阅读说明：本技术 一种足浴用泡腾片 (Effervescent tablet for foot bath ) 是由 郑远元 于 2019-11-18 设计创作，主要内容包括：本发明涉及一种足浴用泡腾片,按重量份由以下原料制成,艾叶1-5份、橘皮3-8份、新疆紫草4-6份、五加皮5-6份、透皮吸收剂1-2份、碳酸氢钠30-60份、柠檬酸10-40份、微晶纤维素3-9份、低取代羟丙基纤维素2-6份、白砂糖1-5份、硬脂酸镁1-2份、香精0.5-2份、十二烷基硫酸钠0.5-3份、色素0.5-2份、β-环糊精3-10份。本发明还提供了通过制备足浴泡腾片的方法。本发明不但能够起到抑菌、抗菌的作用,而且能够使得在使用的过程中散发一定的香气,从而提高足浴过程中的舒适度；而且,本发明中设置色素,能够起到一定的保护用户隐私的作用；最后,本发明采用干法制粒的工艺来加工泡腾片,能够防止出现吸潮问题,从而提高了工业生产效率,可广泛应用在保健药品技术领域。(The invention relates to an effervescent tablet for foot bath, which is prepared from the following raw materials, by weight, 1-5 parts of folium artemisiae argyi, 3-8 parts of orange peel, 4-6 parts of arnebia euchroma, 5-6 parts of cortex acanthopanacis, 1-2 parts of a transdermal absorbent, 30-60 parts of sodium bicarbonate, 10-40 parts of citric acid, 3-9 parts of microcrystalline cellulose, 2-6 parts of low-substituted hydroxypropyl cellulose, 1-5 parts of white granulated sugar, 1-2 parts of magnesium stearate, 0.5-2 parts of essence, 0.5-3 parts of sodium dodecyl sulfate, 0.5-2 parts of pigment and 3-10 parts of β -cyclodextrin.)

1. An effervescent tablet for foot bath is characterized by being prepared from the following raw materials, by weight, 1-5 parts of folium artemisiae argyi, 3-8 parts of orange peel, 4-6 parts of arnebia euchroma, 5-6 parts of cortex acanthopanacis, 1-2 parts of a transdermal absorbent, 30-60 parts of sodium bicarbonate, 10-40 parts of citric acid, 3-9 parts of microcrystalline cellulose, 2-6 parts of low-substituted hydroxypropyl cellulose, 1-5 parts of white granulated sugar, 1-2 parts of magnesium stearate, 0.5-2 parts of essence, 0.5-3 parts of sodium dodecyl sulfate, 0.5-2 parts of pigment and 3-10 parts of β -cyclodextrin.

2. The effervescent tablet for foot bath according to claim 1, wherein the transdermal absorbent comprises one or more of azone, borneol, menthol and eucalyptus oil.

3. The preparation method of the effervescent tablet for foot bath according to claim 1, which is characterized by comprising the following preparation process steps:

(1) taking folium Artemisiae Argyi and pericarpium Citri Tangerinae, and adopting supercritical CO₂Extracting volatile oil with supercritical CO₂The extraction pressure is controlled to be 20-35MPa, the separator pressure is 15-25MPa, and CO is added₂The flow rate is 15-45L/h, the extraction temperature is 25-50 ℃, the extraction time is 3-6h, and the volatile oil is collected for later use;

(2) mixing the residues in the step (1) with the rest Chinese medicines, decocting with water for 2 times, adding 10 times of water for the first time, adding 8 times of water for the second time, each time for 2.0h, mixing the decoctions, filtering with 200 mesh sieve, concentrating the filtrate under reduced pressure to relative density of 1.10 at 60 deg.C, and drying to obtain extract powder;

(3) embedding the volatile oil extracted in the step (1) by adopting β -cyclodextrin to obtain a volatile oil inclusion compound for later use;

(4) selecting, washing, drying and breaking the wall of arnebia eucommiae and cortex acanthopanacis, crushing into fine powder, adding 75% ethanol with the amount of 6 times of the fine powder, leaching for 24 hours, filtering, drying under reduced pressure, and crushing to obtain dry extract powder for later use;

(5) mixing the volatile oil obtained in the step (1), the dry extract powder obtained in the step (2), the alcohol-extracted dry extract powder obtained in the step (3), sodium bicarbonate, citric acid, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, white granulated sugar, magnesium stearate, essence, sodium dodecyl sulfate and pigment, performing dry granulation, and tabletting to obtain the effervescent tablet for foot bath with the functions of bacteriostasis and antibiosis.

4. The preparation method of the effervescent tablet for foot bath according to claim 3, wherein in the preparation process, dry granulation is adopted.

5. The preparation method of the effervescent tablet for foot bath according to claim 3, wherein the folium artemisiae argyi and orange peel volatile oil is extracted by a supercritical extraction method, and the volatile oil is subjected to inclusion by using an inclusion technology.

6. The preparation method of the effervescent tablet for foot bath according to claim 3, wherein the arnebia euchroma and the cortex acanthopanacis are crushed into fine powder by adopting a wall breaking and crushing technology.

7. The preparation method of the effervescent tablet for foot bath according to claim 3, wherein the specification of the effervescent tablet is 10 g/tablet.

Technical Field

The invention relates to the technical field of health care medicines, in particular to an effervescent tablet for foot bath.

Background

With the acceleration of the pace of life, the pressure of people in life and work is gradually increased, and some people need to make business negotiation frequently on a business trip and rush to airports, stations and other places, so that feet are easy to sweat; in addition, some people can not well nurse feet, and the problems of sweaty feet, bubble grinding and even beriberi and the like can occur, so that the comfort level of people can be influenced, and an embarrassed scene can occur when the slippers are needed when people go out.

Disclosure of Invention

In order to solve the technical problems, the technical scheme provided by the invention is as follows:

an effervescent tablet for foot bath is prepared from the following raw materials, by weight, 1-5 parts of folium artemisiae argyi, 3-8 parts of orange peel, 4-6 parts of arnebia euchroma, 5-6 parts of cortex acanthopanacis, 1-2 parts of transdermal absorbent, 30-60 parts of sodium bicarbonate, 10-40 parts of citric acid, 3-9 parts of microcrystalline cellulose, 2-6 parts of low-substituted hydroxypropyl cellulose, 1-5 parts of white granulated sugar, 1-2 parts of magnesium stearate, 0.5-2 parts of essence, 0.5-3 parts of sodium dodecyl sulfate, 0.5-2 parts of pigment and 3-10 parts of β -cyclodextrin.

Further, the transdermal absorbent comprises one or more of azone, borneol, menthol and eucalyptus oil.

The invention also provides a technical scheme that:

the preparation method of the effervescent tablet for foot bath comprises the following preparation process steps:

(1) taking folium Artemisiae Argyi and pericarpium Citri Tangerinae, and adopting supercritical CO₂Extracting volatile oil with supercritical CO₂The extraction pressure is controlled at 20-35MPa, and the separatorPressure 15-25MPa, CO₂The flow rate is 15-45L/h, the extraction temperature is 25-50 ℃, the extraction time is 3-6h, and the volatile oil is collected for later use;

(2) mixing the residues in the step (1) with the rest Chinese medicines, decocting with water for 2 times, adding 10 times of water for the first time, adding 8 times of water for the second time, each time for 2.0h, mixing the decoctions, filtering with 200 mesh sieve, concentrating the filtrate under reduced pressure to relative density of 1.10 at 60 deg.C, and drying to obtain extract powder;

(3) embedding the volatile oil extracted in the step (1) by adopting β -cyclodextrin to obtain a volatile oil inclusion compound for later use;

(4) selecting, washing, drying and breaking the wall of arnebia eucommiae and cortex acanthopanacis, crushing into fine powder, adding 75% ethanol with the amount of 6 times of the fine powder, leaching for 24 hours, filtering, drying under reduced pressure, and crushing to obtain dry extract powder for later use;

(5) mixing the volatile oil obtained in the step (1), the dry extract powder obtained in the step (2), the alcohol-extracted dry extract powder obtained in the step (3), sodium bicarbonate, citric acid, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, white granulated sugar, magnesium stearate, essence, sodium dodecyl sulfate and pigment, performing dry granulation, and tabletting to obtain the effervescent tablet for foot bath with the functions of bacteriostasis and antibiosis.

Further, during the preparation process, dry granulation is adopted.

Further, the folium artemisiae argyi and orange peel volatile oil is extracted by a supercritical extraction method, and the volatile oil is subjected to inclusion by using an inclusion technology.

Furthermore, the arnebia euchroma and the cortex acanthopanacis are crushed into fine powder by adopting a wall breaking and crushing technology.

Furthermore, the specification of the product is 10 g/tablet.

After the components and the preparation method are adopted, the invention has the following advantages:

the footbath effervescent tablet prepared by the method provided by the invention not only can play a role in bacteriostasis and antibiosis, but also can emit certain fragrance in the footbath process of the product prepared by the method, so that the comfort level in the footbath process is improved; moreover, the pigment is arranged in the invention, so that the function of protecting the privacy of the user can be achieved to a certain extent; finally, the invention adopts the dry granulation process to process the effervescent tablets, can prevent the moisture absorption problem, thereby improving the industrial production efficiency.

Detailed Description

The present invention is described in further detail below.

The folium Artemisiae Argyi extract is a powdery substance extracted by organic solvent under multiple heating reflux, retains effective components of folium Artemisiae Argyi, and has antibacterial and antiviral effects. The orange peel extract is widely applied to the field of medical and health-care products, and has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm. Sodium bicarbonate, also known as baking soda, dissolves in hot water and releases some carbon dioxide. The citric acid can react with various acid-base substances in hot water; the microcrystalline cellulose can be used as additive for preparing health-care medicine; the low-substituted hydroxypropyl cellulose can be used as a binder in pharmaceutical preparation to facilitate tablet formation; magnesium stearate has lubricant and antisticking effects in pharmaceutical preparations. The transdermal absorption agent can achieve transdermal absorption of the antibacterial ingredient.