阅读说明：本技术 一种可降解医用薄膜材料及其制备方法 (Degradable medical film material and preparation method thereof ) 是由 韩俊女 赵英杰 于 2020-04-13 设计创作，主要内容包括：本发明属于医用材料技术领域,公开了一种可降解医用薄膜材料及其制备方法。该可降解医用薄膜材料,按照重量份数计,包括如下组分：改性聚乳酸120份～140份、聚碳酸纤维80份～100份、壳聚糖20份～40份、淀粉30份～50份、魔芋精粉5份～20份、乙酸丁酸纤维素3份～10份、乙酰柠檬酸酯5份～20份、润滑剂1份～3份。本发明的可降解医用薄膜材料不仅具有高的拉伸强度,良好的断裂伸长率,而且还具有较长的保质期和较快的降解速率。本发明的制备方法操作简单,易于操作,而且还能提高医用薄膜材料的力学性能。(The invention belongs to the technical field of medical materials, and discloses a degradable medical film material and a preparation method thereof. The degradable medical film material comprises the following components in parts by weight: 120 to 140 portions of modified polylactic acid, 80 to 100 portions of polycarbonate fiber, 20 to 40 portions of chitosan, 30 to 50 portions of starch, 5 to 20 portions of konjaku flour, 3 to 10 portions of cellulose acetate butyrate, 5 to 20 portions of acetyl citrate and 1 to 3 portions of lubricant. The degradable medical film material has high tensile strength, good elongation at break, long shelf life and high degradation rate. The preparation method of the invention has simple operation and easy operation, and can also improve the mechanical property of the medical film material.)

1. The degradable medical film material is characterized by comprising the following components in parts by weight: 120 to 140 portions of modified polylactic acid, 80 to 100 portions of polycarbonate fiber, 20 to 40 portions of chitosan, 30 to 50 portions of starch, 5 to 20 portions of konjaku flour, 3 to 10 portions of cellulose acetate butyrate, 5 to 20 portions of acetyl citrate and 1 to 3 portions of lubricant.

2. The degradable medical film material of claim 1, comprising the following components in parts by weight: 120 to 130 portions of modified polylactic acid, 80 to 90 portions of polycarbonate fiber, 20 to 30 portions of chitosan, 30 to 40 portions of starch, 5 to 10 portions of konjac powder, 3 to 5 portions of cellulose acetate butyrate, 5 to 10 portions of acetyl citrate and 1 to 3 portions of lubricant.

3. The degradable medical film material of claim 1, comprising the following components in parts by weight: 130 parts of modified polylactic acid, 90 parts of polycarbonate fiber, 30 parts of chitosan, 40 parts of starch, 10 parts of konjac powder, 5 parts of cellulose acetate butyrate, 10 parts of acetyl citrate and 2 parts of lubricant.

4. The degradable medical film material of any one of claims 1 to 3, wherein the lubricant is at least one of glycerin, PE-wax, polyethylene wax, or potassium sorbate.

5. The degradable medical film material of any one of claims 1 to 3, wherein the konjac powder is: the natural konjac fine powder without any modification treatment comprises special-grade, first-grade, second-grade and third-grade common konjac fine powder and purified konjac gum powder, and is extracted from at least one of konjac, Tianyang konjac, West allied konjac, Youle konjac or Menghai konjac.

6. The degradable medical film material of any one of claims 1 to 3, wherein the starch is a pure natural starch without any modification treatment, extracted from at least one of potato, tapioca, pea, corn, or sweet potato.

7. A method for preparing the degradable medical film material of any one of claims 1 to 6, which comprises the following steps:

(1) weighing the components according to the required weight parts, adding the modified polylactic acid, the polycarbonate fiber, the chitosan, the starch, the konjac powder and the lubricant into a mixer, and stirring and mixing at a low speed to obtain a mixture A for later use;

(2) adding the cellulose acetate butyrate and the acetyl citrate into the mixture A, and stirring and mixing at a high speed to obtain a mixture B for later use;

(3) and putting the mixture B into a cold mixer for stirring and cold mixing, discharging the mixture to an extruder for extruding granulation, and calendering to form a film to prepare the medical film material.

8. The method for preparing the degradable medical film material of claim 7, wherein the low-speed stirring speed in the step (1) is 100r/min to 200r/min, the stirring temperature is 50 ℃ to 60 ℃, and the stirring time is 30min to 50 min.

9. The method for preparing the degradable medical film material of claim 7, wherein the high-speed stirring speed in the step (2) is 300r/min to 500r/min, the stirring temperature is 100 ℃ to 120 ℃, and the stirring time is 20min to 30 min.

10. The method for preparing the degradable medical film material of claim 7, wherein the stirring speed of the cold mixing in the step (3) is 100r/min to 200r/min, the stirring temperature is 20 ℃ to 40 ℃, and the stirring time is 1h to 2 h.

Technical Field

The invention belongs to the technical field of medical materials, and particularly relates to a degradable medical film material and a preparation method thereof.

Background

The thin film material refers to a thin metal or organic layer with the thickness ranging from a single atom to a few millimeters, and the species classification of the thin film is not always uniformly specified. It is common practice to divide films into the following: the method comprises the following steps of: the film is divided into a polyethylene film, a polypropylene film, a polyvinyl chloride film, a polyester film and the like; classified by film use: one is an agricultural film: according to the specific application of the agricultural film, the agricultural film can be divided into a mulching film and a greenhouse film, one is a packaging film: the packaging film can be classified into a food packaging film, a packaging film for various industrial products, and the like, and further, a breathable film, a water-soluble film, a film having piezoelectric properties, and the like, which are used in a special environment and have special applications, according to the specific applications. The film is classified according to the film forming method: the film is formed by extrusion plasticizing and blow molding, and is called as a blown film; after extrusion and plasticization, the molten material is cast and formed into a film from a die opening, which is called as a cast film; films made from plasticized materials are rolled on a calender by several rollers, known as calendered films.

The medical film has higher requirements on the performance of the film, and the film material is required to have better mechanical property and degradability, otherwise, a large amount of white pollution of the medical material is caused; in addition, the degradation rate of the medical film material is improved, and meanwhile, the quality guarantee period, namely the effective use time, of the medical film material is ensured. Therefore, how to maintain or improve the quality guarantee period of the film and the mechanical properties of the film while improving the degradation rate of the film becomes a research hotspot and difficulty.

Disclosure of Invention

In view of the above, the invention provides a degradable medical film material to solve the problem that the performance of the current medical film material is single.

The invention also aims to provide a preparation method of the degradable medical film material.

The invention is realized by adopting the following scheme: a degradable medical film material comprises the following components in parts by weight: 120 to 140 portions of modified polylactic acid, 80 to 100 portions of polycarbonate fiber, 20 to 40 portions of chitosan, 30 to 50 portions of starch, 5 to 20 portions of konjaku flour, 3 to 10 portions of cellulose acetate butyrate, 5 to 20 portions of acetyl citrate and 1 to 3 portions of lubricant.

Preferably, the composition comprises the following components in parts by weight: 120 to 130 portions of modified polylactic acid, 80 to 90 portions of polycarbonate fiber, 20 to 30 portions of chitosan, 30 to 40 portions of starch, 5 to 10 portions of konjac powder, 3 to 5 portions of cellulose acetate butyrate, 5 to 10 portions of acetyl citrate and 1 to 3 portions of lubricant.

Preferably, the composition comprises the following components in parts by weight: 130 parts of modified polylactic acid, 90 parts of polycarbonate fiber, 30 parts of chitosan, 40 parts of starch, 10 parts of konjac powder, 5 parts of cellulose acetate butyrate, 10 parts of acetyl citrate and 2 parts of lubricant.

Preferably, the lubricant is at least one of glycerol, PE-wax, polyethylene wax or potassium sorbate.

Preferably, the konjac powder is: the natural konjac fine powder without any modification treatment comprises special-grade, first-grade, second-grade and third-grade common konjac fine powder and purified konjac gum powder, and is extracted from at least one of konjac, Tianyang konjac, West allied konjac, Youle konjac or Menghai konjac.

Preferably, the starch is pure natural starch without any modification treatment, and is extracted from at least one of potatoes, cassava, peas, corns or sweet potatoes.

The invention also provides a preparation method of the degradable medical film material, which comprises the following steps:

(1) weighing the components according to the required weight parts, adding the modified polylactic acid, the polycarbonate fiber, the chitosan, the starch, the konjac powder and the lubricant into a mixer, and stirring and mixing at a low speed to obtain a mixture A for later use;

(2) adding cellulose acetate butyrate and acetyl citrate into the mixture A, and stirring and mixing at a high speed to obtain a mixture B for later use;

(3) and putting the mixture B into a cold mixer for stirring and cold mixing, discharging the mixture to an extruder for extruding granulation, and calendering to form a film to prepare the medical film material.

Preferably, the low-speed stirring speed in the step (1) is 100r/min to 200r/min, the stirring temperature is 50 ℃ to 60 ℃, and the stirring time is 30min to 50 min.

Preferably, the high-speed stirring speed in the step (2) is 300r/min to 500r/min, the stirring temperature is 100 ℃ to 120 ℃, and the stirring time is 20min to 30 min.

Preferably, the stirring speed of the cold mixing in the step (3) is 100r/min to 200r/min, the stirring temperature is 20 ℃ to 40 ℃, and the stirring time is 1h to 2 h.

Compared with the prior art, the invention adopting the scheme has the beneficial effects that:

the degradable medical film material has high tensile strength, good elongation at break, long shelf life and high degradation rate.

The preparation method of the invention has simple operation and easy operation, and can also improve the mechanical property of the medical film material.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The modified polylactic acid adopted in the following examples of the invention is prepared by the following method:

adding polylactic acid into a mixer, adding polyvinyl alcohol, a coupling agent, a lubricant and a dispersing agent, uniformly mixing, adding into a double-screw granulator for melt modification, and controlling the modification temperature at 130 ℃ to obtain the modified polylactic acid.

The lubricant used in the following examples of the present invention is at least one of glycerin, PE-wax, polyethylene wax or potassium sorbate.

The konjak fine powder adopted in the following examples of the invention is: the natural konjac fine powder without any modification treatment comprises special-grade, first-grade, second-grade and third-grade common konjac fine powder and purified konjac gum powder, and is extracted from at least one of konjac, Tianyang konjac, West allied konjac, Youle konjac or Menghai konjac.

The starch used in the following examples of the present invention is a pure natural starch without any modification treatment, and is extracted from at least one of potato, tapioca, pea, corn, or sweet potato.