阅读说明：本技术 一种治疗慢心衰的组合物及制备方法 (Composition for treating chronic heart failure and preparation method thereof ) 是由 戚春直 杨书楼 于 2019-10-18 设计创作，主要内容包括：本发明公开了一种治疗慢心衰的组合物及制备方法,所述组合物由如下重量份数的原料药组成：水蛭、人参、益母草、丹参、制附子、三七、红花、黄芪和当归；所述制备方法包括步骤：将所述组合物的各原料药混合后制成汤剂、丸剂、散剂、胶囊剂或片剂。本发明通过制成片、散、丸、胶囊等剂型对冠心病心肌缺血、肺心病、心动过缓病窦综合征、心功能减退、心力衰竭等具有较好的治疗作用,同时具有降脂降粘、降低血小板聚集、扩展血管、改善血流阻力、改善微循环、缩小心肌梗死范围、减少心肌坏死、加强心急收缩幅度、促进心功能恢复等作用。(The invention discloses a composition for treating chronic heart failure and a preparation method thereof, wherein the composition is prepared from the following raw material medicines in parts by weight: hirudo, radix Ginseng, herba Leonuri, radix Salviae Miltiorrhizae, radix Aconiti lateralis Preparata, radix Notoginseng, flos Carthami, radix astragali, and radix Angelicae sinensis; the preparation method comprises the following steps: the raw materials of the composition are mixed and then prepared into decoction, pills, powder, capsules or tablets. The invention has better treatment effect on coronary heart disease, myocardial ischemia, pulmonary heart disease, bradycardia sinus syndrome, cardiac hypofunction, heart failure and the like by preparing into tablets, powder, pills, capsules and other dosage forms, and simultaneously has the effects of reducing fat and viscosity, reducing platelet aggregation, expanding blood vessels, improving blood flow resistance, improving microcirculation, reducing myocardial infarction range, reducing myocardial necrosis, strengthening cardiac contraction amplitude, promoting cardiac function recovery and the like.)

1. A composition for treating chronic heart failure, comprising: the traditional Chinese medicine composition is composed of the following raw material medicines in parts by weight: leech, ginseng, motherwort, salvia miltiorrhiza, prepared aconite, pseudo-ginseng, safflower, astragalus and angelica.

2. The composition for treating chronic heart failure according to claim 1, wherein: the traditional Chinese medicine composition is composed of the following raw material medicines in parts by weight: 1-3 parts of leech, 7-12 parts of ginseng, 10-15 parts of motherwort, 10-15 parts of salvia miltiorrhiza, 2-5 parts of prepared monkshood, 5-10 parts of pseudo-ginseng, 2-5 parts of safflower, 10-15 parts of astragalus and 10-15 parts of angelica.

3. The composition for treating chronic heart failure according to claim 1, wherein: the traditional Chinese medicine composition is composed of the following raw material medicines in parts by weight: 1.4 parts of leech, 8.3 parts of ginseng, 12.4 parts of motherwort, 12.4 parts of salvia miltiorrhiza, 4.1 parts of prepared monkshood, 8.3 parts of pseudo-ginseng, 4.1 parts of safflower, 12.4 parts of astragalus and 12.4 parts of angelica.

4. The composition for treating chronic heart failure according to claim 1, wherein: the traditional Chinese medicine composition is composed of the following raw material medicines in parts by weight: 1 part of leech, 7 parts of ginseng, 10 parts of motherwort, 10 parts of salvia miltiorrhiza, 2 parts of prepared monkshood, 5 parts of pseudo-ginseng, 2 parts of safflower, 10 parts of astragalus and 10 parts of angelica.

5. The composition for treating chronic heart failure according to claim 1, wherein: the traditional Chinese medicine composition is composed of the following raw material medicines in parts by weight: 3 parts of leech, 12 parts of ginseng, 15 parts of motherwort, 15 parts of salvia miltiorrhiza, 5 parts of prepared monkshood, 10 parts of pseudo-ginseng, 5 parts of safflower, 15 parts of astragalus and 15 parts of angelica.

6. The composition for treating chronic heart failure according to claim 1, wherein: the traditional Chinese medicine composition is composed of the following raw material medicines in parts by weight: 2 parts of leech, 8 parts of ginseng, 11 parts of motherwort, 11 parts of salvia miltiorrhiza, 4 parts of prepared monkshood, 6 parts of pseudo-ginseng, 4 parts of safflower, 12 parts of astragalus and 13 parts of angelica.

7. The composition for treating chronic heart failure according to claim 1, wherein: the traditional Chinese medicine composition is composed of the following raw material medicines in parts by weight: 2 parts of leech, 9 parts of ginseng, 12 parts of motherwort, 12 parts of salvia miltiorrhiza, 3 parts of prepared monkshood, 6 parts of pseudo-ginseng, 3 parts of safflower, 14 parts of astragalus and 13 parts of angelica.

8. A method for preparing a composition for the treatment of chronic heart failure according to any one of claims 1 to 7, comprising the steps of: the raw materials of the composition are mixed and then prepared into decoction, pills, powder, capsules or tablets.

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for treating chronic heart failure and a preparation method thereof.

Background

Chronic heart failure, i.e. chronic heart failure, is the result of myocardial damage caused by myocardial infarction, cardiomyopathy, hemodynamic overload, inflammation and other causes, resulting in structural and functional changes of the myocardium, and finally, poor ventricular pumping or filling function. The clinical manifestations are dyspnea, weakness and fluid retention. Chronic Heart Failure (CHF) refers to a persistent state of heart failure that can stabilize, worsen, or decompensate. The goal of treating heart failure is not only to improve symptoms and improve quality of life, but also to delay and prevent the development of myocardial remodeling and reduce the hospitalization rate and mortality rate of heart failure, depending on the mechanism of myocardial remodeling.

Most patients have a history of heart disease, and treatment for the cause of disease will significantly improve the prognosis of heart failure. Coronary heart disease, hypertension and senile degenerative heart valve disease are the main causes of senile heart failure patients; rheumatic heart valve disease, dilated cardiomyopathy, acute severe myocarditis and other diseases are the main causes of heart failure of young people. The common cause of the contractile heart failure is coronary heart disease, and the development and the deterioration of the heart failure can be prevented by actively reconstructing blood circulation; the common diseases of diastolic heart failure (or normal ejection fraction) are caused by hypertension, which is very important for controlling blood pressure, otherwise, the heart failure progresses rapidly and can also induce acute heart failure.

Most heart failure patients seek medical advice due to reduced exercise endurance, with dyspnea or fatigue that can occur at rest or during exercise. There may be a variety of diseases in the same patient, and therefore, it is difficult to say the exact cause of impaired exercise tolerance. Patients may develop abdominal or leg edema and seek medical advice with this as the first or only symptom, and impaired exercise tolerance is gradual and may not be noticed by the patient unless changes in daily living capacity are carefully asked; patients may find a cardiac enlargement or a manifestation of cardiac insufficiency when examining other diseases, such as acute myocardial infarction, arrhythmia, or pulmonary or somatic thromboembolic diseases.

At present, no good traditional Chinese medicine composition exists for chronic heart failure.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a composition for treating chronic heart failure and a preparation method thereof.

The technical scheme adopted by the invention is as follows:

the composition for treating chronic heart failure comprises the following raw material medicines in parts by weight: leech, ginseng, motherwort, salvia miltiorrhiza, prepared aconite, pseudo-ginseng, safflower, astragalus and angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 1-3 parts of leech, 7-12 parts of ginseng, 10-15 parts of motherwort, 10-15 parts of salvia miltiorrhiza, 2-5 parts of prepared monkshood, 5-10 parts of pseudo-ginseng, 2-5 parts of safflower, 10-15 parts of astragalus and 10-15 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 1.4 parts of leech, 8.3 parts of ginseng, 12.4 parts of motherwort, 12.4 parts of salvia miltiorrhiza, 4.1 parts of prepared monkshood, 8.3 parts of pseudo-ginseng, 4.1 parts of safflower, 12.4 parts of astragalus and 12.4 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 1 part of leech, 7 parts of ginseng, 10 parts of motherwort, 10 parts of salvia miltiorrhiza, 2 parts of prepared monkshood, 5 parts of pseudo-ginseng, 2 parts of safflower, 10 parts of astragalus and 10 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 3 parts of leech, 12 parts of ginseng, 15 parts of motherwort, 15 parts of salvia miltiorrhiza, 5 parts of prepared monkshood, 10 parts of pseudo-ginseng, 5 parts of safflower, 15 parts of astragalus and 15 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 2 parts of leech, 8 parts of ginseng, 11 parts of motherwort, 11 parts of salvia miltiorrhiza, 4 parts of prepared monkshood, 6 parts of pseudo-ginseng, 4 parts of safflower, 12 parts of astragalus and 13 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 2 parts of leech, 9 parts of ginseng, 12 parts of motherwort, 12 parts of salvia miltiorrhiza, 3 parts of prepared monkshood, 6 parts of pseudo-ginseng, 3 parts of safflower, 14 parts of astragalus and 13 parts of angelica.

A method for preparing a composition for treating chronic heart failure, comprising the steps of: the raw materials of the composition are mixed and then prepared into decoction, pills, powder, capsules or tablets.

The invention has the beneficial effects that: the composition for treating chronic heart failure and the preparation method thereof have the effects of tonifying qi and blood, strengthening heart yang qi, activating blood and dredging collaterals through leech, ginseng, motherwort herb, salvia miltiorrhiza, prepared monkshood, pseudo-ginseng, safflower, astragalus and angelica, have better treatment effects on coronary heart disease myocardial ischemia, pulmonary heart disease, bradycardia sinus syndrome, cardiac hypofunction, heart failure and the like, and have the effects of reducing fat and viscosity, reducing platelet aggregation, expanding blood vessels, improving blood flow resistance, improving microcirculation, reducing myocardial infarction range, reducing myocardial necrosis, strengthening cardiac contraction amplitude, promoting cardiac function recovery and the like.

Detailed Description

The present invention is further illustrated below with reference to specific examples.

The composition for treating chronic heart failure comprises the following raw material medicines in parts by weight: leech, ginseng, motherwort, salvia miltiorrhiza, prepared aconite, pseudo-ginseng, safflower, astragalus and angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 1-3 parts of leech, 7-12 parts of ginseng, 10-15 parts of motherwort, 10-15 parts of salvia miltiorrhiza, 2-5 parts of prepared monkshood, 5-10 parts of pseudo-ginseng, 2-5 parts of safflower, 10-15 parts of astragalus and 10-15 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 1.4 parts of leech, 8.3 parts of ginseng, 12.4 parts of motherwort, 12.4 parts of salvia miltiorrhiza, 4.1 parts of prepared monkshood, 8.3 parts of pseudo-ginseng, 4.1 parts of safflower, 12.4 parts of astragalus and 12.4 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 1 part of leech, 7 parts of ginseng, 10 parts of motherwort, 10 parts of salvia miltiorrhiza, 2 parts of prepared monkshood, 5 parts of pseudo-ginseng, 2 parts of safflower, 10 parts of astragalus and 10 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 3 parts of leech, 12 parts of ginseng, 15 parts of motherwort, 15 parts of salvia miltiorrhiza, 5 parts of prepared monkshood, 10 parts of pseudo-ginseng, 5 parts of safflower, 15 parts of astragalus and 15 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 2 parts of leech, 8 parts of ginseng, 11 parts of motherwort, 11 parts of salvia miltiorrhiza, 4 parts of prepared monkshood, 6 parts of pseudo-ginseng, 4 parts of safflower, 12 parts of astragalus and 13 parts of angelica.

Further, the composition is prepared from the following raw material medicines in parts by weight: 2 parts of leech, 9 parts of ginseng, 12 parts of motherwort, 12 parts of salvia miltiorrhiza, 3 parts of prepared monkshood, 6 parts of pseudo-ginseng, 3 parts of safflower, 14 parts of astragalus and 13 parts of angelica.

A method for preparing a composition for treating chronic heart failure, comprising the steps of: the raw materials of the composition are mixed and then prepared into decoction, pills, powder, capsules or tablets.

A Chinese medicinal composition

The composition for treating chronic heart failure comprises the following raw material medicines in parts by weight: leech, ginseng, motherwort, salvia miltiorrhiza, prepared aconite, pseudo-ginseng, safflower, astragalus and angelica.

Further, the optimized composition is as follows:

the composition for treating chronic heart failure comprises the following raw material medicines in parts by weight: 1-3 parts of leech, 7-12 parts of ginseng, 10-15 parts of motherwort, 10-15 parts of salvia miltiorrhiza, 2-5 parts of prepared monkshood, 5-10 parts of pseudo-ginseng, 2-5 parts of safflower, 10-15 parts of astragalus and 10-15 parts of angelica.

Further, preferably, the composition is as follows:

the composition for treating chronic heart failure comprises the following raw material medicines in parts by weight: 1.4 parts of leech, 8.3 parts of ginseng, 12.4 parts of motherwort, 12.4 parts of salvia miltiorrhiza, 4.1 parts of prepared monkshood, 8.3 parts of pseudo-ginseng, 4.1 parts of safflower, 12.4 parts of astragalus and 12.4 parts of angelica.

Second, preparation method

The raw materials of the composition are mixed and then prepared into decoction, pills, powder, capsules or tablets.

Three, functional indications

Is suitable for treating coronary heart disease, myocardial ischemia, cor pulmonale, bradycardia, sinus syndrome, cardiac hypofunction, heart failure, etc.; has effects in reducing blood lipid, lowering blood viscosity, reducing platelet aggregation, expanding blood vessel, improving blood flow resistance, improving microcirculation, reducing myocardial infarction range, reducing myocardial necrosis, enhancing cardiac contraction amplitude, and promoting cardiac function recovery.

Fourth, clinical conditions

Through clinical treatment for more than ten years, 630 patients are treated, wherein 520 patients are cured, 95 patients are improved, 15 patients are treated by combining western medicines, and the effective rate is over 95%.