阅读说明：本技术 一种纤维膜层以及带有该纤维膜层的创口贴 (Fiber film layer and adhesive bandage with same ) 是由 王晗 白见福 于 2019-10-30 设计创作，主要内容包括：本发明属于创口贴技术领域,尤其涉及一种纤维膜层以及带有该纤维膜层的创口贴。该纤维膜层包括由疏水性物质以及抗菌药物打印形成的第一纤维层以及由亲水性物质、疏水性物质以及抗菌药物打印形成的第二纤维层；第一纤维层以及第二纤维层均由若干条间隔排布的横向纤维和若干条间隔排布纵向纤维横纵交织形成。该带有纤维膜层的创口贴,从外向内依次包括辅助层、粘结层、纤维膜层以及保护层；纤维膜层为上述的纤维膜层；第一纤维层设置在靠近粘结层一侧,第二纤维层设置在靠近保护层一侧。与现有技术相比,该创口贴能够较大程度的改善现有创口贴的吸水性和通透性,同时具有较好且长效的抗菌效果。(The invention belongs to the technical field of wound dressings, and particularly relates to a fiber film layer and a wound dressing with the fiber film layer. The fiber membrane layer comprises a first fiber layer formed by printing hydrophobic substances and antibacterial drugs and a second fiber layer formed by printing hydrophilic substances, hydrophobic substances and antibacterial drugs; the first fiber layer and the second fiber layer are formed by transversely and longitudinally interweaving a plurality of transverse fibers arranged at intervals and a plurality of longitudinal fibers arranged at intervals. The adhesive bandage with the fiber film layer sequentially comprises an auxiliary layer, an adhesive layer, the fiber film layer and a protective layer from outside to inside; the fiber film layer is the fiber film layer; the first fiber layer is arranged on one side close to the bonding layer, and the second fiber layer is arranged on one side close to the protective layer. Compared with the prior art, the adhesive bandage can improve the water absorption and permeability of the existing adhesive bandage to a greater degree, and has a good and long-acting antibacterial effect.)

1. A fibrous membrane layer, characterized by: the fiber membrane layer comprises a first fiber layer formed by printing hydrophobic substances and antibacterial drugs and a second fiber layer formed by printing hydrophilic substances, hydrophobic substances and antibacterial drugs; the first fiber layer and the second fiber layer are formed by transversely and longitudinally interweaving a plurality of transverse fibers arranged at intervals and a plurality of longitudinal fibers arranged at intervals.

2. The utility model provides a band-aid with fibre rete which characterized in that: the adhesive comprises an auxiliary layer, an adhesive layer, a fiber film layer and a protective layer from outside to inside in sequence; the fibrous film layer is the fibrous film layer of claim 1; the first fiber layer is arranged on one side close to the bonding layer, and the second fiber layer is arranged on one side close to the protective layer.

3. A wound covering with a fibrous film layer as claimed in claim 2, characterised in that: the fiber film layer is prepared by a melt electrostatic spinning method.

4. A wound covering with a fibrous film layer according to claim 2 or claim 3, characterised in that: the antibacterial drug is a broad-spectrum antibiotic.

5. A wound covering with a fibrous film layer according to claim 4, characterised in that: the mass percentage of the broad spectrum antibiotic in the total mass of the first fiber layer is 10%.

6. A wound covering with a fibrous film layer according to claim 4, characterised in that: the mass percentage of the broad spectrum antibiotic in the total mass of the second fiber layer is 10%.

7. A wound covering with a fibrous film layer as claimed in claim 2, characterised in that: a through window is formed in the middle of the bonding layer, and the first fiber layer of the fiber film layer covers the through window.

8. A wound covering with a fibrous film layer as claimed in claim 2, characterised in that: the hydrophobic substance is PCL.

9. A wound covering with a fibrous film layer as claimed in claim 2, characterised in that: the hydrophilic substance is PEG.

Technical Field

The invention belongs to the technical field of wound dressings, and particularly relates to a fiber film layer and a wound dressing with the fiber film layer.

Background

The band-aid is also called benzalkonium chloride band, is commonly called as bactericidal elastic band-aid, and is a surgical medicine most commonly used in life of people. The adhesive bandage mainly comprises a plain cloth adhesive tape and a water absorption pad. Has hemostatic, wound surface protecting, infection preventing, and healing promoting effects. However, the adhesive bandage is not suitable for too long time, generally within one to two days, because the water absorption and the air permeability of the adhesive bandage are poor, which is not beneficial to the drainage of wound secretions and is beneficial to the growth and the propagation of bacteria, so that the wound and the surrounding skin are whitened and softened, and secondary infection is caused.

The Chinese patent with application publication number CN108403296A discloses a double-sided opposite-sex adhesive bandage based on an electrostatic spinning process and a manufacturing method thereof: this two-sided opposite sex adhesive bandage includes adhesive tape, wound nursing layer and leaves type paper from the extroversion, and the transom is seted up in the adhesive tape fretwork, and the wound nursing layer includes that protective layer and two-sided opposite sex apply the bed course, and the protective layer has the hydrophobicity, and two-sided opposite sex apply the bed course outside and inboard have hydrophobicity and hydrophilicity respectively, and protective layer and two-sided opposite sex apply the bed course and all adopt electrostatic spinning technology to make and connection face integrated into one piece between them, and two-sided opposite sex apply the bed course inboard through plasma bombardment and have the hydrophilicity. The manufacturing method comprises the following steps: cutting adhesive tapes, preparing an electrostatic spinning solution, manufacturing a hydrophobic dressing layer, manufacturing a double-sided opposite-nature dressing layer, adding a protective layer and assembling a finished product. The outer side of the wound dressing is hydrophobic, antibacterial, waterproof and breathable, and the inner side of the wound dressing is hydrophilic, so that wound exudate can be quickly absorbed, and a good environment is provided for wound healing; in addition, the biodegradable polylactic acid has good biocompatibility and degradability, simple manufacturing process and excellent performance.

However, in the prior art, if the adhesive bandage is prepared by adopting a solution electrostatic spinning method, toxic solvents are easily remained in the solution electrostatic spinning, and secondary damage to wounds is easily caused. In addition, the adhesive bandage mainly comprises a plain cloth adhesive tape and a water absorption pad. Therefore, the wound plaster has poor water absorption and air permeability, is not beneficial to drainage of wound secretions and growth and reproduction of bacteria, and makes the wound and surrounding skin white and soft, thereby causing secondary infection.

Disclosure of Invention

It is an object of the present invention to address the deficiencies of the prior art by providing a fibrous membrane layer.

The invention also aims to overcome the defects of poor water absorption and permeability of the wound dressings on the market at present, and provides the wound dressings with the fiber film layers.

The invention adopts the following technical scheme:

a fiber membrane layer comprises a first fiber layer formed by printing hydrophobic substances and antibacterial drugs and a second fiber layer formed by printing hydrophilic substances, hydrophobic substances and antibacterial drugs; the first fiber layer and the second fiber layer are formed by transversely and longitudinally interweaving a plurality of transverse fibers arranged at intervals and a plurality of longitudinal fibers arranged at intervals.

A wound plaster with a fiber film layer comprises an auxiliary layer, a bonding layer, the fiber film layer and a protective layer from outside to inside in sequence; the fiber film layer is the fiber film layer; the first fiber layer is arranged on one side close to the bonding layer, and the second fiber layer is arranged on one side close to the protective layer.

Further, the fiber film layer is prepared by a melt electrostatic spinning method.

Further, the antibacterial agent is a broad spectrum antibiotic.

Further, the mass percentage of the broad spectrum antibiotic in the total mass of the first fiber layer is 10%.

Further, the mass percentage of the broad spectrum antibiotic in the total mass of the second fiber layer is 10%.

Furthermore, a through window is formed in the middle of the bonding layer, and the first fiber layer of the fiber film layer covers the through window.

Further, the hydrophobic substance is PCL.

Further, the hydrophilic substance is PEG.

Compared with the prior art, the invention has the following beneficial effects:

1) in the fiber membrane layer, the first fiber layer uses the hydrophobic substance as the carrier of the antibacterial drug, and the second fiber layer uses the hydrophobic substance and the hydrophilic substance as the carrier of the antibacterial drug, and the effects of the fiber membrane layer are basically the same as the effects of the antibacterial drug, the hydrophobic substance and the hydrophilic substance when the fiber membrane layer is layered. The hydrophobic substance in the first fiber layer can effectively prevent external moisture from entering the wound, and the hydrophobic substance contains antibacterial drugs, so that external bacteria can be effectively prevented from invading. Similarly, the antibacterial agent in the second fiber layer can prevent bacteria from breeding, and the hydrophilic substances can lead the wound penetrating fluid to be led away through the fibers in time, so that the healing of the wound is accelerated. Meanwhile, the fiber film layer has simple structure and relatively low manufacturing cost; and the fibers of the fiber film layer are regularly arranged, so that the air permeability is good.

2) According to the wound plaster with the fiber film layer, the hydrophobic substance is used as the carrier of the antibacterial agent in the first fiber layer, the hydrophobic substance can effectively prevent external moisture from entering a wound, and the hydrophobic substance contains the antibacterial agent, so that external bacteria can be effectively prevented from invading. Similarly, the antibacterial agent in the second fiber layer can prevent bacteria from breeding, and the hydrophilic substances can lead the wound penetrating fluid to be led away through the fibers in time, so that the healing of the wound is accelerated. In addition, the adhesive bandage is simple in structure and low in manufacturing cost. The fibers of the fiber film layer are orderly arranged, the permeability can be adjusted according to the requirement, and the air permeability of the fiber film layer is far higher than that of disordered solution electrostatic spinning fibers, so that the wound is not whitened and softened due to poor air permeability, infection is avoided, and the healing of the wound can be accelerated.

3) The fiber film layer of the adhesive bandage is prepared by a melt electrostatic spinning method; in the spinning process of solution electrostatic spinning, an organic solvent is needed to participate, and the organic solvent can volatilize in the process of spinning fibers, but the volatilization is not complete, so that residual organic solvent can be generated, and secondary damage to wounds can be easily caused; the spinning process of melt electrostatic spinning does not need organic solvent, and the mixed material is directly heated and melted, and then an electric field is applied under pressure to form fibers, so that the organic solvent is not existed, and the wound is not damaged, thereby being safer.

4) The mass percentage of the broad spectrum antibiotic in the total mass of the first or second fibrous layer is 10%. Too low a content of broad-spectrum antibiotics affects the antibacterial effect, and too high a content affects the spinning effect.

5) The first fiber layer of the fiber film layer covers the through window, the fiber film layer is guaranteed to cover the through window, the wound is prevented from being directly contacted with the outside through the through window, wound infection is avoided, and healing of the wound is facilitated.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram I of a wound covering prepared based on melt electrostatic spinning according to the present invention;

FIG. 2 is a schematic structural view of a wound covering prepared based on melt electrospinning according to the present invention;

FIG. 3 is a schematic view of a back structure of a conventional wound covering;

fig. 4 is a schematic front structure view of a conventional adhesive bandage;

FIG. 5 is a fiber membrane layer prepared by melt electrospinning;

in the figure: an auxiliary layer 1; an adhesive layer 2, a through window 201; a fiber film layer 3; and a protective layer 4.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The present invention will be discussed in detail below with reference to fig. 1 and 5 and the present embodiment:

a fiber membrane layer 3 comprises a first fiber layer formed by printing after mixing a hydrophobic substance and an antibacterial drug and a second fiber layer formed by printing after mixing a hydrophilic substance, a hydrophobic substance and an antibacterial drug; the first fiber layer and the second fiber layer are formed by transversely and longitudinally interweaving a plurality of transverse fibers arranged at intervals and a plurality of longitudinal fibers arranged at intervals. The arrangement rule between the fibers of the first fiber layer or the second fiber layer may be a grid-shaped arrangement (as shown in fig. 5), a diamond-shaped grid arrangement, or the like, and the present invention is not limited in particular. Preferably, the fibers are arranged in a grid shape like Chinese character 'tian', the scheme is simple, and the implementation is easy. In addition, the specific proportion of the hydrophobic substance and the antibacterial agent in the first fiber layer is not limited; similarly, the specific proportions of the hydrophilic substance, the hydrophobic substance and the antibacterial agent in the second fiber layer are not limited, and those skilled in the art can select the proportions according to actual needs.

In the fibrous membrane layer 3 of the present invention, the first fibrous layer contains a hydrophobic substance as a carrier for an antibacterial agent, and the second fibrous layer contains a hydrophobic substance and a hydrophilic substance as carriers for an antibacterial agent, and the effects achieved when the antibacterial agent, the hydrophobic substance, and the hydrophilic substance are layered are substantially the same as those achieved when the antibacterial agent, the hydrophobic substance, and the hydrophilic substance are layered. The hydrophobic substance in the first fiber layer can effectively prevent external moisture from entering the wound, and the hydrophobic substance contains antibacterial drugs, so that external bacteria can be effectively prevented from invading. Similarly, the antibacterial agent in the second fiber layer can prevent bacteria from breeding, and the hydrophilic substances can lead the wound penetrating fluid to be led away through the fibers in time, so that the healing of the wound is accelerated. Meanwhile, the fiber film layer 3 has simple structure and relatively low manufacturing cost; and the fibers of the fiber film layer 3 are orderly arranged, and the air permeability is far higher than that of the disordered fiber film layer.

A band-aid with a fiber film layer comprises an auxiliary layer 1, an adhesive layer 2, a fiber film layer 3 and a protective layer 4 from outside to inside in sequence; the fiber film layer 3 adopts the fiber film layer; the first fiber layer is arranged on one side close to the bonding layer 2, and the second fiber layer is arranged on one side close to the protective layer 4.

According to the wound plaster with the fiber film layer, the hydrophobic substance is used as the carrier of the antibacterial agent in the first fiber layer, the hydrophobic substance can effectively prevent external moisture from entering a wound, and the hydrophobic substance contains the antibacterial agent, so that external bacteria can be effectively prevented from invading. Similarly, the antibacterial agent in the second fiber layer can prevent bacteria from breeding, and the hydrophilic substances can lead the wound penetrating fluid to be led away through the fibers in time, so that the healing of the wound is accelerated. In addition, the adhesive bandage is simple in structure and low in manufacturing cost. The fibers of the fiber film layer are orderly arranged, the permeability can be adjusted according to the requirement, and the air permeability of the fiber film layer is far higher than that of disordered solution electrostatic spinning fibers, so that the wound is not whitened and softened due to poor air permeability, infection is avoided, and the healing of the wound can be accelerated.

Further, the fiber film layer 3 can be manufactured by various methods; preferably, the fiber membrane layer 3 is prepared by a melt electrospinning method. Specifically, the melt electrostatic spinning method is to complete the whole spinning process through a melt electrostatic spinning device, and the melt electrostatic spinning device is not specifically limited by the invention and belongs to the protection scope of the invention. The process of melt electrospinning is roughly: heating the raw material to form a melt, and extruding the melt out of a spinneret to form a filament strip; finally, the fiber is formed through the procedures of curing, stretching, winding and the like. The melt electrostatic spinning device is controlled by an upper computer (the upper computer can directly send out a control command). The program code written for controlling the interval between the fibers and the related software are all the conventional technical means in the field, and the invention is not limited in detail and belongs to the protection scope of the invention. The interval between the printed fibers is set through an upper computer, corresponding interval numerical values are set according to actual requirements, and corresponding fiber film layer structures are printed by a printing mechanism in the melt electrostatic spinning device. Because the interval size of whole fibre is adjustable, its gas permeability is better than ordinary band-aid, and this can accelerate the healing of wound, can not make the wound whitish because of the gas permeability is poor simultaneously, and the softening leads to the infection. Therefore, the adhesive bandage prepared by the melt electrostatic spinning method can improve the water absorption and permeability of the existing adhesive bandage to a greater extent, and meanwhile, the adhesive bandage prepared by the melt electrostatic spinning method has a good and long-acting antibacterial effect.

The fiber film layer 3 of the adhesive bandage is prepared by a melt electrostatic spinning method; in the spinning process of solution electrostatic spinning, an organic solvent is needed to participate, and the organic solvent can volatilize in the process of spinning fibers, but the volatilization is not complete, so that residual organic solvent can be generated, and secondary damage to wounds can be easily caused; the spinning process of melt electrostatic spinning does not need organic solvent, and the mixed material is directly heated and melted, and then an electric field is applied under pressure to form fibers, so that the organic solvent is not existed, and the wound is not damaged, thereby being safer.

Furthermore, a through window 201 is formed in the middle of the adhesive layer 2, and the first fiber layer of the fiber film layer 3 covers the through window 201. Specifically, the area of the fiber film layer 3 should be larger than the area of the through window 201, so that the fiber film layer 3 is ensured to completely shield the through window 201, the wound is prevented from directly contacting with the outside through the through window 201, wound infection is avoided, and the wound healing is facilitated. Preferably, the adhesive layer 2 is a sterile adhesive tape, so that the use is safer and more reliable.

Further, the antibacterial agent is selected from broad spectrum antibiotics. Preferably, the selected broad spectrum antibiotic may be one or more of chloramphenicol, chlortetracycline, oxytetracycline, and tetracycline. The broad-spectrum antibiotics can resist most bacteria, when a plurality of broad-spectrum antibiotics are selected, the broad-spectrum antibiotics are mixed according to a certain proportion, and the proportion of mixing is not particularly limited.

Further, the mass of the broad spectrum antibiotic accounts for 10% or less of the total mass of the first fiber layer or the second fiber layer. Preferably, the broad spectrum antibiotic accounts for 10% of the total mass of the first fiber layer or the second fiber layer; if the content is too low, the antibacterial effect is affected, and if the content is too high, the spinning effect is affected.

Further, the protective layer 4 is composed of a first release film and a second release film, the first release film and the second release film are arranged oppositely, and overlap is formed in the middle of the adhesive bandage, so that the protective layer can be torn off conveniently; meanwhile, the protective layer is used for protecting the viscosity of the adhesive layer and the performance of the fiber film layer and preventing the adhesive bandage from being stained with dust and the like.

Furthermore, the area of the auxiliary layer 1 is slightly larger than that of the through window 201 formed in the middle of the adhesive layer 2, so that the auxiliary layer 1 completely covers the through window 201, the wound is prevented from being stained with dust and the like, and the problem that the area of the auxiliary layer 1 is too large and materials are wasted is also avoided.

Further, the hydrophobic substance is preferably PCL (polycaprolactone); the hydrophilic substance is preferably PEG (polyethylene glycol). PEG is non-toxic, non-irritant and has good water solubility, so that the hydrophilic effect is good; PCL is non-toxic, insoluble in water and good in biocompatibility, so that the hydrophobic effect is good.

Comparative analysis of the prior wound dressings on the market and of the invention: FIG. 3 is a schematic view of a back structure of a conventional wound covering; fig. 4 is a schematic front structure view of a conventional adhesive bandage; fig. 5 is a fiber membrane layer 3 prepared by a melt electrospinning method (in which the fiber pitch on the right side of fig. 5 is half of the fiber pitch on the left side). As can be seen from fig. 3, 4 and 5, the fiber film layer 3 prepared by the melt electrospinning method has better air permeability, which can accelerate the healing of the wound, and meanwhile, the wound is not whitened and softened due to poor air permeability, thereby causing infection.

The present invention has been further described with reference to specific embodiments, but it should be understood that the detailed description should not be construed as limiting the spirit and scope of the present invention, and various modifications made to the above-described embodiments by those of ordinary skill in the art after reading this specification are within the scope of the present invention.