阅读说明：本技术 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法 (19-nor C3, 3-disubstituted C21-N-pyrazolylsterols and methods of use thereof ) 是由 G.M.博特拉 B.L.哈里森 A.J.罗比肖 F.G.萨里图罗 R.T.贝雷西斯 于 2014-04-17 设计创作，主要内容包括：本发明提供了式(I)的19-去甲C3,3-二取代的C21-吡唑基类固醇,及其可药用盐；其中,、R～(1)、R～(2)、R～(3a)、R～(3b)、R～(4a)、R～(4b)、R～(5)、R～(6)和R～(7)如本文所定义。该化合物可用于预防和治疗各种CNS相关的病症,例如,治疗睡眠障碍、心境障碍、精神分裂症谱系障碍、痉挛性障碍、记忆障碍和/或认知障碍、运动障碍、人格障碍、自闭症谱系障碍、疼痛、外伤性脑损伤、血管疾病、物质滥用障碍和/或戒断综合征和耳鸣。(The present invention provides 19-nor-C3, 3-disubstituted C21-pyrazolylsterols of formula (I) and pharmaceutically acceptable salts thereof; wherein the content of the first and second substances, 、R 1 、R 2 、R 3a 、R 3b 、R 4a 、R 4b 、R 5 、R 6 and R 7 As defined herein. The compounds are useful for the prevention and treatment of various CNS-related disorders, for example, the treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, spastic disorders, memory disorders and/or cognitive disorders, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndrome and tinnitus.)