阅读说明：本技术 冷冻消融系统 (Cryoablation system ) 是由 徐彬凯 常兆华 吴银龙 杨迟 李磊 于 2019-11-21 设计创作，主要内容包括：本发明提供了一种冷冻消融系统,包括：气源、球囊、预冷装置,以及凝结容腔与凝结结构；所述凝结容腔的进口用于接入所述气源提供的气源气体,所述凝结容腔中形成的低温环境能够将所述气源气体中的目标气体凝结成液态冷冻剂,并将所述液态冷冻剂收集在所述凝结容腔底部,所述凝结容腔的出口用于将所收集的液态冷冻剂排出,以使得被排出的液态冷冻剂能够被所述预冷装置预冷,所述凝结结构用于在所述凝结容腔中形成所述低温环境,并捕捉所述凝结容腔内的水蒸气。本发明能够提高例如N<Sub>2</Sub>O气体的目标气体纯度,杜绝或减少球囊堵塞或者收缩等现象,以达到更好的消融效果。(The present invention provides a cryoablation system comprising: the device comprises a gas source, a balloon, a precooling device, a condensation cavity and a condensation structure; the inlet of the condensation cavity is used for being connected with gas source gas provided by the gas source, a low-temperature environment formed in the condensation cavity can condense target gas in the gas source gas into liquid refrigerant, the liquid refrigerant is collected at the bottom of the condensation cavity, the outlet of the condensation cavity is used for discharging the collected liquid refrigerant, so that the discharged liquid refrigerant can be pre-cooled by the pre-cooling device, and the condensation structure is used for forming the low-temperature environment in the condensation cavity and capturing water vapor in the condensation cavity. The invention can increase N 2 The purity of the target gas of O gas avoids or reduces the phenomena of balloon blockage or contraction and the like, so as to achieve better ablation effect.)

1. A cryoablation system comprising: air supply, sacculus and locate the air supply with precooling apparatus between the air inlet of sacculus, its characterized in that still includes: a condensation cavity and a condensation structure;

the inlet of the condensation cavity is used for being connected with gas source gas provided by the gas source, a low-temperature environment formed in the condensation cavity can condense target gas in the gas source gas into liquid refrigerant, the liquid refrigerant is collected at the bottom of the condensation cavity, the outlet of the condensation cavity is used for discharging the collected liquid refrigerant, so that the discharged liquid refrigerant can be pre-cooled by the pre-cooling device, and the condensation structure is used for forming the low-temperature environment in the condensation cavity and capturing water vapor in the condensation cavity.

2. The system of claim 1, wherein the condensation structure comprises a gas condenser disposed within the condensation chamber, the gas condenser being configured to:

the outer surface of the gas condenser is used for exchanging heat with the condensation cavity so as to provide a cold source for the formation of the low-temperature environment, and the water vapor is condensed and attached to the outer surface of the gas condenser;

the gas condenser is spaced from the top end of the condensation cavity, so that the non-condensable gas in the gas source gas is accommodated by utilizing the spacing.

3. The system of claim 2, further comprising a cooling assembly, wherein the refrigerant inlet and the refrigerant outlet of the gas condenser are directly or indirectly communicated to the cooling assembly respectively to form a first circulation path between the cooling assembly and the gas condenser, and the cooling assembly cools the refrigerant when the refrigerant flows to the cooling assembly.

4. The system of claim 3, wherein a refrigerant inlet and a refrigerant outlet of the pre-cooling device are respectively communicated to the cooling assembly to form a second circulation path between the cooling assembly and the pre-cooling device.

5. The system of claim 4, wherein in the first circulation path, the temperature reduction assembly, the refrigerant inlet of the pre-cooling device, the refrigerant outlet of the pre-cooling device, the refrigerant inlet of the gas condenser, the refrigerant outlet of the gas condenser and the temperature reduction assembly are sequentially in direct or indirect communication.

6. The system of claim 3, wherein the temperature reduction assembly comprises a compressor and a condenser, an inlet of the compressor is directly or indirectly communicated to a refrigerant outlet of the gas condenser, an outlet of the compressor is communicated with an inlet of the condenser, and an outlet of the condenser is directly or indirectly communicated to a refrigerant inlet of the gas condenser.

7. The system of any one of claims 2 to 6, further comprising a condensation housing for forming the condensation chamber, the condensation housing having a housing flow-through chamber therein, the gas condenser comprising a plurality of plates connected to an inner wall of the condensation housing, the plates having plate flow-through chambers therein, the housing flow-through chambers being respectively communicated with the plate flow-through chambers of the plurality of plates so that the refrigerant can flow through the housing flow-through chambers to the respective plates.

8. The system of claim 1, wherein the coagulation structure comprises a liner for forming the coagulation volume, the liner being configured to:

and the inner surface of the inner container and the condensation cavity are used for heat exchange to provide a cold source for the formation of the low-temperature environment, and the water vapor is condensed and attached to the inner surface of the inner container.

9. The system of claim 8, wherein the pre-cooling device comprises an outer container through which a refrigerant flows and a pre-cooling pipeline arranged in the outer container, the inner container is also arranged in the outer container, and one end of the pre-cooling pipeline is communicated to the condensation cavity to receive the liquid refrigerant discharged from the condensation cavity;

the inner container is internally circulated with a refrigerant and is also used for: the outer surface of the inner container and a refrigerant circulating in the outer container are utilized to carry out heat exchange, and the cold quantity on the outer surface of the inner container is transferred to the inner surface of the inner container; the condensation structure also includes a metal, gas permeable filler attached within the inner container.

10. The system of any one of claims 1 to 6, 8 or 9, further comprising a solenoid valve disposed between the gas source and the condensation chamber.

11. The system of claim 10, further comprising a level sensor and a level control switch for detecting a level of liquid cryogen collected in the condensation chamber, the level sensor being connected to the level control switch, the level control switch being connected to the solenoid valve.

12. A system according to any one of claims 1 to 6, 8 or 9, further comprising a gas filter and/or a gas pressure regulating device provided between the gas source and the condensation vessel.

13. The system of any one of claims 1 to 6, 8, 9, further comprising a drainage structure; the drainage structure is used for heating liquid accumulated water obtained by capturing water vapor by the condensation structure to a water vapor form and discharging the liquid accumulated water in the water vapor form when drainage is needed.

Technical Field

The invention relates to the field of medical instruments, in particular to a cryoablation system.

Background

Atrial fibrillation (atrial fibrillation) is a common arrhythmia, the incidence of which increases gradually with age, with prevalence of more than 30% in people over 80 years of age. Atrial fibrillation rarely causes death itself, and the main cause of death and disability is thromboembolic complications, especially the most serious harm caused by stroke. The treatment of atrial fibrillation is mainly achieved by drug treatment, catheter ablation treatment and surgical treatment, and each treatment scheme has certain limitations. Pulmonary Vein Isolation (PVI) is a foundation stone for atrial fibrillation ablation, and the circular freezing balloon can be in annular fit with a pulmonary vein opening, so that PVI can be completed in a single step, the operation difficulty and time consumption are greatly reduced, the popularization and promotion of catheter ablation for treating atrial fibrillation are possible, and more patients with atrial fibrillation catheter ablation indications benefit from the method.

In the cryoablation balloon catheter, a balloon is arranged at the far end of the catheter, and a freezing device is arranged at the near end of the catheter. During operation, an operator can place the cryoablation balloon catheter into a heart cavity through a percutaneous puncture access to reach a pulmonary vein orifice and fill the balloon. Then, the outer wall of the adjusting saccule is contacted with myocardial tissue, and then freezing liquid is sprayed, so that the freezing liquid absorbs heat and is quickly gasified, and myocardial cells contacted with the saccule are quickly cooled. Effective lesions can only be formed if sufficient time for hypothermia is reached.

However, the phenomenon of balloon blockage and balloon contraction can often occur in the cooling process, the balloon blockage causes no cooling, the balloon contraction causes the myocardial tissue to be not clung to, and the ablation effect is directly caused to be poor.

Disclosure of Invention

The invention provides a cryoablation system, which aims to solve the problems that a balloon is easy to block and the balloon is easy to shrink.

According to a first aspect of the present invention, there is provided a cryoablation system comprising: air supply, sacculus and locate the air supply with precooling apparatus between the air inlet of sacculus, the system, still include: a condensation cavity and a condensation structure;

the inlet of the condensation cavity is used for being connected with gas source gas provided by the gas source, a low-temperature environment formed in the condensation cavity can condense target gas in the gas source gas into liquid refrigerant, the liquid refrigerant is collected at the bottom of the condensation cavity, the outlet of the condensation cavity is used for discharging the collected liquid refrigerant, so that the discharged liquid refrigerant can be pre-cooled by the pre-cooling device, and the condensation structure is used for forming the low-temperature environment in the condensation cavity and capturing water vapor in the condensation cavity.

Optionally, the condensation structure includes a gas condenser disposed in the condensation chamber, and the gas condenser is configured to:

and the outer surface of the gas condenser is utilized to exchange heat with the condensation cavity so as to provide a cold source for the formation of the low-temperature environment, and the water vapor is condensed and attached to the outer surface of the gas condenser.

Optionally, the gas condenser has a gap with the top end of the condensation cavity, so as to use the gap to contain the non-condensable gas in the gas source gas.

Optionally, the system further includes a cooling assembly, a refrigerant inlet and a refrigerant outlet of the gas condenser are respectively and directly or indirectly communicated to the cooling assembly, so that a first circulation passage is formed between the cooling assembly and the gas condenser, and the refrigerant can be cooled by the cooling assembly when flowing to the cooling assembly.

Optionally, the refrigerant cooled by the cooling assembly enables the outer surface of the gas condenser to be lower than 0 ℃.

Optionally, a refrigerant inlet and a refrigerant outlet of the pre-cooling device are respectively communicated to the cooling assembly, so as to form a second circulation path between the cooling assembly and the pre-cooling device.

Optionally, in the first circulation path, the cooling assembly, the refrigerant inlet of the pre-cooling device, the refrigerant outlet of the pre-cooling device, the refrigerant inlet of the gas condenser, the refrigerant outlet of the gas condenser and the cooling assembly are sequentially and directly or indirectly communicated.

Optionally, the cooling assembly includes a compressor and a condenser, an inlet of the compressor is directly or indirectly communicated to the refrigerant outlet of the gas condenser, an outlet of the compressor is communicated with an inlet of the condenser, and an outlet of the condenser is directly or indirectly communicated to the refrigerant inlet of the gas condenser.

Optionally, the gas condenser includes a pipe capable of circulating a refrigerant.

Optionally, the system further includes a condensation housing for forming the condensation cavity, the condensation housing has a housing circulation cavity therein, the gas condenser includes a plurality of plates connected to an inner wall of the condensation housing, the plates have plate circulation cavities therein, and the housing circulation cavities are respectively communicated with the plate circulation cavities of the plurality of plates, so that the refrigerant can circulate to each plate through the housing circulation cavity.

Optionally, the system further includes a heat dissipation device and/or a solenoid valve disposed between the condensation cavity and the pre-cooling device.

Optionally, the coagulation structure includes an inner container for forming the coagulation cavity, and the inner container is used for:

and the inner surface of the inner container and the condensation cavity are used for heat exchange to provide a cold source for the formation of the low-temperature environment, and the water vapor is condensed and attached to the inner surface of the inner container.

Optionally, the pre-cooling device includes an outer liner through which a refrigerant flows and a pre-cooling pipeline arranged in the outer liner, the inner liner is also arranged in the outer liner, and one end of the pre-cooling pipeline is communicated to the condensation cavity to receive the liquid refrigerant discharged from the condensation cavity;

the inner container is internally circulated with a refrigerant and is also used for: the outer surface of the inner container and the refrigerant circulating in the outer container are utilized to exchange heat, and the cold quantity on the outer surface of the inner container is transferred to the inner surface of the inner container.

Optionally, the condensation structure further comprises a metal gas-permeable filler connected to the inner container.

Optionally, the system further includes a solenoid valve disposed between the gas source and the condensation chamber.

Optionally, the system further includes a liquid level sensor and a liquid level control switch for detecting a liquid level of the collected liquid refrigerant in the condensation cavity, the liquid level sensor is connected to the liquid level control switch, and the liquid level control switch is connected to the electromagnetic valve.

Optionally, the system further includes a gas filter and/or a gas pressure adjusting device disposed between the gas source and the condensation chamber.

Optionally, the system further comprises a drainage structure; the drainage structure is used for heating liquid accumulated water obtained by capturing water vapor by the condensation structure to a water vapor form and discharging the liquid accumulated water in the water vapor form when drainage is needed.

The research on the cryoablation system shows that the reason for the blockage of the balloon is in gas provided by a gas source, such as N₂O gas, which contains water vapor and, for example, N, is not sufficiently pure as the target gas₂Non-condensable gases of the gas. Taking the target gas as N₂O gas, non-condensable gas being N₂Gas as an example, water content follows N₂When the O is throttled and cooled, the O is easy to freeze to block a flow passage, so that the temperature of the balloon cannot be reduced, the balloon shrinks and the like, and the operation effect is influenced. Non-condensable gas with N₂And the freezing effect of the saccule is influenced when the O is throttled and cooled together.

Furthermore, in the cryoablation system provided by the invention, the condensation structure and the condensation cavity can be used for capturing water vapor in gas source gas while condensing to form low-temperature refrigerant, so that N is increased₂The purity of the target gas of O gas is prevented or reduced, the phenomena of balloon blockage or contraction and the like are avoided or reduced, so that a better ablation effect is achieved, in the further scheme, the non-condensable gas in the gas source gas can be contained by utilizing the gas condenser and the interval between the gas condenser and the top end of the condensation containing cavity, and further, the water vapor in the gas source gas and N such as N can be contained₂Separation of non-condensable gases of gases, e.g. increasing N₂The purity of the target gas of O gas fundamentally avoids the phenomena of balloon blockage or contraction and the like, so as toAchieving better ablation effect.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

FIG. 1 is a schematic diagram of the principle of operation of a cryoablation system in accordance with an embodiment of the present invention;

FIG. 2 is a first schematic view of a cryoablation system in accordance with an embodiment of the present invention;

FIG. 3 is a first schematic diagram of a condensation structure and a condensation chamber according to an embodiment of the present invention;

FIG. 4 is a second schematic structural view of a condensation structure and a condensation chamber in an embodiment of the invention;

FIG. 5 is a second schematic illustration of a cryoablation system in accordance with an embodiment of the present invention;

FIG. 6 is a third schematic view of a cryoablation system in accordance with an embodiment of the present invention;

FIG. 7 is a fourth schematic configuration of a cryoablation system in accordance with an embodiment of the present invention;

FIG. 8 is a fifth schematic configuration of a cryoablation system in accordance with an embodiment of the present invention;

FIG. 9 is a sixth schematic configuration of a cryoablation system in accordance with an embodiment of the present invention;

FIG. 10 is a seventh exemplary configuration of a cryoablation system in accordance with an embodiment of the present invention;

FIG. 11 is a schematic view eight of a configuration of a cryoablation system in accordance with an embodiment of the present invention;

FIG. 12 is a schematic diagram of the configuration of the pre-cooling apparatus, the condensation structure and the condensation chamber in an embodiment of the present invention;

fig. 13 is a ninth block diagram illustrating the construction of a cryoablation system in accordance with an embodiment of the present invention.

Description of reference numerals:

101-gas source;

102-a condensation chamber;

103-a condensed structure;

1031-gas condenser;

10311-pipe material;

10312-plate material;

10313-plate flow-through chamber;

1032-inner container;

1033-breathable filler;

104-a pre-cooling device;

1041-a precooling pipeline;

1042-outer container;

105-a balloon;

106-a cooling component;

1061-a compressor;

1062-condenser;

1063-fan;

1064-a throttling member;

107-solenoid valves;

108-a liquid level sensor;

109-liquid level control switch;

110-gas pressure regulating means;

111-a filter;

112-a heat sink;

113-a solenoid valve;

114-a vacuum pump;

115-a gas flow meter;

116-a condensation shell;

1161-shell flow chamber.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.