阅读说明：本技术 一种含多元锌的去屑止痒香波组合物 (Dandruff-removing and itching-relieving shampoo composition containing multi-element zinc ) 是由 赵文忠 李洪波 洪盛杰 林学镁 胡卫华 陈顺章 于 2018-12-26 设计创作，主要内容包括：一种含多元锌的去屑止痒香波组合物,所述组合物除水外,还含有：(A)占组合物重量5.0％至40％的阴离子表面活性剂；(B)占组合物重量1.0％至10.0％的椰油两性醋酸钠和烷基葡糖苷的组合物；(C)占组合物重量0.1％至30％的含多元锌的头皮去屑止痒复合活性物,所述去屑止痒复合活性物是由氧化锌,吡咯烷酮羧酸锌,葡萄糖酸锌,乳酸锌,甘草亭酸锌、核桃壳提取物、改性淀粉、苯氧乙醇和水组成；(D)占组合物重量0.05％至2.0％的阳离子聚合物。(A dandruff-removing and itching-relieving shampoo composition containing multi-element zinc, which comprises the following components in addition to water: (A) anionic surfactant in 5.0-40 wt% of the composition; (B) 1.0% to 10.0% by weight of the composition of sodium cocoamphoacetate and an alkyl glucoside; (C) 0.1 to 30 percent of the weight of the composition of a scalp anti-dandruff and antipruritic compound active substance containing polybasic zinc, wherein the anti-dandruff and antipruritic compound active substance is composed of zinc oxide, zinc pyrrolidone carboxylate, zinc gluconate, zinc lactate, zinc glycyrrhetinate, walnut shell extract, modified starch, phenoxyethanol and water; (D) cationic polymer in an amount of 0.05% to 2.0% by weight of the composition.)

1. A dandruff-removing and itching-relieving shampoo composition containing multi-element zinc comprises the following components in addition to water:

(A) anionic surfactant in 5.0-40 wt% of the composition;

(B) 1.0% to 10.0% by weight of the composition of sodium cocoamphoacetate and an alkyl glucoside;

(C) the anti-dandruff and anti-itching composite active matter comprises 0.1-30% of the composition weight, and consists of the following components:

organic zinc mixture accounting for 10-30% of the weight of the composite active matter, wherein the organic zinc mixture is zinc gluconate, zinc lactate and zinc pyrrolidone carboxylate: zinc glycyrrhetinate, and the weight ratio of zinc glycyrrhetinate to zinc glycyrrhetinate is 1: 1: mixing at a ratio of 0.2;

inorganic zinc accounting for 1-20% of the weight of the composite active matter, wherein the inorganic zinc is zinc oxide, and the particle size of the zinc oxide is 0.01-100 mu m; the specific surface area is 30-100m²/g；

Walnut shell extract accounting for 0.01-5% of the weight of the composite active matter;

the suspending agent accounts for 1-10% of the weight of the composite active matter, and is modified starch;

phenoxyethanol accounting for 0.5-1% of the weight of the composite active matter;

and the balance water;

(D) cationic polymer in an amount of 0.05-2.0% by weight of the composition.

2. A shampoo composition according to claim 1, wherein the zinc oxide has a particle size of from 0.1 μm to 30 μm; the specific surface area is 50-90m²/g。

3. The shampoo composition of claim 1, wherein the anionic surfactant is selected from the group consisting of: alkyl sulfate, alkyl polyoxyethylene ether sulfate, fatty acid monoglyceride sulfate, alkyl sulfonate, coconut oil isethionate, sodium alpha-olefin sulfonate, N-acyl sarcosinate, N-acyl glutamate, and alkyl phosphate.

4. The shampoo composition of claim 1, wherein the ratio of sodium cocoamphoacetate to alkyl glucoside is 1: 1.

5. The shampoo composition of claim 1, wherein the cationic polymer is selected from the group consisting of: a cationic cellulose polymer or a cationic guar polymer.

Technical Field

The invention belongs to the field of daily chemicals, and particularly relates to an anti-dandruff and itching-relieving shampoo composition containing multi-element zinc.

Background

Dandruff is medically known as pityriasis capitis, a skin disease caused by malassezia (one of the fungi). The proliferation of malassezia on the scalp causes the hyperproliferation of the stratum corneum of the scalp, thereby promoting the abnormal desquamation of stratum corneum cells in the form of white dandruff, namely dandruff.

The research results of Lafang and the scalp microecological research project group of the institute of microbiology of Chinese academy of sciences show that the healthy scalp ecological environment is kept balanced by pH value, grease, flora, metabolic balance and the like. When the secretion of oil and fat of scalp is unbalanced, the oil of scalp is greasy; when the scalp flora is unbalanced in environment and lipophilous bacteria are bred in large quantity, the phenomenon of itching can occur; the scalp stratum corneum is metabolized too fast, so that the fungus clusters form dandruff, the scalp is not only itching and even the white objects in blocks fall off, and in addition, the distribution of scalp microorganisms of people in different areas is not the same.

In daily life, people select anti-dandruff shampoo, which is a widely adopted method for solving the dandruff problem. Salicylic acid, Zinc Pyrithione (ZPT), ketorolac ethanolamine salt (OCT), climbazole and ketoconazole are main anti-dandruff agents in the market for anti-dandruff shampoos and other anti-dandruff products, and Zinc Pyrithione (ZPT) has been widely used as an anti-dandruff agent in various hair washing products.

Zinc pyrithione is an organic zinc salt, which is named: the zinc bis (N-pyridine-2-thiol oxide anion) or the zinc N-2-pyrithione salt is a complex formed by coordination of N-2-Pyrithione (PT) serving as a ligand and zinc ions. In the solution, the complex is easy to decompose to form ligand and zinc ions, the zinc ions can adsorb and destroy the functions of cell membranes and enter the cell membranes to enable certain cell components to escape, interfere the cell metabolic process or interfere the action of various enzymes, so that the cells lose the due biological functions, finally the cells die, and finally the sterilization effect is achieved, so that the zinc plays an important role.

Zinc also has the effect of inhibiting 5-a reductase, thereby reducing excessive sebum secretion, supplementing zinc element to skin, and helping to maintain normal metabolism of skin. The zinc complex and the zinc-containing compound comprise organic zinc salt and inorganic zinc salt. The zinc pyrithione as an organic zinc salt has good oil control and bacteriostasis effects, but has certain degreasing property, and the scalp and hair are dry after use. The organic zinc salt also comprises organic zinc such as zinc gluconate, zinc lactate, zinc pyrrolidone carboxylate and the like, has good solubility, and has the effects of synergistically moisturizing, controlling oil, inhibiting bacteria and synergistically removing dandruff; in addition, inorganic zinc salts include zinc oxide, zinc chloride, zinc sulfate, zinc carbonate, and the like,

zinc oxide is insoluble in water like zinc pyrithione. The application of common zinc oxide (such as pharmaceutical grade zinc oxide) is that the zinc oxide ointment sold in the market has certain functions of astringency, antibiosis and antiphlogosis. The research finds that the antibacterial effect of the zinc oxide depends on the specific surface area of the zinc oxide. The zinc oxide has rich raw material sources and low price, and simultaneously, the zinc is also a mineral element necessary for human bodies. Zinc oxide, especially with a large specific surface area, has been one of the hot spots in the research of inorganic antibacterial agents.

The zinc oxide or nano zinc oxide with small particle size generally has large specific surface area and surface effect, is easy to generate affinity with contacted microorganisms to have bactericidal capacity, the mechanism of the zinc oxide or nano zinc oxide is similar to that of zinc pyrithione, ZnO slowly releases zinc ions in an aqueous medium, the zinc ions are gradually released, and due to the redox property of the zinc ions, when the zinc ions are combined with bacterial cell membranes, the zinc ions react with organic matters in the zinc ions to destroy the structure of membrane proteins, so that the activity of the membrane proteins is lost, and the aim of sterilization is fulfilled. Meanwhile, holes on the surface of the nano zinc oxide can generate electrons to directly participate in the reaction, more holes can generate more electrons, and the sterilization capability of the nano zinc oxide is improved. According to the contact type sterilization mechanism, zinc ions directly contact with bacteria to kill the bacteria, and when the bacteria are killed, the zinc ions are dissociated from thalli and then contact with other bacteria to complete a new sterilization task, so that good sterilization activity is displayed.

The invention aims to provide a shampoo composition, which achieves good effects of nourishing, astringing, controlling oil, inhibiting bacteria and relieving itching of scalp by using multi-zinc (organic zinc salt and inorganic zinc salt) and active ingredients which have the functions of relieving scalp, sterilizing and diminishing inflammation and are derived from plants.

Disclosure of Invention

The invention aims to provide an anti-dandruff and anti-itching shampoo composition containing multi-element zinc.

The dandruff-removing and itching-relieving shampoo composition of the invention contains the following components except water:

(A) anionic surfactant in 5.0-40 wt% of the composition;

(B) 1.0% to 10.0% by weight of the composition of sodium cocoamphoacetate and an alkyl glucoside;

(C) the anti-dandruff and anti-itching composite active matter comprises 0.1-30% of the composition weight, and consists of the following components:

an organic zinc mixture accounting for 10-30% of the weight of the composite active matter, wherein the organic zinc mixture is prepared by mixing zinc gluconate, zinc lactate, zinc pyrrolidone carboxylate and zinc glycyrrhetinate in a weight ratio of 1: 0.2;

inorganic zinc accounting for 1-20% of the weight of the composite active matter, wherein the inorganic zinc is zinc oxide, the particle size of the zinc oxide is 0.01-100 mu m, and the specific surface area is 30-100m²/g；

Walnut shell extract accounting for 0.01-5% of the weight of the composite active matter;

the suspending agent accounts for 1-10% of the weight of the composite active matter, and is modified starch;

phenoxyethanol accounting for 0.5-1 percent of the weight of the composite active matter

And the balance water;

(D) cationic polymer in an amount of 0.05-2.0% by weight of the composition.

The shampoo composition of the invention, wherein the anti-dandruff and antipruritic composite active matter is a composition (3 Zn) consisting of inorganic zinc salt such as zinc oxide, organic zinc salt such as organic acid mixture containing zinc pyrrolidone carboxylate, zinc gluconate, zinc lactate and zinc glycyrrhetinate, walnut shell extract and modified starch²⁺ScalpV，5Zn²⁺ScalpV)。

Shampoo compositions of the invention wherein the anionic surfactant is selected from: alkyl sulfate, alkyl polyoxyethylene ether sulfate, fatty acid monoglyceride sulfate, alkyl sulfonate, coconut oil isethionate, sodium alpha-olefin sulfonate, N-acyl sarcosinate, N-acyl glutamate, and alkyl phosphate.

The shampoo composition of the invention, wherein the weight ratio of sodium cocoamphoacetate to alkyl glucoside is 1: 1.

Shampoo compositions of the invention wherein the cationic polymer is selected from the group consisting of: at least one of a cationic cellulose polymer, a cationic guar polymer.

The invention has the following advantages:

the shampoo composition adopts the multi-element zinc technology and active ingredients derived from plants, has the combined effects of nourishing the scalp, controlling oil and inhibiting bacteria, and can realize the effects of removing dandruff and relieving itching for a long time after being used.

Detailed Description

The selection and action of the components of the present invention will be described in detail below.

The shampoo composition contains 0.1 to 25 percent, preferably 5 to 20 percent of the dandruff-removing and itching-relieving compound active matter by weight of the composition, wherein the dandruff-removing and itching-relieving compound active matter is cream viscous liquid, the density of the dandruff-removing and itching-relieving compound active matter is 1.150 to 1.240 at the temperature of 20 ℃, and the pH value is 5.5 to 7.0. The anti-dandruff itching-relieving composite active matter comprises the following specific components and activities: zinc oxide is used as dandruff remover, and can inhibit proliferation of malassezia and regulate oil secretion of scalp, and the zinc oxide is large specific surface zinc oxide (specific surface area of 30-100 m)²/g, particle diameter of 0.01-20 μm) has effect in inhibiting Malassezia; zinc gluconate: zinc lactate: zinc pyrrolidone carboxylate: zinc glycyrrhetinate in the organic acid zinc mixture are mixed according to the weight ratio of 1:0.2 to regulate scalp microecology, and have synergistic effects of nourishing and moisturizing scalp and hair, astringing scalp, regulating scalp grease secretion, inhibiting bacteria, removing dandruff and relieving itching, wherein zinc pyrrolidone carboxylate (ZnPCA) is a metal amino acid compound designed by increasing the synergistic effect, reduces sebum secretion by inhibiting 5 alpha-reductase and plays a role in synergistic antibacterial action, and zinc glycyrrhetinate has the effects of resisting inflammation, bacteria and allergy; the walnut shell extract is an ethanol extract and has the functions of oxidation resistance and bacteriostasis; the modified starch has the functions of suspending and stabilizing the anti-dandruff itching relieving composite active matter and stabilizing the composition system, and is the Suocare HS modified corn starch in Shanghai atlantoal industry.

The shampoo composition contains a composition of coconut oil hydroxyethyl sodium sulfonate and lauryl alcohol polyoxyethylene ether sodium sulfate which account for 5.0-40% of the weight of the composition, the weight ratio of the coconut oil hydroxyethyl sodium sulfonate to the lauryl alcohol polyoxyethylene ether sodium sulfate is 1:2-2:1, the coconut oil hydroxyethyl sodium sulfonate is abbreviated as SCI, and the structural formula of the composition is as follows: RCOOCH2CH2S03Na, R ═ C12-C16 alkyl, 85% active content, white appearance, mildness and hard water resistance. The sodium laureth sulfate is called AES for short, and has a structural formula of RO (CH2CH2O) nSO3Na, wherein R is C12-C16 alkyl, n is 2-3, and preferably, the average ethoxylation degree is n is 3. The content of active substances of the commercial product of the sodium laureth sulfate is 70 percent, and the appearance of the commercial product is white or light yellow paste. The compounding of the sodium coco hydroxyethyl sulfonate and the sodium laureth sulfate can generate good synergistic effects, such as: has good washing ability, excellent mild performance, hard water resistance and the like.

The shampoo composition of the invention contains a composition of sodium cocoamphoacetate and alkyl glucoside, wherein the weight percentage of the composition is 1.0% to 10.0%, and the ratio of the sodium cocoamphoacetate to the alkyl glucoside is 1: 1. the coconut oil based amphoteric sodium acetate is colorless to yellowish transparent viscous liquid, the content of active substances of a commercial product is 30%, the viscosity of the product is 5000-10000 at 25 ℃, the content of sodium chloride is less than 9.0%, the pH value of a 1% aqueous solution is 6.0-8.0, the structural formula of the product is RN (CH2COONa)2, the irritation of the coconut oil based amphoteric sodium acetate is low, the coconut oil based amphoteric sodium acetate is particularly mild to skin and eyes, the irritation of the coconut oil based amphoteric sodium acetate can be obviously reduced by matching with an anionic surfactant, the coconut oil based amphoteric sodium acetate has good foaming power, the foam is rich and fine, the skin feel is good, and the foam state of a formula system can be obviously improved. The alkyl glucosides include lauryl glucoside, coco glucoside, decyl glucoside and octyl/decyl glucoside, preferably decyl glucoside, which are light yellow turbid viscous liquids with an active content of 51% to 55% in a commercial product having a 20% 15% isopropanol solution with a pH of 11.5 to 12.5 and a viscosity of 1000-6000 at 25 ℃. Decyl glucoside, which is naturally derived, has excellent mild cleansing power and can improve the foaming properties of shampoos, is preferred in the present invention. The amount of foam and the foam stability are improved. The combination of cocoampho sodium acetate and decyl glucoside provides good foam and skin compatibility, minimizes irritation and increases foaming speed.

The shampoo composition of the invention comprises 0.05% to 3.0% by weight of the composition of a cationic polymer selected from the group consisting of: at least one of a cationic cellulose polymer, a cationic guar polymer, preferably a cationic guar. The cationic guar gum is a product obtained by quaternizing guar gum, the main component of the cationic guar gum is guar gum propyl trimethyl ammonium chloride, a series of cationic guar gum products can be obtained according to different substitution degrees, the preferable substitution degree is 0.1-0.2, the nitrogen content is 1.3-1.7%, and the viscosity of 1% aqueous solution of the cationic guar gum used in the invention is 3500 mPa.s-4500 mPa.s at 25 ℃; the cationic cellulose polymer is a copolymer of hydroxyethyl cellulose and alkyl trimethyl ammonium chloride, and can be divided into the following components according to different cationic substitution degrees: high cationic degree of substitution JR, medium cationic degree of substitution LR and low cationic degree of substitution LK, preferably medium cationic degree of substitution of cationic cellulose.

The shampoo compositions of the present invention may also contain other optional ingredients including pearlizing agents, viscosity modifiers, chelating agents, pH modifiers, preservatives, coloring agents, fragrances and the like. From 0.05% to 3.0% by weight of the composition of a pearlescent agent, non-limiting examples of which are: ethylene glycol monostearate monoester and ethylene glycol distearate, propylene glycol monostearate and glyceryl palmitate, magnesium alkyl stearamide, finely divided zinc oxide and titanium dioxide, preferably ethylene glycol distearate. The viscosity modifier is 0.1% to 5.0% by weight of the composition, non-limiting examples of which are: sodium chloride, ammonium chloride, monoethanolamine chloride, sodium sulfate, ammonium phosphate, hydroxyethyl cellulose, hydroxypropyl cellulose, copolymers of acrylic acid and long-chain alkyl methacrylates, acrylate/stearyl ether-20/methacrylate copolymers, methyl glucoside polyoxyethylene ether (120) dioleate, and the like. The chelating agent is present in an amount of 0.01% to 0.30% by weight of the composition, non-limiting examples of which are: ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate, trisodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, etc., preferably disodium ethylenediaminetetraacetate; non-limiting examples of such pH adjusting agents are: citric acid, phosphoric acid, triethanolamine, sodium hydroxide, etc., adjusting the pH of the system to 5.0 to 8.0, preferably 6.5 to 7.5; the selection of the preservative, the essence and the pigment meets the regulation of the cosmetic hygiene standard, and safe raw materials are selected.

In the shampoo composition of the present invention, in addition to the above-mentioned components, a desired amount is made up with water.

Preparation method

(1) Preparing the walnut shell extract: drying walnut shells, grinding the walnut shells into 200 meshes by using a three-roller mill, extracting by using 95 ethanol as an extracting agent, wherein the material-liquid ratio is 1: 20, leaching at 45 ℃, adjusting the ultrasonic power to 250W, leaching for 2 hours, filtering and concentrating under reduced pressure to obtain an ethanol extract.

(2) Preparing the anti-dandruff itching-relieving composite active matter: dispersing modified starch in water, heating and stirring until dissolving, adding phenoxyethanol, organic acid zinc mixture (weight ratio 1:0.2), walnut shell extract and zinc oxide, and stirring well for use.

(3) Preparation of shampoo compositions of the invention:

shampoo compositions of the invention may be prepared by any known or otherwise effective technique suitable for providing shampoo compositions, including conventional formulation and mixing techniques, with the addition of the anti-dandruff antipruritic complex active at about 50 ℃ during the final cooling phase of the process.

Application method

The shampoo composition of the invention is used in a conventional manner for cleaning and conditioning hair, and mainly comprises the following steps:

(A) wetting the hair with water;

(B) applying to the hair an effective amount of the shampoo composition of any of the preceding claims, generally in the range of from 1 gram to 50 grams, preferably from 2 to 20 grams;

(C) rinsing the shampoo composition on the hair with water.

These steps can be repeated as many times as necessary to achieve the desired cleansing, moisturizing, conditioning, anti-dandruff, etc. benefits.