阅读说明：本技术 治疗化合物和组合物及其使用方法 (Therapeutic compounds and compositions and methods of use thereof ) 是由 M·扎克 F·A·罗梅罗 Y-X·成 于 2018-05-21 设计创作，主要内容包括：本文描述可用作JAK激酶抑制剂的化合物及其盐。还提供包括所述JAK抑制剂和药学上可接受的载体、佐剂或媒介物的药物组合物,和治疗响应于Janus激酶活性抑制的患者疾病或病症或减轻其严重程度的方法。(Described herein are compounds and salts thereof that are useful as JAK kinase inhibitors. Also provided are pharmaceutical compositions comprising the JAK inhibitors and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or disorder in a patient responsive to inhibition of Janus kinase activity.)