step 3) is one or a mixture of alginate and starch.

Preferably, the alcohol in step 3) is one or a mixture of more than two of ethylene glycol, glycerol and tert-butyl alcohol.

Preferably, the mass ratio of the fibroin, the alcohol and the cross-linking agent aqueous solution in the step 3) is 1 (0.2-15): (10-30).

Preferably, the freeze-drying time in the step 4) is 40-80 hours.

Preferably, the curing treatment time of the fibroin in the step 5) is 20-100 hours.

The anti-allergic fibroin porous functional layer prepared by the preparation method has the thickness of 0.5-5 mm, the pore diameter of 150-400 mu m and the porosity of more than 85 percent

The invention designs the mask functional layer material which takes fibroin as the raw material and has good moisture absorption, ventilation and bacteriostasis properties, and the mask functional layer material at least has the following advantages:

1) the fibroin porous material has uniform microstructure and high porosity, and more importantly, the design of the material greatly improves the moisture absorption and air permeability of the mask, so that the aim of improving the allergy of the mask is fulfilled.

2) The process has good controllability of raw materials and preparation, good degradability of the fibroin and meets the requirements of green and environmental protection in China.

Drawings

Fig. 1 is an atomic force microscope image of the fibroin fiber solution prepared in example 1.

Fig. 2 is a microscopic structure view of the fibroin porous functional layer prepared in example 2.

Detailed Description

The invention will be further explained with reference to the drawings.