阅读说明：本技术 一种抗菌洗洁精 (Antibacterial detergent ) 是由 卢志敏 蔡熙扬 刘保 张世林 于 2019-10-30 设计创作，主要内容包括：本发明涉及一种抗菌洗洁精。本发明所述抗菌洗洁精包括表面活性剂体系和抗菌剂,所述表面活性剂体系为阴离子表面活性剂、非离子表面活性剂、两性表面活性剂中的任意一种或一种以上的组合；所述抗菌剂为包括大麻二酚和银抗菌剂的组合物。与现有技术相比,本发明的一种抗菌洗洁精,通过采用阴离子表面活性剂、非离子表面活性剂、两性表面活性剂组合,可以使得洗洁精达到去污的目的,抗菌剂中大麻二酚可以有效的稳定银抗菌剂,并能增强银抗菌剂的效果,使得洗洁精的抗菌能力更强。(The invention relates to an antibacterial detergent. The antibacterial detergent comprises a surfactant system and an antibacterial agent, wherein the surfactant system is any one or the combination of more than one of an anionic surfactant, a nonionic surfactant and an amphoteric surfactant; the antimicrobial agent is a composition comprising cannabidiol and a silver antimicrobial agent. Compared with the prior art, the antibacterial detergent disclosed by the invention can achieve the purpose of decontamination by adopting the combination of the anionic surfactant, the nonionic surfactant and the amphoteric surfactant, and the cannabidiol in the antibacterial agent can effectively stabilize the silver antibacterial agent and enhance the effect of the silver antibacterial agent, so that the antibacterial capability of the detergent is stronger.)

1. An antibacterial detergent, which comprises a surfactant system and an antibacterial agent, and is characterized in that,

the surfactant system is any one or the combination of more than one of an anionic surfactant, a nonionic surfactant and an amphoteric surfactant;

the antimicrobial agent is a composition comprising cannabidiol and a silver antimicrobial agent.

2. An antibacterial detergent according to claim 1, characterized in that: the dosage of the antibacterial agent is 0.1-3%, the total silver content in the antibacterial agent is 150-1500ppm, and the cannabidiol content is 2.5-50 ppm; the mass ratio of the cannabidiol to the total silver is 1:3-1: 150.

3. The antibacterial detergent as claimed in claim 2, which is characterized in that: the silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions.

4. An antibacterial detergent according to claim 1, characterized in that: the weight percentage of the anionic surfactant in the surfactant system is 0-95%, the weight percentage of the nonionic surfactant in the surfactant system is 0-95%, and the weight percentage of the amphoteric surfactant in the surfactant system is 0-20%.

5. The antibacterial detergent according to any one of claims 1-4, wherein the anionic surfactant is one or a mixture of more than one of linear alkylbenzene sulfonate, fatty alcohol-polyoxyethylene ether sulfate, fatty alcohol sulfate, α -olefin sulfonate, succinate sulfonate, fatty acid methyl ester sulfonate, secondary alkyl sulfonate, fatty alcohol polyether carboxylate, fatty acyl sarcosinate, fatty acyl glutamate and fatty acyl glycinate, the anionic surfactant is sodium salt, ammonium salt, potassium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt and isopropylamine salt, and the alkyl or fatty alcohol carbon chain is a C8-C18 single carbon chain or a mixed carbon chain.

6. An antibacterial detergent according to any one of claims 1-4, wherein: the nonionic surfactant is one or a mixture of more than one of alkanol polyoxyethylene ether, alkyl glycoside, fatty acid methyl ester ethoxylate and alkanolamide, the alkyl of the nonionic surfactant is C10-C18 straight-chain or branched-chain saturated alkyl, and the EO addition number of the polyoxyethylene ether is 6-10.

7. An antibacterial detergent according to any one of claims 1-4, wherein: the amphoteric surfactant is one or more of betaine surfactant, imidazoline surfactant, and amine oxide amphoteric surfactant.

8. An antibacterial detergent according to any one of claims 1-4, wherein: the dosage of the surfactant system is 10-60%.

9. An antibacterial detergent according to claim 8, wherein: when the dosage of the surfactant system is more than 35%, the detergent also contains an alcohol solvent, wherein the alcohol solvent is one or a mixture of more than one of glycerol, 1, 3-propylene glycol and ethanol; the content of the solvent is 5-10%.

10. An antibacterial detergent according to any one of claims 1-4, wherein: the antibacterial liquid detergent also contains an inorganic salt thickener, a preservative, essence, a chelating agent and a pH regulator.

Technical Field

The invention belongs to the technical field of daily chemical production, and particularly relates to an antibacterial detergent.

Background

The detergent is a common cleaning product in daily life and is widely used for washing tableware, vegetables, melons and fruits and the like. At present, the most important requirements for the detergent are that the detergent has strong antibacterial ability in addition to the detergency. Currently, the most commonly used antibacterial agents are triclosan, triclocarban, parachlorometaxylenol and inorganic antibacterial agents, and most of the currently commercialized inorganic antibacterial agents are inorganic substances containing silver or silver ions.

The silver-based antibacterial agent has a long application history and plays a great role in human health. And in terms of safety and antibacterial effect, the inorganic silver antibacterial agent and the silver composite antibacterial agent have the advantages of long acting, high efficiency, broad spectrum, safety and the like. Silver has been found to have natural antibacterial properties and safety in ancient times. At that time, the ancient Egypt people know that the thin silver sheet covers the wound to prevent bacterial infection, the Mongolian people who accelerate wound healing know that the sheep milk contained in the silver container can keep fresh, and the Ministry physicians Li Shizhen in the compendium of materia medica of China has the effects of calming the five internal organs, calming the heart, stopping fright palpitation, eliminating pathogenic qi and the like, can take the sheep milk for a long time to lighten the body and prolong the life, has the raw silver taste and is pungent and cold, is nontoxic, and has the traditional Chinese medicine silver diagnosis and treatment related diseases, and the western medicine silver treatment has the record of over 100 years. In 1884, German obstetrician Crede dropped 1% silver nitrate solution into eyes of newborn infants to prevent conjunctivitis of newborn infants, and the blindness rate of infants was reduced from 10% to 0.2%. In 1893, tests show that silver has a killing effect on microorganisms such as bacteria, and the silver has a wider medical effect until today. 0.5% silver nitrate is a standard solution for treating burns and wounds; the silver nitrate with the concentration of 10-20% can be applied to treat the uterine erosion. Researches show that the silver has strong killing effect on various pathogenic bacteria such as escherichia coli, staphylococcus aureus and the like, the required concentration is extremely low, and the general dosage is 10^-6And (mass fraction) sterilizing. In thatIn the aspect of safety, silver is one of tissue components in a human body, cells treated by silver ions with very low concentration have no obvious changes of cell aggregation, cell deformation, cell lysis, pH value and the like, and a small amount of silver ions have no obvious harm to the human body. Therefore, the silver-based antibacterial agent is used for improving the antibacterial function of the textile and has sufficient safety.

The silver antibacterial agent has many advantages as an inorganic antibacterial agent, but the silver antibacterial agent has unstable property, nano silver is easy to agglomerate and discolor, silver ions are easy to be converted into brown silver oxide or black simple substance silver through ultraviolet light catalytic reduction, and the external quality and antibacterial performance of the product are influenced. The composite antibacterial agent is a development direction of antibacterial materials, and many researches prove that the composite antibacterial agent has a better antibacterial effect than a single metal antibacterial agent.

Disclosure of Invention

Based on the above, the invention aims to provide an antibacterial detergent so as to effectively overcome the defects in the prior art.

In order to achieve the purpose, the invention adopts the following technical scheme:

an antibacterial detergent comprises a surfactant system and an antibacterial agent, wherein the surfactant system is any one or the combination of more than one of an anionic surfactant, a nonionic surfactant and an amphoteric surfactant; the antimicrobial agent is a composition comprising cannabidiol and a silver antimicrobial agent.

Compared with the prior art, the antibacterial detergent disclosed by the invention can achieve the purpose of decontamination by adopting the combination of any two or more of an anionic surfactant, a nonionic surfactant and an amphoteric surfactant, and the cannabidiol and the silver antibacterial agent are compounded, so that the silver antibacterial agent can be effectively stabilized, the drug effect of the silver antibacterial agent can be enhanced, and the antibacterial capability of the detergent is stronger.

Further, the dosage of the antibacterial agent is 0.1-3%, the total silver content in the antibacterial agent is 150-1500ppm, and the cannabidiol content is 2.5-50 ppm; the mass ratio of the cannabidiol to the total silver is 1:3-1: 150.

Further, the silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions.

Further, the weight percentage of the anionic surfactant in the surfactant system is 0-95%, the weight percentage of the nonionic surfactant in the surfactant system is 0-95%, and the weight percentage of the amphoteric surfactant in the surfactant system is 0-20%.

Further, the anionic surfactant is one or a mixture of more than one of linear alkylbenzene sulfonate, fatty alcohol-polyoxyethylene ether sulfate, fatty alcohol sulfate, α -olefin sulfonate, succinate sulfonate, fatty acid methyl ester sulfonate, secondary alkyl sulfonate, fatty alcohol polyether carboxylate, fatty acyl sarcosinate, fatty acyl glutamate and fatty acyl glycinate, the anionic surfactant is sodium salt, ammonium salt, potassium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt and isopropylamine, and the carbon chain of alkyl or fatty alcohol is a single carbon chain or a mixed carbon chain of C8-C18.

Further, the nonionic surfactant is one or a mixture of more than one of alkanol polyoxyethylene ether, alkyl glycoside, fatty acid methyl ester ethoxylate and alkanolamide, the alkyl of the nonionic surfactant is C10-C18 straight-chain or branched-chain saturated alkyl, and the EO addition number of the polyoxyethylene ether is 6-10.

Further, the amphoteric surfactant is one or more of betaine surfactant, imidazoline surfactant and amine oxide amphoteric surfactant.

Further, the amount of the surfactant system is 10-60%. The surfactant is a main substance exerting detergency. The content of the detergent has certain influence on the dirt-removing capacity of the detergent.

Furthermore, when the total active matter of the liquid detergent is more than 35%, the liquid detergent also contains an alcohol solvent, wherein the alcohol solvent is one or a mixture of more than one of glycerol, 1, 3-propylene glycol and ethanol; the content of the solvent is 5-10%.

Further, the antibacterial liquid detergent also contains an inorganic salt thickener, a preservative, essence, a chelating agent and a pH regulator. The detergent is more stable and durable by adding the thickening agent and the preservative into the detergent. The essence can increase the fragrance of the liquid detergent, and the chelating agent and the pH regulator both increase the stability and the persistence of the liquid detergent.

According to the antibacterial detergent, the surfactant and the antibacterial agent are used together, and the antibacterial agent is a compound antibacterial agent formed by compounding and combining cannabidiol and a silver antibacterial agent, wherein the cannabidiol can stabilize the silver antibacterial agent, ensure that silver does not generate physical and chemical reactions, ionic silver does not react with chloride ions in a detergent formula, and also ensure that the effectiveness of the silver ions is ensured, and the product does not yellow. Cannabidiol can also enhance the bactericidal and bacteriostatic effects of the silver antibacterial agent. The antibacterial detergent can obviously improve the antibacterial effect, and the detergent does not change color or deteriorate and has longer antibacterial lasting effect.

For a better understanding and practice, the present invention is described in detail below.

Detailed Description

The present invention will be described in further detail with reference to specific examples.

The invention provides an antibacterial detergent which is composed of a surfactant system and an antibacterial agent. The detergent is characterized in that the surfactant system is any one or combination of more than one of an anionic surfactant, a nonionic surfactant and an amphoteric surfactant, and the detergent also comprises an inorganic salt thickener, a preservative, essence, a chelating agent, a pH regulator and the balance of water.

The antibacterial agent of the present invention comprises a combination of cannabidiol and a silver antibacterial agent. The total silver content in the antibacterial agent is 150-1500ppm, and the cannabidiol content is 2.5-50 ppm; the mass ratio of the cannabidiol to the total silver is 1:3-1: 150. The silver antibacterial agent is one or a mixture of more than one of colloidal silver simple substance, silver ions or silver complex ions, wherein the total content of silver is 150-1500 ppm. The dosage of the antibacterial agent is 0.1-3%.

Cannabidiol (Cannabidial) CBD is white to light yellow resin or crystal, melting point 66-67 deg.C, and is almost insoluble in water or 10% sodium hydroxide solution, and is dissolved in ethanol, methanol, ether, benzene, chloroform and petroleum ether. Cannabidiol is a main chemical component in medicinal plant cannabis sativa, is extracted from female cannabis sativa plants, is a non-addictive component in cannabis sativa, and has pharmacological effects of resisting spasm, anxiety and inflammation. CBD not only can be used for treating various difficult and complicated diseases, but also can effectively eliminate the hallucinogenic effect of Tetrahydrocannabinol (THC) on human bodies, and is called as an anti-drug compound (anti-marijuana compound).

The cannabidiol is extracted from natural plants or chemically synthesized.

Plant extraction of cannabidiol: is extracted from mature industrial hemp stem with Tetrahydrocannabinol (THC) content less than 0.3%.

Biosynthetic pathway of cannabidiol: the C10 terpene moiety in the chemical structure of CBD is synthesized mainly through the deoxyxylulose phosphate pathway, and the phenol moiety comes from the polyketide-type reactivity sequence (polyketide-type reaction sequence), and geranyl diphosphate (GPP) and olyacetoxylic acid (oa) are considered as special intermediates in the hemp chemical composition synthesis pathway. CBD synthases have been found to synthesize CBD from Cannabigerol (CBG). Isopentene diphosphate (IPP) and dimethyl propenyl diphosphate (DM APP) react firstly, generated GPP reacts with OA to generate CBG, and CBG generates CBD, THC and carboxylic acid compounds thereof under the action of CBD synthase.

Chemical synthesis route of cannabidiol: the chemical synthesis pathway of cannabidiol is reported in many documents, and the most classical synthesis method is as follows:

the most classical synthesis of Cannabidiol (CBD)

P-mentha-2, 8-diene-1-ol (1) and 5-amyl-1, 3-benzenediol (2) in BF₃By reaction under catalysis of3 products were obtained, of which the CBD yield was 41%. Since the starting materials are readily available, the reaction is simple, and the CBD yield is high, they have been used for a long time as a common method for synthesizing CBD.

The weight percentage of the anionic surfactant in a surfactant system is 0-95%, the weight percentage of the nonionic surfactant in the surfactant system is 0-95%, and the weight percentage of the amphoteric surfactant in the surfactant system is 0-20%.

Preferably, the anionic surfactant is one or a mixture of more than one of linear alkylbenzene sulfonate, fatty alcohol-polyoxyethylene ether sulfate, fatty alcohol sulfate, α -olefin sulfonate, succinate sulfonate, fatty acid methyl ester sulfonate, secondary alkyl sulfonate, fatty alcohol polyether carboxylate, fatty acyl sarcosinate, fatty acyl glutamate and fatty acyl glycinate, the anionic surfactant is sodium salt, ammonium salt, potassium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt and isopropylamine, and the carbon chain of alkyl or fatty alcohol is a single carbon chain or a mixed carbon chain of C8-C18.

Preferably, the nonionic surfactant is one or a mixture of more than one of alkanol polyoxyethylene ether, alkyl glycoside, fatty acid methyl ester ethoxylate and alkanolamide, the alkyl of the nonionic surfactant is C10-C18 straight-chain or branched saturated alkyl, and the EO addition number of the polyoxyethylene ether is 6-10.

Preferably, the amphoteric surfactant is one or more of betaine surfactant, imidazoline surfactant and amine oxide amphoteric surfactant.

Preferably, the dosage of the surfactant is 10-60%. The surfactant in the antibacterial liquid detergent is a main substance for exerting the dirt-removing power. The content of the detergent has certain influence on the dirt-removing capacity of the detergent. When the dosage of the surfactant in the detergent is more than 35%, the detergent also contains an alcohol solvent, wherein the alcohol solvent is one or a mixture of more than one of glycerol, 1, 3-propylene glycol and ethanol. The content of the solvent is 5-10%.

The following examples are provided to illustrate the composition of the antibacterial detergent of the present invention and its bacteriostatic and bactericidal effects.

Firstly, a basic formula (without an antibacterial agent) of the liquid detergent is prepared, and the liquid detergent comprises a surfactant system, an inorganic salt thickening agent, a preservative, essence, a chelating agent, a pH regulator and the like.

Table 1, this table shows the basic formulations (without added antimicrobial agents) of antimicrobial liquid detergents of the present invention, examples 1-6.

The basic formulations of the above examples were tested for their bactericidal and bacteriostatic ability and irritation against escherichia coli, staphylococcus aureus and candida albicans.

Antibacterial and bacteriostatic properties: the method is carried out according to a 5.1.1 suspension quantitative antibacterial test and a 5.2.1 suspension quantitative antibacterial test in a standard WS/T650-2019 antibacterial and antibacterial effect evaluation method, wherein the test concentration is 1%.

Irritation test method: the surfactant irritation test employed the Zein (Zein) method. Zein is a yellow Zein, practically insoluble in water, whose structure is similar to that of keratin found in skin and hair. Zein reacts with irritant substances, such as surfactant solutions, and the like, to denature and dissolve. More aggressive surfactants are more likely to cause denaturation of Zein than less aggressive surfactants, resulting in increased dissolution of Zein. The amount of Zein dissolved represents the skin irritation of the surfactant or formulation.

Taking a sample to be detected, and preparing a solution with the active substance mass fraction/effective substance of 1%. 100g of the solution was taken, 0.5g of Zein was added in succession until it could not be dissolved, and then stirred for 2 hours, followed by filtration. The filter paper and the precipitate were placed in a 40 ℃ oven overnight to dry, weighed, and the amount of Zein dissolved was calculated. The greater the amount of Zein solubilized, the greater the irritation.

And (4) the number of the washed dishes is tested according to the national standard, and the higher the number of the washed dishes is, the better the dirt-removing capacity is.

Table 2, this table shows the bactericidal and bacteriostatic ability as well as the irritation test, the detergency test of each example described in table 1 against escherichia coli, staphylococcus aureus and candida albicans.

As can be seen from the above tables 1 and 2, the base formulations of the detergents of examples 1 to 6 exhibited poor bactericidal and bacteriostatic abilities against escherichia coli, staphylococcus aureus and candida albicans without adding an antibacterial substance.

The following is the addition of antibacterial substances based on the basic formulation. The following table

Table 3, this table lists the specific compositions of several antimicrobial agents of the present invention.

Table 4, this table lists the specific compositions of the silver antimicrobial agents.

Table 5, which lists several cannabidiols added

The above-mentioned antibacterial agents 1 to 4 and silver antibacterial agents 1 to 4 and cannabidiol 1 to 4 were added to the base formulations of examples 1 to 6, respectively, and the addition of each example and the effect of the test will be described in detail below. The effect test method is the same as table 2.

Table 6, which shows the addition of each antibacterial substance to example 1 and the test effect.

Table 7 shows the addition of each antibacterial substance to example 2 and the test effect. The effect test method is the same as table 2

Table 8, which shows the addition of each antibacterial substance to example 3 and the test effect. The effect test method is the same as table 2

Table 9, which shows the addition of each antibacterial substance to example 4 and the test effect. The effect test method is the same as table 2

Table 10, which shows the addition of each antibacterial substance to example 5 and the test effect. The effect test method is the same as table 2

Table 11, which shows the addition of each antibacterial substance to example 6 and the test effect. The effect test method is the same as table 2

As can be seen from the above tables 3 to 5, the antibacterial agents 1 to 4 of the present invention are respectively composed of silver antibacterial agents 1 to 4 and cannabidiol 1 to 4. Tables 6-11 show the addition of antimicrobial 1-4, silver antimicrobial 1-4, cannabidiol 1-4, respectively, to the base formulations of examples 1-6, respectively. As can be seen from comparison of tables 6-11 and Table 2, the antibacterial agent of the present invention can significantly enhance the antibacterial and bacteriostatic properties of the detergent, and the irritation is reduced, so that the product performance can be optimized. The antibacterial and bacteriostatic performance of the liquid detergent can be enhanced only by adding the silver antibacterial agent, the irritation performance is not reduced, but is slightly increased, and the irritation of the liquid detergent can be increased instead of reducing the irritation by adding the silver antibacterial agent. And only the cannabidiol is added, so that the bacteriostatic and antibacterial performance of the detergent is not greatly influenced, but the irritation of the detergent can be obviously reduced. In addition, as can be seen from tables 6 to 11, when compared with the addition of the silver antibacterial agent alone, cannabidiol in the antibacterial agent of the present invention can significantly enhance the bactericidal and bacteriostatic properties of the silver antibacterial agent and can also reduce the irritation of the silver antibacterial agent.

The antibacterial detergent obtained by compounding the antibacterial agent, the surfactant and other substances has strong decontamination capability and strong sterilization capability. The cannabidiol in the antibacterial agent can effectively stabilize the silver antibacterial agent, can enhance the antibacterial and bacteriostatic effects of the silver antibacterial agent, enables the antibacterial ability of the detergent to be stronger, can reduce the irritation caused by the surfactant in the detergent, enables the detergent to increase the bactericidal and bacteriostatic persistence of the detergent, and is mild and harmless to skin when being used.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.