阅读说明：本技术 一种皮肤美白寡肽组合物及其制备方法 (Skin whitening oligopeptide composition and preparation method thereof ) 是由 项方塔 于 2019-12-19 设计创作，主要内容包括：本发明公开了一种皮肤美白寡肽组合物及其制备方法,所述组合物由以下质量比的原料制备而成：二肽-1 0.6％、十肽-4 0.6％、谷胱甘肽0.6％、肌肽0.6％、光果甘草0.6％、α-熊果苷0.6％、凝血酸0.6％、3-o-乙基抗坏血酸0.6％、葡糖基橙皮苷0.6％、烟酰胺0.6％、去离子水90％、甘油2％、甲基丙二醇1％、异戊二醇1％。本发明使用方便,能够进入皮肤深层,提亮肤色、淡化色斑。(The invention discloses a skin whitening oligopeptide composition and a preparation method thereof, wherein the composition is prepared from the following raw materials, by mass, 10.6% of dipeptide, 40.6% of decapeptide, 0.6% of glutathione, 0.6% of carnosine, 0.6% of glycyrrhiza glabra, 0.6% of α -arbutin, 0.6% of tranexamic acid, 0.6% of 3-o-ethyl ascorbic acid, 0.6% of glucosyl hesperidin, 0.6% of nicotinamide, 90% of deionized water, 2% of glycerol, 1% of methyl propylene glycol and 1% of isoprene glycol.)

1. The skin whitening oligopeptide composition is characterized by being prepared from the following raw materials, by mass, 10.6% of dipeptide, 40.6% of decapeptide, 0.6% of glutathione, 0.6% of carnosine, 0.6% of glycyrrhiza glabra, 0.6% of α -arbutin, 0.6% of tranexamic acid, 0.6% of 3-o-ethyl ascorbic acid, 0.6% of glucosyl hesperidin, 0.6% of nicotinamide, 90% of deionized water, 2% of glycerol, 1% of methyl propylene glycol and 1% of isoprene glycol.

2. The method for preparing the skin whitening oligopeptide composition according to claim 1, wherein the skin whitening oligopeptide composition is prepared by placing deionized water, glycerol, methyl propylene glycol and isoprene glycol in a formula, heating to 100 ℃, mechanically stirring to mix them uniformly, naturally cooling to 45 ℃, adding dipeptide-1, decapeptide-4, glutathione, carnosine, glycyrrhiza glabra, α -arbutin, tranexamic acid, 3-o-ethyl ascorbic acid, glucosyl hesperidin and nicotinamide in the formula, and stirring at the same rotation speed to mix them uniformly.

3. The method for preparing a skin whitening oligopeptide composition according to claim 1, wherein the rotation speed of the stirrer is 1000-1500r/min during the mechanical stirring.

Technical Field

The invention relates to the technical field of cosmetics, and particularly relates to a skin whitening oligopeptide composition and a preparation method thereof.

Background

At present, most plant extract products aiming at skin repair only can maintain the skin condition but cannot improve the skin condition.

Peptides of smaller molecular weight, also called small peptides, oligopeptides, or also called small active whiskers, generally consist of several amino acids, which can be absorbed directly by the skin. With the development of medicine, nutrition, dermatology and molecular biology, oligopeptides are being studied more and more deeply, and scientists find that oligopeptides have various biological activities on skin cells, and these biologically active substances are being revealed more and more.

Disclosure of Invention

Aiming at the technical defects of the existing skin repair products, the invention aims to provide a skin whitening oligopeptide composition and a preparation method thereof, which can effectively regulate skin cells and prevent skin aging.

In order to solve the technical problems, the invention adopts the following technical scheme:

the invention provides a skin whitening oligopeptide composition which is prepared from the following raw materials, by mass, 10.6% of dipeptide, 40.6% of decapeptide, 0.6% of glutathione, 0.6% of carnosine, 0.6% of glycyrrhiza glabra, 0.6% of α -arbutin, 0.6% of tranexamic acid, 0.6% of 3-o-ethyl ascorbic acid, 0.6% of glucosyl hesperidin, 0.6% of nicotinamide, 90% of deionized water, 2% of glycerol, 1% of methyl propylene glycol and 1% of isoprene glycol.

A preparation method of a skin whitening oligopeptide composition comprises the following steps:

the skin whitening oligopeptide composition is prepared by placing deionized water, glycerol, methyl propylene glycol and isoprene glycol in a formula amount into a container, heating to 100 ℃, mechanically stirring to uniformly mix, naturally cooling to 45 ℃, adding dipeptide-1, decapeptide-4, glutathione, carnosine, glycyrrhiza glabra, α -arbutin, tranexamic acid, 3-o-ethyl ascorbic acid, glucosyl hesperidin and nicotinamide in the formula amount, stirring at the same rotating speed to uniformly mix.

Preferably, the rotation speed of the stirrer is 1000-.

The invention has the beneficial effects that: is convenient to use, and can enter deep layer of skin to brighten skin color and lighten color spots.

The following combinations are taken as the main ingredients in the invention to further illustrate the beneficial effects of the invention:

the dipeptide-1 is used as a nursing agent and has good effects of resisting aging and wrinkles and moistening skin.

Decapeptide-4, which can penetrate the dermis to increase collagen, and reverse the aging process of the skin through the reconstruction from inside to outside; stimulating the proliferation of collagen, elastic fiber and hyaluronic acid, increasing the water content and water locking degree of skin, increasing the thickness of skin and reducing fine wrinkles.

Glutathione: glutathione can help to maintain normal immune system function, and has effects of resisting oxidation and removing toxic substance. The sulfhydryl group on cysteine is an active group (therefore, the sulfhydryl group is often abbreviated as G-SH) and is easy to combine with certain drugs, toxins and the like, so that the cysteine has the function of integrated detoxification. The glutathione can be used in medicine, can be used as base material of functional food, and can be widely used in the functional food for delaying senility, enhancing immunity, resisting tumor, etc.

Carnosine has effects of preventing skin aging and whitening skin, and can prevent free radicals generated by smoking, which are harmful to skin than sunlight, and can oxidize other substances in human body.

Glycyrrhiza glabra and glycyrrhiza glabra also contain a large amount of flavonoids which are natural antioxidant components, can not only prevent the generation of oxidation reaction in a human body, but also accelerate the metabolism of lipid peroxide in the human body, and substances such as lipid peroxide, free radicals and the like are important for causing aging of the human body, and after the number of the flavonoids is reduced, the aging speed of the human body is obviously slowed down.

α -arbutin has good therapeutic effect on scar due to ultraviolet burn, has good antiinflammatory, repairing and whitening effects, and can inhibit melanin generation and deposition, and remove mottle and freckle.

3-O-ethyl ascorbic acid has the functions of resisting oxidation, achieving the effects of whitening and removing spots, enabling the skin to be absorbed directly into the dermis and having strong antibacterial and anti-inflammatory effects.

Glucosyl hesperidin: promoting blood circulation and warming effect. Quickly activate the skin damaged by cold, wind and ice.

Nicotinamide: nicotinamide is a component of both coenzyme I and coenzyme II, which is a coenzyme for many dehydrogenases. The deficiency can affect normal respiration and metabolism of cells to cause pellagra.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The skin whitening oligopeptide composition is prepared from the following raw materials, by mass, 16 g of dipeptide, 46g of decapeptide, 6g of glutathione, 6g of carnosine, 6g of glycyrrhiza glabra, 6g of α -arbutin, 6g of tranexamic acid, 6g of 3-o-ethyl ascorbic acid, 6g of glucosyl hesperidin, 6g of nicotinamide, 900g of deionized water, 20g of glycerol, 10g of methyl propylene glycol and 10g of isoprene glycol.

A preparation method of a skin whitening oligopeptide composition comprises the following steps:

placing deionized water, glycerol, methyl propylene glycol and isoprene glycol in a formula amount in a container, heating to 100 ℃, stirring by a stirrer with the rotation speed of 1000-1500r/min to uniformly mix, then naturally cooling to 45 ℃, adding dipeptide-1, decapeptide-4, glutathione, carnosine, glycyrrhiza glabra, α -arbutin, tranexamic acid, 3-o-ethyl ascorbic acid, glucosyl hesperidin and nicotinamide in the formula amount, placing, stirring by the stirrer with the same rotation speed to uniformly mix, and obtaining the skin whitening oligopeptide composition.

Clinical trial

1. The test method comprises the following steps:

120 patients with damaged skin are selected, and the damaged skin is represented as: coarse, black, yellow, and macula; the composition of the embodiment of the invention is applied to the skin 2 times a day, 1-2 ml each time, and the skin damage condition is observed after 30 days.

2. And (4) judging the standard:

and (3) curing: the symptoms of coarse, black, yellow and macula skin disappear; the method has the following advantages: the symptoms of thick, black, yellow, and blotchy skin disappear locally.

3. And (3) test results:

cure 60 bits and effective 60 bits, and the effective rate is 100 percent.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.