阅读说明：本技术 一种药物基因检测项目管理系统 (Drug gene detection project management system ) 是由 陈杨 何瑶 于 2020-03-19 设计创作，主要内容包括：本发明公开了一种药物基因检测项目管理系统,包括药物基检创建模组、药物基检报告模组和数据库模组。药物基检创建模组获取病人信息,使用所述病人信息创建项目,根据所述项目收费；药物基检报告模组,用于存取并识别基因检测文档信息,并解释所述基因检测文档信息得到解释报告,根据所述解释报告建议用药,并生成基因检测报告；数据库模组,用于所述药物基检创建模组存取病人信息和所述药物基检报告模组存取基因检测报告。本发明将药物基因检测项目管理的多种必要功能集成于一个系统,使用方便可靠。(The invention discloses a drug gene detection project management system which comprises a drug basic detection establishing module, a drug basic detection reporting module and a database module. The drug basic examination creation module acquires patient information, creates a project by using the patient information, and charges according to the project; the drug basic inspection report module is used for accessing and identifying gene detection document information, interpreting the gene detection document information to obtain an interpretation report, recommending drug use according to the interpretation report and generating a gene detection report; and the database module is used for accessing the patient information by the medicine basic examination establishing module and accessing the gene detection report by the medicine basic examination report module. The invention integrates a plurality of necessary functions of drug gene detection project management into one system, and is convenient and reliable to use.)

1. A drug gene detection project management system is characterized in that,

comprises a drug basic inspection establishing module, a drug basic inspection reporting module and a database module, wherein the drug basic inspection establishing module is electrically connected with the drug basic inspection reporting module, the drug basic inspection establishing module and the drug basic inspection reporting module are respectively and electrically connected with the database module,

the drug basic check establishing module is used for acquiring patient information, checking the item for duplication, establishing the item by using the patient information and charging according to the item;

the drug basic inspection report module is used for accessing and identifying gene detection document information, interpreting the gene detection document information to obtain an interpretation report, recommending drug use according to the interpretation report and generating a gene detection report;

the database module is used for the medicine basic examination establishing module to access patient information and the medicine basic examination reporting module to access gene detection reporting information.

2. The system for managing drug gene testing items according to claim 1,

the drug basic check establishing module comprises a patient information extraction module, a project duplicate checking module, a detection project establishing module and a charging module, wherein the patient information extraction module, the project duplicate checking module, the detection project establishing module and the charging module are electrically connected in sequence,

the patient information extraction module is used for inquiring and extracting patient information from the database, wherein the patient information comprises name, age, height, weight, race, sex, ethnicity, ID number, hospitalization number, telephone, hospitalization department, doctor in charge, application time, medical advice information, enzyme inducer and amiodarone service condition;

the item duplicate checking module is used for carrying out duplicate checking and retrieval on the examination condition of the patient in the database to obtain a duplicate checking result;

the detection project creating module is used for creating a detection project document of the patient according to the duplicate checking result and the patient information and sending the detection project document to the database module for storage;

and the charging module is used for charging corresponding drug gene detection cost according to the detection project document.

3. The drug gene testing project management system of claim 2, characterized in that

The detection item creating module comprises a storage unit and a detection unit,

the storage unit is used for sending the patient information to the database for storage;

the detection unit is used for detecting the integrity of the patient information.

4. The system for managing drug gene testing items according to claim 1,

the drug basic examination report module comprises a document information extraction module, a document information interpretation module, a medication suggestion module and a report generation module,

the document information extraction module is used for uploading and checking an original document for gene detection, and automatically identifying and extracting a gene detection result in the original document;

the medication suggestion module is used for outputting the clinical significance of the original document, predicting the medication dosage and referring to medication suggestions of historical detection reports;

and the report generation module is used for generating a drug gene detection report and uploading the drug gene detection report to the database module.

5. The system for managing drug gene testing items according to claim 4,

the document information extraction module comprises a document extraction unit and a document identification unit,

the document extraction unit is used for acquiring an original document of a detection result from the drug gene detection instrument and uploading the original document to a gene detection project database;

and the document identification unit is used for reading and analyzing the specific information in the original document.

6. The system for managing drug gene testing items according to claim 4,

the medication suggestion module comprises a gene interpretation unit and a medication suggestion unit,

the gene interpretation unit is used for interpreting the clinical significance of each gene locus;

the medication suggestion unit is used for giving medication suggestions by combining historical medication suggestions, existing detection results and actual conditions of patients, and the medication suggestions are stored in the database.

7. The system for managing drug gene testing items according to claim 1,

the database module comprises a hospital database and a gene detection project database,

the hospital database is used as a data source for acquiring patient information and used for charging for drug gene detection items;

the gene detection project database is used for data access of the drug basic detection establishing module and the drug basic detection report model, the drug basic detection establishing module carries out duplicate search on gene detection conditions, and the drug basic detection report module searches data to output a detection report and accesses the drug gene detection report.

Technical Field

The invention relates to the field of gene detection, in particular to a drug gene detection project management system.

Background

The drug gene detection is based on the existing pharmacogenomics theory, and adopts a proper gene detection method to detect drug metabolizing enzyme and drug action target related genes of a patient, and determines the close relation between genetic factors and drug dynamics and drug effects on the gene level. Through drug gene detection, clinical pharmacists can accurately predict the drug effect of patients, and great help is provided for optimizing the drug administration scheme, improving the curative effect, shortening the treatment course, reducing adverse reactions, saving the medical cost and lightening the economic burden of the patients.

Each drug gene detection technology development company provides drug gene detection project management software, but the drug gene detection project management software is not complete in function and inconvenient to use.

Therefore, a drug gene testing project management system integrating the above functions is required.

Disclosure of Invention

The invention aims to provide a drug gene detection project management system, and aims to solve the problems of incomplete functions and inconvenient use of current drug gene detection project management software.

In order to achieve the above object, the present invention provides a drug gene testing project management system,

comprises a drug basic inspection establishing module, a drug basic inspection reporting module and a database module, wherein the drug basic inspection establishing module is electrically connected with the drug basic inspection reporting module, the drug basic inspection establishing module and the drug basic inspection reporting module are respectively and electrically connected with the database module,

the drug basic check establishing module is used for acquiring patient information, checking the item for duplication, establishing the item by using the patient information and charging according to the item;

the drug basic inspection report module is used for accessing and identifying gene detection document information, interpreting the gene detection document information to obtain an interpretation report, recommending drug use according to the interpretation report and generating a gene detection report;

the database module is used for the medicine basic examination establishing module to access patient information and the medicine basic examination reporting module to access gene detection reporting information.

Wherein the drug basic check establishing module comprises a patient information extraction module, a project duplicate checking module, a detection project establishing module and a charging module, the patient information extraction module, the project duplicate checking module, the detection project establishing module and the charging module are electrically connected in sequence,

the patient information extraction module is used for inquiring and extracting patient information from the database, wherein the patient information comprises name, age, height, weight, race, sex, ethnicity, ID number, hospitalization number, telephone, hospitalization department, doctor in charge, application time, medical advice information, enzyme inducer and amiodarone service condition;

the item duplicate checking module is used for carrying out duplicate checking and retrieval on the examination condition of the patient in the database to obtain a duplicate checking result;

the detection project creating module is used for creating a detection project document of the patient according to the duplicate checking result and the patient information and sending the detection project document to the database module for storage;

and the charging module is used for charging corresponding drug gene detection cost according to the detection project document.

Wherein the detection item creating module comprises a storage unit and a detection unit,

the storage unit is used for sending the patient information to the database for storage;

the detection unit is used for detecting the integrity of the patient information.

Wherein the medicine basic examination report module comprises a document information extraction module, a document information interpretation module, a medication suggestion module and a report generation module,

the document information extraction module is used for uploading and checking an original document for gene detection, and automatically identifying and extracting a gene detection result in the original document;

the medication suggestion module is used for outputting the clinical significance of the original document, predicting the medication dosage and referring to medication suggestions of historical detection reports;

and the report generation module is used for generating a drug gene detection report and uploading the drug gene detection report to the database module.

Wherein the document information extraction module comprises a document extraction unit and a document identification unit,

the document extraction unit is used for acquiring an original document of a detection result from the drug gene detection instrument and uploading the original document to a gene detection project database;

and the document identification unit is used for reading and analyzing the specific information in the original document.

Wherein the medication suggestion module comprises a gene interpretation unit and a medication suggestion unit,

the gene interpretation unit is used for interpreting the clinical significance of each gene locus;

the medication suggestion unit is used for giving medication suggestions by combining historical medication suggestions, existing detection results and actual conditions of patients, and the medication suggestions are stored in the database.

Wherein the database module comprises a hospital database and a gene detection project database,

the hospital database is used as a data source for acquiring patient information and used for charging for drug gene detection items;

the gene detection project database is used for data access of the drug basic detection establishing module and the drug basic detection report model, the drug basic detection establishing module carries out duplicate search on gene detection conditions, and the drug basic detection report module searches data to output a detection report and accesses the drug gene detection report.

The drug gene detection project management system integrates multiple necessary functions of drug gene detection project management into one software, such as medical advice checking, detection project duplication checking, drug administration dosage prediction, automatic filling of drug administration suggestions and the like, and greatly facilitates the work of clinical pharmacists. The invention records gene detection items by using the database, simplifies the query work of a detection report and various statistics of the detection items, thereby solving the problem of incomplete function of the current drug gene detection item management software.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It is obvious that the drawings in the following description are only some embodiments of the invention, and that for a person skilled in the art, other drawings can be derived from them without inventive effort.

FIG. 1 is a view showing the construction of a drug gene testing project management system according to the present invention;

FIG. 2 is a block diagram of a detection project creation module of the present invention;

FIG. 3 is a block diagram of the drug-based test reporting module of the present invention.

The system comprises a 1-drug basic test creation module, a 2-drug basic test report module, a 3-database module, a 11-patient information extraction module, a 14-duplication checking module, a 12-detection item creation module, a 13-charging module, a 121-detection unit, a 122-storage unit, a 21-document information extraction module, a 22-medication suggestion module, a 23-report generation module, a 211-document extraction unit, a 212-document identification unit, a 221-gene interpretation unit, a 222-medication suggestion unit, a 31-gene detection item database and a 32-hospital database.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.

Referring to fig. 1, the embodiment is a drug gene testing project management system, including: a drug basic check establishing module 1, a drug basic check reporting module 2 and a database module 3, wherein the drug basic check establishing module 1 is electrically connected with the drug basic check reporting module 2, the drug basic check establishing module 1 and the drug basic check reporting module 2 are respectively electrically connected with the database module 3,

the drug basic check establishing module 1 is used for acquiring patient information, checking the project for duplication, establishing the project by using the patient information and charging according to the project;

the drug basic examination creation module 1 comprises a patient information extraction module 11, a duplication checking module 14, an examination item creation module 12 and a charging module 13. The patient information extraction module 11 is configured to extract basic information of a patient, including name, age, height, weight, race, gender, ethnicity, ID number, hospital number, telephone number, hospital department, physician, application time, medical advice information, enzyme inducer, and amiodarone usage, and a clinical pharmacist can preliminarily evaluate the necessity of drug gene testing of the patient by using the basic information; the duplication checking module 14 is used for carrying out duplication checking and retrieval on the drug gene examination condition of the patient in the database module 3 to obtain duplication checking results, and prompting a clinical pharmacist whether to continue to create detection items if repeated detection items are found; the detection project creating module 12 creates a detection project document according to the patient information and the duplicate checking result and stores the detection project document in the database module 3 for storage, so that the detection project document is convenient for others to inquire and call in the future, and the filling process is simplified.

Further, the detection item creating module 12 includes a detection unit 121 and a storage unit 122, please refer to fig. 2. The detection unit 121 detects the patient information before storing, confirms the integrity, and can store the data if the data is complete; the storage unit 122 is configured to send the patient information to the database module 3 for storage.

And the charging module 13 is used for charging corresponding drug gene detection cost according to the detection project document.

The drug basic inspection report module 2 is used for accessing and identifying gene detection document information, interpreting the gene detection document information to obtain an interpretation report, suggesting drug use according to the interpretation report, and generating a gene detection report;

the drug basic examination report module 2 comprises a document information extraction module 21, a medication suggestion module 22 and a report generation module 23,

the document information extraction module 21 is configured to extract a gene detection original document from a gene detector, automatically identify and extract a gene detection result in the original document, and upload the gene detection result to the database module 3. The useful information of the gene detection original document is automatically identified and extracted by software so as to simplify the work flow of clinical pharmacists. The extracted information is automatically uploaded to the database module 3 by software, so that a clinical pharmacist can conveniently issue a gene detection report and retrospective query or statistics, and a doctor can conveniently call and check the information when making a medical order.

Further, the document information extraction module 21 includes a document extraction unit 211 and a document identification unit 212, please refer to fig. 3. A document extracting unit 211, configured to extract a gene testing original document from a gene testing apparatus, where the gene testing apparatus may be a real-time fluorescent quantitative PCR testing system (product model: generic 48E) manufactured by tianlong corporation, and the original document may be a text file in pdf format; the document identification unit 212 is configured to read information of a specific region in the pdf document based on objects such as AcroPDDoc, AcroPDTextSelect, AcroRect and the like in Adobe Acrobat SDK, and the read information is compared with possible mutation types of each gene. If the comparison fails, the system prompts that the detection result is possibly wrong; if the comparison is successful, the read information is filled in the graphical user interface and saved to the genetic testing item database 31.

The medication recommendation module 22 is used to automatically interpret the clinical meaning of the original document and predict the appropriate drug and its dosage. The method is greatly convenient for clinical pharmacists to quickly master the physiological state of the patient and evaluate the medication effect, reduces the frequency and time consumption of looking up medication related data by the clinical pharmacists, and improves the working efficiency. In addition, clinical pharmacists can view or quote medication suggestions of historical test reports as medication references for issuing gene test reports;

further, as shown in FIG. 3, the medication suggesting module 22 includes a gene interpreting unit 221 and a medication suggesting unit 222,

the gene interpretation unit 221 is used for filling the detected gene information in the user interface by the system and automatically interpreting the clinical significance of each gene locus;

the medication suggestion unit 222 is configured to give medication suggestions according to historical medication suggestions, existing detection results, and actual conditions of the patient, and store the medication suggestions in the database module 3. If the detected item is warfarin drug gene detection, the system calculates the administration dosage according to the following formula; if the other medicine is used, the administration dosage is selected according to the relevant guidelines of medicine gene detection.

Dosage form^1/2(mg/week) = 5.6044-0.2614 × age + 0.0087 × height (cm) + 0.0128 × 0 body weight (kg) -0.08677 × 1VKORC 1A/G-1.6974 × 2VKORC 1A/a-0.04854 × 3VKORC1 (other genotypes) -0.5211 × 4CYP2C9 1/. times.2-0.9537 × 5CYP2C9 1/. times.3-1.0616 × 6CYP2C 9. times.2/. times.2-1.9206 × CYP2C 9. times.3-2.3312 × CYP2C 9. times.3-0.2188 × CYP2C9 (other genotypes) -0.1092 × asian human-0.2760 × african human species-0.1032 × human species + 1.1816 × enzyme inducer-0.5503 × amiodarone.

The system also compares the gene detection result of the current patient with the historical detection result in the gene detection project database 31, if the comparison is successful, the historical medication suggestions of the corresponding genome are returned, otherwise, the genome in the database is arranged in descending order according to the number of the successfully compared genes so as to check the historical medication suggestions of the similar genome. The cited medication recommendations may be modified to reflect the current patient's true condition. The completed medication recommendation needs to be saved in the gene testing project database 31.

The report generating module 23 is configured to generate a drug gene detection report, and upload the drug gene detection report to the database module 3, so as to facilitate future calling. The system generates an empty new detection report by using an Excel version drug gene detection report template, and then extracts patient information from a gene detection database and fills the empty detection report into the newly generated empty detection report. The generated detection report will be automatically saved to the shared folder as a backup at the same time.

The database module 3, as shown in fig. 1, includes a gene testing item database 31 and a hospital database 32. The gene detection project database 31 is used for accessing the data of the drug basic test creation module 1 and the drug basic test report module 2 and drug gene detection reports, and is convenient for clinical pharmacists and doctors to look up historical examination records.

The gene detection item database 31 is used for the duplication checking module 14 to perform duplication checking search on the current gene detection condition, and is also used for the medication suggestion module 22 to search data so as to output the clinical significance of the original document.

The hospital database 32 serves as a data source for patient information acquisition and for drug gene testing project billing.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.