阅读说明：本技术 一种含有甘草黄酮的牙膏及其制备方法和应用 (Toothpaste containing licoflavone and preparation method and application thereof ) 是由 刘强 黄辉球 于 2018-08-20 设计创作，主要内容包括：本发明提供了一种含有甘草黄酮的牙膏,按重量份数包括以下组分：磷酸氢钙二水合物40-50份、二氧化硅水合物2-4份、十二烷基硫酸钠3-5份、山梨醇8-12份、聚乙二醇-400 5-10份、丙二醇4-6份、羟乙基纤维素0.5-1.5份、黄原胶0.2-0.4份、苯甲酸钠0.10-0.20份、焦四磷酸钠0.15-0.30份、甘草黄酮0.5-1.5份、甘草甜素0.2-0.6份、厚朴酚0.05-0.15份、丹皮酚0.05-0.15份、薄荷油0.3-0.6份、香精0.6-0.8份、1%亮蓝溶液1份、丁香酚0.4-0.6份和单氟磷酸钠0.7-0.9份。该牙膏以甘草黄酮为主药,辅之以牙膏基质,其配方科学简单、原料成本低,性价比高；而且该牙膏对致病菌的抑制针对性强,具有良好的抑菌消炎和清洁口腔的功效。(The invention provides a toothpaste containing licoflavone, which comprises the following components in parts by weight: 40-50 parts of calcium hydrophosphate dihydrate, 2-4 parts of silicon dioxide hydrate, 3-5 parts of lauryl sodium sulfate, 8-12 parts of sorbitol, 5-10 parts of polyethylene glycol-4005, 4-6 parts of propylene glycol, 0.5-1.5 parts of hydroxyethyl cellulose, 0.2-0.4 part of xanthan gum, 0.10-0.20 part of sodium benzoate, 0.15-0.30 part of sodium pyrotetraphosphate, 0.5-1.5 parts of licoflavone, 0.2-0.6 part of glycyrrhizin, 0.05-0.15 part of magnolol, 0.05-0.15 part of paeonol, 0.3-0.6 part of peppermint oil, 0.6-0.8 part of essence, 1 part of 1% brilliant blue solution, 0.4-0.6 part of eugenol and 0.7-0.9 part of sodium monofluorophosphate. The toothpaste takes licoflavone as main drug and is supplemented with toothpaste matrix, and has the advantages of scientific and simple formula, low cost of raw materials, and high cost performance; the toothpaste has strong pertinence to inhibition of pathogenic bacteria, and has good effects of inhibiting bacteria, diminishing inflammation and cleaning oral cavity.)

1. The toothpaste containing licoflavone is characterized by comprising the following components in parts by weight: 40-50 parts of calcium hydrophosphate dihydrate, 2-4 parts of silicon dioxide hydrate, 3-5 parts of lauryl sodium sulfate, 8-12 parts of sorbitol, 5-10 parts of polyethylene glycol-4005, 4-6 parts of propylene glycol, 0.5-1.5 parts of hydroxyethyl cellulose, 0.2-0.4 part of xanthan gum, 0.10-0.20 part of sodium benzoate, 0.15-0.30 part of sodium pyrotetraphosphate, 0.5-1.5 parts of licoflavone, 0.2-0.6 part of glycyrrhizin, 0.05-0.15 part of magnolol, 0.05-0.15 part of paeonol, 0.3-0.6 part of peppermint oil, 0.6-0.8 part of essence, 1 part of 1% brilliant blue solution, 0.4-0.6 part of eugenol and 0.7-0.9 part of sodium monofluorophosphate.

2. The licoflavone-containing toothpaste according to claim 1, characterized by comprising the following components in parts by weight: 45 parts of calcium hydrophosphate dihydrate, 3 parts of silicon dioxide hydrate, 2.5 parts of sodium dodecyl sulfate, 10 parts of sorbitol, 7 parts of polyethylene glycol-4007 parts of propylene glycol, 5 parts of hydroxyethyl cellulose, 0.3 part of xanthan gum, 0.15 part of sodium benzoate, 0.25 part of sodium pyrotetraphosphate, 1 part of licoflavone, 0.5 part of glycyrrhizin, 0.1 part of magnolol, 0.1 part of paeonol, 0.5 part of peppermint oil, 0.6 part of essence, 1 part of 1% brilliant blue solution, 0.5 part of eugenol and 0.8 part of sodium monofluorophosphate.

3. The toothpaste containing licoflavone according to claim 1, wherein licoflavone is an active substance extracted from glycyrrhiza uralensis, which is a Chinese medicine, by various methods and solvents and contains flavonoid as a main ingredient.

4. The licoflavone-containing toothpaste according to claim 1, wherein the essence is one or more of fruit essence, tea essence and drug essence.

5. A method for preparing licoflavone-containing toothpaste according to claim 1, comprising the following steps:

(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;

(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;

(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;

(4) adding magnolol, Mentholum, and licoflavone into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;

(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.

6. Use of a licoflavone-containing toothpaste according to any one of claims 1-4 for the prevention and treatment of oral inflammation.

Technical Field

The invention relates to the technical field of traditional Chinese medicine oral care and health care, in particular to a toothpaste containing licoflavone and a preparation method and application thereof.

Background

Oral ulcer, commonly known as "aphtha", is a common ulcerative injury to the oral mucosa, which is usually found in the inner labial, tongue abdomen, buccal mucosa, vestibular sulcus, soft palate, etc., where the mucosa lacks cutinization layer or has poor keratosis. Tongue ulcer refers to oral ulcer occurring on tongue and tongue abdomen. The pain is severe when the oral ulcer is attacked, the local burning pain is obvious, and serious patients can influence diet and speaking, so that the daily life is inconvenient; can be used for treating halitosis, chronic pharyngitis, constipation, headache, dizziness, nausea, asthenia, dysphoria, fever, and lymphadenectasis.

As a common oral disease, oral ulcer is caused by virus or bacteria, generally caused by streptococcus, staphylococcus aureus and escherichia coli, is related to the reduction of autoimmunity, is a localized ulcer injury of oral mucosa characterized by periodic and repeated outbreak, and can occur at any part of the oral mucosa.

Along with the enhancement of health consciousness and the improvement of life quality of people, more and more consumers tend to use functional toothpaste which has certain functionality and can solve and improve oral inflammation problems such as oral ulcer, and the Chinese herbal medicine toothpaste containing natural plant extracts is popular among consumers due to warm nature, small stimulation, safety and no toxicity.

At present, the traditional Chinese medicine toothpaste in the market contains too many traditional Chinese medicine prescriptions, so that the components are complex, and the content of the limited effective components in the toothpaste is lower. In addition, the antibacterial active ingredients used by the toothpaste have weak pertinence and broad-spectrum antibacterial property, namely, the toothpaste also has an inhibiting effect on nonpathogenic resident bacteria in the oral cavity and reduces the self-healing capacity of each tissue of the oral cavity to injury.

Therefore, there is a need for developing a traditional Chinese medicine toothpaste which has a simple formula and can safely and effectively prevent and treat dental ulcer.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides the toothpaste containing licoflavone, which takes licoflavone as a main drug and is supplemented with a toothpaste matrix, and has scientific and simple formula, low raw material cost and high cost performance; the toothpaste has strong pertinence to inhibition of pathogenic bacteria, and has good effects of inhibiting bacteria, diminishing inflammation and cleaning oral cavity.

In order to achieve the purpose, the invention provides the following technical scheme:

the toothpaste containing licoflavone comprises the following components in parts by weight: 40-50 parts of calcium hydrophosphate dihydrate, 2-4 parts of silicon dioxide hydrate, 3-5 parts of lauryl sodium sulfate, 8-12 parts of sorbitol, 5-10 parts of polyethylene glycol-4005, 4-6 parts of propylene glycol, 0.5-1.5 parts of hydroxyethyl cellulose, 0.2-0.4 part of xanthan gum, 0.10-0.20 part of sodium benzoate, 0.15-0.30 part of sodium pyrotetraphosphate, 0.5-1.5 parts of licoflavone, 0.2-0.6 part of glycyrrhizin, 0.05-0.15 part of magnolol, 0.05-0.15 part of paeonol, 0.3-0.6 part of peppermint oil, 0.6-0.8 part of essence, 1 part of 1% brilliant blue solution, 0.4-0.6 part of eugenol and 0.7-0.9 part of sodium monofluorophosphate.

As further description of the technical scheme of the invention, the toothpaste containing licoflavone comprises the following components in parts by weight: 45 parts of calcium hydrophosphate dihydrate, 3 parts of silicon dioxide hydrate, 2.5 parts of sodium dodecyl sulfate, 10 parts of sorbitol, 7 parts of polyethylene glycol-4007 parts of propylene glycol, 5 parts of hydroxyethyl cellulose, 0.3 part of xanthan gum, 0.15 part of sodium benzoate, 0.25 part of sodium pyrotetraphosphate, 1 part of licoflavone, 0.5 part of glycyrrhizin, 0.1 part of magnolol, 0.1 part of paeonol, 0.5 part of peppermint oil, 0.6 part of essence, 1 part of 1% brilliant blue solution, 0.5 part of eugenol and 0.8 part of sodium monofluorophosphate.

As further description of the technical scheme of the invention, the licoflavone is an active substance which is extracted from the traditional Chinese medicine liquorice by various methods and solvents and takes flavonoid compounds as main components.

The licorice has the functions of resisting virus, bacteria, ulcer and oxidation, and the licorice flavone compounds extracted from licorice have the anti-inflammatory basic material comprising liquiritigenin, isoliquiritigenin, liquiritin, isoliquiritin, licochalcone A and licochalcone B, which reach the anti-inflammatory effect through inhibiting inflammation medium, proinflammatory cell factor or raising immunity regulating effect. The licoflavone-containing toothpaste is applied to treatment of dental ulcer, wherein licochalcone A and licochalcone B have a strong effect on oral pathogenic bacteria, and can be used as effective components to be applied to gingivitis resistance, dental plaque resistance and dental calculus resistance.

Meanwhile, isoliquiritigenin, liquiritin and isoliquiritin in the licoflavone also have strong antibacterial activity on staphylococcus aureus, pseudomonas aeruginosa, escherichia coli and helicobacter pylori. The antibacterial/antimicrobial activity of isoliquiritigenin, liquiritin and isoliquiritin is attributed to the close relationship between phenolic hydroxyl and protein in the glycoside structure; the isoliquiritigenin, liquiritin and isoliquiritin are combined with proteins of pathogenic bacteria, so that the activity of the pathogenic bacteria is reduced and even lost, and the bacteriostatic effect is achieved.

Magnolol of officinalis is an effective component extracted from dried dry bark, root bark and branch bark of Magnolia officinalis or Magnolia obovata Thunb of Magnoliaceae, and has good pharmacological effects of resisting bacteria, resisting pathogenic microorganism, resisting inflammation, resisting ulcer, resisting oxidation, resisting tumor, inhibiting platelet aggregation, etc.

Magnolol in the toothpaste components has remarkable antibacterial activity on gram-positive bacteria, acid-resistant bacteria, yeast-like bacteria and filamentous fungi. Research shows that the minimum antibacterial concentration (MIC) test with streptomycin sulfate and amphotericin B as controls shows that the activity of magnolol against bacillus subtilis is higher than that of streptomycin sulfate; the activity of the anti-trichophyton mentagrophytes is higher than that of amphotericin B; the activity of the aspergillus niger resisting bacteria is the same as that of amphotericin B, the anti-dental caries effect of magnolol is very obvious, the minimum inhibitory concentration to dental caries bacteria is 6.3 mug/ml, and the antibacterial activity of magnolol is stronger than that of a typical antibacterial alkaloid berberine (MIC: 50 mug/ml).

Paeonol (Paeonol) is an effective component extracted from dried root bark of Paeonia suffruticosa Andr. The pharmacological effects of the compound have antibacterial, anti-inflammatory, antipyretic and anti-allergic effects, and the compound also has certain effects of relieving swelling and pain, resisting allergy, resisting oxidation, hypnotizing and reducing blood pressure. Paeonol also has analgesic effect, and can be used for preventing and treating oral ulcer. Researches find that magnolol and paeonol have the sterilization rate of more than or equal to 90 percent on escherichia coli and staphylococcus aureus, so that the magnolol and paeonol have strong bacterium inhibiting (killing) effects.

In the toothpaste matrix, calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, sodium dodecyl sulfate, sorbitol, polyethylene glycol-400, propylene glycol, hydroxyethyl cellulose, xanthan gum, essence and the like are included, and the proportion of the matrix components is optimized to be used as a carrier of licoflavone and glycyrrhizin, so that the traditional Chinese medicine components in the raw materials can be fully dissolved, the paste is fine, compact, bright and uniform in color distribution, and the quality of the paste is further improved.

As further description of the technical scheme of the invention, the essence is one or more of fruit essence, tea essence and drug essence. The essence can clean halitosis, and improve halitosis.

The invention also provides a preparation method of the toothpaste containing licoflavone, which comprises the following steps:

(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;

(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;

(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;

(4) adding magnolol, Mentholum, and licoflavone into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;

(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.

In the preparation method, the invention fully protects the effective antibacterial and bactericidal component in the licoflavone, which has obvious inhibiting and killing effects on pathogenic bacteria causing oral cavity.

The invention also provides the toothpaste containing licoflavone and application of the toothpaste containing licoflavone prepared by the preparation method of the toothpaste in preventing and treating oral inflammation.

Based on the technical scheme, the invention has the following technical effects:

(1) the toothpaste containing licoflavone provided by the invention takes licoflavone as a main drug, is added with glycyrrhizin, magnolol and paeonol, is supplemented with a toothpaste matrix, has definite active ingredients and action mechanism, has good antibacterial, anti-inflammatory and analgesic effects, and has strong pertinence to pathogenic bacteria and small inhibition effect on nonpathogenic resident bacteria, so that the self-healing capacity and the oral cavity repair capacity of oral tissues to injury are effectively improved.

(2) The toothpaste containing licoflavone can promote healing of oral inflammation wound surface, so it has good therapeutic effect on oral inflammation such as oral ulcer and gingival swelling and pain, and its formula is scientific and simple, raw material cost is low, and cost performance is high. Compared with the traditional medicinal toothpaste for treating oral ulcer, the toothpaste has the advantages of less side effect, higher safety and good antibacterial and anti-inflammatory effects and oral cavity cleaning effects.

(3) The preparation method of the toothpaste containing licoflavone provided by the invention can fully protect the effective antibacterial and bactericidal components of licoflavone, magnolol and paeonol, and ensure that the effective components in the toothpaste can play the role of inhibiting and killing pathogenic bacteria, thereby effectively preventing and treating stomatitis. The preparation method has the advantages of low cost of raw materials, simple operation, no influence on the activity of the traditional Chinese medicine components, few process steps and contribution to industrial production.

Detailed Description

In order that the invention may be more fully understood, reference will now be made to the specific embodiments illustrated. The invention provides a preferred embodiment. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.