阅读说明：本技术 一种带有汗液集取结构的贴纸式汗液传感器 (Paper-pasted sweat sensor with sweat collection and collection structure ) 是由 王洋洋 胡雨涵 咸婉婷 刘继江 宋成君 徐冬 于 2020-04-22 设计创作，主要内容包括：一种带有汗液集取结构的贴纸式汗液传感器,涉及一种汗液传感器。目的是解决现有汗液传感器存在汗液样品的蒸发和污染的问题。本发明传感器由汗液采集层和防水保护膜层构成,汗液采集层上表面中心的微腔室四周呈辐射状设置有数条与其连通的微流体通道,微流体通道的凹槽底部均与设置有贯通汗液采集层的毛细孔；微腔室中心设置有检测电极,检测电极中工作电极上表面设置有选择性敏感膜。本发明传感器使用时贴于皮肤表面,毛细孔、微流体通道和微腔室利用毛细现象实现对汗液的采集、输送和富集,检测需要样品量少；防水保护膜层可以有效避免汗液样品的蒸发与污染；传感器具有柔性、实时性、可穿戴、易集成、无创检测的优点。(A paper-pasted sweat sensor with a sweat collecting and taking structure relates to a sweat sensor. The sweat sensor aims to solve the problems of evaporation and pollution of a sweat sample in the existing sweat sensor. The sensor consists of a sweat collection layer and a waterproof protective film layer, wherein a plurality of micro-fluid channels communicated with a micro-chamber are radially arranged around the micro-chamber at the center of the upper surface of the sweat collection layer, and the bottoms of grooves of the micro-fluid channels are provided with capillary holes penetrating through the sweat collection layer; the center of the micro-chamber is provided with a detection electrode, and the upper surface of the working electrode in the detection electrode is provided with a selective sensitive film. When the sensor is used, the sensor is attached to the surface of skin, the pores, the microfluidic channel and the micro-chamber realize the collection, the transportation and the enrichment of sweat by utilizing the capillary phenomenon, and the amount of a sample required for detection is small; the waterproof protective film layer can effectively avoid evaporation and pollution of a sweat sample; the sensor has the advantages of flexibility, real-time performance, wearing, easy integration and non-invasive detection.)

1. The utility model provides a sticker formula sweat sensor with structure is got to sweat collection which characterized in that: the paper-attached sweat sensor with the sweat collecting structure comprises a sweat collecting layer (1) and a waterproof protective film layer (10), wherein the sweat collecting layer (1) is a polyimide double-sided adhesive tape, and the waterproof protective film layer (10) covers the upper surface of the sweat collecting layer (1);

the sweat collection layer is characterized in that a micro chamber (2) is arranged in the center of the upper surface of the sweat collection layer (1), the micro chamber (2) is a circular groove, a plurality of micro fluid channels (5) are radially arranged on the periphery of the micro chamber (2), the micro fluid channels (5) are snake-shaped grooves, each micro fluid channel (5) is communicated with the micro chamber (2), and capillary holes (6) penetrating through the sweat collection layer (1) are formed in the bottom of each groove of each micro fluid channel (5); the center of the micro-chamber (2) is provided with a detection electrode, the upper surface of a working electrode in the detection electrode is provided with a selective sensitive film (9), and each electrode in the detection electrode is provided with a signal outgoing line on the upper surface of the sweat collection layer (1).

2. The taped sweat sensor with a sweat collection structure of claim 1, wherein:

the detection electrode is a two-electrode system formed by the working electrode (3) and the counter electrode (4), or the detection electrode is a three-electrode system formed by the working electrode (3), the counter electrode (4) and the reference electrode.

3. The taped sweat sensor with a sweat collection structure of claim 1, wherein:

the sweat collection layer (1) is 90-110 microns thick and 0.5-1 cm in area²。

4. The taped sweat sensor with a sweat collection structure of claim 1, wherein:

the volume of the micro chamber (2) is 10-100 mu l, the groove width of the micro fluid channel (5) is 10-100 mu m, the depth is 10-50 mu m, and the diameter of the capillary hole (6) is 5-20 mu m.

5. The taped sweat sensor with a sweat collection structure of claim 1, wherein:

the thickness of the selective sensitive film (9) is 5-10 mu m.

6. The taped sweat sensor with a sweat collection structure of claim 1, wherein:

the thickness of the waterproof protective film layer (10) is 5-10 mu m, and the material is polyimide.

7. The taped sweat sensor with a sweat collection structure of claim 1, wherein:

the electrodes in the detection electrodes are one or more of interdigital electrodes, circular ring electrodes and disk electrodes.

8. The taped sweat sensor with a sweat collection structure of claim 1, wherein:

the detection electrode is a Pt electrode, an Au electrode, an Ag electrode, a C electrode or an Ag/Pd electrode.

9. The taped sweat sensor with a sweat collection structure of claim 1, wherein:

the selective sensitive membrane (9) is a biological sensitive membrane or an ion exchange membrane.

Technical Field

The present invention relates to a sweat sensor.

Background

With the rapid development of the field of flexible intelligent wearable sensing, home-based medical diagnosis gradually enters our lives, and numerous wearable devices such as intelligent clothes, intelligent patches, electronic tattoos and the like are all dedicated to realizing efficient real-time human health management. Compared with physical signals such as heartbeat respiration and the like, the sweat contains complex biomolecule information which is closely related to human health, and meanwhile, the sweat becomes a potential development target of a human body biochemical sensor due to the advantages of continuous secretion, non-invasive collection, stable microenvironment and the like.

The analysis to sweat composition is mostly large-scale analytical equipment in general, and large-scale analytical equipment is not only bulky, and the price is high moreover, can not dress. The sweat sensor's rise provides probably for wearable equipment, but at present the sweat sensor is mostly laboratory principle research stage, and sample mode, sensor wearing mode scheduling problem are still being researched, and the evaporation of sweat sample and the problem of pollution also have not been solved, therefore the practicality is relatively poor.

Disclosure of Invention

The invention provides a paper-pasted sweat sensor with a sweat collection structure, which aims to solve the problems of evaporation and pollution of a sweat sample in the conventional sweat sensor.

The paper-pasted sweat sensor with the sweat collecting structure comprises a sweat collecting layer and a waterproof protective film layer, wherein the sweat collecting layer is a polyimide double-sided adhesive tape, and the waterproof protective film layer covers the upper surface of the sweat collecting layer;

the center of the upper surface of the sweat collection layer is provided with a micro chamber which is a circular groove, a plurality of micro fluid channels are radially arranged around the micro chamber, the micro fluid channels are snake-shaped grooves, each micro fluid channel is communicated with the micro chamber, and the bottom of each groove of each micro fluid channel is provided with a capillary hole penetrating through the sweat collection layer; the center of the micro-chamber is provided with a detection electrode, the upper surface of a working electrode in the detection electrode is provided with a selective sensitive film, and each electrode in the detection electrode is provided with a signal outgoing line on the upper surface of the sweat collection layer.

The principle and the beneficial effects of the invention are as follows:

when the paper-pasted sweat sensor with the sweat collection structure is used, the paper-pasted sweat sensor is pasted on the surface of skin, the capillary hole, the micro-fluid channel and the micro-cavity realize the collection, the transportation and the enrichment of sweat by utilizing the capillary phenomenon, and the quantity of samples required for detection is small; the detection electrode and the signal outgoing line are used for signal detection and output; the selective sensitive membrane is used for selectively identifying sweat components; the waterproof protective film layer is used for protecting the internal structure of the sensor, so that evaporation and pollution of a sweat sample can be effectively avoided;

compared with large-scale analysis equipment, the sensor has the advantages of flexibility, real-time performance, wearability, easy integration and noninvasive detection, and provides possibility for real-time, prospective and customized medical health management.

Drawings

FIG. 1 is a schematic structural view of a paper-backed sweat sensor with a sweat collection structure according to example 1; in the figure, 11 is a connecting wire between the working electrode signal outgoing wire 7 and the signal processing circuit, and 12 is a connecting wire between the counter electrode signal outgoing wire 8 and the signal processing circuit;

FIG. 2 is a schematic structural view of a sweat acquisition layer 1;

FIG. 3 is a cross-sectional view at A-A of the sweat acquisition layer 1;

FIG. 4 is an enlarged view of the capillary hole 6 of FIG. 3;

FIG. 5 is a graph showing the response of the sensor of example 1 to NaCl solutions of different concentrations.

Detailed Description

The technical scheme of the invention is not limited to the specific embodiments listed below, and any reasonable combination of the specific embodiments is included.