阅读说明：本技术 用于生物组织检测的磁感应分子成像方法及系统 (Magnetic induction molecular imaging method and system for biological tissue detection ) 是由 王露露 于 2019-10-25 设计创作，主要内容包括：本发明实施例公开了一种用于生物组织检测的磁感应分子成像方法及系统,属于磁感应成像技术领域,克服相关磁感应成像技术中图像分辨率低,成像时间长,计算成本高等问题,磁性纳米粒子装置向检测床的待测区域发送磁性纳米粒子；磁场发生装置产生并向所述的信号收发装置传输电磁波；信号收发装置,用于接收所述磁场发生装置传输的电磁波；磁场信号采集装置采集传感器阵列上每个传感器探测到的待测区域的基于磁性纳米粒子的散射电场信息和散射磁场信息；计算机设备根据散射电场信息和散射磁场信息解析待测器官内部组织结构状态并形成图像,该方法和系统主要用于医学检测。(The embodiment of the invention discloses a magnetic induction molecular imaging method and a magnetic induction molecular imaging system for biological tissue detection, which belong to the technical field of magnetic induction imaging and solve the problems of low image resolution, long imaging time, high calculation cost and the like in the related magnetic induction imaging technology; the magnetic field generating device generates and transmits electromagnetic waves to the signal receiving and transmitting device; the signal receiving and transmitting device is used for receiving the electromagnetic waves transmitted by the magnetic field generating device; the magnetic field signal acquisition device acquires the scattering electric field information and the scattering magnetic field information based on the magnetic nanoparticles in the region to be detected, which are detected by each sensor on the sensor array; the computer equipment analyzes the internal tissue structure state of the organ to be detected according to the scattered electric field information and the scattered magnetic field information and forms an image.)

1. A magnetically inductive molecular imaging system for biological tissue detection, comprising: the device comprises a detection bed, a magnetic nanoparticle device, a magnetic field generating device, a signal receiving and transmitting device, a magnetic field signal collecting device and computer equipment;

the detection bed is used for bearing organisms to be detected;

the magnetic nanoparticle device comprises a slow release device, wherein the slow release device is filled with magnetic nanoparticles, and when an organism to be detected is measured, the slow release device sends the magnetic nanoparticles to a region to be detected of the detection bed;

the magnetic field generating device comprises an electromagnetic wave generating module and a Helmholtz coil module, wherein the electromagnetic wave generating module is used for generating and transmitting electromagnetic waves to the signal receiving and transmitting device, and the Helmholtz coil module is used for generating an excitation magnetic field for a region to be detected;

the signal receiving and transmitting device comprises a scanner comprising N sensor arrays, wherein N is a natural number, the distance between each sensor array and an organ to be measured is far greater than one working wavelength, and the sensors are used for receiving electromagnetic waves transmitted by the magnetic field generating device;

the magnetic field signal acquisition device comprises a data acquisition card, wherein the data acquisition card is used for acquiring scattering electric field information and scattering magnetic field information based on magnetic nanoparticles in a region to be detected, which is detected by each sensor on a sensor array, and sending the scattering electric field information and the scattering magnetic field information to the computer equipment;

and the computer equipment analyzes the internal tissue structure state of the organ to be detected according to the scattered electric field information and the scattered magnetic field information and forms an image.

2. The system of claim 1, wherein the slow release device is a fiber tube, the upper end and the lower end of the fiber tube are fixed by a bracket positioning device, and the bracket positioning device comprises a positioning shell fixedly connected with the end of the fiber tube.

3. The system of claim 1, wherein there are two Helmholtz coil modules, one at each end of the sensor array.

4. The system of claim 1, wherein the sensor array is implemented as a columnar sensor array, and all sensors are uniformly distributed around the target area in a circular ring shape at the same height around the axis of the detection bed.

5. The system of claim 1, wherein the magnetic nanoparticles are ferroferric oxide.

6. A magnetically responsive molecular imaging method for biological tissue detection based on the system of any one of claims 1-5, comprising:

s1, the organism to be detected is laid on the detection bed, and the organ to be detected is exposed in the area to be detected;

s2, sending quantitative magnetic nanoparticles to the region to be detected by the magnetic nanoparticle device according to the preset setting;

s3, the magnetic field generating device emits uninterrupted time harmonic electromagnetic wave signals with specific frequency and transmits the signals to a sensor array of the signal receiving and transmitting device, and the scanning position of the Helmholtz coil is adjusted so that the Helmholtz coil generates an excitation magnetic field for the region to be detected of the detection bed;

s4, detecting the time harmonic electromagnetic wave signals of the region to be detected of the detection bed by the sensor array of the signal transceiver;

s5, the magnetic field signal acquisition device acquires the information of the scattering electric field and the scattering magnetic field based on the magnetic nanoparticles in the region to be detected, which is detected by each sensor on the sensor array, through a data acquisition card:

and S6, analyzing the internal tissue structure state of the organ to be detected according to the information of the scattering electric field and the scattering magnetic field by the computer and forming an image.

7. The method of claim 6, wherein the computer analyzing the tissue structure state inside the organ under test according to the scattered electric field and the scattered magnetic field information and forming an image comprises: and the computer constructs a two-dimensional image of the target object by means of inverse Fourier transform processing based on the dielectric properties of the biological tissue, the amplitude and the phase of the conductivity distribution and the magnetic susceptibility information of the internal tissue.

8. The method of claim 7, wherein the computer constructing a two-dimensional image of the object by an inverse Fourier transform process based on the magnitude and phase of the dielectric properties and conductivity distribution of the biological tissue and the magnetic susceptibility information of the internal tissue comprises: and performing two-dimensional inverse Fourier transform on the visibility function signals acquired by any two sensors to obtain a two-dimensional reconstruction image of the target object.

9. The method according to claim 8, wherein the visibility function obtaining process comprises:

extracting the information of the scattering magnetic field of the magnetic nanoparticles in the region to be detected containing the magnetic nanoparticles, which is detected by any two sensors;

the differences of the scattered magnetic field information detected by the two sensors are compared to obtain the visibility functions of the two sensors.

10. The method according to claim 8, wherein the visibility function obtaining process further comprises:

extracting magnetization information and scattered electric field information of the magnetic nanoparticles in the region to be detected, which are detected by all sensors;

and comparing the information difference detected by any two sensors one by one to obtain the sum of the visibility functions containing the phase delay and/or amplitude difference information, namely the total visibility function.

Technical Field

The invention belongs to the technical field of magnetic induction imaging, and particularly relates to a magnetic induction molecular imaging method and a magnetic induction molecular imaging system for biological tissue detection.

Background

Magnetic induction imaging is a new medical imaging method, and provides possibility for early diagnosis of brain diseases. With the application and popularization of magnetic induction imaging technology in the field of biological imaging, people increasingly demand high-definition microwave images and rapid imaging. However, due to the defects of the algorithm and the imaging system design, magnetic induction imaging still has many defects, such as low image resolution, long imaging time, high calculation cost, low sensitivity to small tumors, and the like.

Disclosure of Invention

In order to overcome the problems of low image resolution, long imaging time, high calculation cost, low sensitivity to small tumors and the like in related magnetic induction imaging technologies at least to a certain extent, the embodiment of the invention provides a magnetic induction molecular imaging method and system for biological tissue detection, which specifically comprise the following steps:

in one aspect, a magnetically responsive molecular imaging system for biological tissue detection, comprising: the device comprises a detection bed, a magnetic nanoparticle device, a magnetic field generating device, a signal receiving and transmitting device, a magnetic field signal collecting device and computer equipment;

the detection bed is used for bearing organisms to be detected;

the magnetic nanoparticle device comprises a slow release device, wherein the slow release device is filled with magnetic nanoparticles, and when an organism to be detected is measured, the slow release device sends the magnetic nanoparticles to a region to be detected of the detection bed;

the magnetic field generating device comprises an electromagnetic wave generating module and a Helmholtz coil module, wherein the electromagnetic wave generating module is used for generating and transmitting electromagnetic waves to the signal receiving and transmitting device, and the Helmholtz coil module is used for generating an excitation magnetic field for a region to be detected;

the signal receiving and transmitting device comprises a scanner comprising N sensor arrays, wherein N is a natural number, the distance from each sensor array to an organ to be measured is far greater than one working wavelength, and the sensors are used for receiving electromagnetic waves transmitted by the magnetic field generating device;

the magnetic field signal acquisition device comprises a data acquisition card, wherein the data acquisition card is used for acquiring scattering electric field information and scattering magnetic field information based on magnetic nanoparticles in a region to be detected, which is detected by each sensor on a sensor array, and sending the scattering electric field information and the scattering magnetic field information to the computer equipment;

and the computer equipment analyzes the internal tissue structure state of the organ to be detected according to the scattered electric field information and the scattered magnetic field information and forms an image.

Further optionally, the slow release device is a fiber tube, the upper end and the lower end of the fiber tube are fixed by a bracket positioning device, and the bracket positioning device comprises a positioning shell fixedly connected with the end part of the fiber tube.

Further optionally, two helmholtz coil modules are arranged and respectively arranged at two ends of the sensor array.

Further optionally, the sensor array is implemented by a columnar sensor array, and all the sensors are uniformly distributed in a ring shape around the target area and at the same height with respect to the axis of the detection bed.

Further optionally, the magnetic nanoparticles are ferroferric oxide.

In another aspect, a magnetic induction molecular imaging method for biological tissue detection based on the above system includes:

s1, the organism to be detected is laid on the detection bed, and the organ to be detected is exposed in the area to be detected;

s2, sending quantitative magnetic nanoparticles to the region to be detected by the magnetic nanoparticle device according to the preset setting;

s3, the magnetic field generating device emits uninterrupted time harmonic electromagnetic wave signals with specific frequency and transmits the signals to a sensor array of the signal receiving and transmitting device, and the scanning position of the Helmholtz coil is adjusted so that the Helmholtz coil generates an excitation magnetic field for the region to be detected of the detection bed;

s4, detecting the time harmonic electromagnetic wave signals of the region to be detected of the detection bed by the sensor array of the signal transceiver;

s5, the magnetic field signal acquisition device acquires the information of the scattering electric field and the scattering magnetic field based on the magnetic nanoparticles in the region to be detected, which is detected by each sensor on the sensor array, through a data acquisition card:

and S6, analyzing the internal tissue structure state of the organ to be detected according to the information of the scattering electric field and the scattering magnetic field by the computer and forming an image.

Further optionally, the analyzing, by the computer, the state of the internal tissue structure of the organ to be measured according to the information of the scattering electric field and the scattering magnetic field and forming an image includes: and the computer constructs a two-dimensional image of the target object by means of inverse Fourier transform processing based on the dielectric properties of the biological tissue, the amplitude and the phase of the conductivity distribution and the magnetic susceptibility information of the internal tissue.

Further optionally, the computer constructs a two-dimensional image of the object by inverse fourier transform processing based on the amplitude and phase of the dielectric property and conductivity distribution of the biological tissue and the magnetic susceptibility information of the internal tissue, including: and performing two-dimensional inverse Fourier transform on the visibility function signals acquired by any two sensors to obtain a two-dimensional reconstruction image of the target object.

Further optionally, the obtaining of the visibility function includes:

extracting the information of the scattering magnetic field of the magnetic nanoparticles in the region to be detected containing the magnetic nanoparticles, which is detected by any two sensors;

the differences of the scattered magnetic field information detected by the two sensors are compared to obtain the visibility functions of the two sensors.

Further optionally, the obtaining of the visibility function further includes:

extracting magnetization information and scattered electric field information of the magnetic nanoparticles in the region to be detected, which are detected by all sensors;

and comparing the information difference detected by any two sensors one by one to obtain the sum of the visibility functions containing the phase delay and/or amplitude difference information, namely the total visibility function.

The embodiment of the invention provides a magnetic induction molecular imaging method and a magnetic induction molecular imaging system for biological tissue detection, which utilize the imaging property of magnetic nanoparticles and the dielectric property of biological tissue to detect organisms, and the basic principle is as follows: according to the different magnetic susceptibility of different magnetic nano particles, the strain is different after an external magnetic field is applied or the alternating vibration is applied, the change of the magnetic susceptibility is different, meanwhile, according to the difference of the dielectric property and the electric conductivity of different biological tissues, under the irradiation of electromagnetic waves, the scattering magnetic field of a target biological tissue is different, the appearance image of the target or the structural imaging of the interior of a medium target are reconstructed by analyzing and processing the form change and the scattering magnetic field, and the visual display of the spatial magnetic field distribution can also be realized.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present application and together with the description, serve to explain the principles of the application.

FIG. 1 is a schematic structural diagram of a magnetic induction molecular imaging system for biological tissue detection according to an embodiment of the present invention;

fig. 2 and 3 are schematic diagrams illustrating a relative position relationship between a sensor array and an object to be measured in a signal transceiver in the system shown in fig. 1;

FIG. 4 is a schematic flow chart of a magnetic induction molecular imaging method for biological tissue detection according to an embodiment of the present invention;

fig. 5-18 are schematic diagrams of the calculation principle and related images when the system shown in fig. 1 is applied to the detection of the brain.

Detailed Description

Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the present application, as detailed in the appended claims.

The magnetic nano-particles have wide application value due to the unique performance, and particularly bring new opportunities and hopes for the treatment of human diseases in the fields of bioseparation, clinical diagnosis, tumor treatment, targeted transportation and tissue engineering. In recent years, magnetic nanoparticles have attracted much attention from researchers because they can be used as contrast agents for magnetic resonance imaging, as hyperthermia media for cancer hyperthermia, and as magnetic tissue engineering.

Molecular imaging is a technique for quantitatively measuring physiological changes in a living body using probes or signals, and can develop specific molecular and cellular targets as a source of image contrast, and is an important tool in biomedical and theranostic research. In recent years, molecular imaging techniques have been developed with a tremendous leap forward due to the application of nanotechnology. By using nanotechnology, both imaging tools and marker molecules are greatly improved in order to achieve early diagnosis of diseases and to monitor the efficacy of treatments.

In the magnetic induction imaging technology research process, the applicant finds that, if the magnetic nanoparticle technology and the molecular imaging technology can be applied to the magnetic induction imaging technology, unexpected imaging effect can be brought to the existing magnetic induction imaging mode, so as to promote great progress of the medical imaging technology.