阅读说明：本技术 一种复合材料及其制成的呼吸机管路及管路的应用 (Composite material, breathing machine pipeline made of composite material and application of pipeline ) 是由 张瑜 吴夏鑫 曹超宇 袁猛 龚卫娟 王赪胤 孙进 张道周 戴佳旸 毕雅昕 张露 于 2019-11-29 设计创作，主要内容包括：本发明公开了一种呼吸机管路的制备方法和应用,采用复合材料制成呼吸机管路,所述制备方法,包括：使含有氮化碳、高分子材料、有机溶剂的前驱体熔融液经造粒机造粒后,采用挤出成型技术制作出内管径为22mm,外管径为25mm的透明管路,本发明应用于呼吸机内部气路消毒,鲍曼不动杆菌杀菌率为99.9%,金黄色葡萄球菌杀菌率为99.9%,符合终末消毒标准,所述氮化碳复合材料还可应用于消毒柜,消毒箱和医疗器械消毒盒等领域。(The invention discloses a preparation method and application of a breathing machine pipeline, wherein the breathing machine pipeline is made of a composite material, and the preparation method comprises the following steps: the carbon nitride composite material is applied to the internal gas path sterilization of a respirator, the sterilization rate of acinetobacter baumannii is 99.9%, the sterilization rate of staphylococcus aureus is 99.9%, the terminal sterilization standard is met, and the carbon nitride composite material can also be applied to the fields of disinfection cabinets, disinfection boxes, medical instrument disinfection boxes and the like.)

1. The composite material for preparing the breathing machine pipeline is characterized by comprising the following components in parts by weight: 0.5-1.5 parts of carbon nitride, 35-45 parts of high polymer material and 90-100 parts of organic solvent.

2. The composite material for the preparation of ventilator circuits according to claim 1, characterized in that said carbon nitride is urea-synthesized carbon nitride.

3. The composite material for preparing the breathing machine pipeline according to claim 1, wherein the high polymer material is one or more selected from polypropylene, polyethylene, thermoplastic polyurethane, polylactic acid and epoxy resin, and is a transparent material.

4. The composite material for manufacturing a ventilator circuit according to claim 1, wherein the organic solvent is a solution of N, N-Dimethylformamide (DMF).

5. A method of making a ventilator circuit using the composite material of claim 1, comprising the steps of:

step 1) preparing raw materials according to the proportion;

step 2) breaking the carbon nitride synthesized by urea by using ultrasonic waves to ensure that the carbon nitride is uniformly distributed in DMF (dimethyl formamide);

step 3) adding the molten polylactic acid melt liquid for 120 r/min-180 r/min in the magnetic stirring process, and heating and stirring at a high speed for 15 +/-1 min to uniformly disperse carbon nitride in the precursor melt liquid;

step 4), feeding the precursor melt into a double-screw extruder, and extruding and granulating;

step 5) drying the particles in a vacuum drying oven;

and 6) putting the dried particles into a high-temperature hopper of a plastic extruder, cooling and drying the particles outside the extruder to obtain the prepared breathing machine pipeline.

6. The method for preparing a ventilator circuit according to claim 5, wherein the set temperature of the twin screw extruder in the granulation process of step 4) is 170 ℃.

7. The method for preparing the breathing machine pipeline according to the claim 5, wherein the drying time of the particles in the step 5) in a vacuum drying oven is as follows: 2 h, the drying temperature is as follows: 80 ℃.

8. The method for preparing the breathing machine pipeline according to the claim 5, wherein the temperature of the plastic extruder in the step 6) is as follows: cooling with air at 80 deg.C for 1 hr, and oven drying at 80 deg.C for 1 hr.

9. The application of the breathing machine pipeline is characterized in that two ends of the breathing machine pipeline are connected with an air inlet and an air outlet of the breathing machine, the breathing machine is started under the irradiation of visible light for cyclic disinfection, and the disinfection time is 120 min.

Technical Field

The invention relates to a composite material, in particular to a breathing machine pipeline made of the composite material.

Background

The respirator is used as an important medical appliance for the treatment of critical patients, and the maintenance and the terminal disinfection of the respirator are important guarantees for the life safety of the patients. At the present stage, the cleaning and disinfection mode of the breathing machine only stops on the surface of the disinfection liquid for wiping, and the internal gas circuit cannot be subjected to disinfection and sterilization treatment. Pathogenic bacteria carried by sick patients can survive in the internal gas path of the respirator for a long time and comprise pneumonia bacillus, staphylococcus aureus, acinetobacter baumannii, escherichia coli and the like. This results in that each ventilator may be subjected to the attack and transfer of pathogenic bacteria remaining on the machine when it is put into the next patient's rescue use, causing nosocomial infections. In 2018, the feasibility of utilizing hydrogen peroxide vapor as sterilization of an internal gas path system of a respirator is provided in a literature, a new method is provided for sterilization of the internal gas path of the respirator, but no introduction of practical application and production of related tools exist at present, and the market is vacant.

Disclosure of Invention

The invention aims to provide a composite material, a breathing machine pipeline made of the composite material and application of the pipeline, so that the pipeline can generate e under the excitation of visible light^-The oxygen is reduced to generate hydrogen peroxide gas, and the sterilization and disinfection functions of the internal gas circuit of the respirator are performed under the conveying of the high-pressure airflow of the respirator.

The purpose of the invention is realized as follows: a composite material for preparing a breathing machine pipeline comprises the following components in parts by weight: 0.5-1.5 parts of carbon nitride, 35-45 parts of high polymer material and 90-100 parts of organic solvent.

As a further limitation of the invention, the carbon nitride is urea-synthesized carbon nitride.

As a further limitation of the invention, the polymer material is one or more selected from polypropylene, polyethylene, thermoplastic polyurethane, polylactic acid and epoxy resin, and is a transparent material.

As a further limitation of the invention, the organic solvent is DMF solution.

A method for preparing a breathing machine pipeline comprises the following steps:

step 1) preparing raw materials according to the proportion;

step 2) breaking the carbon nitride synthesized by urea by using ultrasonic waves to ensure that the carbon nitride is uniformly distributed in DMF (dimethyl formamide);

step 3) adding molten polylactic acid melt liquid for 120-180 r/min in the magnetic stirring process, and heating and stirring at a high speed for 30min to uniformly disperse carbon nitride in the precursor melt liquid;

step 4), feeding the precursor melt into a double-screw extruder, and extruding and granulating;

step 5) drying the particles in a vacuum drying oven;

and 6) putting the dried particles into a high-temperature hopper of a plastic extruder, cooling and drying the particles outside the extruder to obtain the prepared breathing machine pipeline.

As a further limitation of the invention, the set temperature of the twin screw extruder during the pelletization of step 4) is 170 ℃.

As a further limitation of the invention, step 5) the particles are dried in a vacuum oven for a time of: 2 h, the drying temperature is as follows: 80 ℃.

As a further limitation of the invention, the temperature of the plastic extruder of step 6) is: cooling with air at 80 deg.C for 1 hr, and oven drying at 80 deg.C for 1 hr.

The application of a breathing machine pipeline comprises connecting two ends of the breathing machine pipeline with an air inlet and an air outlet of the breathing machine, starting the breathing machine under the irradiation of visible light, and performing circulating disinfection for 120 min; in operation, under the excitation of visible light, carbon nitride valence band electrons (e)^-) Electron (e)^-) Contacting with oxygen in air to reduce oxygen to produce superoxide radical (O)₂ ^-) Further generation of hydrogen peroxide by superoxide radicals; the hydrogen peroxide gas can be sterilized and disinfected in the respirator in a high-pressure air flow conveying mode.

Compared with the prior art, the invention has the following advantages:

(1) the invention makes up the defect that the terminal disinfection of the existing respirator can not disinfect the internal gas circuit of the respirator;

(2) the sterilization rate of the respirator pipeline prepared by the invention to relevant pathogenic bacteria of the respirator is high;

(3) the breathing machine pipeline prepared by the invention is transparent and nontoxic, and can be repeatedly used for terminal disinfection of the breathing machine;

(4) the high polymer material of the invention is polylactic acid, polypropylene, polyethylene and the like, has wide sources and can be applied to production;

(5) the hydrogen peroxide gas generated by the composite material prepared by the invention is nontoxic;

(7) the extrusion molding technology applied by the invention can help to realize the printing of the powdery particles, and the adopted microfluidic technology and the needle valve type structure can accurately control the outflow flow and the extrusion time of the melt.

Drawings

Fig. 1 is a three-dimensional view of a carbon nitride composite respirator tube made in accordance with the present invention.

Fig. 2 is an electron microscope image of the ventilator circuit fabricated in example 1.

Fig. 3 is an electron microscope image of the ventilator circuit fabricated in example 2.

Fig. 4 is an electron microscope image of the ventilator circuit manufactured in example 3.

FIG. 5 is a diagram of the terminal sterilization of a ventilator for which the ventilator circuit made in example 2 is applicable.

FIG. 6 is a graph showing the results of sterilization of the culture of Acinetobacter baumannii and Staphylococcus aureus in example 2.

FIG. 7 is a graph showing the bactericidal activity against Acinetobacter baumannii and Staphylococcus aureus in example 2.

Detailed Description

The present invention is further illustrated by the following specific examples.