Administration device for inhaling powder inhalation
阅读说明:本技术 一种吸入粉雾剂给药装置 (Administration device for inhaling powder inhalation ) 是由 聂毅 刘珊姗 张樱 史楷岐 于 2019-11-18 设计创作,主要内容包括:公开了一种吸入粉雾剂给药装置,其载药器内部设有装载药囊的第一载药腔和/或第二载药腔,第一载药腔和/或第二载药腔的底部设有空气入口,载药器包括位于左侧面的至少一个第一孔和/或右侧面的至少一个第二孔,左侧面设有第一凸台和/或右侧面设有第二凸台;戳针一端连接按钮,另一端可滑动连接于第一孔和/或第二孔以在克服弹性元件的弹性力时戳穿药囊;螺旋器包括圆筒本体以及设在圆筒本体内的用于产生涡流的叶片结构,叶片结构沿竖直方向扭转预定角度形成螺旋流道,来自空气入口的气体携带来自药囊的药物粉末依次通过栅格流道、螺旋流道以及平流流道进入嘴部。(The drug delivery device comprises a drug carrier, wherein a first drug loading cavity and/or a second drug loading cavity for loading a drug bag are/is arranged in the drug carrier, an air inlet is formed in the bottom of the first drug loading cavity and/or the bottom of the second drug loading cavity, the drug carrier comprises at least one first hole positioned on the left side surface and/or at least one second hole positioned on the right side surface, a first boss is arranged on the left side surface, and/or a second boss is arranged on the right side surface; one end of the puncture needle is connected with the button, and the other end of the puncture needle is slidably connected with the first hole and/or the second hole so as to puncture the medicine bag when overcoming the elastic force of the elastic element; the spiral device comprises a cylinder body and a blade structure which is arranged in the cylinder body and used for generating vortex, the blade structure is twisted by a preset angle along the vertical direction to form a spiral flow channel, and the gas from the air inlet carries the medicine powder from the medicine bag to sequentially pass through the grid flow channel, the spiral flow channel and the advection flow channel to enter the mouth.)
1. A drug delivery device for inhalation of a dry powder inhalation comprising a drug loading unit and a mouthpiece unit, wherein,
the medicine carrying unit comprises a medicine carrying unit,
the base is provided with a first opening above the base and comprises a second opening positioned on the left side wall and/or a third opening positioned on the right side wall;
the medicine carrier is assembled inside the base through the first opening, a first medicine carrying cavity and/or a second medicine carrying cavity for carrying a medicine bag are/is arranged inside the medicine carrier, an air inlet is formed in the bottom of the first medicine carrying cavity and/or the bottom of the second medicine carrying cavity, the medicine carrier comprises at least one first hole positioned on the left side surface and/or at least one second hole positioned on the right side surface, and a first boss is arranged on the left side surface and/or a second boss is arranged on the right side surface;
a button arrangement, comprising,
a button movably connected to the second opening and/or the third opening,
an elastic element, one end of which is assembled on the first boss and/or the second boss, and the other end of which is connected with the button,
a piercing needle having one end connected to the button and the other end slidably connected to the first and/or second hole to pierce the capsule while overcoming the elastic force of the elastic member;
the suction nozzle unit movably connected with the medicine carrying unit comprises,
a mouthpiece, which comprises a mouth for inhalation,
a grill positioned within the nozzle and positioned at the first opening, the grill including a grill flow passage,
the screw is arranged above the grid and positioned in the suction nozzle, the screw comprises a cylinder body and a blade structure which is arranged in the cylinder body and used for generating vortex, the blade structure is twisted by a preset angle along the vertical direction to form a spiral flow channel,
wherein, the suction nozzle lower surface forms the inhalation flow channel with the upper surface laminating of medicine carrying unit, and the inhalation flow channel includes grid runner, spiral runner and the advection runner between spiral ware and the mouth, and the gas that comes from air inlet carries the medicine powder that comes from the anther sac and loops through grid runner, spiral runner and advection runner entering the mouth.
2. The inhalation device according to claim 1, wherein preferably the sachet comprises first particles of a first size and second particles of a second size, the first size being larger than the second size, the second size being in the micron range.
3. The inhalation device of claim 2, wherein the second particles releasably attach to the first particles.
4. The inhalation device according to claim 1, wherein the inhalation device further comprises a cap detachably attached to the mouthpiece unit to close and open the mouthpiece.
5. The inhalation device according to claim 1, wherein the mouthpiece bottom is provided with a fourth opening in gaseous communication with the air inlet.
6. The inhalation device according to claim 1 wherein the cross-section of the advection flow path remains substantially constant and the vertical length of the straight flow path is more than 2 times the vertical length of the spiral flow path.
7. The inhalation device of claim 1, wherein the cross-sectional dimensions of the first drug-loaded chamber and the second drug-loaded chamber are proportioned to mix the drug powder proportionally.
8. The inhalation device according to claim 1, wherein the height of the cylindrical body is more than one-half of its diameter, the number of blades of the blade structure is 2, 3 or 4, and the cylindrical body is twisted with the blade structure.
9. The inhalation device of claim 1, wherein the first aperture and/or the second aperture has a diameter greater than 2 mm.
Technical Field
The invention relates to the field of oral inhalation preparations, in particular to a drug delivery device for inhalation of a powder inhalation.
Background
An oral inhalation formulation refers to a formulation that delivers a drug to the respiratory tract and/or lungs by the inhalation route for local or systemic action, primarily for the treatment of respiratory and other diseases. Clinically, the common oral inhalation preparation comprises an inhalation aerosol and an inhalation powder aerosol. In contrast to aerosols, inhalation powders are no longer dissolved using a propellant and are stored directly in sachets, blisters or reservoirs. When in use, the medicine powder enters the body by the inspiration of the patient, thereby avoiding the problem of the matching of the breath and the external power.
Inhalation of the dry powder inhalation needs to be performed by a drug delivery device (inhalation device), and representative drug delivery devices in the present use include those of GlaxoSmithKlineOf (blister type), AstraZeneca
(of the repository type) and of Boringer Invehringer Boehringer Ingelheim(drug capsule type). The difference is mainly in the loading unit of the medicine powder, but the inhalation flow channel is often very simple, so that the medicine powder flows unevenly in the inhalation process, the intermediate flow velocity is too large and easily impacts the oral cavity of a patient, and the inhalation efficiency of the effective ingredients is relatively low, usually less than 30%. Also, typically, the drug delivery device has only one drug-carrying chamber, and can only be used to administer a single drug component, or a mixture of drug components. In the case of a mixture of pharmaceutical ingredients, the high temperature and heat generated during mixing using a blender may cause the active ingredients therein to interact and cause their decomposition, resulting in poor therapeutic effect or even danger to the patientAnd (5) risking.The above information disclosed in this background section is only for enhancement of understanding of the background of the invention and therefore it may contain information that does not form the prior art that is well known to those of ordinary skill in the art.
Disclosure of Invention
In order to solve the above problems, the present invention provides a device for administering an inhalation powder formulation, which is adapted to generate a vortex flow in an inhalation flow path, can prevent the powder of a medicinal ingredient from hitting the oral cavity of a patient, and can sufficiently mix the powder of the medicinal ingredient. The purpose of the invention is realized by the following technical scheme.
A drug delivery device for inhalation of a dry powder inhalation comprising a drug loading unit and a mouthpiece unit, wherein,
the medicine carrying unit comprises a medicine carrying unit,
the base is provided with a first opening above the base and comprises a second opening positioned on the left side wall and/or a third opening positioned on the right side wall;
the medicine carrier is assembled inside the base through the first opening, a first medicine carrying cavity and/or a second medicine carrying cavity for carrying a medicine bag are/is arranged inside the medicine carrier, an air inlet is formed in the bottom of the first medicine carrying cavity and/or the bottom of the second medicine carrying cavity, the medicine carrier comprises at least one first hole positioned on the left side surface and/or at least one second hole positioned on the right side surface, and a first boss is arranged on the left side surface and/or a second boss is arranged on the right side surface;
a button arrangement, comprising,
a button movably connected to the second opening and/or the third opening,
an elastic element, one end of which is assembled on the first boss and/or the second boss, and the other end of which is connected with the button,
a piercing needle having one end connected to the button and the other end slidably connected to the first and/or second hole to pierce the capsule while overcoming the elastic force of the elastic member;
the suction nozzle unit movably connected with the medicine carrying unit comprises,
a mouthpiece, which comprises a mouth for inhalation,
a grill positioned within the nozzle and positioned at the first opening, the grill including a grill flow passage,
the screw is arranged above the grid and positioned in the suction nozzle, the screw comprises a cylinder body and a blade structure which is arranged in the cylinder body and used for generating vortex, the blade structure is twisted by a preset angle along the vertical direction to form a spiral flow channel,
wherein, the suction nozzle lower surface forms the inhalation flow channel with the upper surface laminating of medicine carrying unit, and the inhalation flow channel includes grid runner, spiral runner and the advection runner between spiral ware and the mouth, and the gas that comes from air inlet carries the medicine powder that comes from the anther sac and loops through grid runner, spiral runner and advection runner entering the mouth.
In the administration device, the sachet comprises first particles of a first size and second particles of a second size, the first size being larger than the second size, the second size being in the micron range.
In the administration device, the second particles are releasably attached to the first particles.
In the medication administering device, the medication administering device further includes a cap detachably coupled to the suction nozzle unit to close and open the suction nozzle.
In the administration device, the bottom of the suction nozzle is provided with a fourth opening which is in gas communication with the air inlet.
In the administration device, the cross section of the advection flow channel is basically kept unchanged, and the vertical length of the straight flow channel is more than 2 times of that of the spiral flow channel.
In the administration device, the cross-sectional dimensions of the first drug-loaded cavity and the second drug-loaded cavity are in a proportional relationship to proportionally mix the particles.
In the administration device, the height of the cylinder body is larger than one half of the diameter of the cylinder body, the number of the blades of the blade structure is 2, 3 or 4, and the cylinder body is twisted along with the blade structure.
In the administration device, the diameter of the first hole and/or the second hole is larger than 2 mm.
Compared with the prior art, the invention has the beneficial effects that:
the invention can prevent and overcome the over-fast intermediate flow velocity in the traditional flow passage, so that the flow velocity distribution of the flow passage is uniform, and the medicine powder is prevented from impacting the oral cavity of a patient. The combination of single or multiple components of the drug can be administered and the helical flow path can generate a vortex flow to thoroughly mix the drug powder upon inhalation by the patient. The spiral flow channel can also generate centrifugal force, increase collision of drug particles with the wall surface of the flow channel, improve separation of micron-sized effective particles of the drug from large particle carriers, and generate high shear stress on the wall surface of the flow channel, so that the flow channel has a self-cleaning effect. Meanwhile, the spiral flow channel generates small resistance, and even and stable flow can be generated at the outlet of the suction nozzle under different suction flow rates.
The above description is only an overview of the technical solutions of the present invention, and in order to make the technical means of the present invention more clearly apparent, and to make the implementation of the content of the description possible for those skilled in the art, and to make the above and other objects, features and advantages of the present invention more obvious, the following description is given by way of example of the specific embodiments of the present invention.
Drawings
Various other advantages and benefits of the present invention will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. It is obvious that the drawings described below are only some embodiments of the invention, and that for a person skilled in the art, other drawings can be derived from them without inventive effort. Also, like parts are designated by like reference numerals throughout the drawings.
In the drawings:
FIG. 1 is a schematic view of the construction of a drug delivery device according to the present invention;
FIG. 2 is a schematic view showing the construction of a mouthpiece unit of the medication administering device according to the present invention;
fig. 3 is a schematic view of a drug delivery unit of a drug delivery device according to the present invention;
FIG. 4 is a vertical cross-section of the drug delivery device and the airflow diagram during inhalation;
FIG. 5 is a view of the internal and external construction of the screw of the present invention;
FIG. 6 is a cross-sectional view of a screw of various configurations of the present invention;
FIG. 7 is a schematic illustration of the manner in which a sachet of the present invention is placed in the present device and its manner of puncturing;
fig. 8 is a schematic diagram of the process of use of the present invention.
The invention is further explained below with reference to the figures and examples.
Detailed Description
Specific embodiments of the present invention will be described in more detail below with reference to fig. 1 to 8. While specific embodiments of the invention are shown in the drawings, it should be understood that the invention may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
It should be noted that certain terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description which follows is a preferred embodiment of the invention, but is made for the purpose of illustrating the general principles of the invention and not for the purpose of limiting the scope of the invention. The scope of the present invention is defined by the appended claims.
For the purpose of facilitating understanding of the embodiments of the present invention, the following description will be made by taking specific embodiments as examples with reference to the accompanying drawings, and the drawings are not to be construed as limiting the embodiments of the present invention.
For better understanding, as shown in fig. 1, a drug delivery device includes a medicated unit C and a mouthpiece unit B, wherein,
the medicine carrying unit C comprises a medicine carrying unit C,
the
a
a button arrangement, comprising,
a
an
a piercing
the suction nozzle unit B movably connected with the medicine carrying unit C comprises,
the mouthpiece 1, which comprises a
a
the screw 2 is arranged above the
wherein, the lower surface of the suction nozzle 1 is attached to the upper surface of the medicine carrying unit C to form a suction flow channel, the suction flow channel comprises a
The administration device of the invention generates vortex flow through the
For further understanding of the present invention, in one embodiment, the pharmaceutical powder may be a single component or a combination of two components. Each pharmaceutical component is packaged within the
As shown in fig. 2, the nozzle unit B includes a nozzle 1, a screw 2, and a
Fig. 3 shows an example of a medicated unit C. It includes
Figure 5 shows the geometry of the screw 2. The outer part of the suction nozzle is a
As shown in fig. 6, the
Figure 7 shows the manner in which the
Figure 4 also shows the flow pattern of the air stream during inhalation. Air enters the interior of the device through an opening 9 in the bottom of the mouthpiece 1 as shown in figure 2. Air then enters the
In a preferred embodiment of the drug delivery device, the sachet comprises first particles of a first size and second particles of a second size, the first size being larger than the second size, the second size being in the micrometer range.
In a preferred embodiment of the drug delivery device, the second particles are releasably attached to the first particles.
In a preferred embodiment of the medication delivery device, the medication delivery device further comprises a cap A, which is detachably connected to the suction nozzle unit B for closing and opening the suction nozzle 1.
In the preferred embodiment of the medication delivery device, the mouthpiece 1 is provided with a fourth opening 9 at its bottom, which is in air communication with the
In the preferred embodiment of the administration device, the cross-section of the
In the preferred embodiment of the device, the
In the preferred embodiment of the drug delivery device, the height of the
In a preferred embodiment of the drug delivery device, the
In one embodiment, the drug powder in the
In one embodiment, the suction nozzle unit B comprises an inner and an outer part, the outer part being divided into the suction nozzle 1, in which the patient is placed during inhalation. The inner part consists of two parts, one of which is fixed to the top of the other. The upper part is usually a screw 2, the top of which is the outlet from which the powder exits the device, and the bottom of which is fixed to the top of the lower part. The lower part is of a
In one embodiment, the screw 2 in the nozzle unit B is also divided into an outer part and an inner part. The outer portion is a cylindrical body structure having a height generally exceeding 50% of the outer diameter. The inner part is a
In one embodiment, medicated unit C includes two parts, a medicated mechanism and a piercing mechanism. The medicine carrying mechanism comprises 2 medicine carrying cavities, the number of the medicine carrying cavities is generally 2, the medicine carrying cavities are used for carrying
In one embodiment, the user lifts the cap a from its original position to open the medication delivery device, and continues to lift the mouthpiece unit B to open the medication loading chamber. Depending on the formulation requirements, the user may place one or two
As shown in fig. 8, the medicine bag is loaded in the first
The
Industrial applicability
The drug delivery device of the present invention may be manufactured and used in the field of inhalation drug delivery.
The foregoing describes the general principles of the present application in conjunction with specific embodiments, however, it is noted that the advantages, effects, etc. mentioned in the present application are merely examples and are not limiting, and they should not be considered essential to the various embodiments of the present application. Furthermore, the foregoing disclosure of specific details is for the purpose of illustration and description and is not intended to be limiting, since the foregoing disclosure is not intended to be exhaustive or to limit the disclosure to the precise details disclosed.
The foregoing description has been presented for purposes of illustration and description. Furthermore, the description is not intended to limit embodiments of the application to the form disclosed herein. While a number of example aspects and embodiments have been discussed above, those of skill in the art will recognize certain variations, modifications, alterations, additions and sub-combinations thereof.
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