阅读说明：本技术 含高效氯氟氰菊酯和毒死蜱的复合杀虫杀螨纳米水剂及其用途 (Composite insecticidal and acaricidal nano-water agent containing efficient cyhalothrin and chlorpyrifos and application thereof ) 是由 邢刚 白杰 郭祥蕊 洪鹏 杨琴 于 2019-11-11 设计创作，主要内容包括：本发明公开了一种含高效氯氟氰菊酯和毒死蜱的复合杀虫杀螨纳米水剂,以高效氯氟氰菊酯和毒死蜱为活性成分,与表面活性剂、水配制成的；其中,高效氯氟氰菊酯和毒死蜱的重量百分含量为3～50％,表面活性剂5～20％,余量为水,高效氯氟氰菊酯和毒死蜱的重量比为20:1～1:20。本发明利用表面活性剂形成的纳米级胶束承载难溶于水高效氯氟氰菊酯和毒死蜱,有效成分以纳米级微粒存在于纳米水剂中,利于其在靶标上附着、展布和渗透,更耐雨水冲刷。两个有效成分能产生协同增效作用,可防治农作物上发生的害虫害螨,杀虫杀螨速度快,持效期长,防治效果明显高于其单剂使用。(The invention discloses a composite insecticidal and acaricidal nano-water agent containing efficient cyhalothrin and chlorpyrifos, which is prepared by taking the efficient cyhalothrin and the chlorpyrifos as active ingredients, a surfactant and water; the efficient cyhalothrin and the chlorpyrifos are 3-50 wt%, 5-20 wt% of surfactant and the balance of water, and the weight ratio of the efficient cyhalothrin to the chlorpyrifos is 20:1-1: 20. The invention utilizes the nano micelle formed by the surfactant to bear the water-insoluble efficient cyhalothrin and chlorpyrifos, and the effective components exist in the nano water agent as nano particles, thereby being beneficial to the attachment, the distribution and the permeation of the nano water agent on a target and being more resistant to rain wash. The two effective components can generate a synergistic effect, can prevent and control pests and mites on crops, and has the advantages of high pest and mite killing speed, long lasting period and obviously higher prevention and control effect than that of a single agent.)

1. A composite nano water agent for killing insects and mites containing efficient cyhalothrin and chlorpyrifos is characterized in that the nano water agent is prepared by taking the efficient cyhalothrin and the chlorpyrifos as active ingredients, a surfactant and water; in the nano water agent, the weight percentage content of the efficient cyhalothrin and the chlorpyrifos is 3-50%, the weight percentage content of the surfactant is 5-20%, and the balance is water.

2. The nano water aqua according to claim 1, wherein the weight percentage of the lambda-cyhalothrin and the chlorpyrifos is 3-21%.

3. The nano water aqua according to claim 1, wherein the weight ratio of the lambda-cyhalothrin to the chlorpyrifos is 20:1-1: 20.

4. The nano water aqua according to claim 1, wherein the weight ratio of the lambda-cyhalothrin to the chlorpyrifos is 5:1-1: 5.

5. The nano-water agent as claimed in claim 1, wherein the surfactant is selected from one or more of alkylphenol formaldehyde resin polyoxyethylene ether, styrylphenol polyoxyethylene ether, sodium fatty alcohol polyoxyethylene ether sulfate, tristyrylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether phosphate, sodium fatty acid methyl ester sulfonate, and sodium alcohol ether succinic acid monoester sulfonate.

6. The method for preparing the nano water agent according to claim 1, wherein the method comprises the following steps:

mixing and stirring a raw efficient cyhalothrin and a raw chlorpyrifos with a surfactant at normal temperature to uniformly disperse the efficient cyhalothrin and the chlorpyrifos in the surfactant;

and (2) adding water under the stirring state, and uniformly stirring to form a surfactant micelle solution containing the efficient cyhalothrin and the chlorpyrifos, namely the transparent efficient cyhalothrin and chlorpyrifos nano-water agent.

7. The method for preparing the nano water aqua according to claim 6 is characterized in that in the step (1) and the step (2), the stirring speed is 60-100 revolutions per second.

8. The use of the nano water aqua of claim 1 in controlling pests and mites on fruit trees, cotton and vegetables.

9. The use according to claim 8, characterized in that the pests are rice planthoppers and the pest mites are spider mites.

Technical Field

The invention belongs to the field of pesticides, and particularly relates to an insecticidal and acaricidal nano-water agent taking efficient cyhalothrin and chlorpyrifos as main active ingredients and application thereof.

Background

Lambda-cyhalothrin (lambda-cyhalothrin), molecular formula: c₂₃H₁₉ClF₃NO₃The 3- (2-chloro-3, 3, 3-trifluoropropenyl) -2, 2-dimethylcyclopropanecarboxylic acid α -cyano-3-phenoxybenzyl ester is a high-efficiency, broad-spectrum and quick-acting pyrethroid insecticide and acaricide, mainly has contact poisoning and stomach poisoning effects, has no systemic action, has good effects on various pests such as lepidoptera, coleoptera, hemiptera and the like and other pests, as well as leaf mites, rust mites, gall mites and the like, can be used for controlling cotton bollworms, cabbage caterpillars, cabbage aphids, tea geometrids, tea caterpillars, tea orange mites, leaf gall mites, citrus leaf moths, orange aphids, citrus leaf mites, orange mites, peach fruit borers, pear fruit borers and the like, and can also be used for controlling various surface and public health pests.

Chlorpyrifos (Chlorpyrifos Standard), molecular formula: c₉H₁₁Cl₃NO₃PS. Chemical name: o, O-diethyl-O- (3,5, 6-trichloro-2-pyridyl) thiophosphate. Chlorpyrifos is an acetylcholinesterase inhibitor and belongs to phosphorothioate insecticides. Has the triple functions of stomach toxicity, contact killing and fumigation, and has better control effect on various chewing and piercing-sucking mouthpart pests on rice, wheat, cotton, fruit trees, vegetables and tea trees.

Pesticide varieties containing a single component often have defects in pesticide pest control: the pesticide resistance is easy to generate after continuous use, the insecticidal spectrum is narrow, the comprehensive protection can not be provided for crops, the pesticide cost of farmers is high, and the like. The combination and blending of two or more active ingredients with synergistic effect can improve the control effect, reduce the dosage of the active ingredients, save the cost, slow down the resistance of pests and mites, expand the control spectrum, play a role in controlling multiple pests and reduce the use cost of farmers.

Disclosure of Invention

The invention aims to provide a composite insecticidal and acaricidal nano-water agent containing efficient cyhalothrin and chlorpyrifos, wherein the compounding of the efficient cyhalothrin and the chlorpyrifos in the nano-water agent has an obvious synergistic effect; in addition, creatively discovers that certain surfactants are adopted, a surfactant micelle solubilization technology is adopted, under the condition that organic solvents are not used for assisting dissolution, the nano-scale micelles formed by the surfactants are used for bearing the water-insoluble efficient cyhalothrin and chlorpyrifos, and active ingredients exist in the nano-water agent in the form of nano-scale particles, so that the nano-water agent is more convenient to attach, spread and permeate on a target and is more resistant to rain washing, and the nano-water agent does not contain organic solvents, and is safe and environment-friendly.

The purpose of the invention is realized by the following technical scheme:

a composite insecticidal and acaricidal nano-water agent containing efficient cyhalothrin and chlorpyrifos is prepared by taking efficient cyhalothrin and chlorpyrifos as main active ingredients, a surfactant and water; in the nano water agent, the sum of the weight percentages of chlorpyrifos and lambda-cyhalothrin is 3-50%, the weight percentage of the surfactant is 5-20%, and the balance is water.

The weight ratio of the lambda-cyhalothrin to the chlorpyrifos is 20:1-1:20, preferably 5:1-1: 5.

The sum of the weight percentage of the efficient cyhalothrin and the chlorpyrifos in the nano water agent is preferably 3-21%.

The nano water aqua of the invention can only contain the active ingredients of the efficient cyhalothrin and the chlorpyrifos, other components can also be added into the active ingredients during the use or preparation, and the active ingredients in the insecticidal composition can also exist in the composition in a synergistic effective amount.

The composite insecticidal composition only contains the active ingredients of the lambda-cyhalothrin and the chlorpyrifos, other components can be added into the active ingredients during use or preparation, and the active ingredients in the insecticidal composition can be present in the composition in a synergistic effective amount.

The surfactant is selected from one or more of alkylphenol formaldehyde resin polyoxyethylene ether, styryl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether sodium sulfate, tristyryl phenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether phosphate, sodium fatty acid methyl ester sulfonate, alcohol ether succinic acid monoester sulfonate and the like.

The invention also aims to provide a preparation method of the nano water agent containing the efficient cyhalothrin and the chlorpyrifos, which comprises the following steps:

mixing and stirring a raw efficient cyhalothrin and a raw chlorpyrifos with a surfactant at normal temperature (10-35 ℃) to uniformly disperse the efficient cyhalothrin and the chlorpyrifos in the surfactant;

and (2) adding water under the stirring state, and uniformly stirring to form a surfactant micelle solution containing the efficient cyhalothrin and the chlorpyrifos, namely the transparent efficient cyhalothrin and chlorpyrifos nano-water agent.

The efficient cyhalothrin and chlorpyrifos nano water aqua is transparent in appearance, and the average particle size of the surfactant micelle is in a nano level; after entering water, the water-soluble polymer can be quickly dissolved with water to form a completely transparent solution, and the dilution stability is qualified; the nano water agent has stable performance, is still stable after being stored at 0 ℃ for 7 days and stored at 54 ℃ for 14 days, does not precipitate chlorpyrifos, and is convenient to store.

In the step (1), the stirring speed is 60-100 revolutions per second, the stirring time is 0.5h, and technicians can adjust the time so as to ensure that the efficient cyhalothrin and the chlorpyrifos are uniformly dispersed in the surfactant.

In the step (2), the stirring speed is 60-100 r/s, and the stirring is continued for 0.5-1 h after the water is added.

The invention also aims to provide the application of the nano water aqua in preventing and treating pests and mites on fruit trees, cotton and vegetables.

Further, the pests are rice planthoppers, and the pest mites are cotton red spiders.

The nano water aqua can reduce the using amount, delay the generation of drug resistance of pests and mites, improve the control effect, is superior to single-dose use, saves time and labor, saves cost, reduces the pollution to the environment and lightens the burden of farmers.

Compared with the prior art, the invention has the beneficial effects that:

(1) the compound has obvious synergistic effect, and improves the control effect on pests and mites compared with the single dose used alone;

(2) has quick and long-acting effects;

(3) the two effective components are compounded, so that the using amount of the pesticide is reduced, and the production and use cost and the pollution to the environment are reduced;

(4) the resistance of pests and mites to pesticides is delayed, and the effect is obviously higher than that of single dose use of the pesticide.

(5) The invention is a novel dosage form, namely a nano water aqua, has the nano particle size, is more convenient for the attachment, the spreading and the penetration on a target, is more rain-wash resistant, does not contain organic solvent, and is safe and environment-friendly.

Drawings

FIG. 1 shows 4% aqueous solution of lambda-cyhalothrin-chlorpyrifos in example 5.

FIG. 2 shows a 4% aqueous unqualified formulation of lambda-cyhalothrin/chlorpyrifos of comparative example 4.

Detailed Description

The invention is further illustrated but is not in any way limited by the following examples.

Indoor virulence determination

1. Determining toxicity of high-efficiency cyhalothrin, chlorpyrifos and compound sample thereof to Aranea by dipping slide method, repeating for 3 times each treatment, treating for 30 heads each concentration, and performing toxicity determination by LC₅₀Values co-toxicity coefficients (CTC values) were calculated according to the grandsinope method:

single dose of LC50 as standard medicine/single dose of LC 50X 100

Theoretical virulence index (TTI) ═ A virulence index of single agent, x proportion of single agent in mixed agent + B virulence index, x proportion of single agent in mixed agent

Measured virulence index (ATI) ═ standard single dose LC50 value/LC 50 value of the mix × 100

Co-toxicity coefficient (CTC) measured toxicity index (ATI)/Theoretical Toxicity Index (TTI) x 100

Grading co-toxicity coefficients: the mixture has synergistic effect when CTC is greater than 120, is antagonistic when CTC is less than 80, and has additive effect between 80 and 120.

The results are shown in Table 1:

TABLE 1 indoor toxicity determination of high-performance cyhalothrin and chlorpyrifos for cotton red spider

As can be seen from Table 1, the ratio of lambda-cyhalothrin to chlorpyrifos is in the range of 20:1-1:20, the co-toxicity coefficient is more than 120, and the composition has a synergistic effect on the prevention and treatment of the cotton red spider, particularly the composition is 5:1-1:5, the co-toxicity coefficient is over 180, and the synergistic effect is obvious.

2. The toxicity of the high-efficiency cyhalothrin, the chlorpyrifos and the compound sample thereof to the rice planthopper is determined by adopting a test method of soaking leaves firstly and then inoculating insects, the toxicity is repeated three times per treatment, and LC is used₅₀The degree of similarity coefficient was calculated according to the Sun cloud method, and the results are shown in Table 2:

TABLE 2 determination of toxicity of highly effective cyhalothrin and chlorpyrifos mixture to rice planthopper

As can be seen from Table 2, the ratio of efficient cyhalothrin to chlorpyrifos is in the range of 20:1-1:20, the co-toxicity coefficient is more than 120, and the pesticide composition has a synergistic effect on the control of rice planthoppers, and particularly has a toxicity coefficient of 5:1-1:5, the co-toxicity coefficient is above 165, and the synergistic effect is obvious.