阅读说明：本技术 一种自动化采血系统 (Automatic blood sampling system ) 是由 鲁杨州 于 2018-09-18 设计创作，主要内容包括：发明公开了一种血液自动采集系统以及其所使用的一种血液采集装置,实现规模化受试者中精确定时采血的功能。本发明使用一台采血装置即可完成多个受试者定时连续采血,节约了采集过程中需要的时间,提高了采集效率,且显著减少了采血时间误差。(The invention discloses an automatic blood collection system and a blood collection device used by the same, which realize the function of accurately collecting blood at regular time in large-scale subjects. The invention can complete the regular and continuous blood sampling of a plurality of testees by using one blood sampling device, saves the time required in the collecting process, improves the collecting efficiency and obviously reduces the error of the blood sampling time.)

1. A control method of a blood sampling system comprises

A fixing unit setting step of setting the fixing units so that a plurality of subjects are sequentially fixed on the transfer unit, respectively;

a transfer unit setting step of setting an operation parameter of the transfer unit to sequentially transfer the plurality of subjects to the plurality of blood sampling units or to sequentially transfer the plurality of blood sampling units to the plurality of subjects; and

a blood collection unit control step of connecting the plurality of blood collection units to the subjects to collect blood by recognizing blood collection positions of the plurality of subjects.

2. The control method according to claim 1, wherein

In the fixing unit setting step, the fixing unit is provided with a holding unit that sequentially fixes a plurality of holding units that previously hold the plurality of subjects, respectively, to the transfer unit.

3. The control method according to claim 2, wherein

In the blood collection unit control step, the blood collection unit determines a position of a blood vessel indwelling needle previously provided on the subject by recognizing a position sensor provided on a holding portion, thereby connecting the blood vessel indwelling needle to the blood collection unit to collect blood.

4. The control method according to any one of claims 1 to 3, wherein

The control method further includes, between or before the fixing unit setting step and the transferring unit setting step, a dosing unit setting step in which the dosing unit is controlled to dose the subject, and a time of the dosing is set as an initial time.

5. The control method according to claim 4, wherein

In the transfer unit setting step, a transfer speed of the transfer unit is set to correspondingly transfer the subject to the plurality of blood collection units at a plurality of given time points after the initial time.

6. The control method according to claim 5, wherein

The control method further comprises a collection unit control step, wherein the collection unit is controlled to classify and arrange the blood samples collected by the blood collection unit.

7. A control device for a blood collection system, comprising:

a fixing unit setting module for setting the fixing unit to sequentially fix the plurality of subjects on the transfer unit, respectively;

a transfer unit setting module for setting an operation parameter of the transfer unit to sequentially transfer the plurality of subjects to a plurality of blood sampling units or to sequentially transfer the plurality of blood sampling units to the plurality of subjects; and

a blood collection unit control module which connects the plurality of blood collection units with the subjects to collect blood by recognizing blood collection positions of the plurality of subjects.

8. The control device of claim 7, wherein

The fixing unit includes a holding unit configured to sequentially fix the plurality of holding units, which previously hold the plurality of subjects, to the transfer unit.

9. The control device of claim 8, wherein

The blood collection unit identifies a position of a blood vessel indwelling needle provided in advance on the subject by recognizing a position sensor provided on a holding portion, and connects the blood vessel indwelling needle to the blood collection unit to collect blood.

10. The control device according to any one of claims 7 to 9, wherein

The control device further includes a dosing unit setting module that controls the dosing unit to dose the drug to the subject, and sets a time of the drug administration as an initial time.

11. The control device of claim 10, wherein

The transfer unit setting module sets a transfer speed of the transfer unit to correspondingly transfer the subject to the plurality of blood collection units at a plurality of given time points after the initial time.

12. The control device of claim 11, wherein

The control device also comprises a collection unit control module which is used for controlling the collection unit to classify and arrange the blood samples collected by the blood collection unit.

13. A blood collection system comprises

The control device according to any one of claims 7 to 12;

a fixing unit that fixes a plurality of subjects on the transfer unit in sequence;

the transfer unit sequentially transfers the plurality of subjects to a plurality of blood sampling units or sequentially transfers the plurality of blood sampling units to a plurality of subjects;

the blood sampling unit is connected with the subject so as to collect blood.

14. The blood collection system of claim 13, further comprising

A dosing unit for dosing the plurality of subjects.

15. The blood collection system of claim 13 or 14, further comprising

A collection unit that collects blood samples of the plurality of subjects and performs sorting.

Technical Field

The present invention relates to medical devices, and more particularly to a collection system and device for pharmacokinetic blood collection.

Background

The basic experiment design of the pharmacokinetics in vivo experiment is that after a tested medicament is fed into an animal body in a specific administration mode, blood samples of the animal are collected at specific time points, the blood collecting interval of each blood collecting point has strict requirements, and the blood collecting points in the first 1 hour need to be collected within plus or minus 1 minute.

In the current technology, administration is manual operation, and blood collection is still manual operation. When the number of the animals to be dosed is large, due to the fact that no overall planning is available, after a batch of animals to be dosed are dosed, the dosing of subsequent animals is carried out after a blood sampling neutral position appears. The confusion situation easily appears, leads to the blood sampling untimely, and influences the continuity of dosing and blood sampling, influences the experiment flux. Moreover, all operations are manual operations, and the technical level of operators is uneven, which often causes errors in blood collection or unsatisfactory blood collection quality. However, in the existing automation technology, only one set of blood sampling device can be equipped for each animal, and after a program is set, blood sampling is carried out at a specific time. When the number of the experimental animals is large, a large number of blood sampling devices are needed, and the cost investment is very large.

Therefore, high-throughput automated blood collection devices and systems are urgently needed for large-scale pharmacokinetic in vivo experimental blood collection of experimental animals, and the present invention aims to solve the problem.

Disclosure of Invention

The invention discloses a control method of a blood sampling system, which ensures that automatic blood sampling functions of a plurality of testees at a plurality of given time can be completed on one blood sampling device.

The control method of the blood sampling system comprises the following steps

A fixing unit setting step of setting the fixing units so that a plurality of subjects are sequentially fixed on the transfer unit, respectively;

a transfer unit setting step of setting an operation parameter of the transfer unit to sequentially transfer the plurality of subjects to the plurality of blood sampling units or to sequentially transfer the plurality of blood sampling units to the plurality of subjects; and

a blood collection unit control step of connecting the plurality of blood collection units to the subjects to collect blood by recognizing blood collection positions of the plurality of subjects.

In one embodiment, in the fixing unit setting step, the fixing unit is provided with holding portions that sequentially fix a plurality of holding portions that respectively hold the plurality of subjects in advance on the transfer unit.

Preferably, in order to prevent the subject from moving when stimulated by factors such as startle or pain, the subject is held in advance in a holding portion provided with a sensor for identification and positioning by the blood sampling unit. Sequentially fixing the plurality of holding parts to the start position of the transfer unit by manual placement or robotic placement; the conveying unit is a device capable of performing a conveying function, such as a conveyor belt, a mechanical turntable, or an automated mechanical arm.

In one embodiment, in the transfer unit setting step, the operation parameter includes at least one of an initial time setting, a plurality of subject administration time interval setting, a blood collection time point setting, a number of subjects setting, a speed setting of a conveyor belt, and a blood collection volume setting.

In one embodiment, in the blood collection unit control step, the blood collection unit identifies a position of a blood vessel indwelling needle previously provided on the subject by identifying a position sensor provided on the holding portion, precisely inserts the blood collection needle into the blood vessel indwelling needle, completes a quantitative blood collection operation on the subject according to a previously set flushing blood collection flow, transfers the collected blood sample into a corresponding sample tube and performs a blending operation, thereby connecting the blood vessel indwelling needle with the blood collection unit to collect blood.

In one embodiment, the control method further includes a drug administration unit setting step of controlling the drug administration unit to administer the drug to the subject and setting a time of administration as an initial time, between or before the fixation unit setting step and the transfer unit setting step.

Preferably, in the step of administering the unit, the route of administration may be appropriately selected according to the clinical requirements of the drug, such as oral administration, intravenous injection, intramuscular injection, subcutaneous injection. The medicine can also be administered by sublingual buccal administration, rectal infusion, eye drop, nasal spray, oral spray, or topical or systemic transdermal administration.

In a specific embodiment, in the transfer unit setting step, a transfer speed of the transfer unit is set to correspondingly transfer the subject to the plurality of blood collecting units at a plurality of given time points after the initial time. Preferably, the transfer speed of the transfer unit is constant, and the distance of the plurality of blood sampling units from the initial position is proportional to the blood sampling given time.

In one embodiment, in the administration unit setting step, the length of the administration time interval between adjacent subjects is less than the given time of the corresponding first blood sampling unit; for example, the administration time is set as an initial time, and when the first blood sampling unit is given a time of 5 minutes, the administration time interval between adjacent subjects is 1 minute or 2 minutes.

In one embodiment, the given time of the blood sampling unit may be set to 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours, respectively; or the given time of the blood sampling unit may be set to 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 24 hours, respectively.

In one embodiment, the number of the collection units is the same as the number of the blood collection units.

In a particular embodiment, the subject is a mammal, preferably a mouse, rat, monkey, dog, macaque, or human.

In one embodiment, the control method further comprises a collecting unit control step of controlling a collecting unit to classify and sort the blood samples collected by the blood collecting unit.

In a particular embodiment, the sorting step comprises the numbering and collection of all blood samples collected by the same subject at different blood collection units.

In one embodiment, the collection unit may be disposed with a container for storing blood, which may be a normal serum tube without additive, a serum tube with coagulant inside, a blood collection tube with inert gel and coagulant inside, a heparin blood collection tube with inert gel separation tube, EDTA anticoagulant tube purple head cover, sodium citrate coagulation test tube, sodium citrate sedimentation test tube, potassium oxalate/sodium fluoride blood collection tube, etc., and one skilled in the art may select the type of container for storing blood according to the purpose of the collected blood. The collecting unit can also be provided with a label marking function.

In a specific embodiment, the blood sampling unit includes 5 to 9 blood sampling units, for example, a blood sampling unit 1, a blood sampling unit 2, a blood sampling unit 3, a blood sampling unit 4, a blood sampling unit 5, a blood sampling unit 6, a blood sampling unit 7, a blood sampling unit 8, and a blood sampling unit 9, a plurality of subjects respectively pass through all the blood sampling units in sequence, each blood sampling unit correspondingly collects blood samples collected by the subjects at the timing of the blood sampling unit, and after all the blood samples are collected by all the subjects, all the blood samples corresponding to each subject are sorted and arranged by the collecting unit.

On the other hand, the invention also discloses a control device of the blood sampling system, which comprises:

a fixing unit setting module for setting the fixing unit to sequentially fix the plurality of subjects on the transfer unit, respectively;

a transfer unit setting module for setting an operation parameter of the transfer unit to sequentially transfer the plurality of subjects to a plurality of blood sampling units or to sequentially transfer the plurality of blood sampling units to the plurality of subjects; and

a blood collection unit control module which connects the plurality of blood collection units with the subjects to collect blood by recognizing blood collection positions of the plurality of subjects.

The control device performs a series of operations through programmed steps, and the control device can control the conveying speed in the conveying unit, the matching and connection before the retainer and the blood sampling unit, and the sorting in the collecting unit.

Optionally, the fixing unit arrangement comprises holding the subject on a holder and placing the subject in the start position of the transfer unit by manual or robotic placement. The holder is provided with a sensor for identification of the blood-drawing unit. The time intervals at which the plurality of subjects are fixed at the starting positions of the transfer units are the same.

The conveying unit is a conveying belt, a mechanical turntable or an automatic mechanical arm.

In one embodiment, the blood collection unit in the control device determines the position of a blood vessel indwelling needle previously provided on the subject by recognizing a position sensor provided on the holding portion, thereby connecting the blood vessel indwelling needle to the blood collection unit to collect blood.

In one embodiment, a position sensor is provided at one side of the holder to ensure that the distance between the blood collection unit and the sensor is closest and can be identified.

In one embodiment, the control device further comprises a drug administration unit setting module that controls the drug administration unit to administer the drug to the subject, and sets a time of the drug administration as an initial time.

After the subject on the holder is dosed, the dosing time is set as an initial time, the transfer unit starts to operate, blood is collected at the set time point after reaching the blood collection unit, and the blood is conveyed to the next blood collection point by the transfer unit after the blood collection is finished.

Wherein the route of administration to the subject comprises oral, intravenous, intramuscular, subcutaneous. The medicine can also be administered by sublingual buccal administration, rectal infusion, eye drop, nasal spray, oral spray, or topical or systemic transdermal administration. The route of administration of the drug is related to the kind of disease and the type of drug, and the like, and the mode of administration can be appropriately selected by those skilled in the art. The administration may be either manual or automated using an administration device.

In one embodiment, the transfer unit setting module sets a transfer speed of the transfer unit to correspondingly transfer the subject to the plurality of blood collection units at a plurality of given time points after the initial time.

In one embodiment, the transport speed of the transport unit is constant, and the distance of the plurality of blood collection units from the initial position is proportional to the blood collection given time.

In one embodiment, in the administration unit setting step, the length of the administration time interval between adjacent subjects is less than the given time of the corresponding first blood sampling unit; for example, the administration time is set as an initial time, and when the first blood sampling unit is given a time of 5 minutes, the administration time interval between adjacent subjects is 1 minute or 2 minutes.

In one embodiment, the given time of the blood sampling unit may be set to 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours, respectively; or the given time of the blood sampling unit may be set to 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 24 hours, respectively.

In one embodiment, the number of the collection units is the same as the number of the blood collection units.

In a particular embodiment, the subject is a mammal, preferably a mouse, rat, monkey, dog, macaque, or human.

In one embodiment, the control device further comprises a collection unit control module for controlling a collection unit to classify and sort the blood samples collected by the blood collection unit.

In another aspect, the invention also discloses a blood sampling system, comprising

A control device as claimed in any preceding claim;

a fixing unit that fixes a plurality of subjects on the transfer unit in sequence;

the transfer unit sequentially transfers the plurality of subjects to a plurality of blood sampling units or sequentially transfers the plurality of blood sampling units to a plurality of subjects;

the blood sampling unit is connected with the subject so as to collect blood.

In one embodiment, the system further comprises a dosing unit for dosing the plurality of subjects.

In one embodiment, the blood collection system as described above further comprises a collection unit that collects blood samples of the plurality of subjects and performs sorting.

Advantageous effects

The function of accurately timing blood collection in large-scale subjects is realized. The invention can complete the regular and continuous blood sampling of a plurality of testees by using one blood sampling device, saves the time and equipment cost required in the collecting process, improves the collecting efficiency and obviously reduces the error of the blood sampling time.

Drawings

FIG. 1 shows a logical block diagram of the blood collection system of the present invention.

FIG. 2 shows a schematic view of the blood collection system of the present invention.

Detailed Description

The present invention will be further illustrated by the following detailed description. The following terms, unless otherwise indicated, shall be understood to have the following meanings. Unless defined otherwise herein, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

In this application, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.

The structures, proportions, and dimensions shown in the drawings and described in the specification are for understanding and reading the present disclosure, and are not intended to limit the scope of the present disclosure, which is defined in the claims, and are not essential to the skilled in the art. In addition, the terms "upper", "lower", "front", "rear" and "middle" used in the present specification are for clarity of description, and are not intended to limit the scope of the present invention, and the relative relationship between the terms and the relative positions may be changed or adjusted without substantial technical changes.

Definition of

The term "plurality" as used herein refers to an integer greater than one, and the number of blood collection units in the plurality of blood collection units described herein may be specifically determined according to the number of specific blood collection time points for a specific pharmacokinetic experiment, for example, the number of blood collection units may be 5 or more; the number of subjects in the plurality of subjects described herein can be any integer greater than one, e.g., 10, 20, 30, 40, 50, 80, 100, 120, 140, 160, 200, etc.

The term "vascular indwelling needle", also referred to as a vascular trocar, as used herein, is, for example, a catheter and a needle core are punctured into a blood vessel together at the time of use, and after the catheter has been fully advanced into the blood vessel, the needle core is withdrawn, leaving only the soft catheter indwelling in the blood vessel. The blood vessel indwelling needle used herein includes a venous indwelling needle, an arterial indwelling needle, and although the venous indwelling needle is used in the embodiments, it is only for illustrative purposes, and those skilled in the art can select different kinds of indwelling needles according to specific blood sampling requirements.

The term "mammal" as used herein refers to humans, primates, dogs, rats and other higher organisms having hair overlying the skin and, for females, the mammary glands feeding young children. According to the present invention, experimental animals such as rat, mouse, dog, macaque are preferred. In addition, as used throughout, "subject" is used to describe mammals and preferably laboratory animals or humans that are tested or treated, including prophylactic treatment, using the methods and reagents provided herein.