阅读说明：本技术 一种阳离子聚合物抗病毒材料及其制备方法和应用 (Cationic polymer antiviral material and preparation method and application thereof ) 是由 徐福建 段顺 胡杨 于 2020-05-18 设计创作，主要内容包括：本发明公开了一种阳离子聚合物抗病毒材料的制备方法,将多氨基聚合物与长烷基链卤代烷烃反应,将氨基聚合物的部分氨基转化为长烷基链季铵基团,所述长烷基链卤代烷烃的碳原子数为9～28,多氨基聚合物上氨基与长烷基链卤代烷烃的摩尔投料比为1:0.03～12。本发明的多氨基聚合物通过与长烷基链卤代烷烃的季铵盐化反应,将部分氨基转化为长烷基季铵盐基团,可以实现对病毒颗粒的有效粘附,并通过正电性电荷/疏水长烷基链对病毒颗粒进行杀伤。(The invention discloses a preparation method of a cationic polymer antiviral material, which comprises the steps of reacting a polyamino polymer with long alkyl chain halogenated alkane, converting part of amino groups of the amino polymer into long alkyl chain quaternary ammonium groups, wherein the number of carbon atoms of the long alkyl chain halogenated alkane is 9-28, and the molar charge ratio of the amino groups on the polyamino polymer to the long alkyl chain halogenated alkane is 1: 0.03-12. The polyamino polymer of the invention converts part of amino groups into long alkyl quaternary ammonium salt groups through quaternary salinization reaction with long alkyl chain halogenated alkane, can realize effective adhesion to virus particles, and kills the virus particles through electropositive charge/hydrophobic long alkyl chain.)

1. A method for preparing a cationic polymer antiviral material is characterized in that: reacting the polyamino polymer with long alkyl chain halogenated hydrocarbon, and converting partial amino groups of the amino polymer into long alkyl chain quaternary ammonium groups, wherein the number of carbon atoms of the long alkyl chain halogenated hydrocarbon is 9-28, and the molar charge ratio of the amino groups on the polyamino polymer to the long alkyl chain halogenated hydrocarbon is 1: 0.03-12.

2. The method for preparing a cationic polymer antiviral material according to claim 1, wherein: the molecular weight of the polyamino polymer is 3000-150000 daltons.

3. The method for preparing a cationic polymer antiviral material according to claim 1, wherein: the amino group of the polyamino polymer is one or more of primary amine, secondary amine and tertiary amine; the polyamino polymer has a molecular weight of 4500-.

4. The method for preparing a cationic polymer antiviral material according to claim 1, wherein: the polyamino polymer is poly-2- (dimethylamino) ethyl methacrylate, poly-2- (diethylamino) ethyl acrylate, polyethyleneimine or dendritic polyamidoamine, and the molecular weight of the polyamino polymer is 7000-90000 daltons.

5. The method for preparing a cationic polymer antiviral material according to claim 1, wherein: the halogenated alkane with the long alkyl chain is brominated, chlorinated or iodoalkane with 10-24 carbon atoms.

6. The method for preparing a cationic polymer antiviral material according to claim 1, wherein: the molar charge ratio of the amino on the polyamino polymer to the long alkyl chain halogenated alkane is 1: 0.06 to 10.

7. A cationic polymeric antiviral material produced according to the process of any one of claims 1 to 6.

8. Use of a cationic polymeric antiviral material according to claim 7 in the manufacture of an antiviral agent, wherein said agent is capable of killing or inhibiting enveloped viruses such as coronavirus, influenza virus, measles virus and adenovirus, rhinovirus or reovirus.

Technical Field

The invention belongs to the field of biomedical materials, and relates to a cationic polymer antiviral material, and a preparation method and application thereof.

Background

Particularly, compared with the development of clinical antiviral drugs and vaccines, the safe and efficient antiviral material in daily life is more important for killing, inhibiting and preventing daily-life virus infection. The existing broad-spectrum effective antiviral materials (preparations) are alcohol disinfectants, 84 disinfectants and chlorine disinfectants, but have obvious defects of safety and convenience (flammability, pungent smell, ventilation and the like). Currently, a lot of antibacterial agents of cationic materials are researched, but common cationic antibacterial agents such as benzalkonium chloride and cetrimide have been proved by research to be incapable of killing viruses such as new coronavirus in a broad spectrum due to the difference of virus and bacterium structures. Therefore, there is a need for a new cationic antibacterial agent that can effectively kill and inhibit viruses, and can be safely and conveniently applied to killing, inhibiting and preventing viral infections in daily life and medical environments.

Disclosure of Invention

In view of the above, the present invention provides a cationic polymer antiviral material, and a preparation method and an application thereof.

The invention specifically provides the following technical scheme:

1. the preparation method of the cationic polymer antiviral material comprises the steps of reacting a polyamino polymer with long alkyl chain halogenated alkane to convert part of amino groups of the amino polymer into long alkyl chain quaternary ammonium groups, wherein the number of carbon atoms of the long alkyl chain halogenated alkane is 9-28, and the molar feeding ratio of the amino groups on the polyamino polymer to the long alkyl chain halogenated alkane is 1: 0.03-12.

Further, the polyamino polymer has a molecular weight of 3000-150000 daltons.

Further, the amino group of the polyamino polymer is one or more of primary amine, secondary amine and tertiary amine; the molecular weight of the polyamino polymer is 4500-110000 daltons.

Further, the polyamino polymer is poly-2- (dimethylamino) ethyl methacrylate, poly-2- (diethylamino) ethyl acrylate, polyethyleneimine or dendritic polyamidoamine, and the molecular weight of the polyamino polymer is 7000-90000 daltons.

Furthermore, the halogenated alkane with the long alkyl chain is brominated, chlorinated or iodoalkane with 10-24 carbon atoms.

Further, the molar charge ratio of the amino group on the polyamino polymer to the long alkyl chain halogenated alkane is 1: 0.06 to 10.

2. The cationic polymer antiviral material prepared by the method.

3. The application of the cationic polymer antiviral material in preparing antiviral medicaments can kill or inhibit viruses, wherein the viruses are enveloped viruses such as coronavirus, influenza virus, measles virus and the like, and adenovirus, rhinovirus or reovirus.

The invention has the beneficial effects that: the polyamino polymer of the invention converts part of amino groups into long alkyl quaternary ammonium salt groups through quaternization reaction with long alkyl chain halogenated alkane, can realize effective adhesion to virus particles, and kills the virus particles through electropositive charge/hydrophobic long alkyl chain. In addition, compared with the development of the conventional cationic polymer antibacterial agent, the invention has the advantages that the molecular weight of the polyamino polymer, the carbon atom number of the long alkyl chain halogenated alkane, the molar charge ratio of the amino group on the polyamino polymer to the long alkyl chain halogenated alkane, the prepared long alkyl quaternary ammonium salt with proper content (charge ratio) and proper alkyl length (carbon atom number) and the cationic polymer with proper molecular weight can effectively play a role in wrapping the virus, deforming the protein and inactivating the structure of the virus, and finally realize the effective antiviral effect.

Detailed Description

The following describes in detail preferred embodiments of the present invention.