Analysis device, sample introduction system, sample introduction method and medium

文档序号:1597968 发布日期:2020-01-07 浏览:9次 中文

阅读说明:本技术 一种分析装置及进样系统、进样方法和介质 (Analysis device, sample introduction system, sample introduction method and medium ) 是由 孙娟娟 翁彦雯 王俊 于 2018-06-29 设计创作,主要内容包括:一种分析装置及其进样系统和进样方法,该进样系统包括用于存放样本架的样本架放置区、进样推进机构和回收推进机构,样本架放置区包括用于放入样本架的放入区及用于回收样本架的回收区,所述放入区及回收区所占的空间比例可调;所述进样推进机构可移动地设置在样本架放置区,用于推送放置在放入区的待测样本架;所述回收推进机构可移动地设置在样本架回收区,用于推送进入所述回收区的待回收样本架。本发明通过进样推进机构将样本架放置区分隔出放入区和回收区,通过进样推进机构的移动,使得放入区和回收区的容量可调。(An analytical device and its sample introduction system and sample introduction method, the sample introduction system includes the sample shelf used for depositing the sample shelf places the area, advances the sample and advances the mechanism and retrieves and advances the mechanism, the sample shelf places the area including putting into the area used for putting into the sample shelf and retrieving the area used for retrieving the sample shelf, said putting into the area and space proportion that the retrieving area accounts for is adjustable; the sample feeding and pushing mechanism is movably arranged in the sample rack placing area and used for pushing a sample rack to be tested placed in the placing area; the recovery pushing mechanism is movably arranged in the sample rack recovery area and used for pushing the sample rack to be recovered, which enters the recovery area. The sample frame placing area is divided into the placing area and the recovery area by the sample feeding propulsion mechanism, and the volume of the placing area and the capacity of the recovery area are adjustable by the movement of the sample feeding propulsion mechanism.)

1. A sample introduction system for an analytical device, comprising:

the sample rack placing area (1) comprises a placing area (13) for placing the sample rack and a recovery area (14) for recovering the sample rack, and the space proportion occupied by the placing area and the recovery area is adjustable;

the sample feeding and pushing mechanism (M1) is movably arranged in the sample rack placing area and used for pushing the sample rack to be tested placed in the placing area;

a retrieval pushing mechanism (M3) movably disposed at the retrieval area for pushing the sample rack into the retrieval area.

2. The sample introduction system according to claim 1, wherein the sample introduction propulsion mechanism is disposed in the sample rack placement area and divides the sample rack placement area into the placement area and the recovery area, and when the sample introduction propulsion mechanism moves to a side where the placement area is located, a proportion of space occupied by the placement area decreases, and a proportion of space occupied by the recovery area increases; when the sample feeding and pushing mechanism moves to one side where the recovery area is located, the space proportion occupied by the placing area is increased, and the space proportion occupied by the recovery area is reduced.

3. The sample introduction system according to claim 2, further comprising a controller for controlling the movement of the sample introduction propulsion mechanism and/or the recovery propulsion mechanism within respective movement strokes, wherein the movement strokes of the sample introduction propulsion mechanism are determined based on the number of sample racks to be tested placed in the deposit area and/or the number of sample racks to be recovered placed in the recovery area.

4. The sample injection system of claim 3, wherein the controller is further configured to control the sample injection propulsion mechanism to move to the side of the retrieval area when the sample rack is absent from the input area to expand the capacity of the input area, and/or to control the retrieval propulsion mechanism to propel the sample rack to be retrieved by the width of at least one sample rack to the side of the input area when the sample rack to be retrieved enters the retrieval area.

5. The sample introduction system according to claim 3, wherein the controller is further configured to control the sample introduction propulsion mechanism to move to a side of the recovery area when no sample to be recovered enters the recovery area for more than a preset time; and when the sample feeding and pushing mechanism touches the sample rack to be recovered in the recovery area, the sample feeding and pushing mechanism is controlled to stop moving.

6. The sample introduction system according to claim 4 or 5, further comprising a first detection component, wherein the first detection component is connected to the controller, and is configured to detect a motion state of the sample introduction propulsion mechanism and output a detection signal to the controller, and the controller controls the sample introduction propulsion mechanism to move or stop according to the detection signal.

7. The sample introduction system according to claim 6, wherein the input zone is provided with a sample introduction channel (11) at its end remote from the recovery zone, and the recovery zone is provided with a recovery channel (12) at its end remote from the input zone; the first detection part comprises a first initial position sensor (101), a limit position sensor (102), a retreating in-place sensor (103) and an advancing in-place sensor (104), the first initial position sensor is arranged at a position close to the recovery channel and used for detecting whether the sample feeding propulsion mechanism moves to the direction of the recovery channel to the position of the farthest stroke when the sample rack placing area has no sample rack, the limit position sensor is arranged at a position close to the sample feeding channel and used for detecting whether the sample feeding propulsion mechanism moves to the position of the farthest stroke in the direction of the sample feeding channel when the sample rack placing area has no sample rack, the advancing in-place sensor is arranged on the sample feeding propulsion mechanism and used for detecting whether the sample rack to be detected in the sample feeding area is abutted to the sample rack to be detected in front when the sample feeding propulsion mechanism propels the sample rack to be detected in the sample feeding channel, the retreating in-place sensor is arranged on the sample feeding, the sample feeding and pushing mechanism is used for detecting whether the sample feeding and pushing mechanism touches the sample rack to be recovered in the direction moving process of the recovery channel when the sample rack to be recovered is placed in the recovery area.

8. The sample introduction system according to claim 7, wherein the sample introduction propulsion mechanism (M1) comprises a motor (M11), a first moving member (M12) and a pushing member (M13), the motor is connected with the controller, the motor is used for driving the first moving member to move or stop at the sample rack placing area according to a control signal output by the controller, the pushing member is arranged on the first moving member and extends out of the bottom supporting surface of the sample rack, the first moving member comprises a first slide block (M121), a second slide block (M122) and a spring (M123), two ends of the spring are respectively fixed on the first slide block and the second slide block, the forward position sensor is arranged on the first slide block or the second slide block, a baffle plate for triggering the forward position sensor is correspondingly arranged on the second slide block or the first slide block, the backward position sensor is arranged on the motor, the motor is used for detecting whether the motor is locked.

9. The sample injection system of claim 4 or 5, wherein the recovery propulsion mechanism is switched between an initial position and an extended position under control of the controller, the initial position being outside the recovery channel and the extended position being inside the recovery channel.

10. The sample introduction system according to claim 9, further comprising a second detection component for detecting or defining whether the recovery propulsion mechanism is in the initial position or the extended position.

11. The sample introduction system according to claim 1, further comprising a dispatching mechanism (3) for transporting the sample rack.

12. The sample introduction system according to claim 1, further comprising a buffer area (2) for temporarily storing the sample rack to be tested or the sample rack requiring automatic retesting.

13. An analysis apparatus, comprising:

an analyzer (6) comprising a sampling mechanism for aspirating a sample to be analyzed from a sample container located at a sample aspirating position;

the sample introduction system according to any of claims 1 to 11, for providing sample racks to be tested and recovering the completed test sample racks.

14. A sample introduction method for an analysis apparatus, comprising:

an input area expanding step, which comprises controlling the sample feeding propulsion mechanism to move to one side of the recovery area when the input area has no sample rack, so as to expand the capacity of the input area;

a sample rack pushing step, which comprises controlling a sample feeding pushing mechanism to push a sample rack to be detected placed in the placing area so as to provide the sample rack to be detected for the analysis device;

and a recovery area expanding step, which comprises controlling a recovery pushing mechanism to push the sample rack to be recovered to the position of at least one sample rack towards the direction of the sample feeding pushing mechanism when the sample rack to be recovered enters the recovery area, so that the subsequent sample rack to be recovered continues to enter the recovery area.

15. The method of claim 13, wherein the deposit zone expanding step further comprises, when the retrieval zone is free of sample racks to be retrieved:

controlling the recovery propulsion mechanism to move from the initial position to the extending position so as to shield the recovery channel when the sampling propulsion mechanism moves to one side of the recovery area;

controlling the sample feeding propulsion mechanism to stop moving when touching the recovery propulsion mechanism;

controlling the recovery propulsion mechanism to move from the extension position to the initial position after the sample feeding propulsion mechanism stops moving;

when the sample rack is to be recovered in the recovery area, the placing area expanding step further comprises the following steps:

when the sample feeding and pushing mechanism touches the sample rack to be recovered in the process of moving to one side of the recovery area, the sample feeding and pushing mechanism is controlled to stop moving.

16. The method of claim 13, wherein the put-in zone expanding step further comprises: when no sample to be recovered enters the recovery area after the preset time, controlling the sample feeding propulsion mechanism to move to one side of the recovery area; and when the sample feeding and pushing mechanism touches the sample rack to be recovered in the recovery area, the sample feeding and pushing mechanism is controlled to stop moving.

17. The method of claim 13, wherein the reclamation area expansion step further comprises: when the sample rack to be recovered is touched and the sample rack still needs to be recovered in the recovery channel, the sample feeding and pushing mechanism is controlled to move towards the placing area.

18. A sample introduction system for an analytical device, comprising:

a memory for storing a program;

a processor for implementing the method of any one of claims 13-16 by executing a program stored by the memory.

19. A computer-readable storage medium, comprising a program executable by a processor to implement the method of any one of claims 13-16.

Technical Field

The invention relates to an analysis device, in particular to a sample introduction system and a sample introduction method of the analysis device.

Background

The analyzing device is used for analyzing body fluid (such as blood, urine or other liquid in vivo) collected from a living body and diagnosing according to the analysis result. In order to improve the detection efficiency, some analysis devices adopt a flow line type sample introduction system to provide samples to be detected for the analysis devices, and the sample introduction system mainly has the functions of inputting, dispatching, transmitting, positioning and recovering the sample rack and has the function of automatically identifying the barcode information of the sample rack and the sample tubes.

At present, the sample introduction system of the analysis device mainly has the following 2 types of modes in the input area and the recovery area.

1. Fixed bin channel type

In patent CN 203929791U, a sample rack conveying system is introduced, which comprises a sample rack conveying track and a sample rack. Wherein, the sample rack conveying track is in a fixed bin channel type. Each bin channel can be used for storing the sample rack to be tested and also can be used for recovering the sample rack after the test is finished. Each channel has sample rack in-position detection and status indication functions. Each channel is provided with a travel switch, whether a sample rack is placed or not is detected, and the state of the position is prompted to a user through an indicator lamp.

This configuration, due to the use of fixed bin lanes as compartments between the sample racks, allows a user to pick and place sample racks individually, which is not suitable for large sample runs. Meanwhile, each bin channel only corresponds to one sample rack, so that when samples are sucked, other sample racks to be detected cannot be stored even if the bin is idle, the occupied space is large, and resource waste is caused.

2. Independent placing area and recovery area

The sample introduction system of some instruments adopts an input area and a recovery area which are mutually independent. When the placing area has a space, a user is supported to place the sample rack at any time. The recovery area is positioned at one side of the placing area, and a user can take a plurality of sample racks from the recovery area in a centralized way.

Disclosure of Invention

The application provides an analytical equipment and sampling system and sampling method thereof, makes the capacity of sample frame input area and recovery area can adjust as required.

According to a first aspect, an embodiment provides a sample introduction system for an analysis device, comprising:

the sample rack placing area comprises a placing area for placing the sample rack and a recovery area for recovering the sample rack, and the space proportion occupied by the placing area and the recovery area is adjustable;

the sample feeding and pushing mechanism is movably arranged in the sample rack placing area; the sample feeding and pushing mechanism is used for pushing a sample rack to be tested, which is placed in the placing area;

and the recovery pushing mechanism is movably arranged in the sample rack recovery area and used for pushing the sample rack to be recovered entering the recovery area.

According to a second aspect, there is provided in an embodiment an analysis apparatus comprising:

an analyzer including a sampling mechanism for aspirating a sample to be tested by the analyzer from a sample container located at a sample aspirating position;

the sample introduction system is used for providing the sample rack to be detected and recovering the sample rack which is completely detected.

According to a third aspect, there is provided in one embodiment a method of sample injection for an analytical device, comprising:

an input area expanding step, which comprises controlling the sample injection propulsion mechanism to move towards one side of the sample frame recovery area when the input area has no sample frame, so as to expand the capacity of the sample frame input area;

a sample rack pushing step, which comprises controlling a sample feeding pushing mechanism to push a sample rack to be detected placed in the placing area so as to provide the sample rack to be detected for the analysis device;

and a recovery area expanding step, which comprises controlling a recovery pushing mechanism to push the sample rack to be recovered to the position of at least one sample rack towards the direction of the sample feeding pushing mechanism when the sample rack to be recovered enters the recovery area, so that the subsequent sample rack to be recovered continues to enter the recovery area.

According to a fourth aspect, an embodiment provides a sample introduction system for an analysis device, comprising:

a memory for storing a program;

a processor for implementing the above method by executing the program stored in the memory.

According to a fifth aspect, an embodiment provides a computer-readable storage medium, characterized by a program, which is executable by a processor to implement the above-mentioned method.

The sample rack placing area comprises the placing area and the recovery area which can be reused, the capacity of the placing area and the capacity of the recovery area are adjustable, the space of the sample rack placing area can be fully utilized, and the capacity of the placing area and the capacity of the recovery area are dynamically adjusted according to actual needs.

Drawings

FIG. 1 is a schematic view of an analysis apparatus;

FIG. 2 is a schematic diagram of a scheduling mechanism in one embodiment;

FIG. 3 is a schematic view of the structure of a finger in one embodiment;

FIG. 4 is a schematic view of a sensor arrangement for moving the guide slot in one embodiment;

FIG. 5 is a flow diagram of a sample introduction system delivering sample racks in one embodiment;

FIG. 6 is a flow diagram illustrating the sample collection system recovering a sample rack in one embodiment;

FIG. 7 is a schematic view of the structural layout of an analysis apparatus in another embodiment;

FIG. 8 is a schematic view showing the structural layout of an analyzing apparatus according to still another embodiment;

FIG. 9 is a schematic illustration of the position of a first sensing element in one embodiment;

FIG. 10 is a schematic view of a sample rack placed in the placement area in one embodiment;

FIG. 11 is a schematic view of a sample pushing mechanism pushing a sample rack according to an embodiment;

fig. 12 is a schematic diagram illustrating the sample rack in the input area being pushed out in one embodiment.

Detailed Description

The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.

Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.

The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).

In the embodiment of the invention, the inventor breaks through the thinking mode that the sample rack placing area and the sample rack recycling area are mutually independent and fixed, combines the sample rack placing area and the sample rack recycling area into one area, enables the sample rack to move in the area without obstacles through pulling or pushing of external force, separates the sample rack placing area and the sample rack recycling area through a movable sample feeding and pushing mechanism, and can adjust the space or the volume of the placing area and the sample rack recycling area through the position movement of the sample feeding and pushing mechanism.

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