阅读说明：本技术 一种崩解仪 (Disintegration tester ) 是由 邝翠琼 邓卫东 王妍 蒲海翔 杜卓 朱斌 詹惠因 詹彩娟 于 2019-10-30 设计创作，主要内容包括：本发明创造公开了一种崩解仪,包括机身和吊篮,所述机身上放置有水浴箱,所述水浴箱内设有加热装置,所述机身上设有由升降机构驱动的支架,所述支架的末端设有带有螺纹孔的矩形块；所述吊篮位于所述水浴箱的上方,所述吊篮的上端固定连接有连接杆,所述连接杆上设有矩形通槽,所述矩形块在所述矩形通槽内上下滑动,所述矩形块的长度不大于所述矩形通槽的深度；所述崩解仪还包括手拧螺栓,所述连接杆与所述支架通过所述手拧螺栓进行可拆连接。所述水浴箱内设有烧杯,当本发明创造停止工作后,用户可以手动地将所述吊篮整体往上提升,使得烧杯的取出不会受到吊篮的阻碍,与此同时,用户只需拧松所述手拧螺栓便能拆卸所述吊篮,方便吊篮的清洗。(The invention discloses a disintegration tester, which comprises a machine body and a hanging basket, wherein a water bath tank is arranged on the machine body, a heating device is arranged in the water bath tank, a support driven by a lifting mechanism is arranged on the machine body, and a rectangular block with a threaded hole is arranged at the tail end of the support; the hanging basket is positioned above the water bath tank, the upper end of the hanging basket is fixedly connected with a connecting rod, a rectangular through groove is formed in the connecting rod, the rectangular block slides up and down in the rectangular through groove, and the length of the rectangular block is not greater than the depth of the rectangular through groove; the appearance that disintegrates still includes the hand and screws up the bolt, the connecting rod with the support passes through the hand is screwed up the bolt and is carried out releasable connection. The beaker is arranged in the water bath tank, after the water bath tank stops working, a user can manually lift the whole hanging basket upwards, so that the taking-out of the beaker is not hindered by the hanging basket, and meanwhile, the hanging basket can be detached only by unscrewing the hand-screwed bolt, so that the hanging basket is convenient to clean.)

1. A appearance that disintegrates, its characterized in that: the water bath device comprises a machine body (100) and a hanging basket (200), wherein a water bath box (300) is placed on the machine body (100), a heating device is arranged in the water bath box (300), a support (110) driven by a lifting mechanism is arranged on the machine body (100), a rectangular block (111) with a threaded hole (112) is arranged at the tail end of the support (110), and the size of the support (110) is larger than that of the rectangular block (111); the hanging basket (200) is positioned above the water bath tank (300), the upper end of the hanging basket (200) is fixedly connected with a connecting rod (400), a rectangular through groove (410) is formed in the connecting rod (400), the rectangular block (111) slides up and down in the rectangular through groove (410), and the length of the rectangular block (111) is not greater than the depth of the rectangular through groove (410); the connecting rod (400) and the bracket (110) are detachably connected through the hand-screwed bolt (500).

2. A disintegration apparatus according to claim 1, wherein: further comprising a beaker (600), the beaker (600) being placed inside the water bath tank (300).

3. A disintegration apparatus according to claim 2, wherein: the beaker (600) is positioned right below the hanging basket (200), and the size of the beaker (600) is larger than that of the hanging basket (200).

4. A disintegration apparatus according to claim 3, wherein: the top surface of the water bath box (300) is provided with a taking hole, the size of the taking hole is larger than that of the beaker (600), and the beaker (600) penetrates through the taking hole.

5. A disintegration apparatus according to claim 3, wherein: the lifting mechanism, the support (110), the connecting rod (400) and the hanging basket (200) jointly form a disintegration mechanism, the number of the disintegration mechanisms is one to three, and the number of the beakers (600) is consistent with the number of the disintegration mechanisms.

6. A disintegration apparatus according to claim 1, wherein: the hanging basket (200) comprises an upper baffle (210) and a lower baffle (220), the upper baffle (210) is fixedly connected with the connecting rod (400), and a connecting shaft (230) is connected between the upper baffle (210) and the lower baffle (220) together.

7. A disintegration tester according to claim 6, wherein: a plurality of upper positioning holes (211) are annularly distributed on the upper baffle plate (210), a plurality of lower positioning holes are annularly distributed on the lower baffle plate (220), the positions of the upper positioning holes (211) correspond to the positions of the lower positioning holes one by one, and a screen (221) is arranged in each lower positioning hole.

8. A disintegration tester according to claim 7, wherein: the hanging basket (200) further comprises a plurality of glass tubes (240), one glass tube (240) is placed on each screen (221), and each glass tube (240) penetrates through the corresponding upper positioning hole (211).

9. A disintegration apparatus according to claim 1, wherein: the water bath tank (300) is made of a transparent material.

Technical Field

The invention relates to the field of medicine detection equipment, in particular to a disintegration tester.

Background

Disintegration refers to the physical dissolution process of a pharmaceutical formulation prior to absorption. The disintegration time refers to the time for pills, tablets and capsules to be disintegrated into granules under certain conditions, is considered as a main factor influencing the bioavailability of oral medicaments, and according to the examination method of disintegration time limit of Chinese pharmacopoeia 95, the disintegration means that a solid preparation is completely disintegrated and dissolved or broken into granules within the examination time limit and can pass through a screen except insoluble coating materials or broken capsule shells. The determination of disintegration time limit adopts a lifting disintegration apparatus, the common tablet can be completely disintegrated within 15min, the hard capsule in the capsule can be completely disintegrated within 30min, and the soft capsule can be completely disintegrated within 1 h. The degree of disintegration means the limit of time required for some pharmaceutical dosage forms (tablets, pills, etc.) to completely disintegrate and pass through a screen, which is measured under certain conditions using a detection apparatus prescribed in pharmacopoeia, and is one of the indexes for measuring the quality of a pharmaceutical product. The disintegration medium used is usually water, artificial intestinal juice or artificial gastric juice, and the measurement temperature is 37 + -0.5 deg.C.

Although the existing disintegration tester can complete the disintegration test of the pharmaceutical preparation, after the disintegration tester completes the disintegration test, a user needs to take out a beaker in the disintegration tester and pour out turbid liquid in the beaker, and in the process of taking out the beaker, the hanging basket can cause certain obstruction to the taking out of the beaker due to the too close distance between the hanging basket and the beaker; meanwhile, the hanging basket of the existing disintegration apparatus is difficult to disassemble, and is not beneficial to cleaning the hanging basket.

Disclosure of Invention

The invention aims to solve the technical problems that: the disintegration tester is provided, the height position of a hanging basket in the disintegration tester is adjustable, and the disassembly is convenient.

The invention creates the solution for solving the technical problem that:

a disintegration tester comprises a machine body and a hanging basket, wherein a water bath tank is placed on the machine body, a heating device is arranged in the water bath tank, a support driven by a lifting mechanism is arranged on the machine body, a rectangular block with a threaded hole is arranged at the tail end of the support, and the size of the support is larger than that of the rectangular block; the hanging basket is positioned above the water bath tank, the upper end of the hanging basket is fixedly connected with a connecting rod, a rectangular through groove is formed in the connecting rod, the rectangular block slides up and down in the rectangular through groove, and the length of the rectangular block is not greater than the depth of the rectangular through groove; the appearance that disintegrates still include with screw hole accordant connection's hand is twisted the bolt, the connecting rod with the support passes through hand is twisted the bolt and is carried out releasable connection.

Further, the disintegration tester also comprises a beaker, and the beaker is placed in the water bath tank.

In addition, the beaker is positioned right below the hanging basket, and the size of the beaker is larger than that of the hanging basket.

In addition, a taking hole is formed in the top surface of the water bath box, the size of the taking hole is larger than that of the beaker, and the beaker penetrates through the taking hole.

In addition, elevating system, support, connecting rod and hanging flower basket constitute disintegration mechanism jointly, the quantity of disintegration mechanism is one to three, the quantity of beaker with the quantity of disintegration mechanism is unanimous.

Further, the hanging basket comprises an upper blocking piece and a lower blocking piece, the upper blocking piece is fixedly connected with the connecting rod, and a connecting shaft is connected between the upper blocking piece and the lower blocking piece.

In addition, a plurality of upper positioning holes are annularly distributed on the upper baffle, a plurality of lower positioning holes are annularly distributed on the lower baffle, the positions of the upper positioning holes correspond to the positions of the lower positioning holes one to one, and a screen is arranged in each lower positioning hole.

In addition, the hanging basket further comprises a plurality of glass tubes, one glass tube is placed on each screen, and each glass tube penetrates through the corresponding upper positioning hole.

Further, the water bath box is made of a transparent material.

The beneficial effects of the invention are as follows: the beaker is arranged in the water bath tank, after the water bath tank stops working, a user can manually lift the whole hanging basket upwards, so that the taking-out of the beaker is not hindered by the hanging basket, and meanwhile, the hanging basket can be detached only by unscrewing the hand-screwed bolt, so that the hanging basket is convenient to clean. The invention is used for disintegration of pharmaceutical preparations.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described below. It is obvious that the described drawings are only a part of the embodiments of the invention, not all embodiments, and that a person skilled in the art will be able to derive other designs and drawings from these drawings without the exercise of inventive effort.

FIG. 1 is a perspective view of an embodiment of the present invention;

FIG. 2 is a left side view of FIG. 1;

FIG. 3 is a schematic view of the connection state of the bracket and the connecting rod in the invention;

fig. 4 is a schematic view of another connection state of the bracket and the connecting rod in the invention.

In the drawings: 100-machine body, 200-hanging basket, 300-water bath tank, 110-support, 210-upper baffle plate, 220-lower baffle plate, 230-connecting shaft, 211-upper positioning hole, 221-screen, 240-glass tube, 112-threaded hole, 111-rectangular block, 400-connecting rod, 410-rectangular through groove, 500-hand screw bolt, 510-screw rod, 520-screw rod head, 530-screw plate, 600-beaker, 310-positioning seat and 120-control panel.

Detailed Description

The conception, the specific structure and the technical effects of the present invention will be described clearly and completely with reference to the accompanying drawings and the embodiments, so that the objects, the features and the effects of the present invention can be fully understood. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and other embodiments obtained by those skilled in the art without any inventive work based on the embodiments of the present invention belong to the protection scope of the present invention. In addition, all the connection relations mentioned herein do not mean that the components are directly connected, but mean that a better connection structure can be formed by adding or reducing connection accessories according to the specific implementation situation. All technical characteristics in the invention can be interactively combined on the premise of not conflicting with each other. Finally, it should be noted that the terms "center, upper, lower, left, right, vertical, horizontal, inner, outer" and the like are used herein to indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only used for convenience of describing and simplifying the present invention, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms first, second and third as used herein are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

Fig. 1 and 2 show an embodiment of a disintegration tester, which comprises a machine body 100 and a hanging basket 200, wherein a water bath tank 300 is placed on the machine body 100, the hanging basket 200 is located above the water bath tank 300, an inlet valve is arranged at the upper part of the water bath tank 300, a drain valve is arranged at the lower part of the water bath tank 300, a heating device (not shown in the drawing) is arranged in the water bath tank 300, the heating device comprises but is not limited to an electric heating wire or an electric heating pipe, the heating temperature of the heating device is kept at about 37 ℃, but the heating temperature of the heating device can be set by a user in a customized manner. The body 100 is provided with a support 110 driven by a lifting mechanism (not shown in the drawings), which includes but is not limited to a rack and pinion lifting mechanism, a cam lifting mechanism or a cylinder lifting mechanism. The hanging basket 200 comprises an upper baffle 210 and a lower baffle 220, a connecting shaft 230 is connected between the upper baffle 210 and the lower baffle 220, a plurality of upper positioning holes 211 are annularly distributed on the upper baffle 210, a plurality of lower positioning holes are annularly distributed on the lower baffle 220, the positions of the upper positioning holes 211 correspond to the positions of the lower positioning holes one by one, and a screen 221 is arranged in each lower positioning hole; the basket 200 further comprises a plurality of glass tubes 240, one glass tube 240 is disposed on each screen 221, and each glass tube 240 passes through the corresponding upper positioning hole 211. The present invention requires that the pharmaceutical formulation be placed separately in each glass tube 240 prior to operation, and that the pharmaceutical formulation not pass through the screen 221 until it disintegrates.

As shown in fig. 3 and 4, a rectangular block 111 having a threaded hole 112 is provided at an end of the bracket 110, a size of the bracket 110 is larger than a size of the rectangular block 111, and the bracket 110 is integrally formed with the rectangular block 111 or is integrally formed by welding. The upper baffle plate 210 is fixedly connected with a connecting rod 400, a rectangular through groove 410 matched with the rectangular block 111 for use is arranged on the connecting rod 400, when the rectangular block 111 extends into the rectangular through groove 410, the rectangular block 111 can slide up and down in the rectangular through groove 410, and the rectangular block 111 cannot rotate in the rectangular through groove 410; in order to enable the connecting rod 400 to be fixedly connected with the bracket 110, the length of the rectangular block 111 is not greater than the depth of the rectangular through groove 410. The disintegration tester further comprises a hand-screwed bolt 500 which is in matched connection with the threaded hole 112, the hand-screwed bolt 500 comprises a screw 510, a screw head 520 and a screwing piece 530 which are sequentially arranged, the width of the screw head 520 is greater than that of the rectangular through groove 410, and particularly, the hand-screwed bolt 500 is preferably a butterfly bolt; when the rectangular block 111 extends into the rectangular through groove 410, a user can screw the hand-screwed bolt 500 into the threaded hole 112, at this time, the hand-screwed bolt 500 generates pressure on one side of the rectangular through groove 410, and the bracket 110 generates pressure on the other side of the rectangular through groove 410, so that the connecting rod 400 can be fixedly connected with the bracket 110.

It should be noted that, if the end of the support 110 is provided with a cylinder and the connecting rod 400 is provided with an oblong hole, after the connecting rod 400 is fixedly connected with the support 110, it cannot be guaranteed that the hanging basket 200 can be kept in a vertical state, and the position of the hanging basket 200 may be deflected. In addition, the present invention is invented to work, because the load on the basket 200 is not large, the connecting rod 400 and the bracket 110 can be fixedly connected together without slippage due to insufficient pressing force by screwing the bolt 500. Finally, although the present invention creates the preferred hand bolt 500, the user can still use a conventional bolt, which requires a wrench to tighten or loosen the conventional bolt.

As shown in fig. 1 and 2, the disintegration tester further includes a beaker 600, the beaker 600 is placed in the water bath 300, in order to better position the beaker 600, a positioning seat 310 is fixedly arranged on the inner bottom surface of the water bath 300, a positioning groove is arranged on the bottom surface of the beaker 600, the beaker 600 is positioned on the positioning seat 310, at this time, the beaker 600 is positioned under the hanging basket 200, and the size of the beaker 600 is larger than that of the hanging basket 200. In order to better maintain the temperature of water in the water bath 300, the water bath 300 is provided with a top surface (not shown in the drawings), and in order to enable the beakers 600 to be placed in the water bath 300, a taking hole is formed in the top surface of the water bath 300, the size of the taking hole is larger than that of the beakers 600, the beakers 600 pass through the taking hole, and each beaker 600 corresponds to one taking hole. In order to facilitate the user's observation of the inside of the beaker 600, the water bath 300 is made of a transparent material, including but not limited to glass or transparent plastic, etc.

In other embodiments, the lifting mechanism, the bracket 110, the connecting rod 400 and the basket 200 together form a disintegration mechanism, so that a user can conveniently perform comparison and detection, the number of the disintegration mechanisms is two to three, each disintegration mechanism can independently operate, and the number of the positioning seats 310 and the number of the beakers 600 are the same as the number of the disintegration mechanisms.

In addition, still be equipped with control panel 120 on the fuselage 100, control panel 120 can control every elevating system's operating duration and control heating device's heating temperature, every elevating system's the predetermined operating duration is 15min, heating device's heating temperature is predetermined at 37 ℃, but the user still can self-define the setting elevating system's operating duration and heating device's heating temperature.

The detection steps after the invention is adopted are as follows:

1. turning on a switch of the heating device to heat the liquid in the water bath 300;

2. placing the beaker 600 filled with the disintegration liquid in the water bath 300, and detecting the temperature of the liquid in the beaker 600 by using a thermometer;

3. placing the pharmaceutical formulation to be disintegrated in glass tube 240;

4. placing the connecting rod 400 on the support 110 and properly adjusting the position of the basket 200, and then tightening the hand-tightening bolts 500 so that the support 110 and the connecting rod 400 are fixedly connected together;

5. when the temperature of the liquid in the beaker 600 reaches about 37 ℃, a switch of the lifting mechanism is turned on, so that the lifting mechanism starts to operate;

6. the hanging basket 200 is driven by the lifting mechanism to move up and down back and forth, so that the medicinal preparation in the glass tube 240 is disintegrated in a disintegration solution;

7. after a period of time, the lifting mechanism stops running, the hand-screwed bolt 500 is unscrewed, and the hanging basket 200 is lifted to the highest position;

8. taking out and cleaning the beaker 600;

9. the basket 200 is disassembled and the test data is recorded, and then the basket 200 is cleaned.

It should be further noted that the order of step 2 and step 3 can be interchanged, and the order of step 8 and step 9 can be interchanged.

While the preferred embodiments of the present invention have been described in detail, it will be understood by those skilled in the art that the invention is not limited to the details of the embodiments shown, but is capable of various modifications and substitutions without departing from the spirit of the invention.