阅读说明：本技术 一种丁香复方水凝胶及其制备方法 (Clove compound hydrogel and preparation method thereof ) 是由 陈琳 唐志书 宋忠兴 刘妍如 魏思敏 胡锦航 孙琛 张天龙 于 2019-12-31 设计创作，主要内容包括：本发明公开了一种丁香复方水凝胶及制备方法,属于中药复方水凝胶领域。该丁香复方水凝胶由活性成分和水凝胶介质制成,其中,活性成分包含丁香提取物12.5-18份、甘草提取物1.5-2份。本发明以丁香和甘草为活性成分制备复方水凝胶,其中不含有透皮促进剂,能够避免其它杂质的影响；并且两者配伍时产生协同促进作用,减少了药物用量,也增强了透皮吸收效果。(The invention discloses a clove compound hydrogel and a preparation method thereof, belonging to the field of traditional Chinese medicine compound hydrogels. The clove compound hydrogel is prepared from active ingredients and a hydrogel medium, wherein the active ingredients comprise 12.5-18 parts of clove extract and 1.5-2 parts of liquorice extract. The compound hydrogel is prepared by taking clove and liquorice as active ingredients, does not contain a transdermal enhancer, and can avoid the influence of other impurities; and when the two are compatible, a synergistic promotion effect is generated, the dosage of the medicine is reduced, and the transdermal absorption effect is also enhanced.)

1. The clove compound hydrogel is prepared from active ingredients and a hydrogel medium, and is characterized in that the active ingredients comprise the following components in parts by mass: 12.5-18 parts of clove extract and 1.5-2 parts of liquorice extract.

2. The clove compound hydrogel according to claim 1, wherein the clove extract is 12.5 parts, and the licorice extract is 1.5 parts.

3. The clove compound hydrogel according to claim 1 or 2, wherein the hydrogel medium comprises tartaric acid, glycerin, sodium polyacrylate, polyvinylpyrrolidone, aluminum glycinate and distilled water.

4. The preparation method of the clove compound hydrogel as claimed in any one of claims 1 to 3, comprising the following steps:

preparing the clove extract and the licorice extract respectively;

and mixing the clove extract and the licorice extract obtained by preparation with a hydrogel medium to obtain the clove compound hydrogel.

5. The preparation method of the clove compound hydrogel as claimed in claim 4, wherein the clove extract is prepared by a reflux water extraction flocculation method or an ultrasonic alcohol extraction concentration method.

6. The method for preparing the clove compound hydrogel according to claim 4 or 5, wherein the hydrogel medium comprises tartaric acid, glycerin, sodium polyacrylate, polyvinylpyrrolidone, aluminum glycinate and distilled water;

mixing the clove extract and the licorice extract obtained by the preparation with a hydrogel medium, comprising:

adding tartaric acid into the distilled water solution, and dissolving to obtain phase A;

putting glycerol into vacuum stirring container, adding sodium polyacrylate, stirring, and dispersing to obtain mixed solution(ii) a Adding polyvinylpyrrolidone to the mixed solution

and adding the phase A into the phase B in batches, and uniformly stirring to obtain the clove compound hydrogel.

7. A clove compound hydrogel patch, which is characterized by comprising the clove compound hydrogel as claimed in any one of claims 1 to 3, a backing material and a protective layer covering the clove compound hydrogel.

Technical Field

The invention relates to the field of traditional Chinese medicine hydrogel, in particular to the field of traditional Chinese medicine compound hydrogel, and specifically relates to clove compound hydrogel and a preparation method thereof.

Background

The hydrogel is a hydrophilic reticular polymer swelling body prepared from a medicament and a hydrogel medium, can swell in water, absorbs and retains a large amount of water, and cannot be dissolved in water. Generally, the method is divided into two main categories, namely natural and synthetic. Due to the existence of hydrophilic groups in the gel, the hydrogel can absorb water and swell by 10-98 percent under in vivo physiological conditions, and a considerable part of water is retained in the skeleton. The hydrogel has excellent physicochemical and biological properties, can control the release of the drug, and has the characteristics of bioadhesion, biocompatibility, biodegradation and the like. The preparation method is currently used for the development of novel drug delivery systems such as controlled release, pulse release and triggered release, and is widely applied in the field of medicine.

The hydrogel is mainly used as a medicine external preparation in the past, can be used for transdermal administration of skin, mucosa and the like, can avoid the first pass effect of liver and the degradation of gastrointestinal tract during oral administration, reduces the toxic and side effect of the medicine, and is convenient and fine to use and free of greasy feeling and accepted by patients. China is in the development and improvement stage of hydrogel, and particularly Chinese medicine hydrogel is in the initial stage. In recent years, the development of the traditional Chinese medicine single-dose hydrogel is rapid, but the traditional Chinese medicine compound hydrogel is developed slowly, and the main reasons are that the traditional Chinese medicine components are complex, the dosage is large, the extraction process is extensive, effective active ingredients are difficult to obtain, and the selection of compatible matrixes is not facilitated.

The clove is rich in volatile oil, and the main component of the oil is eugenol. Flos Caryophylli has effects of warming middle warmer, warming kidney, and lowering adverse qi, and can be used for treating stomach cold, pain and distention, singultus, vomiting and diarrhea, arthralgia, hernia pain, halitosis, and toothache. Modern medical research proves that the clove also has the effects of antibiosis, antioxidation, anti-aging, promotion of transdermal absorption and the like. At present, the reports about the clove hydrogel are rarely seen, and the reports about the clove compound hydrogel are not seen.

Disclosure of Invention

The invention aims to: solves the problems of the existing single-dose hydrogel of the traditional Chinese medicine, thereby providing the clove compound hydrogel, the patch and the preparation method.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides a clove compound hydrogel which is prepared from active ingredients and a hydrogel medium, wherein the active ingredients comprise the following components in parts by mass: 12.5-18 parts of clove extract and 1.5-2 parts of liquorice extract.

The clove compound hydrogel comprises 12.5 parts of clove extract and 1.5 parts of liquorice extract.

The hydrogel medium comprises tartaric acid, glycerol, sodium polyacrylate, polyvinylpyrrolidone, aluminum glycinate and distilled water.

The invention provides a preparation method of clove compound hydrogel, which comprises the following steps:

preparing the clove extract and the licorice extract respectively;

and mixing the clove extract and the licorice extract obtained by preparation with a hydrogel medium to obtain the clove compound hydrogel.

The clove extract is prepared by a reflux water extraction flocculation method or an ultrasonic alcohol extraction concentration method.

The preparation method of the clove compound hydrogel comprises the following steps of (1) preparing a hydrogel medium, wherein the hydrogel medium comprises tartaric acid, glycerol, sodium polyacrylate, polyvinylpyrrolidone, aluminum glycinate and distilled water;

mixing the clove extract and the licorice extract obtained by the preparation with a hydrogel medium, comprising:

adding tartaric acid into the distilled water solution, and dissolving to obtain phase A;

putting glycerol into a vacuum stirring container, adding sodium polyacrylate, stirring to disperse uniformly,to obtain mixed liquid

(ii) a Adding polyvinylpyrrolidone to the mixed solution

Neutralizing and stirring to disperse the mixture evenly to obtain mixed solution

(ii) a Adding aluminum glycinate to the mixed solution

Stirring to disperse uniformly to obtain mixed solution

(ii) a Finally adding the clove extract and the licorice extract to the mixed solution

Uniformly stirring to obtain a phase B;

and adding the phase A into the phase B in batches, and uniformly stirring to obtain the clove compound hydrogel.

The invention also provides a clove compound hydrogel patch, which comprises the clove compound hydrogel, a backing material and a protective layer covering the clove compound hydrogel.

Compared with the prior art, the invention has the beneficial effects that:

the invention takes clove and liquorice as active ingredients to prepare the compound hydrogel, wherein the clove has antibacterial and antioxidant effects, the liquorice has sterilization, antioxidant and attenuation effects, and the two have synergistic promotion effect when being compatible, thereby reducing the dosage of the medicine and enhancing the transdermal absorption effect.

Drawings

FIG. 1 is an appearance diagram of a clove compound hydrogel patch;

fig. 2 is a graph comparing the cumulative transdermal flux at different time periods for the experimental group and the control group.

Detailed Description

In order to make the technical solution and advantages of the present invention clearer, embodiments of the present invention will be described in detail below with reference to examples. It should be understood that the following examples are only for illustrating the present invention and are not intended to limit the scope of the claims of the present invention.

The medicinal materials used in the invention are all the medicinal materials collected in the pharmacopoeia of 2015 edition, and after identification, all indexes of the medicinal materials accord with the regulations; the hydrogel media are not specifically indicated, and are all commercially available conventional products or materials obtained by conventional methods.

The clove compound hydrogel is prepared from active ingredients and a hydrogel medium, wherein the active ingredients comprise the following components in parts by mass: 12.5-18 parts of clove extract and 1.5-2 parts of liquorice extract.

The clove compound hydrogel comprises 12.5 parts of clove extract and 1.5 parts of liquorice extract.

The invention takes clove and liquorice as active ingredients to prepare the compound hydrogel, wherein the clove has antibacterial and antioxidant effects, the liquorice has sterilization, antioxidant and attenuation effects, and the two have synergistic promotion effect when being compatible, thereby reducing the dosage of the medicine and enhancing the transdermal absorption effect.

The hydrogel medium of the present invention may contain any of propylene glycol and cellulose derivatives, carbomer and sodium alginate, gelatin, starch, tartaric acid, glycerol, sodium polyacrylate, polyvinylpyrrolidone, and aluminum glycinate, and distilled water, and is not limited thereto.

In an embodiment of the invention, the hydrogel medium is tartaric acid, glycerol, sodium polyacrylate, polyvinylpyrrolidone, aluminum glycinate and distilled water.

In the following examples, ZTC1+ l clarifying agent (Tianjin Zhenshirai science and technology, Inc.); partially neutralized sodium polyacrylate NP700 (international specialty inc.); polyvinylpyrrolidone (shanghai chemical company); tartaric acid (sienna chemical industries); glycerol (red rock chemical reagent factory, Tianjin); absolute ethanol (assay alcohol); the Franz cell port modified is a common instrument in the art and is only configured to be effectiveDiffusion area 2.27cm²And a volume of 25 mL.

A preparation method of the clove compound hydrogel comprises the following steps:

preparing the clove extract and the licorice extract respectively;

and mixing the clove extract and the licorice extract obtained by preparation with a hydrogel medium to obtain the clove compound hydrogel.

Wherein the clove extract is prepared by a reflux water extraction flocculation method or an ultrasonic alcohol extraction concentration method.

The reflux water extraction flocculation method comprises the following steps:

flos Caryophylli is subjected to reflux water extraction, concentration, and flocculation and clarification by adding ZTC1+ l clarifier B component.

The extractive solution obtained by refluxing and water extracting has high content of active ingredients, but the medicinal liquid is turbid and needs to be clarified. The ZTC1+1 clarifying agent is a natural macromolecule, and can remove impurities such as tannin, protein, gum, etc. in the solution by utilizing the bridging action of charges and macromolecules to obtain a stable and clarified solution with good effect of alcohol precipitation. Therefore, after water extraction and concentration of the clove, the ingredient B of ZTC1+ l clarifying agent with different concentrations is added for flocculation and clarification, so that stable and clarified clove extracting solution with high obtaining rate is obtained.

The ultrasonic alcohol extraction concentration method comprises the following steps:

flos Caryophylli is prepared by ultrasonic ethanol extraction, and vacuum concentration.

The method for ultrasonically extracting clove is simple and convenient, and does not need to add clarification operation, but the content of active ingredients in the liquid medicine is lower. Therefore, after the clove is ultrasonically extracted by alcohol, the pressure reduction concentration is carried out to obtain the extracting solution with higher active ingredient content.

A clove compound hydrogel patch comprises the clove compound hydrogel, a backing material and a protective layer covering the clove compound hydrogel.

The clove compound hydrogel patch has clove fragrance, relatively good properties, no bubbles and moderate viscosity; after being applied to the skin for 24 hours, the skin-care product has no obvious itching feeling and has less residue when being taken off.