阅读说明：本技术 一种乙酰水杨酸稀土的制备方法 (Preparation method of acetylsalicylic acid rare earth ) 是由 陈明光 张玉玺 赵峰 曹鸿璋 于晓丽 葛瑞祥 芦婷婷 吴豪 曹露雅 于 2020-05-16 设计创作，主要内容包括：本发明涉及一种乙酰水杨酸稀土的制备方法,将乙酰水杨酸分散于溶剂中,并滴加适量碱溶液,控制pH值在特定范围,然后加入稀土盐溶液,于60℃反应一段时间后,产生固体沉淀,经蒸馏水洗涤、过滤,并于80℃干燥即得成品。其优点是：本发明是在常压下反应,不需要任何催化剂即可实现,而且制备成本低廉,合成工艺简单易行,安全可靠。另外,乙酰水杨酸和稀土盐反应后的滤液,又可以作为溶剂循环使用,绿色环保,无任何危险和三废污染。同时该产品化学性质稳定,无毒,无味,易于产业化生产和储存运输。(The invention relates to a preparation method of acetylsalicylic acid rare earth, which comprises the steps of dispersing acetylsalicylic acid in a solvent, dropwise adding a proper amount of alkali solution, controlling the pH value within a specific range, then adding a rare earth salt solution, reacting for a period of time at 60 ℃, generating solid precipitate, washing by distilled water, filtering, and drying at 80 ℃ to obtain a finished product. The advantages are that: the invention can be realized under normal pressure without any catalyst, and has the advantages of low preparation cost, simple and easy synthesis process, safety and reliability. In addition, the filtrate obtained after the reaction of the acetylsalicylic acid and the rare earth salt can be recycled as a solvent, so that the method is green and environment-friendly, and has no any danger or three-waste pollution. Meanwhile, the product has stable chemical property, is nontoxic and tasteless, and is easy for industrial production, storage and transportation.)

1. The preparation method of the acetylsalicylic acid rare earth is characterized by comprising the following steps: dispersing acetylsalicylic acid in a solvent, adding an alkali solution to control the pH value to be in a specific range, then adding a rare earth salt solution, reacting for a period of time at 60 ℃, generating solid precipitate, washing by distilled water, filtering, and drying at 80 ℃ to obtain a finished product.

2. The method for preparing the acetylsalicylic acid rare earth as claimed in claim 1, which is characterized in that: the solvent is one of ethanol, deionized water or acetone.

3. The method for preparing the acetylsalicylic acid rare earth as claimed in claim 1, which is characterized in that: the alkali is one of sodium hydroxide, potassium hydroxide, sodium bicarbonate or potassium bicarbonate.

4. The method for preparing the acetylsalicylic acid rare earth as claimed in claim 1, which is characterized in that: the concentration range of the alkali solution is 0.01 mol/L-0.05 mol/L.

5. The method for preparing the acetylsalicylic acid rare earth as claimed in claim 1, which is characterized in that: the pH value range is 7.5-9.0.

6. The method for preparing the acetylsalicylic acid rare earth as claimed in claim 1, which is characterized in that: the rare earth salt is nitrate or chloride of rare earth.

7. The method for preparing the acetylsalicylic acid rare earth as claimed in claim 1, which is characterized in that: the concentration range of the rare earth salt solution is 0.01mol/L-0.1 mol/L.

8. The method for preparing the acetylsalicylic acid rare earth as claimed in claim 1, which is characterized in that: the reaction time is 0.5-2 h.

The technical field is as follows:

the invention relates to a preparation method of acetylsalicylic acid rare earth, belonging to the technical field of rare earth chemical synthesis.

Background art:

acetylsalicylic acid, also known as Aspirin (ASP), is widely used clinically in the treatment of fever, headache, neuralgia, myalgia, rheumatic fever, acute rheumatic arthritis and other diseases. However, with the wide application of aspirin, its adverse reactions are also gradually increasing, mainly manifested in: nausea, vomiting, gastrointestinal discomfort, allergic reaction, liver damage and the like. Therefore, in recent years, its wide application has been greatly limited.

Rare earth is 15 lanthanide elements with atomic numbers from 57-71 in the third subgroup of the periodic table of the elements, and two elements, scandium (Sc) and yttrium (Y), closely related to the lanthanide elements. The application of rare earth in medicines is also widely researched, for example, cerium oxalate can be used for treating marine dizziness and vomiting of pregnancy, inorganic cerium salt can be used as a wound disinfectant, and besides, the rare earth also has the effects of anticoagulation, anti-inflammatory sterilization, anti-arteriosclerosis, anti-tumor and the like.

After the acetylsalicylic acid and the metal ions form a complex, the toxic and side effects of the aspirin can be obviously reduced, and the drug effect and the physiological function of the aspirin are improved. For example, after acetylsalicylic acid and zinc ions form zinc Acetylsalicylate (ASZ), the analgesic effect of the compound is obviously better than that of ASP, and copper acetylsalicylate (CuAsp) has better effects of diminishing inflammation, relieving pain, resisting rheumatism, resisting epilepsy and the like than ASP, and has the advantages of small toxic and side effects and light gastrointestinal adverse reaction. However, most of the acetylsalicylic acid complexes reported so far are concentrated on transition metal ions, and few of the acetylsalicylic acid complexes related to rare earths are reported.

The invention prepares acetylsalicylic acid rare earth with different properties by reacting rare earth ions with acetylsalicylic acid under certain conditions. Research shows that the acetylsalicylic acid rare earth has special effect in the fields of agriculture, fluorescence and the like. For example, the rare earth acetylsalicylic acid has obvious effects of disease resistance induction, early fruiting and yield increase and quality improvement on ginkgo, and a complex formed by the acetylsalicylic acid and a rare earth terbium (Tb) ion has strong green fluorescence. Besides, the rare earth ions have a plurality of 4f and 5d empty electron energy levels, and the 4f and 5d empty electron energy levels can accept lone-pair electrons of 6-12 ligands as coordination center ions. The formed acetylsalicylic acid rare earth can absorb hydrogen chloride generated by PVC decomposition, and has an important effect of slowing down the aging decomposition of PVC resin. Based on the important role of rare earth and acetylsalicylic acid in medicine, the acetylsalicylic acid rare earth also has good prospect in the field of medicine application.

The invention content is as follows:

the invention aims to provide a preparation method of acetylsalicylic acid rare earth.

The invention is implemented by the following technical scheme: a process for preparing the rare-earth acetylsalicylate includes such steps as dispersing acetylsalicylic acid in solvent, adding alkali solution to control pH value to a certain range, adding rare-earth salt solution, reacting at 60 deg.C for a certain time to generate solid deposit, washing with distilled water, filtering and drying at 80 deg.C.

Further, the solvent is one of ethanol, deionized water or acetone.

Further, the alkali is one of sodium hydroxide, potassium hydroxide, sodium bicarbonate or potassium bicarbonate.

Further, the concentration range of the alkali solution is 0.01 mol/L-0.05 mol/L.

Further, the pH value range is 7.5-9.0.

Further, the rare earth salt is nitrate or chloride of rare earth.

Further, the concentration range of the rare earth salt solution is 0.01mol/L-0.1 mol/L.

Further, the reaction time is 0.5-2 h.

The invention has the advantages that:

1. the acetylsalicylic acid rare earth prepared by the invention is reacted under normal pressure, can be realized without any catalyst, and has the advantages of low preparation cost, simple and feasible synthesis process, safety and reliability.

2. The filtrate generated by preparing the acetylsalicylic acid rare earth, namely the filtrate obtained after the reaction of the acetylsalicylic acid and the rare earth salt solution, can be used as a solvent for recycling. Therefore, the invention has no three-waste pollution, is green and environment-friendly and is easy for industrialized production.

3. The product has stable chemical property, no toxicity, no smell and easy storage and transportation. The product has good application prospect in the fields of agriculture, medicine, fluorescence, PVC heat stabilizer and the like.

The specific implementation mode is as follows:

the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.