阅读说明：本技术 活性多肽复配植物提取物抗衰修复组合物及应用与含该组合物的精华乳 (Active polypeptide compound plant extract anti-aging repair composition, application and essence milk containing composition ) 是由 万笑宇 于 2020-06-15 设计创作，主要内容包括：本发明提供一种活性多肽复配植物提取物抗衰修复组合物及应用与含该组合物的精华乳,所述组合物包括植物提取物和修复活性多肽；所述修复活性多肽包括：2-8份乙酰基六肽-8、0.5-4份棕榈酰五肽-3和0.3-2份五肽-3；所述植物提取物包括：20-200份的紫苏叶提取物,18-160份的马缨丹叶提取物和16-140份的三叶鬼针草提取物,50-400份欧洲七叶树提取物、48-200份的麝香草提取物、30-360份的库拉索芦荟提取物、30-340份的积雪草提取物和14-120份的水飞蓟提取物。本发明在强抗氧化活性的植物提取物组合基础之上复配再生修复活性多肽,对肌肤全方位的修复、保护与滋养,使肌肤远离自由基及紫外线的损害,恢复弹性、柔嫩,消除岁月侵蚀的痕迹。(The invention provides an active polypeptide compounded plant extract anti-aging repair composition, application and essence milk containing the composition, wherein the composition comprises a plant extract and repair active polypeptide; the repair-active polypeptides include: 2-8 parts of acetyl hexapeptide-8, 0.5-4 parts of palmitoyl pentapeptide-3 and 0.3-2 parts of pentapeptide-3; the plant extract comprises: 20-200 parts of perilla leaf extract, 18-160 parts of lantana leaf extract and 16-140 parts of bidens pilosa extract, 50-400 parts of aesculus hippocastanum extract, 48-200 parts of thyme extract, 30-360 parts of aloe barbadensis extract, 30-340 parts of centella asiatica extract and 14-120 parts of silybum marianum extract. The plant extract composition with strong antioxidant activity is compounded with the regeneration and repair active polypeptide, so that the skin is repaired, protected and nourished in an all-around way, the skin is far away from the damage of free radicals and ultraviolet rays, the elasticity is recovered, the skin is tender, and the trace of the corrosion of years is eliminated.)

1. An active polypeptide compound plant extract anti-aging repair composition is characterized by comprising a plant extract and repair active polypeptide; the repair-active polypeptides include: 2-8 parts of acetyl hexapeptide-8, 0.5-4 parts of palmitoyl pentapeptide-3 and 0.3-2 parts of pentapeptide-3; the plant extract comprises: 20-200 parts of perilla leaf extract, 18-160 parts of lantana leaf extract and 16-140 parts of bidens pilosa extract, 50-400 parts of aesculus hippocastanum extract, 48-200 parts of thyme extract, 30-360 parts of aloe barbadensis extract, 30-340 parts of centella asiatica extract and 14-120 parts of silybum marianum extract.

2. The anti-aging repair composition according to claim 1, wherein the composition comprises the following plant extracts and repair-active polypeptides in parts by weight: 6.6 parts of acetyl hexapeptide-8, 2.2 parts of palmitoyl pentapeptide-3 and 0.66 part of pentapeptide-3;

230 parts of perilla leaf extract, 210 parts of lantana leaf extract, 180 parts of bidens pilosa extract, 340 parts of aesculus hippocastanum extract, 320 parts of thymus vulgaris extract, 290 parts of aloe vera extract, 260 parts of centella asiatica extract and 80 parts of silybum marianum extract.

3. Use of a composition according to claim 1 or 2 for the preparation of a skin care product.

4. An essence milk for skin anti-aging and repairing, which is characterized by comprising 8-32% by mass of the plant extract composition as claimed in claim 1 or 2, 13-26% by mass of an essence milk base component, and the balance of deionized water.

5. The skin-antiaging essence milk according to claim 4, characterized in that the essence milk further comprises, in mass%, an antioxidant active ingredient consisting of 0.02 to 0.06% of kinetin, 2 to 4% of tea polyphenol, 0.5 to 1% of hydroxydecyl ubiquinone, 1 to 5% of colloidal oat flour, and 0.5 to 1.5% of tocopherol.

6. The essence for skin anti-aging repair as claimed in claim 5, wherein the essence further comprises, in mass percent, a microcirculation promotion active ingredient consisting of 0.1-0.3% of arginine, 0.1-1.5% of adenosine, and 0.01-1% of biotin, and a natural moisturizing active factor; the natural moisturizing active factor consists of 0.01-0.08% of sodium hyaluronate and 0.2-0.5% of wild mango kernel fat.

7. The essence for skin anti-aging repair as claimed in claim 6, wherein the essence further comprises tetrahydrocurcumin which is a natural whitening ingredient and is added in an amount of 1% by mass.

8. The skin anti-aging repair essence according to claim 4, wherein the cosmetic base component is composed of, by weight, 8 parts of glycerin, 1 part of butylene glycol, 1 part of propylene glycol, 1 part of caprylic/capric triglyceride, 1 part of polydimethylsiloxane, 1 part of hydrogenated coco glyceride, 1 part of isononyl isononanoate, 0.2 part of stearyl alcohol, 1 part of cetyl alcohol, 1 part of jojoba esters, 0.2 part of glyceryl stearate, 0.2 part of hydrogenated lecithin, 3 parts of steareth-2, 1 part of steareth-21, 1 part of polymethylmethacrylate, 1 part of acrylic acid/C10-30 alkanol acrylate crosspolymer, 0.2 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.1 part of titanium dioxide, 0.5 part of phenoxyethanol, 1 part of disodium EDTA, 1 part of chlorphenesin, 1,2 pentanediol, 1 part of ethylhexylglycerin, 1 part of p-hydroxyacetophenone, 1 part of potassium sorbate, 1 part of a colorant CI 19140, 1 part of a colorant CI 14700 and 1 part of essence.

9. The preparation method of the skin anti-aging repair essence cream according to claims 4 to 8, wherein the preparation method comprises:

1) adding water into a water phase pot, adding glycerol, butanediol, propylene glycol, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, xanthan gum, hydroxyethyl cellulose, titanium dioxide, phenoxyethanol, p-hydroxyacetophenone, EDTA disodium and 1,2 pentanediol according to the weight ratio under the condition of stirring, and then stirring and heating to 75-85 ℃ to obtain a water phase solution;

2) adding caprylic/capric triglyceride, polydimethylsiloxane, hydrogenated coconut oil glyceride, isononyl isononanoate, stearyl alcohol, cetyl alcohol, jojoba esters, glyceryl stearate, hydrogenated lecithin, steareth-2, steareth-21, polymethyl methacrylate, chlorphenesin and ethylhexylglycerin into an oil phase pot in proportion, and heating to 75-85 ℃ to melt the materials to obtain an oil phase solution;

3) vacuum pumping the water phase solution into a main pot of a homogenizing and liquefying machine, vacuum pumping the oil phase solution into the main pot of the homogenizing and liquefying machine under stirring, opening the homogenizing and liquefying machine, and homogenizing at the rotating speed of 2800r/min for 7-10 minutes; homogenizing, stirring at 40r/min, and keeping the temperature at 80 deg.C for 5 min;

4) after heat preservation, opening cooling water, cooling the mixed material obtained in the step 3) to 40-45 ℃, adding the active polypeptide compound plant extract anti-aging repair composition, the antioxidant active ingredient, the natural moisturizing active factor, the microcirculation promoting active ingredient and the tetrahydrocurcumin, and fully and uniformly stirring;

5) adding potassium sorbate, a coloring agent CI 19140, a coloring agent CI 14700 and essence into the material obtained in the step 4); stirring uniformly, standing for 1 hour, continuing stirring for 5-10 minutes, and adjusting the pH value to 6.0-6.5; and (6) ending.

Technical Field

The invention relates to the field of compositions, and in particular relates to an active polypeptide compound plant extract anti-aging and repairing composition, application thereof and essence milk containing the composition.

Background

With the increase of age, the skin begins to be in an aging state, mainly comprising the reduction of the content of collagen, elastin, mucopolysaccharide and the like in the skin in different degrees, the atrophy of blood vessels for supplying skin nutrition, the reduction of the elasticity of blood vessel walls, the gradual thinning and swelling of skin epidermis, the reduction of subcutaneous fat, and the visual manifestation of wrinkles, chloasma and senile plaques.

The belief that aging is a continuation of the activity developed by a genetically-set organism has been partially negated. Aging is now recognized as a balance between the body's repair potential and the frequency and intensity of the injuries it suffers. Skin is the most damaging organ to the environment, and ultraviolet radiation and free radicals produced by metabolism in the body are considered to be the most important harmful substances that accelerate the aging of cellular proteins, lipids, polysaccharides and DNA.

Specifically, the increase of one free radical (free radical) is an atom or molecule with unpaired electrons generated by the homolytic cleavage of covalent bonds, has high chemical activity, and is oxidized with unsaturated lipids to generate Lipid Peroxides (LPO), and the final product Malondialdehyde (MDA) can react with most substances of living cells to reduce the permeability of biological membranes, damage DNA molecules and cause cell death or mutation. Second, medium-wave Ultraviolet (UVB) and long-wave Ultraviolet (UVA) in sunlight cause skin photoaging. Whereas ultraviolet radiation causes skin aging mainly by the following mechanisms: firstly, DNA is damaged; collagen crosslinking; thirdly, the immune response is reduced by inducing the inhibition way of the antigen stimulation reaction; generating highly reactive free radicals to interact with various intracellular structures to cause the damage of cells and tissues; fifthly, directly inhibiting the function of epidermal Langerhans cells to cause photo-immune inhibition and weaken the immune function of skin. In addition, skin aging can be affected by nonenzymatic glycosylation, metabolic imbalance, matrix metalloproteinase aging, and the like.

Extensive research on these factors has led to the production of anti-aging skin care products. In order to achieve a good anti-aging effect, some anti-aging cosmetics use industrial ingredients with strong oxidation resistance, and the anti-aging cosmetics take effect quickly in a short time but are extremely harmful to human bodies after being used for a long time. The cosmetic prepared by using the plant extract as an active ingredient overcomes the defect that the traditional cosmetic depends on a chemical synthetic product, so that the safety performance of the product is higher; the natural components are easier to be absorbed by the skin, so that the effect of the product is more obvious; the functionality is more prominent. The plant extract as natural elastase inhibitor is the hot spot of recent research, such as scutellaria baicalensis, sanguisorba officinalis, morinda citrifolia seeds, moringa oleifera, poa aquatica, forsythia suspensa, salvia miltiorrhiza, angelica sinensis and the like.

However, the efficacy of a single plant extract is limited, and a more excellent plant extract combination is searched in a vast amount of plants, and the plant extract combination can be compounded with the plant extract to form a composition with more powerful, comprehensive and excellent performance, so that the research hotspot needed to be broken through in the field is provided.

Disclosure of Invention

In view of the above, in order to overcome the defects of the prior art, the invention provides a repair active polypeptide compound plant extract anti-aging repair composition.

The anti-aging repair composition provided by the invention comprises plant extracts and repair active polypeptides; the repair-active polypeptides include: 2-8 parts of acetyl hexapeptide-8, 0.5-4 parts of palmitoyl pentapeptide-3 and 0.3-2 parts of pentapeptide-3; the plant extract comprises: 20-200 parts of perilla leaf extract, 18-160 parts of lantana leaf extract and 16-140 parts of bidens pilosa extract, 50-400 parts of aesculus hippocastanum extract, 48-200 parts of thyme extract, 30-360 parts of aloe barbadensis extract, 30-340 parts of centella asiatica extract and 14-120 parts of silybum marianum extract.

Preferably, the composition consists of the following plant extracts and repair-active polypeptides in parts by weight: 6.6 parts of acetyl hexapeptide-8, 2.2 parts of palmitoyl pentapeptide-3 and 0.66 part of pentapeptide-3; 160 parts of perilla leaf extract, 150 parts of lantana leaf extract, 120 parts of bidens pilosa extract, 340 parts of aesculus hippocastanum extract, 200 parts of thymus vulgaris extract, 290 parts of aloe barbadensis extract, 260 parts of centella asiatica extract and 80 parts of silybum marianum extract.

The present invention provides the use of said composition or preferred composition in the preparation of a skin care product.

The invention also provides the skin anti-aging repair essence milk which comprises, by mass, 8-32% of the plant extract composition as claimed in claim 1 or 2, 13-26% of essence milk base components, and the balance of deionized water.

Further, the essence milk also comprises antioxidant active ingredients according to the mass percentage, wherein the antioxidant active ingredients comprise 0.02-0.06% of kinetin, 2-4% of tea polyphenol, 0.5-1% of hydroxydecyl ubiquinone, 1-5% of colloidal oat powder and 0.5-1.5% of tocopherol.

Further, the essence milk also comprises active ingredients for promoting microcirculation and natural moisturizing active factors according to the mass percentage, wherein the active ingredients for promoting microcirculation comprise 0.1-0.3% of arginine, 0.1-1.5% of adenosine and 0.01-1% of biotin; the natural moisturizing active factor consists of 0.01-0.08% of sodium hyaluronate and 0.2-0.5% of wild mango kernel fat.

Further, the essence milk is added with 1% of natural whitening component tetrahydrocurcumin by mass percent.

Further, the cosmetic base component is composed of, by weight, 8 parts of glycerin, 1 part of butylene glycol, 1 part of propylene glycol, 1 part of caprylic/capric triglyceride, 1 part of polydimethylsiloxane, 1 part of hydrogenated coconut oil glyceride, 1 part of isononyl isononanoate, 0.2 part of stearyl alcohol, 1 part of cetyl alcohol, 1 part of jojoba esters, 0.2 part of glyceryl stearate, 0.2 part of hydrogenated lecithin, 3 parts of steareth-2, 1 part of steareth-21, 1 part of polymethyl methacrylate, 1 part of acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer, 0.2 part of xanthan gum, 1 part of hydroxyethyl cellulose, 0.1 part of titanium dioxide, 0.5 part of phenoxyethanol, 1 part of disodium EDTA, 1 part of chlorphenesin, 1,2 pentanediol, 1 part of ethylhexylglycerin, 1 part of p-hydroxyacetophenone, 1 part of potassium sorbate, 1 part of colorant 19140, 1 part of colorant CI 14700 and 1 part of essence.

The invention also comprises a preparation method of the skin anti-aging repair essence milk, which comprises the following steps:

1) adding water into a water phase pot, adding glycerol, butanediol, propylene glycol, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, xanthan gum, hydroxyethyl cellulose, titanium dioxide, phenoxyethanol, p-hydroxyacetophenone, EDTA disodium and 1,2 pentanediol according to the weight ratio under the condition of stirring, and then stirring and heating to 75-85 ℃ to obtain a water phase solution;

2) adding caprylic/capric triglyceride, polydimethylsiloxane, hydrogenated coconut oil glyceride, isononyl isononanoate, stearyl alcohol, cetyl alcohol, jojoba esters, glyceryl stearate, hydrogenated lecithin, steareth-2, steareth-21, polymethyl methacrylate, chlorphenesin and ethylhexylglycerin into an oil phase pot in proportion, and heating to 75-85 ℃ to melt the materials to obtain an oil phase solution;

3) vacuum pumping the water phase solution into a main pot of a homogenizing and liquefying machine, vacuum pumping the oil phase solution into the main pot of the homogenizing and liquefying machine under stirring, opening the homogenizing and liquefying machine, and homogenizing at the rotating speed of 2800r/min for 7-10 minutes; homogenizing, stirring at 40r/min, and keeping the temperature at 80 deg.C for 5 min;

4) after heat preservation, opening cooling water, cooling the mixed material obtained in the step 3) to 40-45 ℃, adding the repairing active polypeptide compound plant extract anti-aging repairing composition, the antioxidant active ingredient, the natural moisturizing active factor, the microcirculation promoting active ingredient and the tetrahydrocurcumin, and fully and uniformly stirring;

5) adding potassium sorbate, a coloring agent CI 19140, a coloring agent CI 14700 and essence into the material obtained in the step 4); stirring uniformly, standing for 1 hour, continuing stirring for 5-10 minutes, and adjusting the pH value to 6.0-6.5; and (6) ending.

The extract is as follows: refers to a solution obtained by soaking or mixing a substance to be extracted in a solvent. The extraction process can be carried out with the aid of the selection of suitable solvents, such as: water, ethanol/water mixture, methanol, propanol, butanol, chloroform, acetone or other organic solvent, and extracting by separation, percolation, decoction, countercurrent extraction, ultrasonic extraction, microwave extraction, or supercritical fluid extraction to obtain extract, and further evaporating and concentrating the extract to obtain extract and dried extract.

The anti-aging repair composition provided by the invention comprises repair active polypeptides and plant extracts, wherein the repair active polypeptides comprise:

acetyl hexapeptide-8 is a biomimetic peptide, a novel hexapeptide, which is entitled "wrinkle-reducing novelties" and has a superior effect, particularly in terms of lightening the depth of ocular wrinkles. The composition can inhibit the release of nerve conduction element acetylcholine and weaken the contraction of muscles, so that dynamic line expression lines are reduced, wrinkles are reduced, the activity of elastin is increased, the renewal capacity of epidermis is maintained, the skin is smooth and compact, the skin age is challenged to be reversed, and the youthful luster of the skin is displayed.

The active small molecule in the palmitoyl pentapeptide-3 is micro collagen, and the small molecule polypeptide penetrates into the skin through the cream containing the palmitoyl pentapeptide-3 and reaches fibroblasts. Small molecules of the connective tissue of the skin, such as collagen and sucromosamine, are synthesized in fibroblasts and these synthesized molecules participate in the formation of the skin matrix.

Pentapeptide-3 is an improved peptide having lipophilicity, and is effective in alleviating contraction of facial muscles, increasing arrangement of collagen and elastin, thereby preventing formation of wrinkles and wrinkles in the skin, and maintaining the tight state of the skin.

The compounded plant extract composition of the invention has a detoxification and anti-allergy combination and a repairing and conditioning combination.

Detoxification and anti-allergy combination: the perilla leaf relieves allergic skin; herba Bidentis Bipinnatae has effects of removing toxic substance, relieving swelling, reducing red blood streak, and soothing red skin; the lantana camara has the effects of clearing heat and removing toxicity, dispelling wind and relieving itching, and relieving the symptoms of allergic skin pruritus, and is especially suitable for acne muscles, allergic skin and hormone faces.

The perilla leaf relieves allergic skin; herba Bidentis Bipinnatae has effects of removing toxic substance, relieving swelling, reducing red blood streak, and soothing red skin; the lantana camara has the effects of clearing heat and removing toxicity, dispelling wind and relieving itching, and relieving the symptoms of allergic skin pruritus, and is especially suitable for acne muscles, allergic skin and hormone faces. Twisting the unhealthy state of the skin.

The Aesculus hippocastanum extract can accelerate the self-repair ability of skin cells, improve microcirculation and maintain the normal metabolism of cells. The aescin can maintain the health of blood vessel, increase blood circulation, reduce capillary blood vessel penetration and reduce red blood streak; and edema of the eye due to poor circulation of blood vessels. Wherein the aescin can repair inflammation and promote wound healing: the effects of eliminating edema, removing acne and repairing are achieved through the activated leucocyte, and the anti-skin inflammation and the promotion of wound healing are achieved. The escin has the effects of resisting free radicals and oxidation, and can effectively resist aging and improve skin microcirculation after being frequently used.

The thyme extract inhibits cyclic AMP phosphodiesterase activity and promotes arginase activity, indicating anti-inflammatory and wound healing effects; can eliminate free radicals, can be used as antioxidant, and has antiaging effect; it also can be used as skin red blood streak preventing agent, antibacterial and dandruff removing agent, humectant and insect repellent.

The Aloe Barbadensis Miller extract contains polysaccharides, anthraquinone compounds, proteins, vitamins, and minerals. Can comprehensively repair the damaged tissues of the human body, quickly eliminate various toxins in the human body, enhance the immunity of the organism, delay the aging of the skin, decompose fat, reduce the weight, whiten the skin and improve simple obesity.

Centella asiatica extracts exhibit a broad spectrum of biological activities, most importantly antioxidant, anti-inflammatory, antibacterial and anticancer activities. In dermatology, centella asiatica extracts are used for the treatment of small wounds, value-added scars, burns, psoriasis, etc. Centella asiatica extract stimulates fibroblast proliferation and activates SMAD signaling pathways, thus increasing collagen type I production and reducing the formation of stretch marks and inflammatory responses.

Silymarin has effects of resisting radiation and aging, preventing and treating arteriosclerosis, and delaying skin aging.

The invention has the beneficial effects that:

1. the plant extract composition with strong antioxidant activity is compounded with the regeneration and repair active polypeptide, so that the skin is repaired, protected and nourished in an all-around way, the skin is far away from the damage of free radicals and ultraviolet rays, the elasticity is recovered, the skin is tender, and the trace of the corrosion of years is eliminated.

2. The invention provides a novel anti-aging cosmetic functional component combination to overcome the defects in the prior art. The invention starts from the mechanism of skin aging formation, regulates the expression of aging genes, prevents the skin from being damaged by ultraviolet rays, eliminates harmful free radicals, enhances the cell proliferation activity, reconstructs extracellular matrix, reduces the activity of MMPs protease, prevents the degradation of the extracellular matrix of I, III, IV type collagen, proteoglycan, elastin, laminin and the like, reduces the level of inflammatory factors induced by skin aging, supplements various amino acids required by the synthesis of collagen, promotes the synthesis of collagen, regulates the metabolism level of skin cells and stimulates the cell activity. In addition, the skin barrier function is enhanced on the outer layer of the skin, the capacity of skin cells for resisting external injury is improved, the water content of the skin is improved, the elasticity of the skin is recovered, and the skin aging is comprehensively delayed. Not only makes each component fully play its own role, but also realizes the synergistic effect among the components.

The specific implementation mode is as follows:

the following examples are illustrative of the present invention and the present invention is not limited to the following examples.

Preparation of the anti-aging repair composition