阅读说明：本技术 3-羟基-5-取代基苯甲酸在制备化妆品组合物或非治疗性皮肤处理组合物中的应用 (Use of 3-hydroxy-5-substituted benzoic acids for the preparation of cosmetic or non-therapeutic skin treatment compositions ) 是由 吴杰军 陈景才 于 2019-10-23 设计创作，主要内容包括：本发明涉及3-羟基-5-取代基苯甲酸在制备化妆品组合物或非治疗性皮肤处理组合物中的应用,可有效解决现有化妆品抗皱效果不好、不能满足人们的需求,及非治疗性皮肤处理组合物不能有效改善皮肤斑点和痤疮的问题,其解决的技术方案是,包括3-氟-5-羟基苯甲酸、3-氯-5-羟基苯甲酸、3-溴-5-羟基苯甲酸、3-羟基-5-甲基苯甲酸中的一种,本发明相对于已有的化妆品中的抗皱成分或非治疗性皮肤处理组合物中改善皮肤斑点和痤疮成分,化妆品中3-羟基-5-取代基苯甲酸的优点是其通过乳酸受体GPR81产生的抗炎作用,能促进皮下脂肪合成,抑制皮下脂肪降解,增加胶原蛋白合成,并且表现出无刺激性,是抗皱成分、改善皮肤斑点和痤疮成分上的一大创新。(The invention relates to the application of 3-hydroxy-5-substituted benzoic acid in preparing cosmetic composition or non-therapeutic skin treatment composition, can solve existing cosmetic wrinkle resistant effect not good, can't meet people's demand, and non-therapeutic skin treatment composition can't improve skin spot and acne problem effectively, its technical scheme to solve, include 3-fluoro-5-hydroxybenzoic acid, 3-chloro-5-hydroxybenzoic acid, 3-bromo-5-hydroxybenzoic acid, one in 3-hydroxy-5-methylbenzoic acid, the invention is compared with wrinkle resistant component or non-therapeutic skin treatment composition in existing cosmetic improve skin spot and acne component, the advantage of 3-hydroxy-5-substituted benzoic acid in the cosmetic is its anti-inflammatory effect produced through lactate receptor GPR81, can promote the synthesis of subcutaneous fat, inhibit the degradation of the subcutaneous fat and increase the synthesis of collagen, has no irritation, and is a great innovation in anti-wrinkle components and components for improving skin spots and acnes.)

Use of 3-hydroxy-5-substituted benzoic acids for the preparation of cosmetic or non-therapeutic skin treatment compositions.

2. The 3-hydroxy-5-substituted benzoic acid of claim 1, comprising one of 3-fluoro-5-hydroxybenzoic acid, 3-chloro-5-hydroxybenzoic acid, 3-bromo-5-hydroxybenzoic acid, and 3-hydroxy-5-methylbenzoic acid, each having the following structural formula:

3. the cosmetic or non-therapeutic skin treatment composition according to claim 1, which comprises 0.01 to 30% by weight of 3-hydroxy-5-substituted benzoic acid.

4. The cosmetic or non-therapeutic skin treatment composition according to claim 3, characterized by consisting of 0.01-30% by weight of 3-hydroxy-5-substituted benzoic acid; 1-10% of grease; 1-10% of hydrocarbon compounds; 1-10% of wax compound; 1-10% of synthetic oil raw material; 0.1-5% fatty acid; 0.1-5% fatty alcohol; 0.1-5% of glycerol; 0.1-5% sorbitol; 0.1-5% of a surfactant; 0.01-1% of essence; 5-95% deionized water.

5. The cosmetic or non-therapeutic skin treatment composition of any one of claims 1-4 comprising one of an aqueous solution, an oil, a water-alcohol solution, an oil-in-water emulsion, a water-in-oil emulsion, a microemulsion, an aqueous gel, a water-free gel, a microcapsule, a microparticle, or a particulate dispersion.

6. Cosmetic or non-therapeutic skin treatment composition according to claim 4, characterized in that the oil phase: 2% of vaseline, 1% of lanolin, 5% of paraffin, 3% of octadecanol, 1% of stearic acid and span-601%; water phase: 0.5% of 3-chloro-5-hydroxybenzoic acid, 2% of glycerol, 2% of propylene glycol, 2% of sorbitol, 1% of polyethylene glycol, 801% of tween-801, 0.01% of lavender essential oil and deionized water, and the balance being 100%, the oil phase and the water phase are mixed uniformly at 80-90 ℃, stirred for 15 minutes and then cooled to room temperature, thus obtaining the product.

7. Cosmetic or non-therapeutic skin treatment composition according to claim 4, characterized in that the oil phase: 5% of vaseline, 3% of lanolin, 5% of paraffin, 3% of octadecanol, 1% of stearic acid and span-601%; water phase: 0.5% of 3-hydroxy-5-methylbenzoic acid, 3% of glycerol, 2% of propylene glycol, 2% of sorbitol, 2% of polyethylene glycol, 801% of tween-801, 0.01% of lavender essential oil and deionized water, and adding the rest to 100%, uniformly mixing the oil phase and the water phase at 80-90 ℃, stirring for 15 minutes, and then cooling to room temperature to obtain the lavender essential oil.

8. Cosmetic or non-therapeutic skin treatment composition according to claim 4,

the oil is one or the combination of more than one of vegetable oil, animal oil, mineral oil and petrolatum;

the hydrocarbon compound is one or the combination of more than one of vaseline, octadecanol and hexadecanol;

the wax compound is one or more of paraffin, ceresin, spermaceti wax, carnauba wax, candelilla wax, jojoba wax, wood wax, lanolin and beeswax;

the synthetic oil raw material is one or the combination of more than one of stearic acid, palmityl alcohol, cetyl alcohol, palmitate, polysiloxane, squalane, lanolin derivatives and fatty acid ester;

the fatty acid is one or more of lauric acid, myristic acid, palmitic acid and isostearic acid;

the fatty alcohol is one or more of lauryl alcohol, cetyl alcohol, stearyl alcohol, propylene glycol, glycerol and sorbitol;

the surfactant is one or more of fatty acid soap, lauryl sodium sulfate, lauryl polyoxyethylene ether sodium sulfate, cetyl polyoxyethylene ether sodium phosphate and soybean lecithin, primary, secondary and tertiary amines of high-carbon alkyl and quaternary ammonium salts, such as octadecyl trimethyl ammonium chloride, C12-14 alkyl dimethyl benzyl ammonium chloride, dioctadecyl dimethyl sodium chloride, cocamidopropyl betaine, imidazoline, sorbitan monolaurate, ethylene oxide addition product, lauryl polyoxyethylene ether, cocodiethanolamide, oleic acid monoglyceride, polyoxyethylene castor oil and polyoxyethylene lanolin;

the essence is one or the combination of more than one of plant spice, animal spice and synthetic spice.

Technical Field

The invention relates to the technical field of daily necessities, in particular to application of 3-hydroxy-5-substituted benzoic acid in preparation of a cosmetic composition or a non-therapeutic skin treatment composition.

Background

With age, the metabolism of the human body gradually decreases, leading to a decrease in subcutaneous fat synthesis and a decrease in collagen and elastin synthesis, resulting in the formation of wrinkles. In addition, external factors such as ultraviolet rays, insufficient rest, improper diet, smoking, drinking, etc. accelerate the formation of wrinkles, spots or acne.

Although there are many kinds of anti-wrinkle cosmetics and non-therapeutic skin treatment compositions for improving skin spots and acne on the market, the ratio of the poor effects of anti-wrinkle, skin spots and acne improvement is not good enough to satisfy the needs, and 3-hydroxy-5-substituted benzoic acid has a structure similar to 3, 5-dihydroxybenzoic acid in which one of the hydroxyl groups at the 3-or 5-positions is substituted with a bromine molecule (Br) to produce 3-bromo-5-hydroxybenzoic acid, or a fluorine molecule (F) to produce 3-fluoro-5-hydroxybenzoic acid, or a chlorine molecule (Cl) to produce 3-chloro-5-hydroxybenzoic acid, or a methyl molecule (CH)₃) To generate 3-hydroxy-5-methyl benzoic acid. Although there have been previous reports of the use of 3-hydroxybenzoic acid (U.S. Pat. No. 3,35297,antonelli et al) and dihydroxybenzoic acid (U.S. Pat. No. 5,613,araudeeau et al) in cosmetics, there has been no published report of the use of the above 3-hydroxy-5-substituted benzoic acids in the preparation of anti-wrinkle cosmetic compositions or non-therapeutic skin treatment compositions.

Disclosure of Invention

In view of the above situation, in order to overcome the defects of the prior art, the present invention aims to provide a 3-hydroxy-5-substituted benzoic acid in the preparation of a cosmetic composition or a non-therapeutic skin treatment composition, which can effectively solve the problems that the existing cosmetic has poor anti-wrinkle effect and cannot meet the requirements of people, and the non-therapeutic skin treatment composition cannot effectively improve skin spots and acne.

The technical scheme of the invention is that the 3-hydroxy-5-substituted benzoic acid is a 3, 5-dihydroxybenzoic acid (compound 1) structural analogue, and comprises one of 3-fluoro-5-hydroxybenzoic acid (compound 2), 3-chloro-5-hydroxybenzoic acid (compound 3), 3-bromo-5-hydroxybenzoic acid (compound 4) and 3-hydroxy-5-methylbenzoic acid (compound 5), and the structural formulas are respectively as follows:

the cosmetic composition or non-therapeutic skin treatment composition contains 0.01-30% of 3-hydroxy-5-substituted benzoic acid by weight, and the optimal content of the 3-hydroxy-5-substituted benzoic acid is 0.05-5%; the cosmetic composition containing the 3-hydroxy-5-substituted benzoic acid has obvious anti-wrinkle effect, can increase collagen synthesis, enhance skin elasticity and keep skin moisture; non-therapeutic skin treatment compositions containing 3-hydroxy-5-substituted benzoic acid have the effect of improving skin spots and acne.

The cosmetic composition or non-therapeutic skin treatment composition comprises 0.01-30% by weight of 3-hydroxy-5-substituted benzoic acid; 1-10% of grease; 1-10% of hydrocarbon compounds; 1-10% of wax compound; 1-10% of synthetic oil raw material; 0.1-5% fatty acid; 0.1-5% fatty alcohol; 0.1-5% of glycerol; 0.1-5% sorbitol; 0.1-5% of a surfactant; 0.01-1% of essence.

The oil is one or more of vegetable oil, animal oil, mineral oil, and petrolatum.

The hydrocarbon compound is one or more of vaseline, octadecanol, hexadecanol and the like.

The wax compound is one or more of paraffin, ceresin, spermaceti wax, carnauba wax, candelilla wax, jojoba wax, wood wax, lanolin, beeswax, etc.

The synthetic oil raw material is one or more of stearic acid, palmityl alcohol, cetyl alcohol, palmitate, polysiloxane, squalane, lanolin derivatives, fatty acid ester and the like.

The fatty acid is one or more of lauric acid, myristic acid, palmitic acid, isostearic acid, etc.

The fatty alcohol is one or more of lauryl alcohol, cetyl alcohol, stearyl alcohol, propylene glycol, glycerol, sorbitol, etc.

The surfactant is one or more of fatty acid soap, lauryl sodium sulfate, lauryl polyoxyethylene ether sodium sulfate, cetyl polyoxyethylene ether sodium phosphate and soybean lecithin (lecithin), primary, secondary and tertiary amines of high-carbon alkyl, and quaternary ammonium salts, such as octadecyl trimethyl ammonium chloride, C12-14 alkyl dimethyl benzyl ammonium chloride, dioctadecyl dimethyl sodium chloride, cocamidopropyl betaine, imidazoline, sorbitan monolaurate, ethylene oxide adduct, lauryl polyoxyethylene ether, cocodiethanolamide, oleic acid monoglyceride, polyoxyethylene castor oil, and polyoxyethylene lanolin.

The essence is one or more of plant spice, animal spice, synthetic spice, etc.

The cosmetic composition or non-therapeutic skin treatment composition comprises one of an aqueous solution, an oil solution, a water-alcohol solution, an oil-in-water emulsion, a water-in-oil emulsion, a microemulsion, an aqueous gel, a water-free gel, a microcapsule, a microparticle or a particle dispersant.

Compared with the existing anti-wrinkle component in cosmetics or the component for improving skin spots and acne in non-therapeutic skin treatment compositions, the 3-hydroxy-5-substituted benzoic acid in the cosmetics has the advantages that the anti-inflammatory effect generated by the lactic acid receptor GPR81 can promote subcutaneous fat synthesis, inhibit subcutaneous fat degradation, increase collagen synthesis and show no irritation. The 3-hydroxy-5-substituted benzoic acid in the non-therapeutic skin treatment composition provides anti-inflammatory effects through the lactate receptor GPR81, thereby improving skin spots and reducing or even eliminating acne, and exhibits no irritation, a great innovation in anti-wrinkle, skin spot improvement and acne components.

Detailed Description

The following examples further illustrate the embodiments of the present invention in detail.

For a better understanding of the present invention, several examples of the present invention are given below, but the present invention is not limited to the examples listed herein since the present invention can be embodied in various forms; the scientific and technical terms used herein are for the purpose of describing particular embodiments and are not intended to be limiting; unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and the term "and/or" as used herein refers to any and all combinations of one or more of the listed items.