阅读说明：本技术 Bcl-2相关死亡促进因子(BAD)磷酸化的小分子抑制剂 (Small molecule inhibitors of Bcl-2-associated death promoting factor (BAD) phosphorylation ) 是由 彼得·爱德华·罗别 维贾伊·库马·潘迪 兰加帕·坎楚加拉科帕尔苏贝戈达 巴萨帕·萨隆地 莫汉 于 2018-04-18 设计创作，主要内容包括：本发明涉及通式(I)化合物：其中R<Sup>1</Sup>、n、R<Sup>2a</Sup>、R<Sup>2b</Sup>和R<Sup>3</Sup>如本文中所限定。所述化合物是Bcl-2相关死亡促进因子(BAD)磷酸化的抑制剂并且具有抗凋亡活性,并且可用于治疗癌症,特别是乳腺癌、子宫内膜癌、卵巢癌、肝癌、结肠癌、前列腺癌或胰腺癌。<Image he="311" wi="700" file="DDA0002238818000000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The present invention relates to compounds of general formula (I): wherein R is 1 、n、R 2a 、R 2b And R 3 As defined herein. The compounds are inhibitors of Bcl-2-related death promoting factor (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, in particular breast cancer, endometrial cancer,Ovarian, liver, colon, prostate, or pancreatic cancer.)