阅读说明：本技术 一种含生物活性因子的化妆水及其制备方法 (Toning lotion containing bioactive factors and preparation method thereof ) 是由 谌智鑫 于 2018-06-27 设计创作，主要内容包括：本发明涉及一种含生物活性因子的化妆水,按重量计,包含如下组分：透明质酸钠2份；羟苯甲酯0.1份；甘油3份；丁二醇4份；人表皮细胞生长因子hEGF0.0003份；成纤维细胞生长因子FGF0.00004份；角质细胞生长因子KGF0.0006份；辣蓼1份；酵母提取物0.6份；余量为水,组分总量和为100；该生物活性因子的化妆水,对促进皮肤再生和创伤修复具有很好的效果,而且安全性、稳定性非常好。(The invention relates to a toning lotion containing bioactive factors, which comprises the following components in percentage by weight: 2 parts of sodium hyaluronate; 0.1 part of methylparaben; 3 parts of glycerol; 4 parts of butanediol; 0.0003 part of human epidermal growth factor hEGFR; fibroblast growth factor FGF0.00004 weight portions; 0.0006 part of keratinocyte growth factor KGF; 1 part of polygonum hydropiper; 0.6 part of yeast extract; the balance of water, the total amount of the components is 100; the lotion containing the bioactive factor has good effects of promoting skin regeneration and wound repair, and has good safety and stability.)

1. The toning lotion containing the bioactive factors is characterized by comprising the following components in parts by weight:

2 parts of sodium hyaluronate;

0.1 part of methylparaben;

3 parts of glycerol;

4 parts of butanediol;

0.0003 part of human epidermal growth factor hEGF;

fibroblast growth factor FGF0.00004 weight portions;

0.0006 part of keratinocyte growth factor KGF;

1 part of polygonum hydropiper;

0.6 part of yeast extract;

the balance of water,

the sum of the total amount of the components is 100.

2. The toner containing a bioactive factor as claimed in claim 1, wherein: the yeast extract can be replaced by one of purslane extract and witch hazel extract.

3. The method for preparing a cosmetic lotion containing a bioactive factor as claimed in claim 1, comprising the steps of:

step 1, heating enough water to 80 ~ 85 ℃, adding enough sodium hyaluronate, methylparaben, glycerin and butanediol, fully stirring and dissolving, and cooling to below 35 ℃ to obtain a solution A;

step 2, adding sufficient amounts of human epidermal growth factor hEGF, fibroblast growth factor FGF, keratinocyte growth factor KGF, yeast extract and polygonum hydropiper extract into water, and dissolving at the temperature of below 35 ℃ to obtain solution B;

and 3, fully and uniformly stirring the solution A obtained in the step 1 and the solution B obtained in the step 2 to obtain the toning lotion.

Technical Field

The invention belongs to the technical field of biological cosmetology, and particularly relates to toning lotion containing bioactive factors and a preparation method thereof.

Background

With the development of the biological genetic engineering technology, the aspects of biological science are influenced, and a brand new development opportunity is brought to the cosmetic industry. The beauty cosmetics are developed from traditional chemical beauty and plant beauty to biological beauty and gene beauty. The activity of bioactive factors in the skin varies with its ability to pass through the skin barrier and is closely related to the condition of the skin and the conditions of contact, such as the size of the contact area, the time, etc. Some modern formulators apply bioactive factors to the field of personal care products by using a pharmaceutical carrier system, a sustained release concept and an embedding technology so as to enhance the efficacy of the product, improve the stability of the product, prolong the shelf life and improve the appearance of the product. A plurality of ultramicrocarrier technologies capable of controlling the local release of active ingredients, such as microemulsion, microcapsules, liposomes, nano-energy drags, transfersomes, glucose microspheres and the like, are applied to the production of cosmetics, so that the cosmetics are endowed with excellent performance, and the traditional cosmetic industry is revolutionized. However, these processes are complex, and the safety and stability of the technology and the product are to be further improved and verified.

Disclosure of Invention

The invention aims to overcome the defects of insufficient safety and stability of the existing toning lotion containing biological active factors.

Therefore, the invention provides the toning lotion containing the bioactive factors, which comprises the following components in percentage by weight:

2 parts of sodium hyaluronate;

0.1 part of methylparaben;

3 parts of glycerol;

4 parts of butanediol;

0.0003 part of human epidermal growth factor hEGF;

fibroblast growth factor FGF0.00004 weight portions;

0.0006 part of keratinocyte growth factor KGF;

1 part of polygonum hydropiper;

0.6 part of yeast extract;

the balance of water,

the sum of the total amount of the components is 100.

The yeast extract can be replaced by one of purslane extract and witch hazel extract.

The preparation method of the toning lotion containing the bioactive factors comprises the following steps:

step 1, heating enough water to 80 ~ 85 ℃, adding enough sodium hyaluronate, methylparaben, glycerin and butanediol, fully stirring and dissolving, and cooling to below 35 ℃ to obtain a solution A;

step 2, adding sufficient amounts of human epidermal growth factor hEGF, fibroblast growth factor FGF, keratinocyte growth factor KGF, yeast extract and polygonum hydropiper extract into water, and dissolving at the temperature of below 35 ℃ to obtain solution B;

and 3, fully and uniformly stirring the solution A obtained in the step 1 and the solution B obtained in the step 2 to obtain the toning lotion.

The invention has the beneficial effects that: the toning lotion containing the bioactive factor provided by the invention has good effects of promoting skin regeneration and wound repair, and has very good safety and stability. Specifically, human epidermal growth factor EGF plays an important role in regulating growth, differentiation and proliferation of epidermal and epithelial cells, promoting growth of capillary vessels, improving growth microenvironment of cells, maintaining cell activity and the like. The EGF in a trace amount can strongly promote the division and growth of skin cells, so that the effects of promoting the metabolism of human skin, repairing skin injury, slowing down skin aging are achieved, even the mature epidermal cells are regulated and reversely differentiated into skin stem cells, the stem cells are induced to be rapidly and directionally differentiated into new skin cells, and the elasticity and the luster of the skin are restored again; FGF can promote the growth of fibroblasts, improve the collagen synthesis capability of skin and essentially improve the skin condition; the efficacy is mainly expressed in repairing damage, removing wrinkles, whitening, removing freckles, preventing acnes and the like; KGF plays an important role in tissue repair, including stimulation of DNA synthesis, promotion of the maintenance of proliferation, migration, differentiation, survival of human keratinocytes, epidermal cells and epithelial cells, and the like; KGF has obvious ultraviolet radiation resisting and wrinkle eliminating effects; the yeast extract has the functions of whitening, moisturizing, removing wrinkles and delaying skin aging; in addition, the compound bioactive factor also plays a role in protecting the bioactivity of the compound bioactive factor in conventional cosmetics; the herba Polygoni Hydropiperis extract can improve skin tolerance, relieve skin swelling, and eliminate skin swelling.

Drawings

Fig. 1 is a schematic flow chart of a preparation method of a lotion containing bioactive factors according to the technical scheme of the invention.

Detailed Description

To further explain the technical means and effects of the present invention adopted to achieve the intended purpose, the following detailed description of the embodiments, structural features and effects of the present invention will be made with reference to the accompanying drawings and examples.

Comparative example:

for convenience, the lotion of the control example was referred to as a B formulation.

Preparation of formula B:

2 parts of sodium hyaluronate, 0.1 part of methyl hydroxybenzoate, 3 parts of glycerol, 4 parts of butanediol and 40 parts of water are fully stirred and dissolved at the temperature of 80 ~ 85 ℃, and the solution is cooled to the temperature below 35 ℃ for later use;

the weight portion of the material is as follows: dissolving 0.0003 parts of human epidermal growth factor hEGF, 0.00004 parts of fibroblast growth factor FGF, 0.0006 parts of keratinocyte growth factor KGF and 1 part of polygonum hydropiper extract in water at a temperature below 35 ℃. And fully stirring and uniformly mixing the aqueous solutions of the two components to obtain the toning lotion of the formula B. The sodium hyaluronate with high molecular weight can form a layer of breathable protective film on the surface of skin, generate good lubricating feeling and moistening feeling, and can organize the water inside the skin to evaporate so as to maintain the luster and the fineness of the skin; methylparaben is effective in controlling the growth of bacteria, mold and yeast in most types of personal care products; the chemical name of glycerin is glycerol, which has strong water absorption and is generally used as a humectant; butanediol is often used as a humectant and a solvent in cosmetics, and also has a certain bacteriostatic action.