阅读说明：本技术 用于在体内递送治疗剂的b细胞及其剂量 (B cells and dosages thereof for in vivo delivery of therapeutic agents ) 是由 马修·瑞恩·舒尔茨 埃里克·J·赫比格 斯科特·R·麦基弗 里安·德拉特 埃里克·奥尔森 于 2018-04-27 设计创作，主要内容包括：本发明涉及用于施用经遗传修饰以产生诸如治疗性蛋白的治疗剂的自体和/或同种异体B细胞的方法。特别公开了用于施用单个最大有效剂量的经遗传修饰的B细胞和用于施用多剂量的经遗传修饰的B细胞的方法。本文公开的组合物和方法可用于长期体内递送治疗剂。(The present invention relates to methods for administering autologous and/or allogeneic B cells genetically modified to produce therapeutic agents, such as therapeutic proteins. Specifically disclosed are methods for administering a single maximally effective dose of genetically modified B cells and for administering multiple doses of genetically modified B cells. The compositions and methods disclosed herein are useful for long-term in vivo delivery of therapeutic agents.)