阅读说明：本技术 一种药品包装膜及其制备方法 (Medicine packaging film and preparation method thereof ) 是由 肖瑶 张辉 于 2020-04-14 设计创作，主要内容包括：本发明公开了一种药品包装膜及其制备方法,所述药品包装膜由内到外依次包括聚乙烯层和镀铝聚酯层,所述镀铝聚酯层包括以下重量份组分：聚己内酯30-40重量份,共聚酯20-25重量份,聚酯酰胺20-30重量份,纳米二氧化钛3-8重量份,特丁基苯二酚4-12重量份,没食子酸内酯10-25重量份。本发明解决了现有包装膜的镀铝聚酯层在使用过程中容易出现老化的问题。(The invention discloses a medicine packaging film and a preparation method thereof, wherein the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, and the aluminized polyester layer comprises the following components in parts by weight: 30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone. The invention solves the problem that the aluminized polyester layer of the existing packaging film is easy to age in the using process.)

1. The medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, and is characterized in that the aluminized polyester layer comprises the following components in parts by weight:

30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone.

2. The medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, and is characterized in that the aluminized polyester layer comprises the following components in parts by weight:

30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone.

3. The pharmaceutical packaging film of claim 2, wherein the aluminized polyester layer comprises the following components in parts by weight:

35 parts of polycaprolactone, 25 parts of copolyester, 30 parts of polyesteramide, 6 parts of nano titanium dioxide, 12 parts of tert-butyl benzenediol and 24 parts of gallic acid lactone.

4. The pharmaceutical packaging film of claim 1, further comprising the following components in parts by weight:

1-5 parts of graphene.

5. The pharmaceutical packaging film of claim 1, further comprising the following components in parts by weight:

8-15 parts of glass fiber.

6. The pharmaceutical packaging film of claim 1, further comprising the following components in parts by weight:

1-3 parts of ultraviolet absorbent.

7. A method of manufacturing a pharmaceutical packaging film according to claim 1 or 2, comprising the steps of:

1) weighing materials: weighing the components in parts by weight respectively;

2) mixing materials: uniformly mixing polycaprolactone, copolyester and polyesteramide, adding gallic acid lactone in batches under a stirring state, uniformly mixing, adding nano titanium dioxide and tert-butyl benzenediol, and uniformly stirring;

3) and extrusion molding: extruding the uniformly mixed materials at 380-420 ℃ by a double-rod screw extruder to prepare a polyester material;

4) and preparing a film: preparing a polyester film from a polyester material on a film preparation machine;

5) and aluminizing: aluminizing the polyester film by adopting a spraying technology to prepare an aluminized polyester layer;

6) and compounding: compounding the aluminized polyester layer and the polyethylene layer to prepare the medicine packaging film.

Technical Field

The invention relates to the technical field of medicine packaging, in particular to a medicine packaging film and a preparation method thereof.

Background

Currently, solid drug packaging mainly includes glass bottles, plastic bottles and film packaging. Because the glass bottle and the plastic bottle are rigid and are only suitable for medicines such as medicine granules or powder, the solid bulk drug cannot be solved. Therefore, for some solid raw medicines, packaging films are usually adopted for packaging, or the packaging films are prepared into packaging bags for medicine packaging.

The existing packaging film mainly considers tensile resistance and thermal stability in the preparation process, the aging of the packaging film in the use process can be ignored, and most of the packaging films can have an aging phenomenon after being used for a period of time. The packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, and the polyethylene layer has certain ageing resistance, so that the ageing of the packaging film is mainly reflected in the aluminized polyester layer, the aluminized polyester layer becomes fragile after ageing, and the aluminized polyester layer is cracked or even broken when being rubbed or pulled and extruded on the outer side.

Disclosure of Invention

The invention aims to provide a medicine packaging film, which solves the problem that an aluminized polyester layer of the existing packaging film is easy to age in the using process.

In addition, the invention also provides a preparation method of the medicine packaging film.

The invention is realized by the following technical scheme:

the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:

30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone.

The medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:

30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone.

The polyethylene layer adopts the prior art, and comprises the following components: polyethylene, natural rubber, plasticizers and stabilizers.

In the formulation of the present invention: the polycaprolactone, the copolyester and the polyesteramide are base materials of the aluminized polyester layer, and the aluminized polyester layer prepared by only adopting the base materials is easy to age in the using process; the tert-butyl benzenediol has an excellent antioxidant effect, the anti-aging function of the aluminized polyester layer can be obviously improved by adding the tert-butyl benzenediol, the gallic acid lactone has a certain antioxidant effect, and meanwhile, the gallic acid lactone has good thermal stability, the nano titanium dioxide also has the antioxidant effect, and the tert-butyl benzenediol can be assisted in improving the anti-aging performance.

Through a large number of experiments, the applicant finds that when the tert-butyl benzenediol and the gallic acid lactone are added simultaneously, the thermal stability and the anti-aging function of the aluminized polyester layer can be improved, the anti-aging function is obviously improved compared with that when the tert-butyl benzenediol or the gallic acid lactone is added independently, particularly when the tert-butyl benzenediol and the gallic acid lactone are added according to the weight ratio of 1:2, the effect is optimal, and the anti-aging function of the prepared aluminized polyester layer is obviously improved by adding the nano titanium dioxide.

According to the invention, the nano titanium dioxide, the tert-butyl benzenediol and the gallic acid lactone are added into the base material for preparing the aluminum-plated polyester layer, and the tert-butyl benzenediol and the gallic acid lactone generate a synergistic effect, so that the anti-aging function is obviously improved compared with that of the method of independently adding tert-butyl benzenediol or gallic acid lactone, and the nano titanium dioxide is used as an auxiliary material, so that the anti-aging function of the prepared aluminum-plated polyester layer is obviously improved. Therefore, the invention solves the problem that the aluminized polyester layer of the existing packaging film is easy to age in the using process. And simultaneously has good thermal stability.

Further, the aluminized polyester layer is composed of the following components in parts by weight:

35 parts of polycaprolactone, 25 parts of copolyester, 30 parts of polyesteramide, 6 parts of nano titanium dioxide, 12 parts of tert-butyl benzenediol and 24 parts of gallic acid lactone.

Further, the composition also comprises the following components in parts by weight:

1-5 parts of graphene.

The graphene has certain lubricity and high toughness, is not only beneficial to playing a lubricating role when raw materials are mixed, improves the uniform mixing effect of materials, but also can enhance the toughness of the aluminized polyester layer, improves the tensile resistance of the aluminized polyester layer while meeting the ageing resistance function of the aluminized polyester layer, and prolongs the service life of the aluminized polyester layer.

Further, the composition also comprises the following components in parts by weight:

8-15 parts of glass fiber.

The glass fiber can enhance the toughness of the aluminized polyester layer and improve the tensile resistance of the aluminized polyester layer.

Further, the composition also comprises the following components in parts by weight:

1-3 parts of ultraviolet absorbent.

The ultraviolet absorbent can prevent the corrosion of ultraviolet rays to the aluminized polyester layer, can improve the ageing resistance and the stability of the aluminized polyester layer when the aluminized polyester layer is used outdoors,

a preparation method of a medicine packaging film comprises the following steps:

1) weighing materials: weighing the components in parts by weight respectively;

2) mixing materials: uniformly mixing polycaprolactone, copolyester and polyesteramide, adding gallic acid lactone in batches under a stirring state, uniformly mixing, adding nano titanium dioxide and tert-butyl benzenediol, and uniformly stirring;

3) and extrusion molding: extruding the uniformly mixed materials at 380-420 ℃ by a double-rod screw extruder to prepare a polyester material;

4) and preparing a film: preparing a polyester film from a polyester material on a film preparation machine;

5) and aluminizing: aluminizing the polyester film by adopting a spraying technology to prepare an aluminized polyester layer;

6) and compounding: compounding the aluminized polyester layer and the polyethylene layer to prepare the medicine packaging film.

In the preparation method, the nano titanium dioxide, the tert-butyl benzenediol and the gallic acid lactone in a certain proportion are added into the raw materials, and the tert-butyl benzenediol and the gallic acid lactone generate a synergistic effect, so that the anti-aging function is obviously improved compared with that of the method of independently adding the tert-butyl benzenediol or the gallic acid lactone, and the anti-aging function of the prepared aluminized polyester layer is obviously improved by adding the nano titanium dioxide.

Compared with the prior art, the invention has the following advantages and beneficial effects:

according to the invention, the nano titanium dioxide, the tert-butyl benzenediol and the gallic acid lactone are added into the base material for preparing the aluminum-plated polyester layer, and the tert-butyl benzenediol and the gallic acid lactone generate a synergistic effect, so that the anti-aging function is obviously improved compared with that of the method of independently adding tert-butyl benzenediol or gallic acid lactone, and the nano titanium dioxide is used as an auxiliary material, so that the anti-aging function of the prepared aluminum-plated polyester layer is obviously improved. Therefore, the invention solves the problem that the aluminized polyester layer of the existing packaging film is easy to age in the using process. And simultaneously has good thermal stability.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not used as limitations of the present invention.