阅读说明：本技术 一种用于预防感染新型冠状病毒的浓缩颗粒及其制备方法 (A concentrated granule for preventing infection of novel coronavirus and its preparation method ) 是由 姚娜 黄燕明 陈桂生 李雪银 汪静 康志英 于 2020-05-18 设计创作，主要内容包括：本申请公开了一种用于预防感染新型冠状病毒的浓缩颗粒及其制备方法,先称取定量组方的饮片,再对定量组方的饮片进行第一次提取和第二次提取,然后用过滤器一过滤得到第一溶液和第二溶液,然后将第一溶液和第二溶液混合得到混合液,再将混合液减压浓缩为浸膏,在浸膏中加入糊精并混匀后得浸膏糊,用过滤器二对浸膏糊过滤后,采用干燥机干燥得干膏粉,然后在干膏粉中加入乳糖混匀后得混合粉,将混合粉放入干法制粒机中处理得到用于预防感染新型冠状病毒的浓缩颗粒,这种浓缩颗粒与目前市场上推荐处方的组方相同,有同样的疗效,制作成的浓缩颗粒在装袋后使患者服用和携带方便,而且容易保存。(The application discloses a concentrated granule for preventing infection of novel coronavirus and a preparation method thereof, wherein decoction pieces with a quantitative formula are weighed firstly, the decoction pieces with the quantitative formula are subjected to primary extraction and secondary extraction, then a first solution and a second solution are obtained by filtering with a first filter, then the first solution and the second solution are mixed to obtain a mixed solution, the mixed solution is concentrated under reduced pressure to obtain an extract, dextrin is added into the extract and uniformly mixed to obtain an extract paste, the extract paste is filtered with a second pair of the extract pastes with the first filter, a drier is used for drying to obtain a dry paste powder, then lactose is added into the dry paste powder and uniformly mixed to obtain a mixed powder, the mixed powder is put into a dry granulator to be treated to obtain the concentrated granule for preventing infection of the novel coronavirus, the concentrated granule has the same formula as the formula recommended in the market at present and has the same curative effect, and the prepared concentrated granule is convenient for patients to take and carry after being bagged, and is easy to store.)

1. A concentrate particle for preventing infection with a novel coronavirus and a method for preparing the same, comprising:

weighing decoction pieces with quantitative composition;

the decoction pieces of the quantitative prescription comprise 330g of raw astragalus root, 330g of fried bighead atractylodes rhizome, 330g of divaricate saposhnikovia root, 198g of cyrtomium rhizome, 330g of honeysuckle, 330g of fortune eupatorium herb and 198g of tangerine peel;

carrying out first extraction on the decoction pieces with the quantitative formula for 0.5-1.5 hours, adding 8-10 times of water, and filtering by using a filter I to obtain a first solution;

carrying out secondary extraction on the decoction pieces with the quantitative formula, wherein the secondary extraction time is 0.5-1.5 hours, the water addition amount is 8-10 times, and filtering by using the first filter to obtain a second solution;

mixing the first solution and the second solution to obtain a mixed solution;

concentrating the mixed solution under reduced pressure until the relative density is 1.05-1.08 to obtain an extract;

adding dextrin into the extract, uniformly mixing to obtain extract paste, filtering the extract paste by using a filter, and drying by using a dryer to obtain dry paste powder;

adding lactose into the dry paste powder, uniformly mixing for 10-30 minutes to obtain mixed powder, and putting the mixed powder into a dry granulating machine for treatment to obtain concentrated granules for preventing infection of the novel coronavirus.

2. The enriched particles for preventing infection with the novel coronavirus and the preparation method thereof as claimed in claim 1, wherein the dextrin is included at a percentage of 3%.

3. The enriched granule for preventing infection with the novel coronavirus as claimed in claim 1, wherein the first filter has a 300-mesh screen.

4. The enriched granule for preventing infection with the novel coronavirus according to claim 1, wherein the second filter has a 200 mesh screen.

5. The enriched particles for preventing infection with the novel coronavirus according to claim 1, wherein the dryer is a vacuum type dryer or a spray dryer.

6. The enriched particles for preventing infection with the novel coronavirus according to claim 1, wherein the mixing time is 15 min.

Technical Field

The application relates to the field of medicines, in particular to a concentrated particle for preventing infection of novel coronavirus and a preparation method thereof.

Background

2019A novel coronavirus, temporarily named 2019-nCoV coronavirus, is a new strain of coronavirus found in human in 2019. The symptoms of the virus are fever, hypodynamia, dry cough and gradual dyspnea, and severe patients show acute respiratory distress syndrome, septic shock, metabolic acidosis and blood coagulation dysfunction which are difficult to correct. About half of patients have dyspnea and disease changes after one week, and may become heavy. Some patients have mild initial symptoms, and may have no fever, with the majority of patients having a good prognosis. The total number of peripheral blood leukocytes in the early stage of onset is normal or reduced, and the lymphocyte count is reduced. The early stage shows multiple small spot shadows and interstitial changes, and the disease condition progresses to the development of multiple wearing and infiltrating shadows of the double lungs, and the serious patients can have lung excess changes and pleural effusion is rare. The virus has long latent period and infectivity, and no specific treatment method exists for diseases caused by the novel coronavirus. The prescription for preventing pneumonia infected by the novel coronavirus recommended in the market at present is as follows: the traditional Chinese medicine composition is prepared by taking 10g of raw astragalus membranaceus, 10g of fried bighead atractylodes rhizome, 10g of divaricate saposhnikovia root, 6g of cyrtomium rhizome, 10g of honeysuckle, 10g of fortune eupatorium herb and 6g of dried orange peel (decocted for oral administration, one dose is taken twice a day, and the dose is 7-10 days, and the prescription has the curative effect of preventing pneumonia infected by novel coronavirus.

Therefore, how to achieve the same curative effect as the prescription recommended in the current market, so that the medicine is convenient for patients to take and carry, and is easy to store is a problem to be solved by the technical personnel in the field.

Disclosure of Invention

The application provides a concentrated particle for preventing infection of novel coronavirus and a preparation method thereof, and solves the problems that the prescription recommended in the existing market needs to be subjected to complicated treatment before being taken, so that a patient is inconvenient to take and carry and is not easy to store.

In order to solve the above technical problems, the present application provides a concentrated particle for preventing infection with a novel coronavirus and a method for preparing the same, comprising:

weighing decoction pieces with quantitative composition;

the decoction pieces of the quantitative prescription comprise 330g of raw astragalus root, 330g of fried bighead atractylodes rhizome, 330g of divaricate saposhnikovia root, 198g of cyrtomium rhizome, 330g of honeysuckle, 330g of fortune eupatorium herb and 198g of tangerine peel;

carrying out first extraction on the decoction pieces with the quantitative formula for 0.5-1.5 hours, adding 8-10 times of water, and filtering by using a filter I to obtain a first solution;

carrying out secondary extraction on the decoction pieces with the quantitative formula, wherein the secondary extraction time is 0.5-1.5 hours, the water addition amount is 8-10 times, and filtering by using the first filter to obtain a second solution;

mixing the first solution and the second solution to obtain a mixed solution;

concentrating the mixed solution under reduced pressure until the relative density is 1.05-1.08 to obtain an extract;

adding dextrin into the extract, uniformly mixing to obtain extract paste, filtering the extract paste by using a filter, and drying by using a dryer to obtain dry paste powder;

adding lactose into the dry paste powder, uniformly mixing for 10-30 minutes to obtain mixed powder, and putting the mixed powder into a dry granulating machine for treatment to obtain concentrated granules for preventing infection of the novel coronavirus.

Preferably, the percentage of dextrin is 3%.

Preferably, the filter screen of the first filter is 300 meshes.

Preferably, the filter screen of the second filter is 200 meshes.

Preferably, the dryer is a vacuum dryer or a spray dryer.

Preferably, the time for blending is 15 minutes.

The invention provides a concentrated granule for preventing infection of novel coronavirus and a preparation method thereof, which comprises the following steps of firstly weighing decoction pieces with a quantitative formula, wherein the decoction pieces with the quantitative formula comprise: 330g of raw astragalus root, 330g of fried bighead atractylodes rhizome, 330g of divaricate saposhnikovia root, 198g of cyrtomium rhizome, 330g of honeysuckle flower, 330g of fortune eupatorium herb and 198g of dried orange peel, then carrying out first extraction on decoction pieces with a quantitative prescription, wherein the time of the first extraction is 0.5-1.5 hours, the water addition amount is 8-10 times, filtering by using a first filter to obtain a first solution, then carrying out second extraction on the decoction pieces with the quantitative prescription, wherein the time of the second extraction is 0.5-1.5 hours, the water addition amount is 8-10 times, similarly, filtering by using the first filter to obtain a second solution, then mixing the first solution and the second solution to obtain a mixed solution, concentrating the mixed solution under reduced pressure to obtain an extract with a relative density of 1.05-1.08, adding dextrin into the extract and mixing uniformly to obtain an extract paste, filtering the two pairs of the extract pastes by using the filters, drying by using a dryer to obtain dry paste powder, then adding lactose and mixing uniformly for, the mixed powder is put into a dry-method granulator to be processed to obtain concentrated granules for preventing infection of the novel coronavirus, the formula of the concentrated granules containing the raw astragalus, the fried bighead atractylodes rhizome, the divaricate saposhnikovia root, the cyrtomium rhizome, the honeysuckle, the fortune eupatorium herb and the dried orange peel is the same as that of the formula recommended in the existing market, so that the concentrated granules have the same curative effect, and the prepared concentrated granules are convenient for patients to take and carry after being bagged and easy to store.

Drawings

In order to more clearly explain the technical solution of the present application, the drawings needed to be used in the embodiments are briefly described below, and it is obvious to those skilled in the art that other drawings can be obtained according to the drawings without making any inventive changes.

FIG. 1 is a flow chart of a method for preparing a concentrated particle for preventing infection with a novel coronavirus according to an embodiment of the present invention;

FIG. 2 is a chart of critical relative humidity according to an embodiment of the present invention.

Detailed Description

In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.

The core of the application is to provide a concentrated particle for preventing infection of novel coronavirus and a preparation method thereof, which can solve the problems that the prescription recommended in the existing market needs to be subjected to complicated treatment before being taken, and the decoction is inconvenient to carry and is not easy to store.

FIG. 1 is a flow chart of a method for preparing a concentrated particle for preventing infection with a novel coronavirus according to an embodiment of the present invention; FIG. 2 is a chart of critical relative humidity according to an embodiment of the present invention. As shown in fig. 1, the method comprises the steps of:

s1 weighing decoction pieces with quantitative prescription;

the decoction pieces with quantitative prescription comprise 330g of raw astragalus root, 330g of fried white atractylodes rhizome, 330g of divaricate saposhnikovia root, 198g of cyrtomium rhizome, 330g of honeysuckle, 330g of fortune eupatorium herb and 198g of tangerine peel;

s2, carrying out first extraction on the decoction pieces with quantitative formula for 0.5-1.5 hours, adding 8-10 times of water, and filtering with a filter I to obtain a first solution;

s3, carrying out second extraction on the decoction pieces with the quantitative formula for 0.5-1.5 hours, adding 8-10 times of water, and filtering with a filter I to obtain a second solution;

s4, mixing the first solution and the second solution to obtain a mixed solution;

s5, concentrating the mixed solution under reduced pressure until the relative density is 1.05-1.08 to obtain an extract;

s6 adding dextrin into the extract, mixing to obtain paste, filtering with a filter, and drying with a drier to obtain dried powder;

s7 adding lactose into the dry paste powder, mixing for 10-30 minutes to obtain mixed powder, and treating the mixed powder in a dry granulator to obtain concentrated granules for preventing infection of the novel coronavirus.

Specifically, firstly, a prescription extraction test is carried out, and firstly, the following prescription is weighed: 60g of raw astragalus membranaceus, 60g of fried bighead atractylodes rhizome, 60g of divaricate saposhnikovia root, 36g of cyrtomium rhizome, 60g of honeysuckle, 60g of fortune eupatorium herb and 36g of dried orange peel, wherein the total amount is 372g, and the test is carried out according to the following three process modes of process 1, process 2 and process 3:

it should be noted that, the method adopted for measuring the paste collecting rate is to precisely suck 25mL of sample, place the sample in a known constant weight evaporation dish, evaporate the sample in a water bath, measure the sample according to a drying weight loss measurement method (appendix IXG of first part of the version 2010 of Chinese pharmacopoeia), and finally calculate the paste collecting rate, and the specific formula is as follows:

the process 1 comprises the following steps: 372g of decoction pieces with a quantitative prescription are weighed and placed in a decoction pot, and extraction is carried out twice, wherein water is added 10 times of the first time, the water amount is about 2cm higher than the height of the decoction pieces with the quantitative prescription, and the extraction is carried out for 0.5 hour. Adding 8 times of water for the second time, and extracting for 0.5 hour. And filtering the extracting solutions extracted twice by using a first filter, weighing the extracting solutions extracted twice, and refrigerating for later use.

And (2) a process: 372g of decoction pieces with a quantitative prescription are weighed and placed in a decoction pot, and extraction is carried out twice, wherein 12 times of water is added for the first time to extract for 0.5 hour, and 10 times of water is added for the second time to extract for 0.5 hour. And filtering the extracting solutions extracted twice by using a first filter, weighing the extracting solutions extracted twice in the same way, and refrigerating for later use.

And (3) a process: weighing 372g of decoction pieces with a quantitative formula, placing the decoction pieces in a decoction pot, extracting for two times, adding 10 times of water for the first time to extract for 1 hour, adding 8 times of water for the second time to extract for 1 hour, filtering the extracting solutions extracted for two times by using a first filter respectively, weighing the extracting solutions extracted for two times, refrigerating for later use, and finally measuring the cream yield of the extracting solutions, wherein the results are shown in the following table 2-1.

TABLE 2-1

Test number	The paste yield%
		Process 1	37.36
Process 2	39.03
		Process 3	44.23

Comparing the cream yield of the process 1 and the process 2 in the table 2-1 shows that the increase of the water adding times has smaller influence on the cream yield, and comparing the cream yield of the process 1 and the process 3 shows that the increase of the decoction time has obvious influence on the cream yield. In order to save production cost and reduce energy consumption, the extraction process of the decoction pieces for determining the quantitative formula comprises the following steps: extracting twice, adding 8-10 times of water for the first extraction, extracting for 0.5-1.5 hours, filtering with a first filter to obtain a first solution, adding 8-10 times of water for the second extraction, extracting for 0.5-1.5 hours, filtering with the first filter to obtain a second solution, and mixing the first solution and the second solution to obtain a mixed solution, wherein the preferred filter screen of the first filter is 300 meshes.

In order to further determine the extraction rate of the extraction process of the decoction pieces with quantitative composition, experimental study is carried out, firstly, a multifunctional extraction tank is selected, the type is T-0.5, a single-effect vacuum concentrator is selected, the type is DJN-200, a spherical concentrator is selected, the type is R450, 30 times of the decoction pieces with quantitative composition are weighed, the total amount is 61.38kg, the extraction process determined in the extraction test of the prescription is verified, finally, sampling is carried out to determine the extraction rate, the extraction rate is 41.44%, the results are similar to the test results of the three processes of the process 1, the process 2 and the process 3, and the extraction process is reasonable.

Specifically, a reduced pressure concentration mode needs to be determined, and considering that the common concentration mode in the traditional Chinese medicine production is reduced pressure concentration, the drying modes comprise spray drying and vacuum belt drying, and the two drying technologies have respective advantages. The spray drying method has the characteristics of high drying speed, short material heating time, simple production process, simple and convenient operation, good controllability, uniform product texture, good dissolubility and the like. The vacuum belt type drying technology has the advantages of high drying speed, high evaporation strength and the like. To further select a drying mode suitable for the concentrated particles for preventing infection with the novel coronavirus, the drying mode was determined by observing the drying condition, measuring the moisture content, calculating the cream yield, and combining the production conditions with the following tests.

First, the spray drying mode was tested, and the test mode and results were as follows:

selecting a spray dryer with the model of OPD-8 and a peristaltic pump with the model of BT100-1L, taking 3kg of extract to perform a spray drying test in order to investigate whether auxiliary materials need to be added in the spray drying process, adjusting equipment parameters to achieve the optimal spray state, recording process parameters, observing the spray drying condition, collecting dry extract powder, measuring water content, and calculating the extract yield. The test results are shown in Table 2-2.

TABLE 2-2 (results of spray drying test)

As can be seen from the test results, the spray drying condition is generally slightly tower-sticking, the fluidity of the dried paste powder is poor, and the paste yield is 40.58%, so that the spray drying process research needs to be carried out by adding auxiliary materials. Further, the amount of the auxiliary materials in the spray drying mode is considered, and the investigation method and the result are as follows:

and (3) taking two parts of the extract, adding 2% and 3% of dextrin into each part of 5kg of the extract, mixing uniformly, and filtering by using a second filter, wherein the preferred filter screen of the second filter is 200 meshes. The inlet air temperature is controlled at 175 ℃, the inlet liquid speed is controlled at 8-11 rpm, the rotation speed of the atomizer is controlled at 45Hz, spray drying is carried out, the drying condition is observed, dry paste powder is collected, and the paste yield is calculated, and the result is shown in tables 2-3.

TABLE 2-3 (investigation of spray drying adjuvant dosage)

From the above results, when the adjuvant is 2% dextrin, the dextrin does not stick to the tower, the fluidity of the dry paste powder is improved compared with that without the adjuvant, and the paste yield is 41.15%; the increased amount of the auxiliary material was 3% dextrin, which resulted in good spraying, no sticking to the tower, good fluidity of the dried paste powder and 45.44% of the cream yield, and it was found that the cream yield increased when the amount of the auxiliary material was increased, and therefore, it was preferable to add dextrin at a ratio of 3% dextrin during spray drying.

Specifically, when the relative density of the extract was examined, the results are shown in tables 2 to 4 by the following method;

taking four parts of extract, 5kg of each part, respectively adopting a method of decompression concentration or water dilution to ensure that the relative densities of the extracts are 1.03, 1.05, 1.08 and 1.10, then adding 3% of dextrin, uniformly mixing, filtering by using a second filter, controlling the air inlet temperature at 175 ℃, the liquid inlet speed at 8-12 rpm, and the rotational speed of an atomizer at 45Hz for spray drying, observing the drying condition, collecting dry extract powder, and calculating the paste collection rate, wherein the results are shown in tables 2-4.

TABLE 2-4 (examination of relative density of spray-dried extract)

The test result shows that when the relative density of the extract is 1.05-1.08 (60 ℃), the paste yield is high, the spray drying condition is good, and therefore the relative density of the extract is determined to be 1.05-1.08 (60 ℃). Finally, the spray drying parameters are determined by tests, and the specific test mode and the results are as follows:

firstly, taking 10kg of concentrated extract, adding 3% dextrin, uniformly mixing, filtering by using a second filter, controlling the air inlet temperature to be 175 ℃, controlling the liquid inlet speed to be 11-12 rpm, controlling the rotating speed of an atomizer to be 45Hz, carrying out spray drying, observing the drying condition, collecting dry extract powder, calculating the paste recovery rate, and determining the dissolubility. The results are shown in tables 2 to 5.

Tables 2-5 (spray drying parameters determination of investigation results)

From the above test results, it was found that the spray drying was good, the tower was not stuck, the fluidity of the dried powder was good, and the yield was 42.30%. Therefore, the spray drying process is determined as follows: taking the extract with the relative density of 1.05-1.08 (60 ℃), adding 3% dextrin, uniformly mixing, and setting spraying parameters: and (3) carrying out spray drying with the atomizer frequency of 45Hz, the inlet air temperature of 175 ℃ and the rotation speed of a peristaltic pump of 11-12 rpm.

Specifically, the vacuum belt drying mode was tested, and the test mode and results were as follows: firstly, selecting a vacuum belt dryer with the model of BVD205, selecting 10kg of extract to perform a vacuum drying test, and setting process parameters as follows: the vacuum degree is 1500-1800 Pa; heating control parameters: first-stage heating: 120 ℃; and (3) second-stage heating: 110 ℃; three-stage heating: 100 ℃; cooling temperature: 20 ℃; feeding control parameters: the rotating speed of the distributing machine is as follows: 240 rpm; the angle of the material distributor is as follows: 15 degrees; liquid inlet speed: 4L/h; discharging control parameters: the track speed is 7 cm/min. Observing the drying condition, collecting dry extract powder, and calculating the extract yield. The test results are shown in tables 2-6.

Tables 2-6 (vacuum belt drying suitability test results)

As can be seen from the above table, when the extract is subjected to vacuum belt drying, the material is better foamed and stripped, and the extract yield is 42.17%, so that auxiliary materials are not required to be added to improve the drying condition. The results of the spray drying and the vacuum belt drying were analyzed as compared with the above results in the following tables 2 to 7.

Tables 2 to 7 (examination results of drying method)

From the results, the spray drying condition is good, the tower is not stuck, the fluidity of the dry paste powder is good, and the yield of the dry paste powder is 42.30%; in the vacuum belt drying, foaming and belt release are preferred, and the yield is 42.17%, and therefore, the dryer is preferably a vacuum dryer or a spray dryer.

The concentration and drying process was preliminarily determined according to the test results in tables 2 to 2, tables 2 to 3, tables 2 to 4, tables 2 to 5, tables 2 to 6 and tables 2 to 7 above as follows: and (3) concentrating the mixed solution under reduced pressure at the temperature of 60-70 ℃ and the vacuum degree of-0.06-0.08 MPa until the relative density is 1.05-1.08 (60 ℃), adding 3% dextrin, mixing uniformly, filtering by using a second filter, and drying in a spray drying or vacuum belt drying manner.

Specifically, a granulation process needs to be determined, and considering that the dry granulation process has the advantages of small using amount of auxiliary materials, direct granulation, no need of processes of wetting, mixing, granulating, drying and the like, simple and convenient process, and capability of effectively ensuring the quality of the traditional Chinese medicine, the dry granulation is selected. To further determine the process conditions, molding rate and granule state of dry granulation, experimental studies of formulation molding were conducted. The model number of the selected dry granulating machine is as follows: LG-S20.

Firstly, in order to determine whether auxiliary materials are required to be added in the dry granulation process, 500g of dry extract powder is taken for dry granulation, the dry granulation condition and the particle property are observed, the process parameters are recorded, the particle dissolubility is measured, meanwhile, the compressibility of the dry extract powder is investigated and tested, and the specific test results are shown in tables 2-8.

Tables 2 to 8 (Dry extract powder compressibility test results)

The examination result of the compressibility of the dry paste powder shows that the material is in strip shape during dry pressing, does not stick to a wheel, has moderate particle hardness, uniform size, no color difference and no powder falling, so that auxiliary materials are not required to be added during the preparation forming.

Next, the types of fillers for dry granulation were examined experimentally: firstly, 500g of dry paste powder is selected, dextrin, maltodextrin and lactose are respectively added according to the proportion that the auxiliary material accounts for 20 percent of the prescription amount, then the dry granulation is started, the process parameters are recorded, the dry granulation condition and the particle properties are respectively observed, the particle dissolubility is measured, and the forming rate is calculated, and the results are shown in tables 2-9.

Tables 2 to 9 (examination result of filler type)

As can be seen from the test results in tables 2 to 9: when the maltodextrin is adopted, the granules are slightly stuck to the wheel during dry granulation, and the colors of the granules are different. When dextrin is adopted, the material is formed into strips, no wheel is adhered, and the prepared particles have moderate hardness, uniform size and no difference in color, but have slight dusting condition. When the lactose is adopted, the materials are made into strips, the wheels are not adhered, the prepared granules are moderate in hardness, uniform in size, free of color difference, free of powder falling and good in taste, and therefore the type of the filler is determined to be the lactose.

Further, carrying out test investigation on the mixing time;

firstly, the selected equipment is a three-dimensional mixer with the model of KSH-50, 3kg of dry paste powder is taken, lactose is added until the total amount is 3.90kg, then the mixture is mixed, the condition of the mixed powder is observed every 5 minutes, the mixing time is determined, and the results are shown in tables 2-10.

Tables 2-10 (results of mixed time study)

As is clear from the test results in tables 2 to 10, the mixing time is 15 minutes, and the dry extract powder and the auxiliary materials can be sufficiently mixed, so that it is preferable to determine the mixing time to be 15 minutes.

Furthermore, the moisture of the mixed powder is tested and examined:

taking 1.50kg of mixed powder obtained in the 'mixing time inspection' test, dividing the mixed powder into three parts, wherein the three parts have the same mass, drying under reduced pressure or spraying 95% ethanol to obtain mixed powder with different water contents, determining the water content requirement of the mixed powder by taking the dry granulation condition as an index, and the test results are shown in tables 2-11.

Tables 2-11 (examination of moisture content of mixed powder)

As can be seen from the test results in tables 2-11, in order to ensure the compressibility of the material and the controllability of the moisture of the finished product particles, the moisture of the mixed powder is controlled to be 3.5-5.5%.

Meanwhile, the dry granulation process was examined and the results are shown in tables 2 to 12 below.

First, 1kg of the mixed powder obtained in the "mixing time observation" was taken and subjected to dry granulation. The dry granulation condition and the granule properties were observed, respectively, the granule solubility was measured, and the molding rate was calculated, and the results are shown in tables 2 to 12.

Tables 2-12 (examination results of dry granulation process parameters table)

As can be seen from the experimental results in tables 2 to 12, the dry granulation condition was good, the granule shape was good, the molding rate was 86.5%, and the dissolubility was acceptable, so the dry granulation parameters were determined as follows: the interval between the press wheels is 1.0mm, the crushing rotating speed is 90.0rpm, the whole grain rotating speed is 35.0rpm, and the whole grain mesh number is 14 meshes. First granulation: the material conveying and degassing are started, the stirring rotating speed is controlled to be 8.0-10.0 rpm, the material conveying rotating speed is controlled to be 30.0-32.0 rpm, the rotating speed of a pressing wheel is controlled to be 11.0-13.0 rpm, and the oil pressure is 6.0 MPa; and (3) second granulation: the material conveying and degassing are carried out, the stirring rotating speed is 8.0rpm, the material conveying rotating speed is controlled to be 23.0-25.0 rpm, the rotating speed of a pressing wheel is 1.0-13.0 rpm, the oil pressure is 6.0MPa, and the third granulation is carried out: and (3) degassing the material, controlling the stirring speed to be 8.0rpm, controlling the material conveying speed to be 20.0-22.0 rpm, controlling the pressure roller speed to be 10.0-12.0 rpm, and controlling the oil pressure to be 6.0Mpa, so that the obtained concentrated granules have good shapes, higher molding rate and qualified dissolubility.

Specifically, the flowability of the granules needs to be examined experimentally:

first, the repose angle of the concentrated granules was measured by selecting a device for measuring the repose angle, model No. FT-104B, and examining the flowability of the concentrated granules for the convenience of granule packaging. The angle of repose of the concentrated granules was determined by a double funnel method using a suitable amount of the concentrated granules, and the results are shown in tables 2 to 13.

Tables 2 to 13 (results of measurement of particle flowability)

From the results in tables 2 to 13, it is understood that the angle of repose of the concentrated granules is 33.0 °, the flowability is good, and the packaging is convenient.

Specifically, in order to ensure the stability of the granules, whether the granules are easy to absorb moisture is examined, the moisture absorption of the granules is examined through the measurement of critical relative humidity, the specific test method is as follows, and the results are shown in tables 2-14.

First, concentrated particles having a thickness of about 2mm were placed at the bottom of a flat weighing bottle having a constant weight, and the same were accurately weighed and placed in dryers for supersaturated solutions of different salts in tables 2 to 14 below, wherein the RH% was also different, and the concentrated particles were placed in a constant temperature incubator at 25 ℃ for 72 hours, and then weighed, and the moisture absorption rate was calculated, and the results are shown in tables 2 to 14.

Tables 2 to 14 (tables of results of moisture absorption examination of concentrated granules)

It should be noted that the moisture absorption rates in tables 2 to 14 are plotted as ordinate and the relative humidity RH is plotted as abscissa, two tangent lines are drawn at both ends of the curve in the graph, and the abscissa corresponding to the intersection point of the two tangent lines is the critical relative humidity, as shown in fig. 2 (critical relative humidity graph). As can be seen from fig. 2, the critical relative humidity of the concentrated granules was greater than 60%, and the environmental humidity was controlled to be 60% or less during granulation and packaging.

The invention provides a concentrated granule for preventing infection of novel coronavirus and a preparation method thereof, which comprises the following steps of firstly weighing decoction pieces with a quantitative formula, wherein the decoction pieces with the quantitative formula comprise: 330g of raw astragalus root, 330g of fried bighead atractylodes rhizome, 330g of divaricate saposhnikovia root, 198g of cyrtomium rhizome, 330g of honeysuckle flower, 330g of fortune eupatorium herb and 198g of dried orange peel, then carrying out first extraction on decoction pieces with a quantitative prescription, wherein the time of the first extraction is 0.5-1.5 hours, the water addition amount is 8-10 times, filtering by using a first filter to obtain a first solution, then carrying out second extraction on the decoction pieces with the quantitative prescription, wherein the time of the second extraction is 0.5-1.5 hours, the water addition amount is 8-10 times, similarly, filtering by using the first filter to obtain a second solution, then mixing the first solution and the second solution to obtain a mixed solution, concentrating the mixed solution under reduced pressure to obtain an extract with a relative density of 1.05-1.08, adding dextrin into the extract and mixing uniformly to obtain an extract paste, filtering the extract by using a second filter to obtain a paste, drying machine to obtain a dry paste powder, then adding lactose and mixing uniformly for 15-, the mixed powder is put into a dry-method granulator to be processed to obtain concentrated granules for preventing infection of the novel coronavirus, the formula of the concentrated granules containing the raw astragalus, the fried bighead atractylodes rhizome, the divaricate saposhnikovia root, the cyrtomium rhizome, the honeysuckle, the fortune eupatorium herb and the dried orange peel is the same as that of the formula recommended in the market at present, so that the concentrated granules have the same curative effect, and the prepared concentrated granules are convenient for patients to take and carry after being bagged and easy to store.

Other embodiments of the present application will be apparent to those skilled in the art from consideration of the specification and practice of the application disclosed herein. This application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the application and including such departures from the present disclosure as come within known or customary practice in the art to which the invention pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope of the disclosure being indicated by the following claims.

It will be understood that the present application is not limited to the precise arrangements described above and shown in the drawings and that various modifications and changes may be made without departing from the scope thereof. The above-described embodiments of the present application do not limit the scope of the present application.