阅读说明：本技术 人工晶状体制作方法及利用该方法制作的人工晶状体 (Method for manufacturing artificial lens and artificial lens manufactured by same ) 是由 卢英华 李韶华 陈良全 卢伙贵 张正泓 于 2020-05-06 设计创作，主要内容包括：本发明涉及人工晶状体制作技术领域,公开了一种人工晶状体制作方法及利用该方法制作的人工晶状体,人工晶状体包括人工晶状体本体,所述制造方法包括如下步骤：(A)将人工晶状体本体经臭氧氧化处理；(B)采用偶联剂对人工晶状体本体进行改性处理；(C)对人工晶状体本体进行自然晾干；(D)向人工晶状体本体涂布混合液A；本发明提供的一种人工晶状体制作方法及利用该方法制作的人工晶状体,本方法制成的人工晶状体能够降低人工晶状体本体表面的疏水性能,使材料之间不相互粘附,使得人工晶状体在进入晶状体囊袋之后能够顺利展开。(The invention relates to the technical field of artificial lens manufacturing, and discloses an artificial lens manufacturing method and an artificial lens manufactured by the method, wherein the artificial lens comprises an artificial lens body, and the manufacturing method comprises the following steps: (A) carrying out ozone oxidation treatment on the artificial lens body; (B) modifying the artificial lens body by adopting a coupling agent; (C) naturally airing the artificial lens body; (D) applying the mixed solution A to the intraocular lens body; according to the artificial lens manufactured by the method and the artificial lens manufactured by the method, the hydrophobic property of the surface of the artificial lens body can be reduced, materials are not adhered to each other, and the artificial lens can be smoothly unfolded after entering the lens capsular bag.)

1. A method of making an intraocular lens, comprising: the intraocular lens comprises an intraocular lens body, the manufacturing method comprising the steps of:

(A) carrying out ozone oxidation treatment on the artificial lens body;

(B) modifying the artificial lens body by adopting a coupling agent;

(C) naturally airing the artificial lens body;

(D) applying mixture a to the intraocular lens body: the mixed solution A is formed by mixing a mixed monomer and a solvent A, wherein the mass ratio of the mixed monomer to the solvent A is 5-15%; the mixed monomer is formed by blending a fluorine-containing monomer and acrylic acid according to a ratio;

(E) and (4) carrying out heat curing on the intraocular lens body coated with the mixed solution A to obtain a finished intraocular lens.

2. The method of manufacturing an intraocular lens according to claim 1, wherein: the mass ratio of the fluorine-containing monomer to the acrylic acid is 1: 1-1: 10.

3. The method of manufacturing an intraocular lens according to claim 1, wherein: the fluorine-containing monomer is: trifluoroethyl methacrylate, dodecafluoroheptyl methacrylate or hexafluorobutyl methacrylate.

4. The method of manufacturing an intraocular lens according to claim 1, wherein: the solvent A is ethanol.

5. The method of manufacturing an intraocular lens according to claim 1, wherein: in the step (D), the method also comprises the step of coating the mixed solution B on the intraocular lens body, wherein the mixed solution B is coated firstly, and then the mixed solution A is coated after the mixed solution B is cured to form a coating;

the mixed solution B comprises a solution B1 and a solution B2, the solution B1 is formed by mixing a crystal material monomer mixture and a solvent B, and the mass ratio of the crystal material monomer mixture to the solvent B is 5-15%;

the preparation method of the solution B2 is as follows:

(a) preparation of solution b: the composite material is formed by mixing a mixture and a solvent C, wherein the mixture comprises a coupling agent KH-570 and 1-5 micron nano-silica powder, the mass ratio of the coupling agent KH-570 to the 1-5 micron nano-silica powder to the solvent C is respectively 5% -15% and 0.2% -0.6%, and the solvent C is a mixed solution of ethanol and water;

(b) standing the solution b for 25-35 minutes, and filtering to form a filter cake;

(c) washing the filter cake with ethanol and then carrying out vacuum drying;

(d) the dried filter cake was placed in ethanol to form solution B2.

6. The method of manufacturing an intraocular lens according to claim 5, wherein: the solvent B is ethanol, and the mass ratio of ethanol to water in the solvent C is 1: 1.

7. The method of manufacturing an intraocular lens according to claim 5, wherein: in the step (D), the solution B1 and the solution B2 are mixed for 25-35 minutes to form a mixed solution B.

8. Method for manufacturing an intraocular lens according to any one of claims 1 to 7, characterized in that: in the step (B), modifying the artificial lens body by adopting a coupling agent: and (3) soaking the artificial lens body in the prepared solution C for 15-25 minutes, wherein the mass ratio of ethanol to water in the solution C is 1:1, the pH value is 4, and the concentration of the coupling agent is 5-15%.

9. Method for manufacturing an intraocular lens according to any one of claims 5 to 7, characterized in that: in the step (D), the mixed solution A is coated after the coating is formed by curing for 10-20 minutes at the temperature of 60 ℃.

10. An intraocular lens produced by the method of producing an intraocular lens according to any one of claims 1 to 9.

Technical Field

The invention relates to the technical field of artificial lens manufacturing, in particular to an artificial lens manufacturing method and an artificial lens manufactured by the method.

Background

In the process of implanting the artificial lens, the artificial lens needs to be curled, put into an injector and pushed by an injector push rod, enters a fine pipeline and enters a lens capsular bag, and then needs to climb to be naturally unfolded, so that the implantation of the artificial lens is completed. Because the artificial lens is made of soft materials, and the artificial lens is implanted each time, the artificial lens is different in operation method, different artificial lenses are different in size, different injector pipelines are different in size, the artificial lens is different in curling mode, the time from the artificial lens curling to the implantation is different, and the like, the artificial lens is not high in natural expansion rate after being implanted. During the implantation of the artificial lens, the unfolding of the artificial lens can bring much inconvenience to doctors and patients on an operating table, and the lenses which are failed to be implanted by the doctors are required to be taken out, and even the operation is failed.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides the intraocular lens and the manufacturing method thereof.

The technical scheme adopted by the invention is as follows:

a method of manufacturing an intraocular lens comprising an intraocular lens body, the method of manufacturing comprising the steps of:

(A) carrying out ozone oxidation treatment on the artificial lens body;

(B) modifying the artificial lens body by adopting a coupling agent;

(C) naturally airing the artificial lens body;

(D) applying mixture a to the intraocular lens body: the mixed solution A is formed by mixing a mixed monomer and a solvent A, wherein the mass ratio of the mixed monomer to the solvent A is 5-15%; the mixed monomer is formed by blending a fluorine-containing monomer and acrylic acid according to a ratio;

(E) and (4) carrying out heat curing on the artificial lens body coated with the mixed solution A to obtain an artificial lens finished product.

Further, the mass ratio of the fluorine-containing monomer to the acrylic acid is 1: 1-1: 10.

Further, the fluorine-containing monomer is: trifluoroethyl methacrylate, dodecafluoroheptyl methacrylate or hexafluorobutyl methacrylate.

Further, the solvent A is ethanol.

Further, in the step (D), the mixed solution B is coated on the intraocular lens body, wherein the mixed solution B is coated firstly, and then the mixed solution A is coated after the mixed solution B is cured to form a coating;

the mixed solution B comprises a solution B1 and a solution B2, the solution B1 is formed by mixing a crystal material monomer mixture and a solvent B, and the mass ratio of the crystal material monomer mixture to the solvent B is 5-15%;

the preparation method of the solution B2 is as follows:

(a) preparation of solution b: the composite material is formed by mixing a mixture and a solvent C, wherein the mixture comprises a coupling agent KH-570 and 1-5 micron nano-silica powder, the mass ratio of the coupling agent KH-570 to the 1-5 micron nano-silica powder to the solvent C is respectively 5% -15% and 0.2% -0.6%, and the solvent C is a mixed solution of ethanol and water;

(b) standing the solution b for 25-35 minutes, and filtering to form a filter cake;

(c) washing the filter cake with ethanol and then carrying out vacuum drying;

(d) the dried filter cake was placed in ethanol to form solution B2.

Further, the solvent B is ethanol, and the mass ratio of ethanol to water in the solvent C is 1: 1.

Further, in the step (D), the solution B1 and the solution B2 are mixed for 25-35 minutes to form a mixed solution B.

Further, in the step (B), the artificial lens body is modified by adopting a coupling agent: and (3) soaking the artificial lens body in the prepared solution C for 5-25 minutes, wherein the mass ratio of ethanol to water in the solution C is 1:1, the pH value is 4, and the concentration of the coupling agent is 5-15%.

Further, in the step (D), the mixture A is coated after curing for 10 to 20 minutes at a temperature of 60 ℃ to form a coating.

In step (D), the application position of the mixed solution a to the intraocular lens body is the entire surface of the intraocular lens body or only the surface of the support flap; the application of mixture B to the intraocular lens body is carried out either over the entire intraocular lens body surface or only on the support flap surface.

The invention also provides an artificial lens manufactured by the manufacturing method of the artificial lens.

The invention has the beneficial effects that: three fluorine-containing monomers of trifluoroethyl methacrylate, dodecafluoroheptyl methacrylate or hexafluorobutyl methacrylate and acrylic acid are functional monomers, the hydrophilic and hydrophobic properties of the surface of the intraocular lens can be regulated and controlled, so that materials are not adhered to each other, the intraocular lens prepared by the method can be smoothly unfolded after entering a lens capsular bag, and the intraocular lens can be naturally unfolded every time even under the conditions of the problems of different operating methods of different people, different sizes of the intraocular lenses, different sizes of push injector pipelines, different modes of curling the intraocular lenses, different lengths of time from the curling of the intraocular lenses to implantation and the like.

Detailed Description

To make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below, and obviously,

the described embodiments are only some, but not all embodiments of the invention. The components of embodiments of the present invention generally described and illustrated herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.

The invention will be further illustrated with reference to specific examples.