阅读说明：本技术 流量计量系统及其计量方法 (Flow metering system and metering method thereof ) 是由 李为平 乐志鲁 柳和生 周天祥 黄明坚 刘小莉 于 2019-11-29 设计创作，主要内容包括：本申请公开了一种流量计量系统及其计量方法,该流量计量系统包括液体流动装置,真空脱气装置,压力监控装置,温度调节装置和计量处理装置；液体流动装置用于驱动待测液流动；真空脱气装置用于对待测液进行真空脱气；压力监控装置与真空脱气装置连通；温度调节装置与压力测量装置连通；计量处理装置包括处理设备以及与温度调节装置连通的计量管；处理设备分别电性连接压力监控装置、温度调节装置和液体流动装置。本申请的流量计量系统不受待测液体中的气泡、液体的挥发、待测液体的温度和压力变化、测量时间的精准度以及读数误差等因素的影响,操作简便,自动化程度高且计量精度高。(The application discloses a flow metering system and a metering method thereof, wherein the flow metering system comprises a liquid flowing device, a vacuum degassing device, a pressure monitoring device, a temperature regulating device and a metering processing device; the liquid flowing device is used for driving the liquid to be detected to flow; the vacuum degassing device is used for carrying out vacuum degassing on the liquid to be tested; the pressure monitoring device is communicated with the vacuum degassing device; the temperature adjusting device is communicated with the pressure measuring device; the metering processing device comprises processing equipment and a metering pipe communicated with the temperature regulating device; the processing equipment is respectively and electrically connected with the pressure monitoring device, the temperature regulating device and the liquid flowing device. The flow metering system is not influenced by factors such as bubbles in liquid to be measured, volatilization of the liquid, temperature and pressure change of the liquid to be measured, accuracy of measuring time, reading errors and the like, is simple and convenient to operate, and has high automation degree and high metering precision.)

1. A flow metering system, comprising:

the liquid flowing device is used for driving the liquid to be detected to flow;

the vacuum degassing device is used for carrying out vacuum degassing on the liquid to be tested;

a pressure monitoring device in communication with the vacuum degassing device;

a temperature regulating device in communication with the pressure measuring device;

a metering processing device comprising a processing apparatus and a metering tube in communication with the temperature regulating device; the processing equipment is respectively and electrically connected with the pressure monitoring device, the temperature regulating device and the liquid flowing device;

the processing equipment acquires the pressure of the liquid to be detected acquired by the pressure monitoring device and the temperature of the liquid to be detected by the temperature adjusting device, and acquires a liquid image of the metering pipe when the pressure of the liquid to be detected reaches a pressure threshold and the temperature of the liquid to be detected reaches a temperature threshold; and the processing equipment processes the liquid image to obtain the flow of the liquid to be detected.

2. The flow metering system of claim 1, wherein the fluid flow device comprises an infusion pump for driving the fluid to be tested to flow, and a fluid container for storing the fluid to be tested;

the liquid container to be tested is communicated with the vacuum degassing device.

3. The flow metering system of claim 1, wherein the pressure monitoring device comprises a pressure stabilizing chamber communicated between the vacuum degassing device and the temperature regulating device, and a pressure collecting device for collecting the pressure of the liquid to be measured;

the pressure acquisition device is electrically connected with the processing equipment.

4. The flow metering system of claim 3, wherein the pressure pick-up device comprises a pressure sensor disposed in the plenum, an analog-to-digital converter coupled to the processing device, and an amplification circuit coupled between the pressure sensor and the analog-to-digital converter.

5. The flow metering system of claim 1, wherein the temperature regulating device comprises a thermostatic device communicated between the pressure monitoring device and the metering pipe, and a temperature collecting device for collecting the temperature of the liquid to be measured;

the temperature acquisition device is electrically connected with the processing equipment.

6. The flow metering system of claim 1, wherein the processing device comprises an image collector for collecting the liquid measurement image and a processing terminal connected with the image collector.

7. The flow metering system of any one of claims 1 to 6, further comprising a filter in communication between the vacuum degassing device and the pressure monitoring device.

8. The flow metering system of claim 7, further comprising a timed switching controller and a damper tube communicating between the pressure monitoring device and the timed switching controller;

the input end of the timing switching controller is communicated with the damping tube, the first output end of the timing switching controller is communicated with the temperature adjusting device, and the second output end of the timing switching controller is communicated with a waste liquid collector.

9. A flow metering method, comprising the steps of:

acquiring the pressure to be measured acquired by a pressure monitoring device and the temperature of the liquid to be measured acquired by a temperature adjusting device;

when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold, acquiring a liquid image of the metering tube;

and processing the liquid image to obtain the flow of the liquid to be detected.

10. The flow metering method of claim 9, wherein the step of processing the liquid image to obtain the flow rate of the liquid to be measured comprises:

calibrating and processing the liquid image based on the CCD image to obtain unit time displacement corresponding to the liquid to be detected;

and obtaining the flow of the liquid to be detected according to the radius of the metering pipe and the displacement in unit time.

Technical Field

The present disclosure relates to the field of metering technologies, and more particularly, to a flow metering system and a metering method thereof.

Background

The accurate measurement of liquid flow as an important problem in a flow control system is becoming a hot point of research day by day, and the development of analytical instruments marks the gradual progress of liquid chromatography in the field of micro and ultra-micro analysis along with the gradual appearance of micro-nano pumps. The accurate control of the flow becomes a necessary condition for the miniaturization of the liquid chromatograph, the accurate flow control needs to take the high-precision flow measurement as a premise, the flow measurement is used as a necessary link in the research and development work of the high-performance liquid chromatography micro-nano pump, and an effective test means is provided for the research and development of the high-performance liquid chromatography micro-nano pump. The current traditional methods such as weighing method and volume method are easily affected by the factors of air bubbles in the liquid to be measured, volatilization of the liquid, temperature change of the liquid to be measured, accurate control of measurement time, reading error and the like, and all can interfere with the accurate measurement of the flow fluid.

In the implementation process, the inventor finds that at least the following problems exist in the conventional technology: in the traditional flow metering process, the flow meter is easily interfered by the metering environment, the metering error is large, and the metering precision is low.

Disclosure of Invention

Therefore, the problems of high possibility of interference of a metering environment, large metering error and low metering precision in the traditional flow metering process are needed, and the flow metering system and the metering method thereof are provided.

In order to achieve the above object, an embodiment of the present invention provides a flow rate metering system, including:

the liquid flowing device is used for driving the liquid to be detected to flow;

the vacuum degassing device is used for carrying out vacuum degassing on the liquid to be tested;

the pressure monitoring device is communicated with the vacuum degassing device;

the temperature adjusting device is communicated with the pressure measuring device;

the metering processing device comprises processing equipment and a metering pipe communicated with the temperature regulating device; the processing equipment is respectively and electrically connected with the pressure monitoring device, the temperature regulating device and the liquid flowing device;

the processing equipment acquires the pressure to be measured acquired by the pressure monitoring device and the temperature of the liquid to be measured of the temperature regulating device, and acquires a liquid image of the metering tube when the pressure to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold; and processing the liquid image by the processing equipment to obtain the flow of the liquid to be detected.

In one embodiment, the liquid flowing device comprises an infusion pump for driving the liquid to be tested to flow and a liquid container to be tested for storing the liquid to be tested;

the liquid container to be tested is communicated with the vacuum degassing device.

In one embodiment, the pressure monitoring device comprises a pressure stabilizing chamber communicated between the vacuum degassing device and the temperature regulating device and a pressure collecting device used for collecting the pressure of the liquid to be measured;

the pressure acquisition device is electrically connected with the processing equipment.

In one embodiment, the pressure acquisition device comprises a pressure sensor arranged in the pressure stabilizing chamber, an analog-to-digital converter connected with the processing equipment, and an amplifying circuit connected between the pressure sensor and the analog-to-digital converter.

In one embodiment, the temperature regulating device comprises a thermostatic device communicated between the pressure monitoring device and the metering pipe, and a temperature collecting device used for collecting the temperature of the liquid to be measured;

the temperature acquisition device is electrically connected with the processing equipment.

In one embodiment, the processing equipment comprises an image collector for collecting the liquid measurement image and a processing terminal connected with the image collector.

In one embodiment, the vacuum degassing device further comprises a filter communicated between the vacuum degassing device and the pressure monitoring device.

In one embodiment, the device further comprises a timing switching controller and a damping tube communicated between the pressure monitoring device and the timing switching controller;

the input end of the timing switching controller is communicated with the damping pipe, the first output end of the timing switching controller is communicated with the temperature adjusting device, and the second output end of the timing switching controller is communicated with the waste liquid collector.

On the other hand, the embodiment of the invention also provides a flow metering method, which comprises the following steps:

acquiring the pressure to be measured acquired by a pressure monitoring device and the temperature of the liquid to be measured acquired by a temperature adjusting device;

when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold, acquiring a liquid image of the metering tube;

and processing the liquid image to obtain the flow of the liquid to be detected.

In one embodiment, the step of processing the liquid image to obtain the flow rate of the liquid to be measured includes:

calibrating and processing the liquid image based on the CCD image to obtain unit time displacement corresponding to the liquid to be detected;

and obtaining the flow of the liquid to be measured according to the radius of the metering pipe and the displacement in unit time.

One of the above technical solutions has the following advantages and beneficial effects:

in each embodiment of the flow metering system, the liquid flowing device is used for driving the liquid to be measured to flow; the vacuum degassing device is used for carrying out vacuum degassing on the liquid to be tested; the pressure monitoring device is communicated with the vacuum degassing device; the temperature adjusting device is communicated with the pressure measuring device; the metering pipe is communicated with the temperature adjusting device; the processing equipment is respectively and electrically connected with the pressure monitoring device, the temperature regulating device and the liquid flowing device; the processing equipment acquires the pressure of the liquid to be measured and the temperature of the liquid to be measured of the temperature regulating device, which are acquired by the pressure monitoring device, and acquires a liquid image of the metering pipe when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold; and processing the liquid image by the processing equipment to obtain the flow of the liquid to be measured, thereby realizing the measurement of the flow of the liquid to be measured. The flow metering system is not influenced by factors such as bubbles in liquid to be measured, volatilization of the liquid, temperature and pressure change of the liquid to be measured, accuracy of measuring time, reading errors and the like, is simple and convenient to operate, and has high automation degree and high metering precision.

Drawings

The present application will be further described with reference to the accompanying drawings and examples, in which:

FIG. 1 is a schematic diagram of a first configuration of a flow metering system in one embodiment;

FIG. 2 is a second schematic diagram of a flow metering system in one embodiment;

FIG. 3 is a schematic diagram of a third configuration of a flow metering system in one embodiment;

FIG. 4 is a fourth schematic diagram of a flow metering system in accordance with one embodiment;

FIG. 5 is a fifth schematic diagram of a flow metering system in accordance with one embodiment;

FIG. 6 is a sixth schematic diagram of a flow metering system in accordance with one embodiment;

FIG. 7 is a seventh block diagram of a flow metering system in accordance with one embodiment;

FIG. 8 is a first schematic flow diagram of a flow metering method in one embodiment;

FIG. 9 is a second flow diagram of a flow metering method in one embodiment.

Detailed Description

For a more clear understanding of the technical features, objects, and effects of the present application, specific embodiments of the present application will now be described in detail with reference to the accompanying drawings.

The flow metering device aims to solve the problems that in the traditional flow metering process, the flow metering device is easily interfered by a metering environment, the metering error is large, and the metering precision is low. In one embodiment, as shown in fig. 1, there is provided a flow metering system comprising:

the liquid flowing device 110, the liquid flowing device 110 is used for driving the liquid to be tested to flow;

the vacuum degassing device 120, the vacuum degassing device 120 is used for vacuum degassing of the liquid to be tested;

a pressure monitoring device 130, the pressure monitoring device 130 being in communication with the vacuum degassing device 120;

a temperature adjustment device 140, the temperature adjustment device 140 being in communication with the pressure measurement device 130;

a metering device 150, the metering device 150 comprising a processing apparatus 152 and a metering tube 154 in communication with the temperature conditioning device 140; the processing device 152 is electrically connected to the pressure monitoring device 130, the temperature regulating device 140 and the liquid flowing device 110 respectively;

the processing device 152 acquires the pressure to be measured acquired by the pressure monitoring device 130 and the temperature of the liquid to be measured of the temperature regulating device 140, and acquires a liquid image of the metering tube 154 when the pressure to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold; the processing device 152 processes the liquid image to obtain the flow rate of the liquid to be measured.

Wherein, the liquid flowing device 110 refers to a device capable of driving the liquid in the container to flow in the pipeline; the liquid flowing device 110 can drive the liquid to be tested to flow in the system pipeline. The vacuum degassing apparatus 120 refers to an apparatus capable of removing non-condensable gas contained in a liquid by vacuum suction. The pressure monitoring device 130 may be used to monitor the pressure of the fluid to be measured and may also be used to regulate the pressure of the fluid to be measured. The temperature adjustment device 140 may be used to monitor the temperature of the fluid to be measured and may also be used to adjust the temperature of the fluid to be measured. The metrology processing device 150 refers to a processing device having functions of image acquisition, data processing, data transmission, and the like. The metering device 150 may be used to acquire and process liquid images of the liquid under test. The processing device 152 can be used for collecting and processing liquid images of the liquid to be tested in the metering tube, and the diameter of the metering tube 154 can be selected according to actual test requirements; alternatively, the metering tube 154 may receive a riser, a micro-riser, a milliriser, or the like, based on the size of the different diameters. In one example, the metering tube 154 is a capillary tube.

In one example, the vacuum degassing device 120 may be a vacuum degassing instrument, which removes air bubbles in the liquid to be tested and prevents the volume of the liquid to be tested from being too large due to the air bubbles in the liquid to be tested, which affects the accuracy of the experimental result.

Specifically, based on the communication of the pressure monitoring device 130 with the vacuum degassing device 120, the communication of the temperature adjusting device 140 with the pressure measuring device 130, and the communication of the metering pipe 154 with the temperature adjusting device 140; the processing device 152 is electrically connected to the fluid flow apparatus 110. The processing device 152 can control the liquid flowing device 110 to start up, and based on the liquid flowing driving function of the liquid flowing device 110, the liquid to be tested can be driven to flow into the vacuum degassing device 120; performing vacuum degassing on the liquid to be tested through a vacuum degassing device 120, filtering gas included in the liquid to be tested, and driving the liquid to be tested after vacuum degassing to flow into a pressure monitoring device 130; the pressure monitoring device 130 is used for carrying out pressure stabilization treatment on the inflowing liquid to be detected and monitoring the pressure condition of the liquid to be detected in real time; then the liquid to be detected after the pressure stabilization treatment flows into the temperature adjusting device 140, the temperature of the flowing liquid to be detected is adjusted by the temperature adjusting device 140, and the temperature condition of the liquid to be detected is monitored in real time; the liquid to be measured after the temperature adjustment treatment then flows into the metering tube 154.

The processing device 152 is electrically connected to the pressure monitoring device 130 and the temperature adjusting device 140, respectively. The pressure monitoring device 130 can transmit the monitored pressure of the liquid to be measured to the processing device 152, the temperature adjusting device 140 can transmit the monitored temperature of the liquid to be measured to the processing device 152, and the processing device 152 can process the pressure of the liquid to be measured and the temperature of the liquid to be measured according to the pressure of the liquid to be measured transmitted by the pressure monitoring device 130 and the temperature of the liquid to be measured transmitted by the temperature adjusting device 140. The processing device 152 acquires a liquid image corresponding to the liquid to be measured in the metering tube 154 when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold. The processing device 152 processes the acquired liquid image, and further obtains the flow rate of the liquid to be detected.

In the embodiment of the flow metering system, the liquid to be measured is driven to flow based on the liquid flowing device, so that the liquid to be measured sequentially flows through the vacuum degassing device, the pressure monitoring device, the temperature regulating device and the metering pipe, then the gas of the liquid to be measured is filtered and removed sequentially through the vacuum degassing device, the pressure of the liquid to be measured is regulated by the pressure monitoring device, and the temperature of the liquid to be measured is regulated by the temperature regulating device. The processing equipment acquires the pressure of the liquid to be measured and the temperature of the liquid to be measured of the temperature regulating device, which are acquired by the pressure monitoring device, and acquires a liquid image of the metering tube when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold; and processing the liquid image by the processing equipment to obtain the flow of the liquid to be measured, thereby realizing the measurement of the flow of the liquid to be measured. The device is not influenced by factors such as bubbles in the liquid to be measured, volatilization of the liquid, temperature and pressure change of the liquid to be measured, accuracy of measuring time, reading error and the like, and is simple and convenient to operate, high in automation degree and high in metering accuracy.

In one embodiment, as shown in FIG. 2, a flow metering system is provided, comprising a liquid flow device 210, a vacuum degassing device 220, a pressure monitoring device 230, a temperature regulating device 240, and a metering processing device 250; the metering device 250 includes a processing apparatus 252 and a metering tube 254 in communication with the temperature conditioning device 240; the pressure monitoring device 230 is in communication with the vacuum degassing device 220; the temperature adjustment device 240 is in communication with the pressure measurement device 230; the metering pipe 254 communicates with the temperature adjustment device 240; the processing device 252 is electrically connected to the pressure monitoring device 230, the temperature regulating device 240, and the liquid flow device 210, respectively. The liquid flowing device 210 comprises an infusion pump 212 for driving the liquid to be tested to flow, and a liquid container 214 for storing the liquid to be tested; the liquid container 214 to be tested is communicated with a vacuum degassing device 220.

The infusion pump 212 can be used to act on the system tubing to drive the flow of the fluid under test through the tubing. Infusion pump 212 may be, but is not limited to, a micro-nano pump. The liquid container 214 to be tested can be used for storing liquid to be tested; for example, the fluid container 214 may be a reagent bottle.

Specifically, the infusion pump 212 may act on the conduit between the vacuum degassing device 220 and the pressure monitoring device 230, and the processing device 252 may control the infusion pump 212 to start up, so as to drive the liquid to be tested in the liquid container 214 to flow into the vacuum degassing device 220; performing vacuum degassing on the liquid to be tested through the vacuum degassing device 220, and driving the liquid to be tested after vacuum degassing to flow into the pressure monitoring device 230; the pressure monitoring device 230 is used for stabilizing the pressure of the inflowing liquid to be detected; the liquid to be detected after the pressure stabilization treatment flows into the temperature adjusting device 240, the temperature of the flowing liquid to be detected is adjusted through the temperature adjusting device 240, and the temperature condition of the liquid to be detected is monitored in real time; the liquid to be measured after the temperature adjustment treatment then flows into the metering tube 254. The processing device 252 collects a liquid image of the metering tube 254 when the pressure of the liquid to be measured transmitted by the pressure monitoring device 230 reaches a pressure threshold and the temperature of the liquid to be measured transmitted by the temperature adjusting device 240 reaches a temperature threshold; the processing device 252 processes the liquid image to obtain the flow rate of the liquid to be measured, thereby realizing the measurement of the flow rate of the liquid to be measured. The device is not influenced by factors such as bubbles in the liquid to be measured, volatilization of the liquid, temperature and pressure change of the liquid to be measured, accuracy of measuring time, reading error and the like, and is simple and convenient to operate, high in automation degree and high in metering accuracy.

It should be noted that the infusion pump 212 may also act on the conduit between the vacuum degassing device 220 and the liquid container 214 to be tested, and the processing device 252 may control the infusion pump 212 to start working, so that the infusion pump 212 can drive the liquid to be tested to flow in the conduit.

In one example, when the micro-nano pump works and operates, the liquid to be detected enters the micro-nano pump after being degassed by the vacuum degassing device through the reciprocating motion of the plunger rod of the micro-nano pump, and then the liquid to be detected is pushed out by the micro-nano pump and flows into the pressure monitoring device.

In one embodiment, as shown in FIG. 3, a flow metering system is provided, comprising a liquid flow device 310, a vacuum degasser 320, a pressure monitoring device 330, a temperature regulating device 340, and a metering process device 350; the metering process device 350 includes a process apparatus 352 and a metering tube 354 in communication with the temperature conditioning device 340; the pressure monitoring device 330 is in communication with the vacuum degassing device 320; the temperature adjustment device 340 is in communication with the pressure measurement device 330; the metering pipe 354 is communicated with the temperature adjusting device 340; the processing device 352 is electrically connected to the pressure monitoring device 330, the temperature regulating device 340, and the liquid flow device 310, respectively. The pressure monitoring device 330 comprises a pressure stabilizing chamber 332 communicated between the vacuum degassing device 320 and the temperature regulating device 340, and a pressure collecting device 334 for collecting the pressure of the liquid to be measured; the pressure collection device 334 is electrically connected to the processing apparatus 352.

The pressure-stabilizing chamber 332 is a container for stabilizing the pressure of the liquid. The outlet of plenum 332 may be disposed at a height position corresponding to a preset pressure value. For example, the volume of the pressure stabilizing chamber 332 is one third of the volume of the liquid to be measured flowing into the pressure stabilizing chamber, and the liquid to be measured can flow out to the temperature regulating device 340 through the outlet. The pressure collection device 334 can be used to collect the pressure of the fluid to be measured in the surge chamber.

Specifically, the processing device 352 can control the liquid flow device 310 to start up, and further can drive the liquid to be tested to flow into the vacuum degassing device 320 based on the liquid flow driving function of the liquid flow device 310; the liquid to be tested is subjected to vacuum degassing through a vacuum degassing device 320, and the liquid to be tested after vacuum degassing is driven to flow into a pressure stabilizing chamber 332; when the volume of the liquid to be measured in the pressure stabilizing chamber 332 reaches a preset value (for example, one third of the volume of the pressure stabilizing chamber), the liquid to be measured flows out to the temperature regulating device 340, the temperature of the flowing liquid to be measured is regulated by the temperature regulating device 340, and the liquid to be measured after temperature regulation flows into the metering tube. The pressure acquisition device 334 acquires the pressure of the liquid to be detected in the pressure stabilizing chamber in real time and transmits the acquired pressure of the liquid to be detected to the processing equipment 352. The processing device 352 may collect a liquid image corresponding to the liquid to be measured in the metering tube 354 when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured transmitted by the temperature adjusting device 340 reaches a temperature threshold, according to the pressure of the liquid to be measured and the temperature of the liquid to be measured. The processing device 352 processes the acquired liquid image to obtain the flow rate of the liquid to be measured, thereby realizing accurate measurement of the flow rate of the liquid to be measured.

In the above embodiment, after the liquid to be measured enters the pressure stabilizing chamber, when the volume of the liquid to be measured occupies one third of the volume of the pressure stabilizing chamber, the liquid to be measured flows out to the temperature regulating device, so that the pressure in the cavity is ensured not to be obviously changed due to the outflow of the fluid in a certain pressure measuring process, and the accuracy of measuring the flow of the liquid to be measured is improved.

In one specific embodiment, as shown in fig. 3, pressure acquisition device 334 includes a pressure sensor 361 disposed within plenum 332, an analog-to-digital converter 363 coupled to processing equipment 352, and an amplification circuit 365 coupled between pressure sensor 361 and analog-to-digital converter 363.

The pressure sensor 361 may be, but is not limited to, a piezoresistive pressure sensor, a piezoelectric pressure sensor, or a ceramic pressure sensor. Analog-to-digital converter 363 (i.e., an a/D converter, or simply ADC) may be an electronic component that converts analog signals to digital signals. The amplifier circuit 365 refers to a voltage amplifier circuit.

Specifically, based on the amplification circuit 365 connected between the pressure sensor 361 and the analog-to-digital converter 363, the pressure sensor 361 can measure the pressure of the liquid to be measured in the pressure stabilizing chamber 332, and convert and output a voltage signal corresponding to the pressure of the liquid to be measured. The amplifying circuit 365 can amplify the voltage signal transmitted by the pressure sensor 361, and transmit the amplified voltage signal to the analog-to-digital converter 363, and then the analog-to-digital converter 363 can convert the analog voltage signal into a digital voltage signal, and transmit the digital voltage signal to the processing device 352, and then the processing device 352 can process the voltage signal according to the received voltage signal, thereby realizing real-time monitoring of the pressure of the liquid to be measured.

In one embodiment, as shown in FIG. 4, a flow metering system is provided, comprising a liquid flow device 410, a vacuum degasser 420, a pressure monitoring device 430, a temperature regulating device 440, and a metering process device 450; the metering device 450 includes a processing apparatus 452 and a metering tube 454 in communication with the temperature adjustment device 440; the pressure monitoring device 430 is in communication with the vacuum degassing device 420; the temperature regulating device 440 is in communication with the pressure measuring device 430; the metering pipe 454 is communicated with a temperature adjusting device 440; the processing device 452 is electrically connected to the pressure monitoring device 430, the temperature regulating device 440, and the liquid flow device 410, respectively. The temperature adjusting device 440 comprises a thermostatic apparatus 442 communicated between the pressure monitoring device 430 and the metering pipe 454, and a temperature collecting device 444 for collecting the temperature of the liquid to be measured; the temperature acquisition device 444 is electrically connected to the processing apparatus 452.

The thermostatic device 442 can be used to regulate the temperature of the liquid to be measured. The temperature acquisition device 444 is used for acquiring the temperature of the liquid to be measured in the thermostatic equipment 442.

Specifically, the processing device 452 may control the liquid flow device 410 to start up, and based on the liquid flow driving function of the liquid flow device 410, the liquid to be tested may be driven to flow into the vacuum degassing device 420; performing vacuum degassing on the liquid to be tested through a vacuum degassing device 420, and driving the liquid to be tested after vacuum degassing to flow into a pressure monitoring device 430; through the pressure stabilizing treatment of the pressure monitoring device 430, the liquid to be measured after the pressure stabilizing treatment flows out to the thermostatic equipment 442, the constant temperature adjustment treatment is performed on the flowing liquid to be measured through the thermostatic equipment 442, and then the liquid to be measured after the temperature adjustment treatment flows into the metering pipe 454. The temperature acquisition device 444 acquires the temperature of the liquid to be measured of the thermostatic device 442 in real time and transmits the acquired temperature of the liquid to be measured to the processing device 452. The processing device 452 may collect a liquid image corresponding to the liquid to be measured in the metering tube 454 when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold according to the pressure of the liquid to be measured and the temperature of the liquid to be measured. The processing device 452 processes the acquired liquid image to obtain the flow rate of the liquid to be measured, thereby realizing accurate measurement of the flow rate of the liquid to be measured.

In the above embodiment, after the liquid to be measured enters the thermostatic device, the thermostatic device may adjust the temperature of the liquid to be measured to the preset temperature threshold based on the preset temperature threshold, and maintain the temperature of the liquid to be measured at the temperature threshold, so that the influence of the temperature error of the liquid to be measured may be removed, and the accuracy of the flow measurement of the liquid to be measured is improved.

In one example, a thermostatic device may include a thermostatic chamber, a temperature controller, and a thermostatic medium. The thermostatic chamber comprises a pipeline which is communicated with the pressure monitoring device and the metering pipe. The pipeline can be used for transmitting liquid to be detected; for example, the conduit may be a microtube (e.g., a quartz microtube). The thermostatic medium may be filled in a thermostatic chamber, for example the thermostatic medium may be, but is not limited to, water, alcohol, silicone oil or bath salt. The temperature controller may be used to control the temperature of the thermostatic medium.

Specifically, the temperature of the liquid to be measured in the thermostatic equipment can be controlled through the temperature controller and the thermostatic medium, so that the temperature of the liquid to be measured is the same as the fluid temperature set in an experiment, the influence of temperature change on the volume of the fluid is overcome, and the accuracy of flow measurement of the liquid to be measured can be further improved.

In one example, the temperature of the thermostatic medium may be controlled in the range of 0 ℃ to 95 ℃, and a heating rod may be built in, by which the temperature may be kept constant at a set value.

In one example, the temperature controller may be a fluid medium temperature controller.

In a specific embodiment, the temperature acquisition device comprises a temperature sensor arranged on the thermostatic equipment, an analog-to-digital converter connected with the processing equipment, and an amplifying circuit connected between the temperature sensor and the analog-to-digital converter.

The pressure sensor may be a contact temperature sensor or a non-contact temperature sensor, among others. An analog-to-digital converter (i.e., a/D converter, or ADC for short) may be an electronic component that converts an analog signal to a digital signal. The amplifier circuit refers to a voltage amplifier circuit.

Specifically, based on that amplifier circuit connects between temperature sensor and adc, temperature sensor measurable quantity constant temperature equipment awaits measuring liquid temperature to the voltage signal of the corresponding temperature that awaits measuring liquid temperature of conversion output. The amplifying circuit can amplify the voltage signal transmitted by the temperature sensor, and transmits the amplified voltage signal to the analog-to-digital converter, so that the analog-to-digital converter can convert the analog voltage signal into a digital voltage signal, and transmits the digital voltage signal to the processing equipment, and then the processing equipment can process the voltage signal according to the received voltage signal, thereby realizing the real-time monitoring of the temperature of the liquid to be measured.

In one embodiment, as shown in FIG. 5, a flow metering system is provided comprising a liquid flow device 510, a vacuum degasser 520, a pressure monitoring device 530, a temperature regulating device 540, and a metering process device 550; the metering device 550 includes a processing apparatus 552 and a metering tube 554 in communication with the temperature adjustment device 540; the pressure monitoring device 530 is in communication with the vacuum degassing device 520; the temperature regulating device 540 is in communication with the pressure measuring device 530; metering tube 554 communicates with temperature adjustment device 540; the processing equipment 552 is electrically connected to the pressure monitoring device 530, the temperature regulating device 540, and the liquid flow device 510, respectively. The processing device 552 includes an image collector 557 for collecting a liquid measurement image and a processing terminal 559 connected to the image collector.

Among them, the processing terminal 559 may be, but is not limited to, a computer personal computer, a notebook computer, a smart phone, a tablet computer, and a portable wearable device. The image collector 557 may be configured to collect a liquid image corresponding to the liquid to be measured within the metering tube. In one example, the image collector 557 may include a microscope and a camera, where the microscope may be configured to amplify the liquid to be detected in the metering tube, and then the camera may photograph the amplified liquid to be detected, and transmit the photographed liquid image to the processing terminal 559, and then the processing terminal 559 may perform metering processing on the liquid image.

Specifically, the image collector 557 may collect an image of the measuring tube under microscopic visualization, transmit the collected liquid image to the processing terminal 559, and then the processing terminal 559 may perform measurement processing on the liquid image, obtain the flow rate of the liquid to be measured, and further implement measurement of the flow rate of the liquid to be measured.

Further, the processing terminal can process the acquired liquid image based on CCD (Charge-coupled Device) image calibration, and convert the length represented by each pixel in the CCD image under the microscope magnification into the liquid displacement to be measured. And the processing terminal obtains the movement speed of the liquid to be detected by processing the displacement of the liquid to be detected, so as to obtain the flow of the liquid to be detected. Thereby improving the automation degree and the metering precision of the liquid flow metering.

In one embodiment, as shown in FIG. 6, a flow metering system is provided that includes a liquid flow device 640, a vacuum degasser 620, a pressure monitoring device 630, a temperature regulating device 40, and a metering process device 650; the metering device 650 includes a processing apparatus 652 and a metering tube 654 in communication with the temperature adjustment device 640; the pressure monitoring device 630 is in communication with the vacuum degassing device 620; the temperature regulating device 640 communicates with the pressure measuring device 630; the metering pipe 654 is communicated with the temperature adjusting device 640; the processing device 652 is electrically connected to the pressure monitoring device 630, the temperature regulating device 640, and the liquid flow device 610, respectively. Wherein the flow metering system further comprises a filter 660 in communication between the vacuum degassing apparatus 620 and the pressure monitoring apparatus 630.

The filter 660 may include a filter screen, and the filter screen filters impurities of the liquid to be measured.

Specifically, the liquid to be measured enters the metering tube after vacuum degassing, filtering, constant pressure and constant temperature treatment, and then the processing equipment acquires the liquid image of the metering tube 654, and processes the acquired liquid image to obtain the flow rate of the liquid to be measured in the metering tube 654. The impurities of the liquid to be measured are filtered through the filter 660, and the metering precision is improved.

In one particular embodiment, as shown in FIG. 6, the flow metering system further includes a timed switching controller 670 and a damper tube 680 in communication between the pressure monitoring device 630 and the timed switching controller 670. The input end of the timing switching controller 670 is connected to the damping tube 680, the first output end is connected to the temperature adjusting device 640, and the second output end is connected to the waste liquid collector 690.

Wherein, the damping tube 680 refers to a liquid damping tube; the damping tube 680 may function to stabilize fluid pressure and flow. The waste liquid collector 690 may be used to collect the liquid to be tested after the timing switching controller is switched. Timing switching controller 670 may be used to time switch the fluid path between pressure monitoring device 630 and temperature regulating device 640, and may also be used to determine the time for the metering test of the fluid under test. In one example, the timing accuracy error of the timing switching controller is 0.01S.

Specifically, the damping tube 680 is communicated between the pressure monitoring device 630 and the timing switching controller 670, so as to stabilize the pressure and flow of the fluid to be measured, thereby further improving the flow measurement accuracy. The input end of the timer-based switching controller 670 is connected to the damping tube 680, the first output end is connected to the temperature adjusting device 640, and the second output end is connected to the waste liquid collector 690. The timing switching controller 670 may switch the fluid channel when the processing device collects the fluid image, drain the fluid to be measured into the waste fluid collector 690, and record the switching time. The processing device 652 may then obtain the flow rate of the liquid to be measured according to the recorded switching time and the liquid image. Compared with the traditional metering method, the flow metering system is not affected by factors such as bubbles in the liquid to be measured, volatilization of the liquid, temperature of the liquid to be measured, reading error, measuring time and the like on a fluid measuring result, and is high in metering precision and high in automation degree.

In one embodiment, as shown in FIG. 7, a flow metering system is provided comprising a liquid flow device, a vacuum degasser 72, a pressure monitoring device, a temperature regulating device and a metering process device; the metering processing device includes a microscope 751, a computer 753, and a capillary tube 755 communicating with the temperature adjustment device; the liquid flowing device comprises a liquid container 711 to be detected and a micro-nano pump 713; the pressure monitoring device includes a pressure stabilizing chamber 731, a pressure sensor 733, an amplifying circuit 735, and an a/D converter 737; the temperature regulating device comprises a constant temperature equipment 741, a quartz microtube 743 and a temperature collecting device 745. The flow metering system also includes a filter 76, a damper tube 77, a timed switching controller 78 and a waste bottle 79.

The capillary 755 may have an inner diameter of 5 microns, among others.

Specifically, the liquid to be tested in the liquid container 711 enters the micro-nano pump 713 after being degassed by the vacuum degassing device 72, and the micro-nano pump 713 operates to push the liquid to be tested out of the vacuum degassing device 72, the micro-nano pump 7133 and the filter 76 and then enters the pressure stabilizing chamber 731. The volume of the liquid to be measured is about one third of the volume of the pressure stabilizing chamber 731, so that the pressure in the cavity is prevented from being obviously changed due to the outflow of the fluid in a certain pressure measuring process. The liquid to be measured reaches the quartz microtube 743 through the damping tube 77 and the timing switching controller 78, finally reaches the capillary 755, the image of the capillary 755 is collected through the microscope 751 and the computer 753 at the upper end of the capillary 755, the liquid displacement is determined through the liquid image collected by CCD image calibration processing, and then the flow rate of the liquid to be measured in the capillary 755 is obtained through calculation of the computer 753, so that the liquid flow rate measurement with high automation degree and high measurement precision is realized.

In one example, the specific flow metering process of the flow metering system is:

firstly, liquid to be detected is filled into a liquid container to be detected, and the micro-nano pump sucks air in the pipeline of the device for multiple times through low pressure suction and high pressure discharge, so that the interference of the micro-nano pump on an experimental result is prevented.

The micro-nano pump drives the liquid to be detected to enter the vacuum degassing device from the liquid container to be detected through a low-suction and high-pressure discharge working mode, and degassing is carried out under the action of the vacuum degassing device to remove bubbles in the liquid to be detected. The liquid to be measured enters the pressure stabilizing chamber after impurities are removed through the filter, wherein the volume of the liquid to be measured is about one third of the volume of the pressure stabilizing chamber, so that the pressure in the cavity is prevented from obviously changing due to the outflow of fluid in a certain pressure measuring process. The liquid to be measured flows through the damping tube and the timing switching controller and enters the constant temperature equipment. The timing switching controller is used for accurately controlling the time of fluid metering; the thermostatic device is used for controlling the temperature of the liquid to be measured, so that the interference of the temperature on the micro-fluid flow measurement is avoided.

The liquid to be measured enters the capillary at a constant pressure and a constant temperature, the computer is combined with the microscope to collect the liquid image in the capillary, and the liquid image is calibrated and processed based on the CCD image to determine the displacement L₁At which time the time t is recorded₁Then, the flow rate of the liquid to be measured can be calculated:

continuously repeating the above treatment to-be-detected liquid flow treatment, and respectively recording Q₁、Q₂、Q₃、Q₄、Q₅、Q₆The arithmetic mean of the flow rates was then calculated as follows.

Wherein r is the radius of the capillary; n is the number of tests; t is t_nThe time of the nth test; t is t₁Measuring time for the first experiment; l is₁Displacement of the liquid to be detected for the first experiment; q_nThe measured average value of the nth section of flow is taken as the measured average value;

is the arithmetic mean of the flow measurements.

The air in the pipeline of the device is removed before the experiment, the liquid to be measured enters the measuring capillary after the steps of vacuum degassing, filtering, constant pressure, constant temperature and the like, meanwhile, the time for the test is determined by a timing switching controller with the precision error of 0.01S, then, the displacement is determined by combining a microscope, image acquisition and CCD calibration in the capillary, and then, the flow of the liquid to be measured in the capillary is calculated by a computer. The accuracy of the metering result is further improved by testing several groups of data and calculating the arithmetic average value of the flow.

It should be noted that the liquid to be tested may be, but is not limited to, water, biochemical reagents or medical liquid drugs.

In one embodiment, as shown in fig. 8, there is also provided a flow metering method comprising the steps of:

step S810, obtaining the pressure to be measured collected by the pressure monitoring device and the temperature of the liquid to be measured collected by the temperature adjusting device.

And step S820, acquiring a liquid image of the metering tube when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold.

And step S830, processing the liquid image to obtain the flow of the liquid to be detected.

Specifically, the processing equipment can process the pressure to be measured and the temperature of the liquid to be measured according to the pressure to be measured transmitted by the pressure monitoring device and the temperature of the liquid to be measured transmitted by the temperature regulating device; and when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold, acquiring a liquid image corresponding to the liquid to be measured in the metering pipe. And the acquired liquid image is processed, so that the flow of the liquid to be measured can be obtained, and the flow of the liquid to be measured is measured. The device is not influenced by factors such as bubbles in the liquid to be measured, volatilization of the liquid, temperature and pressure change of the liquid to be measured, accuracy of measuring time, reading error and the like, and is simple and convenient to operate and high in measuring accuracy.

In one embodiment, as shown in fig. 9, there is also provided a flow metering method comprising the steps of:

step S910, obtaining the pressure to be measured collected by the pressure monitoring device and the temperature to be measured collected by the temperature adjusting device.

Step S920, when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold, acquiring a liquid image of the metering tube.

Step S930, processing the liquid image based on CCD image calibration to obtain unit time displacement of the corresponding liquid to be detected.

And S940, obtaining the flow of the liquid to be detected according to the radius of the metering pipe and the displacement in unit time.

The specific content process of step S910 and step S920 may refer to the above content, which is not described herein again.

Specifically, the processing equipment can process the pressure to be measured and the temperature of the liquid to be measured according to the pressure to be measured transmitted by the pressure monitoring device and the temperature of the liquid to be measured transmitted by the temperature regulating device; and when the pressure of the liquid to be measured reaches a pressure threshold and the temperature of the liquid to be measured reaches a temperature threshold, acquiring a liquid image corresponding to the liquid to be measured in the metering pipe. The processing equipment can calibrate and process the liquid image based on the CCD image, and convert the length represented by each pixel in the CCD image under the microscope magnification into the displacement of the liquid to be detected, so as to obtain the displacement of the liquid to be detected in unit time. And then the flow of the liquid to be measured can be obtained according to the radius of the metering pipe and the displacement in unit time.

Furthermore, the processing equipment can obtain the arithmetic mean value of the flow by testing the flow data of several groups of liquid to be tested and processing the flow data so as to enable the metering result to be more accurate.

It should be understood that, although the steps in the flowcharts of fig. 8 and 9 are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and described, and may be performed in other orders, unless explicitly stated otherwise. Moreover, at least some of the steps in fig. 8 and 9 may include multiple sub-steps or multiple stages that are not necessarily performed at the same time, but may be performed at different times, and the order of performing the sub-steps or stages is not necessarily sequential, but may be performed alternately or alternately with other steps or at least some of the sub-steps or stages of other steps.

It will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above can be implemented by hardware instructions of a computer program, which can be stored in a non-volatile computer-readable storage medium, and when executed, can include the processes of the embodiments of the division methods described above. Any reference to memory, storage, database, or other medium used in the embodiments provided herein may include non-volatile and/or volatile memory, among others. Non-volatile memory can include read-only memory (ROM), Programmable ROM (PROM), Electrically Programmable ROM (EPROM), Electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), Dynamic RAM (DRAM), Synchronous DRAM (SDRAM), Double Data Rate SDRAM (DDRSDRAM), Enhanced SDRAM (ESDRAM), Synchronous Link DRAM (SLDRAM), Rambus Direct RAM (RDRAM), direct bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.