阅读说明：本技术 一种复方紫草油气雾剂的制备方法 (Preparation method of compound lithospermum oil aerosol ) 是由 曾庆恢 向阳 李丽娟 黄志军 吴木琴 任平远 高凯 吴金刚 于 2019-12-03 设计创作，主要内容包括：本发明公开了一种复方紫草油气雾剂的制备方法,向食用油中按重量加入10-40％二甲基硅油,作为提取油,将紫草、忍冬藤、白芷加入到提取油中进行油炸,油炸结束后滤取油液,放至室温后加入冰片,搅拌使溶化,混匀,最后分装于耐压容器中,装上阀门系统后封口,向耐压容器中灌入抛射剂,气密性检查合格后即得。本发明提高了复方紫草油气雾剂中左旋紫草素的含量和治疗烧烫伤的疗效,降低了复方紫草油气雾剂的生产成本。(The invention discloses a preparation method of compound lithospermum oil aerosol, which comprises the steps of adding 10-40% of dimethyl silicone oil into edible oil by weight to serve as extraction oil, adding lithospermum, honeysuckle stem and angelica dahurica into the extraction oil for frying, filtering the oil liquid after frying, adding borneol after the oil liquid is placed to room temperature, stirring to dissolve, uniformly mixing, finally subpackaging in a pressure-resistant container, installing a valve system and sealing, filling a propellant into the pressure-resistant container, and obtaining the compound lithospermum oil aerosol after the air tightness inspection is qualified. The invention improves the content of the L-alkannin in the compound lithospermum oil aerosol and the curative effect of treating burns and scalds, and reduces the production cost of the compound lithospermum oil aerosol.)

1. The preparation method of the compound lithospermum oil aerosol is characterized by comprising the following steps: adding 10-40% of dimethyl silicone oil by weight into edible oil to serve as extraction oil, adding lithospermum, honeysuckle stem and angelica dahurica into the extraction oil for frying, wherein the frying time is 20-60 minutes, the frying temperature is 120-180 ℃, the weight of the extraction oil is 6-10 times of the weight of the medicinal materials, filtering the oil liquid after the frying is finished, adding borneol after the oil liquid is placed to room temperature, stirring to dissolve, uniformly mixing, finally subpackaging in a pressure-resistant container, sealing after a valve system is installed, filling a propellant into the pressure-resistant container, and obtaining the product after the air tightness inspection is qualified.

2. The preparation method of the compound lithospermum oil aerosol as claimed in claim 1, which is characterized in that: the weight ratio of the lithospermum to the honeysuckle stem to the angelica dahurica to the borneol is 1-5: 1-5: 1-5: 0.5-3.

3. The preparation method of the compound lithospermum oil aerosol as claimed in claim 1, which is characterized in that: the edible oil is olive oil.

4. The method for preparing the compound lithospermum oil aerosol as claimed in claim 3, which is characterized in that: the addition amount of the dimethyl silicone oil is 30 percent of the weight of the olive oil.

5. The preparation method of the compound lithospermum oil aerosol as claimed in claim 1, which is characterized in that: the frying time was 40 minutes.

6. The preparation method of the compound lithospermum oil aerosol as claimed in claim 1, which is characterized in that: the frying temperature is 150 ℃.

7. The preparation method of the compound lithospermum oil aerosol as claimed in claim 1, which is characterized in that: the weight of the extracted oil is 8 times of the weight of the medicinal materials.

8. The process for preparing the compound arnebia oil aerosol as claimed in any of claims 1 to 7, which comprises the following steps: the frying is carried out under the vacuum condition of 0.02-0.06 MPa.

9. The method for preparing the compound lithospermum oil aerosol as claimed in claim 8, which is characterized in that: the frying vacuum degree is 0.06 MPa.

Technical Field

The invention belongs to the field of pharmacy, and relates to a preparation method of a compound lithospermum oil aerosol.

Background

The compound lithospermum oil aerosol is a traditional Chinese medicine prepared from four traditional Chinese medicinal materials of lithospermum, honeysuckle stem, angelica dahurica and borneol, has the functions of clearing heat and cooling blood, and detoxifying and relieving pain, and is mainly used for treating burns and scalds clinically. The existing compound oil aerosol of lithospermum is prepared by frying lithospermum, honeysuckle stem and angelica dahurica in sesame oil, adding borneol into the oil, subpackaging and filling propellant.

The method mainly has the following defects: (1) the extraction efficiency of active ingredients of traditional Chinese medicines by the sesame oil is low, the quality of oil products is uneven, and the curative effect cannot be guaranteed; (2) the edible oil has expensive price, short resource and high production cost. Therefore, the preparation method of the product is urgently needed to be improved, so that the product can be better applied to clinic.

Disclosure of Invention

The invention aims to provide a preparation method of a compound lithospermum oil aerosol, aiming at improving the content and curative effect of medicinal components and reducing the production cost.

A preparation method of a compound lithospermum oil aerosol comprises the following steps: adding 10-40% of dimethyl silicone oil by weight into edible oil to serve as extraction oil, adding lithospermum, honeysuckle stem and angelica dahurica into the extraction oil for frying, wherein the frying time is 20-60 minutes, the frying temperature is 120-180 ℃, the weight of the extraction oil is 6-10 times of the weight of the medicinal materials, filtering the oil liquid after the frying is finished, adding borneol after the oil liquid is placed to room temperature, stirring to dissolve, uniformly mixing, finally subpackaging in a pressure-resistant container, sealing after a valve system is installed, filling a propellant into the pressure-resistant container, and obtaining the product after the air tightness inspection is qualified.

Preferably, the weight ratio of the lithospermum to the honeysuckle stem to the angelica dahurica to the borneol is 1-5: 1-5: 1-5: 0.5-3, and the optimal ratio is 2: 2: 2: 1.

preferably, the edible oil is olive oil.

Preferably, the dimethicone is added in an amount of 30% by weight of the olive oil.

Preferably, the frying time is 40 minutes.

Preferably, the frying temperature is 150 ℃.

Preferably, the weight of the extracted oil is 8 times of the weight of the medicinal materials.

Preferably, the frying is carried out under a vacuum condition of 0.02 to 0.06 MPa.

Further preferably, the frying vacuum degree is 0.06 MPa.

The invention has the beneficial effects that:

(1) the invention improves the content of the L-alkannin in the compound lithospermum oil aerosol.

(2) The invention improves the curative effect of the compound lithospermum oil aerosol on treating burns and scalds.

(3) The invention reduces the production cost of the compound lithospermum oil aerosol.

(4) The quality of the raw materials is more stable, and the resource source is easily ensured.

Detailed Description

The present invention will be described in detail below with reference to examples.