阅读说明：本技术 一种多用血小板血浆制备装置 (Multipurpose platelet and plasma preparation device ) 是由 潘海波 陈怡� 于 2021-07-27 设计创作，主要内容包括：本发明公开一种多用血小板血浆制备装置,涉及血小板血浆制备技术领域,包括多用式分离注射组件、血液采集存储组件、双向限位机构、纯血清过滤单元、混合血小板血清采集存储组件和混合血小板血清过滤单元,双向限位机构能够将混合血小板血清采集存储组件内端的活塞件以及分离注射组件双向固定,分离注射组件在上下推拉时,内活塞筒的上端部分套设于双向限位机构内,使其在推拉时不会晃动,采集存储组件内端的活塞件不直接与分离注射组件连接,不存在脱落的可能；将进入混合血小板血清采集存储组件内混入的红细胞进行过滤去除,将进入多用式分离注射组件内混入的含有少量游离的血小板血清进行过滤去除,从而有效保证提取的富血小板血浆质量。(The invention discloses a multipurpose platelet plasma preparation device, which relates to the technical field of platelet plasma preparation, and comprises a multipurpose separation injection assembly, a blood collection and storage assembly, a bidirectional limiting mechanism, a pure blood filtration unit, a mixed platelet serum collection and storage assembly and a mixed platelet serum filtration unit, wherein the bidirectional limiting mechanism can bidirectionally fix a piston piece at the inner end of the mixed platelet serum collection and storage assembly and the separation injection assembly; the red blood cells mixed in the mixed platelet serum collecting and storing assembly are filtered and removed, and the platelet serum containing a small amount of free platelet serum mixed in the multi-purpose separation injection assembly is filtered and removed, so that the quality of the extracted platelet-rich plasma is effectively ensured.)

1. A multipurpose platelet plasma preparation device is characterized in that: comprises a multipurpose separation injection component (1), a blood collection storage component (2), a two-way limiting mechanism (3), a pure blood serum filtering unit (4), a mixed platelet serum collection storage component (7) and a mixed platelet serum filtering unit (8), wherein the two-way limiting mechanism (3) is provided with at least two groups, a piston piece at the inner end of the mixed platelet serum collection storage component (7) is fixedly connected with one end of the two-way limiting mechanism (3), the inner end of the two-way limiting mechanism (3) is sleeved with the separation injection component (1) and is connected with the separation injection component in a rotating separation way, a connecting seat at the end part of the multipurpose separation injection component (1) is connected with an injection head component (6) in a rotating separation way, the pure blood serum filtering unit (4) is fixedly arranged at the bottom of the inner end of the multipurpose separation injection component (1) or is connected with the connecting seat at the end part of the multipurpose separation injection component (1) in a rotating separation way, the bottom end of the mixed platelet serum collection and storage assembly (7) is sleeved on the inner end of another two-way limiting mechanism (3) and is connected with the same in a rotating and separating manner, the bottom end of another two-way limiting mechanism (3) is fixedly connected with the piston piece at the inner end of the blood collection and storage assembly (2), the mixed platelet serum filtering unit (8) is fixedly arranged at the bottom of the inner end of the mixed platelet serum collection and storage assembly (7) or is connected with the connecting seat at the end part of the mixed platelet serum collection and storage assembly (7) in a rotating and separating manner, and the connecting seat at the end part of the blood collection and storage assembly (2) is connected with the multi-channel unit (5) or the injection head assembly (6) in a rotating and separating manner.

2. The multipurpose platelet plasma preparation device according to claim 1, characterized in that: multipurpose separation injection subassembly (1) is including interior piston cylinder (101), cock stem (102), one-level piston (103), one-level connecting seat (104), inner tube (105), be equipped with one-level piston (103) in interior piston cylinder (101), cock stem (102) one end is connected with one-level piston (103), interior piston cylinder (101) bottom is equipped with one-level connecting seat (104), one-level connecting seat (104) outer fringe is equipped with thread location arch (106), one-level connecting seat (104) inner is equipped with communicating inner tube (105) with interior piston cylinder (101), abdication thread groove (107) have been seted up to inner tube (105) inner wall.

3. The multipurpose platelet plasma preparation device according to claim 2, characterized in that: blood collection storage component (2) are including outer piston cylinder (201), second grade piston (202), second grade connecting seat (203), and seat stopper (204), be equipped with second grade piston (202) in outer piston cylinder (201), outer piston cylinder (201) bottom is equipped with second grade connecting seat (203), be equipped with screw thread groove of stepping down (205) in second grade connecting seat (203), thereby the screw thread groove of stepping down (205) is the rotation separation formula with the outer convex part of seat stopper (204) and is connected second grade connecting seat (203) and cup joint in seat stopper (204).

4. The multipurpose platelet plasma preparation device according to claim 3, characterized in that: two-way stop gear (3) are including spacing lantern ring (301), gag lever post (302), location base (303), spacing screw thread recess seat (304), spacing lantern ring (301) side is fixed and is equipped with gag lever post (302), gag lever post (302) are jaw formula structure, gag lever post (302) tip and second grade piston (202) fixed connection, gag lever post (302) inboard is fixed and is equipped with location base (303), location base (303) upper end is fixed and is equipped with spacing screw thread recess seat (304), and interior piston section of thick bamboo (101) pass spacing lantern ring (301) and downwardly extending makes screw thread location arch (106) be the rotary separation formula with spacing screw thread recess seat (304) and be connected thereby be fixed in two-way stop gear (3) with multi-purpose separation injection subassembly (1) inner.

5. The multipurpose platelet plasma preparation device according to claim 2, characterized in that: pure serum filter unit (4) and mixed platelet serum filter unit (8) are all including filtering connecting cylinder (9), filtration membrane (10) are located and are filtered connecting cylinder (9) inner, it is equipped with screw thread arch (11) to filter connecting cylinder (9) outer fringe, thereby screw thread arch (11) with let in screw thread groove (107) be the rotation separation formula and be connected and will filter connecting cylinder (9) and be fixed in inner tube (105), be equipped with filtration pore (12) on filtration membrane (10).

6. The multipurpose platelet plasma preparation device according to claim 5, wherein: the aperture of the filter hole (12) of the pure serum filter unit (4) is 1-2 um.

7. The multipurpose platelet plasma preparation device according to claim 5, wherein: the aperture of the filter hole (12) of the mixed platelet serum filter unit (8) is 6-9 um.

8. The multipurpose platelet plasma preparation device according to claim 2, characterized in that: the multi-way unit (5) comprises a multi-way pipe (501) and a pipe joint (502), the pipe joint (502) is arranged on the multi-way pipe (501), a pipe joint thread convex part (503) is arranged on the outer edge of the pipe joint (502), and the pipe joint thread convex part (503) is connected with the thread abdicating groove (205) in a rotating and separating mode, so that the pipe joint (502) is fixed in the second-stage connecting seat (203).

9. The multipurpose platelet plasma preparation device according to claim 2, characterized in that: the tip of injection head subassembly (6) is equipped with thread protrusion joint (601), thread protrusion joint (601) is luer joint, thereby thread protrusion joint (601) is rotatory disconnect-type with abdicating thread groove (107) and is connected in being fixed in inner tube (105) with injection head subassembly (6) tip, thereby thread protrusion joint (601) is rotatory disconnect-type with thread abdicating groove (205) and is connected thereby in being fixed in second grade connecting seat (203) with injection head subassembly (6) tip.

10. The multipurpose platelet plasma preparation device according to claim 1, characterized in that: the mixed platelet serum collecting and storing assembly (7) comprises an inner tube (701), a three-level piston (702), a three-level connecting seat (703) and an inner through connecting tube (705), wherein the three-level piston (702) is arranged in the inner tube (701), the three-level connecting seat (703) is arranged at the bottom of the inner tube (701), a threaded rotating bulge (704) is arranged at the outer edge of the three-level connecting seat (703), the inner end of the three-level connecting seat (703) is provided with the inner through connecting tube (705) communicated with the inner tube (701), and the inner wall of the inner through connecting tube (705) is provided with a concave threaded connecting groove (706).

Technical Field

The invention relates to the technical field of platelet plasma preparation, in particular to a multipurpose platelet plasma preparation device.

Background

Platelet-rich plasma (PRP) is Platelet concentrate obtained by centrifuging autologous whole blood, contains a large amount of growth factors and proteins, and has the functions of accurately self-positioning to a damaged part and controlling inflammationThe method has the advantages of promoting the regeneration of cells and tissues from different aspects, accelerating the repair of damaged tissues, and being widely applied to the clinical fields, such as the repair of bone joints, the repair of large-area burned skin, medical and aesthetic plastic surgery and the like. CN201920333426.7 discloses a platelet-rich plasma separation and extraction kit, which can prevent plasma from contacting with the external environment to be polluted, and does not need a full-automatic platelet separator, but the bottom of a needle cylinder is directly in threaded connection with the top of a blood collection cylinder, so that the upper half of the needle cylinder is not fixed, and when blood is collected, separated and extracted, the needle cylinder needs to be pushed and pulled up and down, and the upper half of the needle cylinder is easy to shake, so that the threaded connection between the bottom of the needle cylinder and a cylinder pipe is easy to deform, and the possibility of falling exists; when blood is collected, only a single tube of blood can be collected generally, the blood collecting efficiency is poor, when the requirement for collecting blood is high, the suit needs to be pulled out, and then another suit needs to be inserted for blood collection, so that the comfort level of a patient is greatly reduced; and the blood will be divided into three layers after centrifugation, the upper layer is serum, the middle layer is buff thin layer (platelet), the lower layer is red blood cell, during extraction, some red blood cells and thin layer will enter the syringe along the inner tube, so that the quality of the extracted platelet-rich plasma is not good, and the concentration of platelet is not up to 1000 < 10 > required in the consensus of experts nationwide (2020 version) of concentrated platelet product in wound repair⁹The standard of one/ml affects the therapeutic effect, and therefore, a new platelet rich plasma preparation device needs to be designed by those skilled in the art.

Disclosure of Invention

The invention aims to solve the problems that a bidirectional limiting mechanism is arranged to fix a piston piece at the inner end of a mixed platelet serum collection and storage assembly and a separation injection assembly in a bidirectional manner, so that the fixation of the piston piece at the inner end of the mixed platelet serum collection and storage assembly and the separation injection assembly can be effectively ensured, when the separation injection assembly is pushed and pulled up and down, the upper end part of an inner piston cylinder can be sleeved in the bidirectional limiting mechanism, so that the piston piece cannot shake when pushed and pulled, and meanwhile, the piston piece at the inner end of the collection and storage assembly is not directly connected with the separation injection assembly, so that the possibility of falling does not exist; when blood is collected, the ends of a plurality of blood collecting and storing components can be inserted into the multi-way tube, so that a blood taking needle at one end of the multi-way tube can enter the multi-way tube along a pipeline and enter different blood collecting and storing components in a shunting manner, and the blood taking effect is excellent; mix platelet serum filter unit and can filter the erythrocyte of sneaking into in the mixed platelet serum collection storage module and get rid of, pure serum filter unit can filter the dissociative platelet serum of a small amount that contains of upper strata in the mixed platelet serum collection storage module and get rid of for the platelet concentration satisfies clinical requirement, thereby effectively guarantees the multi-purpose platelet plasma preparation facilities of the rich platelet plasma quality of extraction.

In order to solve the problems, the invention provides a multipurpose platelet and plasma preparation device which comprises a multipurpose separation injection assembly, a blood collection and storage assembly, a bidirectional limiting mechanism, a pure blood serum filtering unit, a mixed platelet and serum collection and storage assembly and a mixed platelet and serum filtering unit, wherein the bidirectional limiting mechanism is provided with at least two groups, a piston piece at the inner end of the mixed platelet and serum collection and storage assembly is fixedly connected with one end of the bidirectional limiting mechanism, a separation injection assembly is sleeved at the inner end of the bidirectional limiting mechanism and is connected with the inner end of the bidirectional limiting mechanism in a rotating and separating manner, a connecting seat at the end part of the multipurpose separation injection assembly is connected with an injection head assembly in a rotating and separating manner, the pure blood serum filtering unit is fixedly arranged at the bottom of the inner end of the multipurpose separation injection assembly or is connected with the connecting seat at the end part of the multipurpose separation injection assembly in a rotating and separating manner, and the bottom end of the mixed platelet and serum collection and storage assembly is sleeved at the inner end of the other bidirectional limiting mechanism and is connected with the inner end part of the other bidirectional limiting mechanism in a rotating and separating manner Be the rotation separation formula and connect, the inner piston spare fixed connection of another two-way stop gear bottom and blood collection storage assembly, mixed platelet serum filter unit is fixed to be located and is mixed platelet serum collection storage assembly inner bottom or be the rotation separation formula with the connecting seat that mixes platelet serum collection storage assembly tip and be connected, the connecting seat of blood collection storage assembly tip is the rotation separation formula with lead to the unit more or the injection head subassembly is connected.

Preferably, the multi-purpose separation injection assembly comprises an inner piston cylinder, a plug rod, a first-stage piston, a first-stage connecting seat and an inner pipe, wherein the first-stage piston is arranged in the inner piston cylinder, one end of the plug rod is connected with the first-stage piston, the first-stage connecting seat is arranged at the bottom of the inner piston cylinder, a thread positioning bulge is arranged at the outer edge of the first-stage connecting seat, the inner end of the first-stage connecting seat is provided with the inner pipe communicated with the inner piston cylinder, and a abdicating thread groove is formed in the inner wall of the inner pipe.

Preferably, the blood collection and storage assembly comprises an outer piston cylinder, a second-stage piston, a second-stage connecting seat and a seat plug, wherein the second-stage piston is arranged in the outer piston cylinder, the second-stage connecting seat is arranged at the bottom of the outer piston cylinder, a thread abdicating groove is formed in the second-stage connecting seat, and the thread abdicating groove is connected with a convex part outside the seat plug in a rotating and separating manner so as to sleeve the second-stage connecting seat in the seat plug.

Preferably, the bidirectional limiting mechanism comprises a limiting sleeve ring, a limiting rod, a positioning base and a limiting thread groove seat, the limiting rod is fixedly arranged at the side end of the limiting sleeve ring, the limiting rod is of a clamping jaw type structure, the end part of the limiting rod is fixedly connected with the second-stage piston, the positioning base is fixedly arranged on the inner side of the limiting rod, the limiting thread groove seat is fixedly arranged at the upper end of the positioning base, and the inner piston cylinder penetrates through the limiting sleeve ring and extends downwards to enable the thread positioning protrusion to be connected with the limiting thread groove seat in a rotating separation mode, so that the bidirectional limiting mechanism is fixed at the inner end of the multi-purpose separation injection assembly.

As preferably, pure blood serum filter unit and mixed platelet serum filter unit all include filtration connecting cylinder, filtration membrane locates filtration connecting cylinder inner, it is protruding to filter the connecting cylinder outer fringe, thereby the screw thread is protruding to be connected with the screw groove of stepping down and is the rotation separation formula and be fixed in the inner tube with filtering the connecting cylinder, be equipped with the filtration pore on the filtration membrane.

Preferably, the pore size of the filtration pores of the pure serum filtration unit is 1-2 um.

Preferably, the pore size of the filtration pore of the mixed platelet serum filtration unit is 6-9 um.

Preferably, the multi-way unit comprises a multi-way pipe and a pipe joint, the multi-way pipe is provided with the pipe joint, the outer edge of the pipe joint is provided with a pipe joint thread convex part, and the pipe joint thread convex part and the thread abdicating groove are connected in a rotating and separating mode so that the pipe joint is fixed in the second-level connecting seat.

Preferably, the tip of injection head subassembly is equipped with the thread protrusion and connects, the thread protrusion connects for luer joint, thereby the thread protrusion connects and is rotatory disconnect-type with stepping down the screw thread recess and be connected injection head subassembly tip and be fixed in the inner tube, thereby the thread protrusion connects and is rotatory disconnect-type with the screw groove and be connected injection head subassembly tip and be fixed in the second grade connecting seat.

Preferably, the mixed platelet serum collecting and storing assembly comprises an inner tube barrel, a third-level piston, a third-level connecting seat and an inner tube, wherein the third-level piston is arranged in the inner tube barrel, the third-level connecting seat is arranged at the bottom of the inner tube barrel, a threaded rotating bulge is arranged at the outer edge of the third-level connecting seat, an inner through connecting tube communicated with the inner tube barrel is arranged at the inner end of the third-level connecting seat, and a concave threaded connecting groove is formed in the inner wall of the inner through connecting tube.

Adopt above-mentioned structure, its beneficial effect lies in:

the piston piece at the inner end of the mixed platelet serum collection and storage assembly is fixedly connected with one end of a bidirectional limiting mechanism, the inner end of the bidirectional limiting mechanism is sleeved with a separation injection assembly and is connected with the separation injection assembly in a rotating and separating manner, the bidirectional limiting mechanism can fix the piston piece at the inner end of the mixed platelet serum collection and storage assembly and the separation injection assembly in a bidirectional manner, the fixation of the piston piece at the inner end of the mixed platelet serum collection and storage assembly and the separation injection assembly can be effectively ensured, when the separation injection assembly is pushed and pulled up and down, the upper end part of an inner tube can be sleeved in the bidirectional limiting mechanism, so that the separation injection assembly cannot shake during pushing and pulling, and meanwhile, the piston piece at the inner end of the mixed platelet serum collection and storage assembly is not directly connected with the separation injection assembly, and the possibility of falling does not exist; the bottom end of the mixed platelet serum collection and storage assembly is sleeved at the inner end of another group of two-way limiting mechanisms and is connected with the blood collection and storage assembly in a rotating and separating manner, the bottom end of the other group of two-way limiting mechanisms is fixedly connected with the piston piece at the inner end of the blood collection and storage assembly, the fixity of the piston piece at the inner end of the blood collection and storage assembly and the mixed platelet serum collection and storage assembly can be effectively ensured, when the separation injection assembly is pushed and pulled up and down, the upper end part of each two-way limiting mechanism can be sleeved in each two-way limiting mechanism, and the fixity of the separation injection assembly in the pushing and pulling process is kept.

The connecting seat at the end part of the blood collecting and storing component of the invention is connected with the multi-way unit in a rotary separating way, the multi-way unit comprises a multi-way pipe and a pipe joint, the pipe joint is arranged on the multi-way pipe, the pipe joint thread convex part is arranged at the upper outer edge of the pipe joint, the pipe joint thread convex part is connected with the thread abdicating groove in a rotary separating way so as to fix the pipe joint in the secondary connecting seat, when in blood collection, the multi-way pipe can be inserted with a plurality of ends of the blood collecting and storing component, so that a blood taking needle at one end of the multi-way pipe can enter the multi-way pipe along the pipeline and can enter different blood collecting and storing components in a shunting way, the blood collecting effect is excellent, the connecting seat at the end part of the multi-purpose separating and injecting component is connected with the injecting head component in a rotary separating way, the connecting fixation of the multi-purpose separating and injecting component and the injecting component can be effectively ensured, meanwhile, the installation and the disassembly are convenient, and the platelet-rich serum extracted from the multi-purpose separating and injecting component can be injected into a sterile bottle for standby in time, so that the split injection assembly has wide application.

The pure blood serum filtering unit is fixedly arranged at the bottom of the inner end of the multi-purpose separation injection assembly or is in rotary separation connection with a connecting seat at the end part of the multi-purpose separation injection assembly, the mixed platelet serum filtering unit is fixedly arranged at the bottom of the inner end of the mixed platelet serum collection and storage assembly or is in rotary separation connection with the connecting seat at the end part of the mixed platelet serum collection and storage assembly, the pure blood serum filtering unit and the mixed platelet serum filtering unit respectively comprise a filtering connecting cylinder and a filtering membrane, the filtering membrane is arranged at the inner end of the filtering connecting cylinder, the outer edge of the filtering connecting cylinder is provided with a threaded bulge, the threaded bulge is in rotary separation connection with a abdication threaded groove so as to fix the filtering connecting cylinder in an inner tube, the filtering membrane of the mixed platelet serum filtering unit is provided with a filtering hole, and the filtering membrane of the mixed platelet serum filtering unit can filter and remove mixed red blood cells when the multi-purpose separation injection assembly is extracted, get into in the mixed platelet serum gathers storage module, gather storage module bottom and another two-way stop gear of group again with mixed platelet serum and separate, the mixed platelet serum that gathers storage module in the mixed platelet serum carries out centrifugal treatment, make and divide into two-layerly in the mixed platelet serum gathers storage module, the upper strata is called the anemia platelet serum for containing a small amount of free platelet serum, the lower floor is rich platelet serum, pure blood filtration unit can be with the upper strata in the mixed platelet serum gather storage module contain a small amount of free platelet serum and filter and get rid of, draw from through the multi-purpose separation injection subassembly and draw anemia platelet serum, make the platelet concentration satisfy clinical requirement, thereby effectively guarantee the rich platelet plasma quality of drawing.

Drawings

FIG. 1 is a schematic view showing the structure of a multipurpose platelet/plasma preparation apparatus according to the present invention.

FIG. 2 is a schematic view showing the structure of the multipurpose platelet/plasma preparation apparatus according to the present invention when blood is collected.

Fig. 3 is a schematic structural view of the multi-use separation injection assembly in combination with a bi-directional stop mechanism.

Fig. 4 is an assembly view of the multiple use split syringe assembly with the bi-directional stop mechanism installed.

Fig. 5 is a schematic structural diagram of the mixed platelet serum collection and storage assembly when mounted with another two-way limiting mechanism.

Fig. 6 is a schematic diagram of the internal structure of the multiple use split syringe assembly.

Fig. 7 is a schematic diagram of the internal structure of the mixed platelet serum collection and storage assembly.

FIG. 8 is a schematic diagram of a pure serum filter unit or a mixed platelet serum filter unit.

Fig. 9 is a schematic structural view of a syringe head assembly mounted on the multipurpose platelet and plasma preparation device.

Fig. 10 is a schematic diagram of a multiple use split syringe assembly mounting syringe head assembly.

Fig. 11 is a schematic structural diagram of a pure serum filter unit installed in a multi-purpose separation injection assembly and a platelet serum filter unit installed in a mixed platelet serum collection and storage assembly.

In the figure: 1-a multi-purpose separation injection component, 101-a piston cylinder, 102-a plug rod, 103-a primary piston, 104-a primary connecting seat, 105-an inner tube, 106-a thread positioning bulge, 107-a abdicating thread groove, 2-a blood collection and storage component, 201-an outer piston cylinder, 202-a secondary piston, 203-a secondary connecting seat, 204-a plug, 205-a thread abdicating groove, 3-a bidirectional limiting mechanism, 301-a limiting lantern ring, 302-a limiting rod, 303-a positioning base, 304-a limiting thread groove seat, 4-a pure blood filtration unit, 5-a multi-way unit, 501-a multi-way tube, 502-a tube connector, 503-a tube connecting thread bulge, 6-an injection head component, 601-a thread bulge connector, and 7-a mixed platelet serum collection and storage component, 701-an inner tube barrel, 702-a three-stage piston, 703-a three-stage connecting seat, 704-a threaded rotary bulge, 705-an inner through connecting tube, 706-a concave threaded connecting groove, 8-a mixed platelet serum filtering unit, 9-a filtering connecting cylinder, 10-a filtering membrane, 11-a threaded bulge and 12-a filtering hole.

Detailed Description

The invention is further explained below with reference to the figures and examples.

The first embodiment is as follows: a multipurpose platelet plasma preparation device comprises a multipurpose separation injection component 1, a blood collection storage component 2, a bidirectional limiting mechanism 3, a pure serum filtering unit 4, a mixed platelet serum collection storage component 7 and a mixed platelet serum filtering unit 8, wherein the bidirectional limiting mechanism 3 is provided with at least two groups, a piston piece at the inner end of the mixed platelet serum collection storage component 7 is fixedly connected with one end of the bidirectional limiting mechanism 3, a separation injection component 1 is sleeved at the inner end of the bidirectional limiting mechanism 3 and is connected with the inner end of the bidirectional limiting mechanism in a rotating and separating way, a connecting seat at the end part of the multipurpose separation injection component 1 is connected with an injection head component 6 in a rotating and separating way, the pure serum filtering unit 4 is fixedly arranged at the bottom of the inner end of the multipurpose separation injection component 1 or is connected with the connecting seat at the end part of the multipurpose separation injection component 1 in a rotating and separating way, mix 7 bottom end covers of platelet serum collection storage module and locate another two-way stop gear 3 the inner and rather than being the rotation separation formula and be connected, the piston spare fixed connection that storage module 2 the inner is gathered to another 3 bottoms of two-way stop gear and blood, mix platelet serum filter unit 8 fixed locate mix platelet serum collection storage module 7 the inner bottom or be the rotation separation formula with the connecting seat that storage module 7 tip was gathered to mixed platelet serum and be connected, the connecting seat of storage module 2 tip is connected with leading to unit 5 or injection head subassembly 6 more and is the rotation separation formula.

Example two: the multi-purpose separation injection assembly 1 comprises an inner piston cylinder 101, a plug rod 102, a first-level piston 103, a first-level connecting seat 104 and an inner tube 105, the first-level piston 103 is arranged in the inner piston cylinder 101, one end of the plug rod 102 is connected with the first-level piston 103, the first-level connecting seat 104 is arranged at the bottom of the inner piston cylinder 101, a thread positioning bulge 106 is arranged at the outer edge of the first-level connecting seat 104, the inner end of the first-level connecting seat 104 is provided with the inner tube 105 communicated with the inner piston cylinder 101, a yielding thread groove 107 is formed in the inner wall of the inner tube 105, and other technical schemes are the same as those of the first embodiment.

Example three: the blood collection and storage assembly 2 comprises an outer piston cylinder 201, a second-stage piston 202, a second-stage connecting seat 203 and a seat plug 204, the second-stage piston 202 is arranged in the outer piston cylinder 201, the second-stage connecting seat 203 is arranged at the bottom of the outer piston cylinder 201, a thread abdicating groove 205 is arranged in the second-stage connecting seat 203, the thread abdicating groove 205 and a convex part outside the seat plug 204 are connected in a rotating and separating mode, so that the second-stage connecting seat 203 is sleeved in the seat plug 204, and other technical schemes are the same as the first embodiment or the second embodiment.

Example four: the bidirectional limiting mechanism 3 comprises a limiting sleeve ring 301, a limiting rod 302, a positioning base 303 and a limiting thread groove seat 304, the limiting rod 302 is fixedly arranged at the side end of the limiting sleeve ring 301, the limiting rod 302 is of a clamping jaw type structure, the end part of the limiting rod 302 is fixedly connected with the secondary piston 202, the positioning base 303 is fixedly arranged on the inner side of the limiting rod 302, the limiting thread groove seat 304 is fixedly arranged at the upper end of the positioning base 303, the inner piston cylinder 101 penetrates through the limiting sleeve ring 301 and extends downwards to enable the thread positioning bulge 106 to be connected with the limiting thread groove seat 304 in a rotating separation mode, so that the bidirectional limiting mechanism 3 is fixed at the inner end of the multipurpose separation injection assembly 1, and the other technical schemes are the same as those of the first embodiment or the second embodiment or the third embodiment.

Example five: pure serum filter unit 4 and mixed platelet serum filter unit 8 all include filtration connecting cylinder 9, filtration membrane 10 is located and is filtered the connecting cylinder 9 inner, it is equipped with screw thread arch 11 to filter the connecting cylinder 9 outer fringe, thereby screw thread arch 11 is the rotation separation formula with stepping down screw thread groove 107 and is connected and will filter the connecting cylinder 9 and be fixed in inner tube 105, be equipped with filtration pore 12 on the filtration membrane 10, all the other technical scheme and embodiment one or two or three or four are the same.

Example six: the aperture of the filter hole 12 of the pure serum filter unit 4 is 1-2um, and the other technical scheme is the same as that of the first embodiment, the second embodiment, the third embodiment, the fourth embodiment and the fifth embodiment.

Example seven: the aperture of the filter hole 12 of the mixed platelet serum filter unit 8 is 6-9um, and the other technical scheme is the same as that of the first embodiment, the second embodiment, the third embodiment, the fourth embodiment and the fifth embodiment.

Example eight: the multi-way unit 5 comprises a multi-way pipe 501 and a pipe joint 502, the multi-way pipe 501 is provided with the pipe joint 502, the outer edge of the pipe joint 502 is provided with a pipe joint thread convex part 503, the pipe joint thread convex part 503 is connected with the thread abdicating groove 205 in a rotating and separating way so as to fix the pipe joint 502 in the second-stage connecting seat 203, and other technical schemes are the same as those of the first embodiment, the second embodiment, the third embodiment, the fourth embodiment, the fifth embodiment, the sixth embodiment and the seventh embodiment.

Example nine: the end of the injection head assembly 6 is provided with a threaded convex joint 601, the threaded convex joint 601 is a luer joint, the threaded convex joint 601 is connected with the abdicating threaded groove 107 in a rotating and separating manner so as to fix the end of the injection head assembly 6 in the inner tube 105, the threaded convex joint 601 is connected with the threaded abdicating groove 205 in a rotating and separating manner so as to fix the end of the injection head assembly 6 in the secondary connecting seat 203, and other technical schemes are the same as those of the first embodiment, the second embodiment, the third embodiment, the fourth embodiment, the fifth embodiment, the sixth embodiment, the seventh embodiment and the eighth embodiment.

Example ten: the mixed platelet serum collecting and storing assembly 7 comprises an inner tube 701, a three-level piston 702, a three-level connecting seat 703 and an inner through connecting tube 705, wherein the three-level piston 702 is arranged in the inner tube 701, the bottom of the inner tube 701 is provided with the three-level connecting seat 703, the outer edge of the three-level connecting seat 703 is provided with a threaded rotating bulge 704, the inner end of the three-level connecting seat 703 is provided with the inner through connecting tube 705 communicated with the inner tube 701, the inner wall of the inner through connecting tube 705 is provided with a concave threaded connecting groove 706, and the rest technical schemes are the same as those of the first embodiment, the second embodiment, the third embodiment, the fourth embodiment, the fifth embodiment, the sixth embodiment, the eighth embodiment and the ninth embodiment.

Example eleven: the upper ends of the piston cylinder 101 and the outer piston cylinder 201 are both provided with a thread groove, and the sealing covers are in threaded connection with the thread grooves in a rotating mode.

Example twelve: the preparation process of the multipurpose platelet plasma preparation device comprises the following steps: s1, connecting the liquid collection and storage component 2 of the multipurpose platelet and plasma preparation device with the injection head component 6, extracting 2ml of ACD-A type anticoagulant, extracting 20ml of blood, rotating and screwing the secondary connecting seats 203 of the liquid collection and storage components 2 with different pipe joints 502 of the multi-way unit 5 respectively when the blood collection requirement is high, inserting a blood taking needle at the front end of the multi-way pipe 501 into a blood vessel of a human body, enabling the blood to flow into the multi-way pipe 501 through a pipeline, separating the plug rod 102 at the bottom end of the injection group 1 through the push-pull multipurpose type, enabling the blood in the multi-way pipe 501 to be shunted and enter different mixed platelet and serum collection and storage components 2, and completing the blood collection;

s2, placing the multipurpose platelet plasma preparation device into a centrifugal rotor of a centrifuge, balancing 200g, centrifuging for 10 minutes, dividing the blood collection and storage component 2 into three layers, wherein the upper layer is serum, the middle layer is a light yellow thin layer, and the lower layer is red blood cells;

s3, the piston cylinder 101 of the push-pull multi-purpose separation injection assembly 1, the bidirectional limiting mechanism 3 below the piston cylinder 101 drives the three-stage piston 702 in the mixed platelet serum collection and storage assembly 7 to move upwards, the piston cylinder 101 is driven to push the inner tube 701 of the mixed platelet serum collection and storage assembly 7 down to the upper limit line (about 8ml position) of the outer piston cylinder 201 of the blood collection and storage assembly 2, the mixed platelet serum filtering unit 8 filters red blood cells, serum and platelets are sucked into the inner tube 701 of the mixed platelet serum collection and storage assembly 7, the upper limit line (about 12ml position) of the inner tube 701 is the upper limit line (about 12ml position), and the part is serum containing blood platelets (point A sampling 0.1ml, and inspection);

s4, rotationally separating the threaded rotary protrusion 704 at the bottom of the mixed platelet serum collection and storage component 7 from the other bidirectional limiting mechanism 3, taking out the mixed platelet serum collection and storage component 7 and the multi-purpose separation injection component 1 in the mixed platelet serum collection and storage component 7, sleeving an upper seat plug on the bottom of the mixed platelet serum collection and storage component 7, putting the mixed platelet serum collection and storage component into a centrifugal rotor of a centrifuge, balancing 200g, centrifuging for 10 minutes, dividing the mixed platelet serum collection and storage component 7 into two layers, wherein the upper layer is called platelet serum containing a small amount of free platelet serum, and the lower layer is platelet serum rich;

s5, by pushing and pulling the plug rod 102 of the multipurpose separation injection component 1, the plug rod 102 drives the primary piston 103 to move upwards, the primary piston 103 is driven to the upper limit line (about 9 ml) of the piston cylinder 101, the pure blood serum filtering unit 4 filters free platelet serum, and the pure blood serum is sucked into the piston cylinder 101;

s6, rotationally separating the thread positioning bulge 106 at the bottom of the multipurpose separation injection component 1 from the bidirectional limiting mechanism 3, taking out the multipurpose separation injection component 1, rotationally connecting and sealing the inner tube 701 of the mixed platelet serum collection and storage component 7 with the thread of the sealing cover, installing the injection head component 6 at the bottom of the multipurpose separation injection component 1, and transferring the pure serum into a sterile vial for later use (sampling 0.1ml at the point B and checking);

s7, inserting the injection head assembly 6 at the bottom of the multipurpose separation injection assembly 1 into the sealing cover, enabling the injection needle to enter the inner tube 701 of the mixed platelet serum collection and storage assembly 7, sucking the platelet-rich serum in the inner tube 701 into the piston tube 101 in the multipurpose separation injection assembly 1, and transferring the platelet-rich serum into another sterile vial for later use (sampling 0.1ml at point C and checking).

And (3) detection results: platelet content in blood, number of platelets in the A, B, C point sample was:

in order to facilitate understanding of the above-described embodiments of the present invention, the following detailed description will be given of the above-described embodiments of the present invention in a specific manner of use.

The specific working process is as follows: firstly, blood collection is carried out, the secondary connecting seats 203 of the blood collection and storage assembly 2 and the injection head assembly 6 are rotated and screwed, the injection head is punctured into a blood vessel of a human body for blood collection, when the requirement of blood collection is high, the secondary connecting seats 203 of a plurality of liquid collection and storage assemblies 2 are respectively rotated and screwed with different pipe joints 502 of the multi-way unit 5, a blood taking needle at the front end of the multi-way pipe 501 is punctured into the blood vessel of the human body, the blood flows into the multi-way pipe 501 through a pipeline, and the plug rod 102 at the bottom end of the injection assembly 1 is separated in a push-pull multi-purpose manner, so that the blood in the multi-way pipe 501 is shunted and enters different mixed platelet and serum collection and storage assemblies 2 to finish the blood collection; then centrifugal separation is carried out, the multipurpose platelet and plasma preparation device is placed in a protective cover in a centrifuge, physiological saline with corresponding weight is added by a balance tube for balance, and the centrifuge is started for centrifugal separation; the blood in the multi-purpose platelet plasma preparation device after centrifugal separation is layered, the multi-purpose platelet plasma preparation device is taken out from a protective cover, then suction separation is carried out, a piston cylinder 101 of the multi-purpose separation injection component 1 is pushed and pulled, a three-stage piston 702 in a mixed platelet serum collection and storage component 7 is driven by a two-way limiting mechanism 3 below the piston cylinder 101 to move upwards, a mixed platelet serum filtering unit 8 filters red blood cells, serum and platelets are sucked into an inner tube 701 of the mixed platelet serum collection and storage component 7, then a threaded rotating bulge 704 at the bottom of the mixed platelet serum collection and storage component 7 is rotationally separated from the other two-way limiting mechanism 3, the mixed platelet serum collection and storage component 7 and the multi-purpose separation injection component 1 in the mixed platelet serum collection and storage component 7 are taken out, and a seat plug is sleeved at the bottom of the mixed platelet serum collection and storage component 7, the blood platelet serum is centrifugally separated in a centrifugal rotor of a centrifuge, the mixed platelet serum collecting and storing assembly 7 is divided into two layers, the upper layer is the platelet serum containing a small amount of free platelet serum and is called as platelet serum, the lower layer is the platelet serum rich, the plug rod 102 of the push-pull multipurpose separation injection assembly 1 drives the primary piston 103 to move upwards, the pure platelet serum is filtered by the pure platelet serum filtering unit 4, and the pure platelet serum is sucked into the piston cylinder 101; rotationally separating the thread positioning bulge 106 at the bottom of the multipurpose separation injection assembly 1 from the bidirectional limiting mechanism 3, taking out the multipurpose separation injection assembly 1, rotationally connecting and sealing an inner tube 701 of a mixed platelet serum collection and storage assembly 7 and a sealing cover thread, then installing an injection head assembly 6 at the bottom of the multipurpose separation injection assembly 1, and transferring pure platelet serum into a sterile vial for later use; then the injection head assembly 6 at the bottom of the multipurpose separation injection assembly 1 is inserted into the sealing cover, the injection needle head enters the inner tube 701 of the mixed platelet serum collection and storage assembly 7, the platelet-poor serum in the inner tube 701 is sucked into the piston tube 101 in the multipurpose separation injection assembly 1, and the platelet-rich serum is transferred into another sterile vial for standby.

In the description of the present invention, it should be noted that the terms "upper", "lower", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, which are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and operate, and thus, should not be construed as limiting the present invention. Unless expressly stated or limited otherwise, the terms "mounted," "connected," and "connected" are intended to be inclusive and mean, for example, that they may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

It is to be noted that, in the present invention, relational terms such as "first" and "second", and the like, are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

The foregoing are merely exemplary embodiments of the present invention, which enable those skilled in the art to understand or practice the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features of the invention described herein.