阅读说明：本技术 一种小金片的制备方法 (Preparation method of Xiaojin tablets ) 是由 刘超 胡彬 殷树荣 喻贵英 张红霞 于 2019-09-25 设计创作，主要内容包括：本发明公开了一种小金片的制备方法,准备原料人工麝香、木鳖子份、制草乌、枫香脂、醋乳香、醋没药、五灵脂、酒当归、地龙、香墨；将枫香脂干燥后冷藏,再将冷藏后的枫香脂粉碎并过筛得到枫香脂粉；将制草乌、醋乳香、醋没药、酒当归、地龙、香墨六味原料粉碎成细粉；将木鳖子粉碎成粗粉,制成木鳖子浸膏；将五灵脂制成五灵脂浸膏；将木鳖子浸膏和五灵脂浸膏合并浓缩成混合浸膏并与制草乌等六味原料的细粉混匀,干燥粉碎成浸膏粉,备用；将枫香脂粉与浸膏粉粉碎成细粉；制粒和压片。本发明一种小金片的制备方法,不仅可以提高生产效率,极大的降低药粉损失,避免药物污染,而且提高了药物内在质量,使生产稳定可靠。(The invention discloses a preparation method of small golden tablets, which comprises the steps of preparing raw materials of artificial musk, semen momordicae parts, prepared kusnezoff monkshood root, sweetgum resin, vinegar frankincense, vinegar myrrh, trogopterus dung, wine angelica, earthworm and Chinese ink; drying and refrigerating the liquidambar formosana fat, crushing the refrigerated liquidambar formosana fat and sieving to obtain liquidambar formosana fat powder; pulverizing radix Aconiti Kusnezoffii Preparata, Olibanum, Myrrha, radix Angelicae sinensis, Lumbricus, and Chinese ink into fine powder; pulverizing semen Momordicae into coarse powder, and making into semen Momordicae extract; preparing Oletum Trogopterori into Oletum Trogopterori extract; mixing semen Momordicae extract and Oletum Trogopterori extract, concentrating into mixed extract, mixing with fine powder of radix Aconiti Kusnezoffii Preparata, drying, and pulverizing into extract powder; pulverizing resina Liquidambaris powder and the extract powder into fine powder; granulating and tabletting. The preparation method of the small gold tablets can improve the production efficiency, greatly reduce the loss of the powder, avoid the pollution of the medicine, improve the internal quality of the medicine and ensure stable and reliable production.)

1. The preparation method of the small gold tablets is characterized by comprising the following steps:

a. preparing materials: preparing 2-3 parts of artificial musk, 12-13 parts of semen momordicae, 12-13 parts of prepared kusnezoff monkshood root, 12-13 parts of resina liquidambaris, 6-7 parts of vinegar frankincense, 6-7 parts of vinegar myrrh, 12-13 parts of trogopterus dung, 6-7 parts of wine angelica, 12-13 parts of earthworm and 0.5-1.5 parts of fragrant ink according to parts by weight;

b. processing the sweetgum resin: drying the liquidambar formosana resin in a hot air circulating oven, setting the drying temperature to be 70-90 ℃, drying for 30-40 hours, and refrigerating for more than 15 hours at the temperature of 2-8 ℃; then crushing the refrigerated sweetgum resin and sieving the crushed sweetgum resin with a 40-mesh sieve to obtain sweetgum resin powder for later use;

c. treatment of other raw materials: pulverizing radix Aconiti Kusnezoffii Preparata, Olibanum, Myrrha, radix Angelicae sinensis, Lumbricus, and Chinese ink into fine powder; pulverizing semen Momordicae into coarse powder, and making into semen Momordicae extract; preparing Oletum Trogopterori into Oletum Trogopterori extract;

d. preparing extract powder: c, mixing the momordica cochinchinensis extract and the trogopterus dung extract, and concentrating into a mixed extract; c, mixing the fine powder of the six raw materials of the processed kusnezoff monkshood root, the vinegar frankincense, the vinegar myrrh, the wine angelica, the earthworm and the xiangmo prepared in the step c with the mixed extract, drying and crushing into extract powder for later use;

e. preparing qualified medicinal powder: b, crushing the liquidambar formosana fat powder prepared in the step b and the extract powder prepared in the step d into fine powder by a series grinding method, and then uniformly mixing to prepare qualified medicinal powder for later use;

f. and (3) granulating and tabletting: and e, granulating the qualified medicinal powder obtained in the step e by using an adhesive, adding artificial musk into the granulated medicinal powder, adding magnesium stearate and talcum powder into the artificial musk, uniformly mixing the mixture, and tabletting to obtain a finished product.

2. The method for preparing small gold pieces according to claim 1, wherein: the relative density of the cochinchina momordica seed extract and the trogopterus dung extract is 1.06-1.10, and the concentration temperature is 50 ℃.

3. The method for preparing small gold pieces according to claim 2, characterized in that: the preparation method of the momordica cochinchinensis seed extract comprises the following steps: pulverizing semen Momordicae into coarse powder, soaking in 70% ethanol for 48 hr, slowly percolating, recovering ethanol from percolate, and concentrating to obtain semen Momordicae extract.

4. The method for preparing small gold pieces according to claim 2, characterized in that: the preparation method of the trogopterus dung extract comprises the following steps: decocting Oletum Trogopterori in water for three times, each for 1 hr, filtering, mixing filtrates, and concentrating to obtain Oletum Trogopterori extract.

5. The method for preparing small gold pieces according to claim 1, wherein: and f, concentrating the mixed extract at a relative density of 1.20-1.25 and a concentration temperature of 50 ℃.

6. The method for preparing small gold pieces according to claim 1, wherein: the binder of step g is a starch paste.

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a Xiaojin tablet.

Background

Chinese pharmacopoeia 2015 year edition records: the Xiaojin tablets have the effects of resolving masses, relieving swelling, removing blood stasis and relieving pain. Can be used for treating carbuncle of yin type, unchanged skin color, swelling, hardness, pain, multiple abscess, goiter, scrofula, mammary rock, and nodules of breast. The resina Liquidambaris, the frankincense and the myrrh in the seven crushed medicines belong to resin medicinal materials, the resina Liquidambaris also contains volatile components, and the total resin components account for 41.8 percent of the solid matters in the prescription. Because the rubbing crusher can produce heat in the operation, and resin medicinal material is heated slightly and easily softens and forms the colloid form, smashes the difficulty, needs frequent clearance to change the sieve among the crushing process, and needs the intermittent type to wait for equipment to smash after cold again, so lead to low in production efficiency, powder loss is big, increases the risk of medicine pollution. The pulverized crude drug powder and the extract are dried and pulverized again, the same situation occurs, and volatile components are easy to dissipate after being heated for one time, and the curative effect of the medicine is reduced.

Disclosure of Invention

In order to solve the technical problems, the invention aims to provide a preparation method of small gold tablets, which can improve the production efficiency, greatly reduce the loss of medicinal powder, avoid the pollution of medicaments, improve the inherent quality of the medicaments and ensure stable and reliable production.

The purpose of the invention is realized as follows:

the preparation method of the small gold tablets is characterized by comprising the following steps:

a. preparing materials: preparing 2-3 parts of artificial musk, 12-13 parts of semen momordicae, 12-13 parts of prepared kusnezoff monkshood root, 12-13 parts of resina liquidambaris, 6-7 parts of vinegar frankincense, 6-7 parts of vinegar myrrh, 12-13 parts of trogopterus dung, 6-7 parts of wine angelica, 12-13 parts of earthworm and 0.5-1.5 parts of fragrant ink according to parts by weight; wherein the vinegar processed Olibanum and vinegar processed Myrrha are prepared by vinegar processing method.

b. Processing the sweetgum resin: drying the liquidambar formosana resin in a hot air circulating oven, setting the drying temperature to be 70-90 ℃, drying for 30-40 hours, and refrigerating for more than 15 hours at the temperature of 2-8 ℃; and then crushing the refrigerated sweetgum resin and sieving the crushed sweetgum resin with a 40-mesh sieve to obtain the sweetgum resin powder for later use.

The method for mixing and crushing the original liquidambar formosana and other medicinal materials has the advantages that the amount of the liquidambar formosana, the frankincense and the myrrh resin medicinal materials is large, the liquidambar formosana, the frankincense and the myrrh resin medicinal materials are softened by heating in the crushing process to form a colloid, the crushing is difficult, a sieve needs to be frequently cleaned and replaced in the crushing process, and the intermittent waiting for the equipment to be cooled and then crushed is needed, so that the production efficiency is. By adopting the method, the liquidambar formosana linn is refrigerated and then crushed to obtain fine powder, and then the fine powder is mixed with other raw material powder, so that the problems of colloid formation and difficult crushing caused by heating and softening in the crushing process can be effectively solved, the yield of the medicine powder is increased from the original 77.6% to 95.8%, the qualified rate of the medicine powder is increased from the original 73% to 100%, and the whole process time is 1/4 of the original process.

c. Treatment of other raw materials: pulverizing radix Aconiti Kusnezoffii Preparata, Olibanum, Myrrha, radix Angelicae sinensis, Lumbricus, and Chinese ink into fine powder; pulverizing semen Momordicae into coarse powder, and making into semen Momordicae extract; making Oletum Trogopterori into Oletum Trogopterori extract.

d. Preparing extract powder: c, mixing the momordica cochinchinensis extract and the trogopterus dung extract, and concentrating into a mixed extract; and c, mixing the fine powder of the six raw materials of the processed kusnezoff monkshood root, the vinegar frankincense, the vinegar myrrh, the wine angelica, the earthworm and the xiangmo prepared in the step c with the mixed extract uniformly, drying and crushing into extract powder for later use.

e. Preparing qualified medicinal powder: and d, crushing the liquidambar formosana fat powder prepared in the step b and the extract powder prepared in the step d into fine powder by a series grinding method, and then uniformly mixing to prepare qualified medicinal powder for later use.

f. And (3) granulating and tabletting: and e, granulating the qualified medicinal powder obtained in the step e by using an adhesive, adding artificial musk into the granulated medicinal powder, adding magnesium stearate and talcum powder into the artificial musk, uniformly mixing the mixture, and tabletting to obtain a finished product.

Preferably, the relative density of the momordica cochinchinensis extract and the trogopterus dung extract is 1.06-1.10, and the concentration temperature is 50 ℃.

Preferably, the preparation method of the momordica cochinchinensis seed extract comprises the following steps: pulverizing semen Momordicae into coarse powder, soaking in 70% ethanol for 48 hr, slowly percolating, recovering ethanol from percolate, and concentrating to obtain semen Momordicae extract.

Preferably, the preparation method of the trogopterus dung extract comprises the following steps: decocting Oletum Trogopterori in water for three times, each for 1 hr, filtering, mixing filtrates, and concentrating to obtain Oletum Trogopterori extract.

Preferably, the relative density of the mixed extract in the step f is 1.20-1.25, and the concentration temperature is 50 ℃.

Preferably, said binder of step g above is a starch paste.

Has the advantages that:

the invention adopts the liquidambar formosana fat crushing and mixing integrated technology to replace the original liquidambar formosana fat and other medicinal materials mixing and crushing method, avoids the problems of colloid formation, difficult crushing and the like caused by the large amount of the liquidambar formosana fat, the frankincense and the myrrh resin medicinal materials in the crushing process due to heating softening, does not need to frequently clean and replace a sieve in the crushing process, has no loss of medicinal powder, and ensures that the yield of the medicinal powder is increased to 95.8 percent from the original 77.6 percent; the risk of pollution of the medicinal powder is reduced, and the qualified rate of the medicinal powder is increased from 73 percent to 100 percent; the intermittent cooling and then crushing of the equipment are not needed, the production is smoother and more stable, the production efficiency is improved, and the process time is shortened to 1/4 of the original process; also avoids the secondary heating of the liquidambar formosana fat, improves the internal quality of the medicine and ensures stable and reliable production.

Detailed Description

The present invention will be further described with reference to the following examples.