阅读说明：本技术 一种干血斑卡片全自动打孔仪及其操作方法 (Full-automatic punching instrument for dry blood spot card and operation method thereof ) 是由 许明 邓永锦 宋庆章 丁强华 顾融 于 2019-10-14 设计创作，主要内容包括：本发明公开了一种干血斑卡片全自动打孔仪及其操作方法,包括搬运杆、未打孔干血斑卡片放置载架、第一机械臂、干血斑质量检测装置、干血斑卡片转移托盘、喷码仪、电器柜、第一和第二机械臂X运动导轨、第二机械臂、第一和第二机械臂X运动电机、定标卡和质控卡放置装置、机器开关、完成打孔或采血不良的干血斑卡片放置载架和打孔机。本发明所述的用于干血斑卡片打孔的全自动打孔仪实现大通量全自动打孔方案,并且具有干血斑卡片采血质量检测和对干血斑卡片自动编码功能,节省了人力成本,避免了人为失误。(The invention discloses a full-automatic perforating instrument for dry blood spot cards and an operating method thereof. The full-automatic punching instrument for punching the dry blood spot card realizes a large-flux full-automatic punching scheme, has the functions of detecting the blood sampling quality of the dry blood spot card and automatically encoding the dry blood spot card, saves the labor cost and avoids human errors.)

1. A full-automatic punching instrument for dry blood spot cards is characterized by comprising an un-punched dry blood spot card placing carrier (2), a first mechanical arm (3), a dry blood spot quality detection device (4), a dry blood spot card transferring tray (5), a code spraying instrument (6), a second mechanical arm (9), a dry blood spot card placing carrier (13) for completing punching or poor blood sampling and a punching machine (14); wherein the content of the first and second substances,

the first mechanical arm (3) and the second mechanical arm (9) are respectively and movably fixed on two sides of the frame of the perforating machine and are positioned above the non-perforating dried blood spot card placing carrier (2) and a dried blood spot card placing carrier (13) which completes perforation or poor blood collection, and the first mechanical arm (3) and the second mechanical arm (9) both comprise a trichosanthes X, Y, Z shaft motion system;

the dried blood spot card transfer tray (5) is positioned above the inner sides of an un-punched dried blood spot card placing carrier (2) and a dried blood spot card placing carrier (13) which completes punching or poor blood sampling, the blood spot quality detection device (4) and the code spraying instrument (6) are sequentially distributed along the dried blood spot card transfer tray (5), and the un-punched dried blood spot card placing carrier (2) and the dried blood spot card placing carrier (13) which completes punching or poor blood sampling are respectively fixed on the two front side surfaces of the puncher frame;

the punch (14) is arranged between the non-punched dried blood spot card placing carrier (2) and the dried blood spot card placing carrier (13) which completes punching or is poor in blood sampling.

2. The full-automatic dried blood spot card puncher according to claim 1, wherein the unpunched dried blood spot card placing carrier (2) comprises a carrier tray (201), a blood spot card placing rack (202), a right adjusting plate (203), a carrier bottom plate (204) and a front adjusting plate (205); the right adjusting plate (202), the carrier bottom plate (204) and the front adjusting plate (205) are arranged on the blood spot card placing rack; a dried blood spot card is placed in a position defined by the carriage floor (204), right adjustment plate (203), and front adjustment plate (205); the non-punched dried blood spot card placement carrier (2) is fixed to the punch instrument frame by a carrier tray (201).

3. The full-automatic perforating machine for dry blood spot cards according to claim 2, characterized in that the unpunched dry blood spot card placing carrier (2) comprises 4 blood spot card placing racks (202), and the number of placed dry blood spot cards can reach 400.

4. The full-automatic perforating instrument for the dried blood spot cards as claimed in claim 1, characterized in that the first mechanical arm (3) and the second mechanical arm (9) both comprise a sucker and a sucker mounting plate, and the sucker is fixed at the bottom of the mechanical arm through the sucker mounting plate; the first mechanical arm (3) and the second mechanical arm (9) respectively comprise an X motion guide rail and an X motion motor thereof, a Y motion slide rail and a Y motion motor thereof, and a Z motion system.

5. The full-automatic perforating instrument for the dry blood spot card according to claim 1, characterized in that the perforating instrument further comprises a carrying rod (1), an electric appliance cabinet (7), a machine switch (12); the carrying rods (1) are fixedly arranged at four end corners of the bottom of the perforating instrument frame; the electric appliance cabinet (7) is mounted to the rear side of the perforating instrument frame; the machine switch (12) is electrically connected with the electric appliance cabinet (7) and is mounted to the side surface of the punching instrument frame.

6. The full-automatic perforating instrument for the dried blood spot card according to claim 1, characterized in that the dried blood spot quality detection device (4) comprises a lower camera shell (401), an upper camera shell (402), and an upper camera and a lower camera respectively positioned inside; the dried blood spot card transfer tray (5) transversely passes through the dried blood spot quality detection device (4) so that the upper camera and the lower camera take pictures of the blood spots on the front side and the back side of the dried blood spot card.

7. The full-automatic perforating instrument for the dry blood spot cards according to claim 1, characterized in that the dry blood spot card transfer tray (5) comprises a card tray (501) and card clamping claws (502), wherein the dry blood spot cards are fixed on the card tray (501) through the card clamping claws (502), and the card tray (501) is mounted on a tray moving base plate (504) through a tray guide rail mounting block (503); the card tray (501) slides along a tray guide (505) provided with a linear bearing (506).

8. The full-automatic perforating machine for dry blood spot cards according to claim 7, characterized by further comprising a calibration card and quality control card placing device (11) installed on one side of the tray moving base plate (504) far away from the dry blood spot quality detection device (4); the calibration card and quality control card placing device (11) comprises a calibration card positioning block (1101) and a calibration card baffle (1103), and a calibration card (1102) is placed in a position defined by the calibration card positioning block (1101) and the calibration card baffle (1103).

9. A dried blood spot detection device comprising the dried blood spot card full-automatic punching instrument according to any one of claims 1-8.

10. The operation method of the full-automatic dried blood spot card perforating machine according to any one of claims 1-8 is characterized by comprising the following steps:

a. the first mechanical arm (3) sucks the dry blood spot card from the non-punched dry blood spot placing carrier (2) through the negative pressure sucker (301) and transfers the dry blood spot card to the card tray (501), and the card tray (501) moves to the dry blood spot quality detection position (4) to perform quality detection on the dry blood spot;

b. the qualified dry blood spot cards detected are moved to a code spraying instrument (6) from a dry blood spot card transferring tray (5) to print codes on the dry blood spot cards, then the dry blood spot cards are moved to a preset position, a second mechanical arm (9) sucks the dry blood spot cards from the card tray (501) of the preset position through a negative pressure sucking disc, the dry blood spot cards are moved to a specified position of a punching machine (14) to be punched, and finally the dry blood spot cards which are punched are moved and placed on a dry blood spot card placing carrier (13) which is punched or badly sampled;

c. the dried blood spot card which is detected to be unqualified is directly moved to a preset position by the card tray (501), and the second mechanical arm (9) sucks up the dried blood spot card from the dried blood spot moving carrier at the preset position through the negative pressure sucking disc and moves to the dried blood spot card placing carrier (13) which is used for completing punching or badly sampling blood.

Technical Field

The invention relates to the field of perforating instruments, in particular to a full-automatic perforating instrument for dry blood spot cards and an operation method thereof.

Background

The dried blood spot is that a whole blood sample is collected on the card, and the dried blood spot has the advantages of small blood collection amount, quick and simple preparation, low biological risk, no need of a freezing chain device and a three-level packaging system in transportation, small storage space, convenient transportation, simple preservation condition and the like, thereby being an effective tool in the rare disease screening process. Meanwhile, the problems that biological samples of infants are difficult to collect, detection conditions do not exist in countries and regions with poor resources, blood samples are difficult to transport and the like are solved if a newborn card blood spot drying method is used for early diagnosis. The extraction technology is expected to be applied to screening and diagnosis of common diseases, and provides a simpler, efficient and accurate method for large-scale disease screening.

The mode that current dry blood spot punched is manual punching or semi-automatic punching, because dry blood spot is the concentrated experiment (general city only has a check point), the experimental volume is big, and manual work or semi-automatic punching are inefficient, and the experiment is arranged the board and is made mistakes easily moreover. Secondly, in the manual punching process or the semi-automatic punching process, manual detection is needed to judge whether the blood sampling quality of the dry blood spots is qualified. And thirdly, the dried blood spots are required to be stored in a concentrated mode (generally for 3-5 years) after the detection of the dried blood spots is finished, so that each dried blood spot is required to be coded in a laboratory, the follow-up query is facilitated, manual coding or semi-automatic coding is adopted at present, and time and labor are wasted.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provides a full-automatic punching instrument for a dry blood spot card and an operation method thereof.

The invention adopts the following technical scheme for solving the technical problems:

the invention provides a full-automatic perforating instrument for dry blood spot cards, which comprises an unpunched dry blood spot card placing carrier, a first mechanical arm, a dry blood spot quality detection device, a dry blood spot card transferring tray, a code spraying instrument, a second mechanical arm, a dry blood spot card placing carrier which completes perforation or poor blood sampling and a perforating machine. Wherein the content of the first and second substances,

the first mechanical arm and the second mechanical arm are respectively and movably fixed on two sides of the perforating instrument frame and are positioned above the non-perforating dried blood spot card placing carrier and the dried blood spot card placing carrier which completes perforation or poor blood collection, and the first mechanical arm and the second mechanical arm both comprise a trichosanthes X, Y, Z shaft motion system;

the dried blood spot card transfer tray is positioned above the inner sides of the dried blood spot card placing carrier which is not punched and the dried blood spot card placing carrier which is punched or badly blood-sampled, the blood spot quality detection device and the code spraying instrument are sequentially distributed along the dried blood spot card transfer tray, and the dried blood spot card placing carrier which is not punched and the dried blood spot card placing carrier which is punched or badly blood-sampled are respectively fixed on the left and right front side surfaces of the frame of the punching instrument;

the perforating machine is arranged between the non-perforating dry blood spot card placing carrier and the dry blood spot card placing carrier which completes perforation or has poor blood sampling.

Further, the non-punched dried blood spot card placing carrier comprises a carrier tray, a blood spot card placing frame, a right adjusting plate, a carrier bottom plate and a front adjusting plate; the right adjusting plate, the carrying frame bottom plate and the front adjusting plate are arranged on the blood spot card placing frame; the dried blood spot card is placed in a position defined by the carrier frame bottom plate, the right adjustment plate and the front adjustment plate; the unpunched dried blood spot card placement carrier is secured to the punch instrument frame by a carrier tray.

Further, the non-punched dried blood spot card placing carrier comprises 4 blood spot card placing racks, and the number of the placed dried blood spot cards can reach 400.

Further, the dried blood spot card placing carrier frame which is punched and has bad blood sampling is completed comprises 4 placing frames, wherein 3 dried blood spot cards which are punched are placed, and 1 dried blood spot card which has bad blood sampling is placed.

Further, the first mechanical arm and the second mechanical arm both comprise a sucker and a sucker mounting plate, and the sucker is fixed at the bottom of the mechanical arm through the sucker mounting plate; the first mechanical arm and the second mechanical arm respectively comprise an X-motion guide rail and an X-motion motor thereof, a Y-motion sliding rail and a Y-motion motor thereof, and a Z-motion system.

Furthermore, the punching instrument also comprises a carrying rod, an electric appliance cabinet and a machine switch. The carrying rods are fixedly arranged at four end corners of the bottom of the perforating instrument frame; the electric appliance cabinet is arranged on the rear side of the perforating instrument frame; the machine switch is electrically connected with the electric appliance cabinet and is installed on the side surface of the punching instrument frame.

Further, the dried blood spot quality detection device comprises a lower camera shell, an upper camera shell, and an upper camera and a lower camera which are respectively positioned in the lower camera shell and the upper camera. The dry blood spot card transfer tray passes through an upper phase machine and a lower phase machine of the dry blood spot quality detection device in a transverse mode to photograph the front and back blood spots of the dry blood spot card.

Furthermore, the dry blood spot card transfer tray comprises a card tray and a card clamping jaw, wherein the dry blood spot card is fixed on the card tray through the card clamping jaw, and the card tray is installed on the tray moving bottom plate through the tray guide rail installation block; the card tray slides along a tray guide provided with linear bearings.

Furthermore, the punching instrument also comprises a calibration card and a quality control card placing device which are arranged on one side of the tray moving bottom plate far away from the dried blood spot quality detection device; the calibration card and quality control card placing device comprises a calibration card positioning block and a calibration card baffle, and the calibration card is placed in the position limited by the calibration card positioning block and the calibration card baffle.

Further, the perforating machine is installed in a drawer type detachable mode, specifically, a bottom plate is arranged at the bottom of the perforating machine, guide rails are arranged on two sides of the bottom plate, and the bottom of the perforating machine body is installed on the perforating instrument through the guide rails.

The second aspect of the invention provides a dried blood spot sheet detection device comprising any one of the above-mentioned dried blood spot card fully-automatic punching instruments, wherein the detection device can comprise a conventional dried blood spot analysis device and the like.

The third aspect of the invention is to provide an operation method of the full-automatic punching instrument for the dried blood spot card.

Further, the specific operation is as follows:

a. the first mechanical arm sucks up the dry blood spot card from the non-punched dry blood spot placing position through the negative pressure sucker and transfers the dry blood spot card to the card tray, and the card tray moves to the dry blood spot quality detection position to perform quality detection on the dry blood spot card.

b. The qualified dry blood spot cards detected are moved to a code spraying instrument from a card tray to print codes on the dry blood spot cards, then the dry blood spot cards are moved to a preset position, a second mechanical arm sucks the dry blood spot cards from the card tray of the preset position through a negative pressure sucking disc, the dry blood spot cards are moved to a specified position of a punching machine to be punched, and finally the dry blood spot cards which are punched are moved and placed on a dry blood spot card placing carrier which is punched or badly sampled;

c. the dried blood spot card which is detected to be unqualified is directly moved to a preset position by the card tray, and the second mechanical arm sucks up the dried blood spot card from the dried blood spot moving carrier at the preset position through the negative pressure sucker and moves to the dried blood spot card placing carrier which is used for completing punching or badly sampling blood.

By adopting the technical scheme, compared with the prior art, the invention has the following technical effects:

1. the full-automatic punching instrument for punching the dried blood spot card has high flux, realizes full automation, does not need manual intervention in the punching process, and saves the labor cost;

2. the full-automatic perforating instrument for perforating the dry blood spot card automatically detects whether the blood sampling quality of the dry blood spot card is qualified or not, so that the labor cost is saved and the omission is avoided;

3. the full-automatic punching instrument for punching the dried blood spot card automatically encodes, and saves labor cost.

Drawings

FIG. 1 is a schematic structural diagram of a fully automatic hole punch for punching a dry blood spot card according to an embodiment of the present invention;

FIG. 2 is a schematic view of an embodiment of an unperforated dried blood spot card placement carrier;

FIG. 3 is a schematic view of a first robot according to an embodiment of the present disclosure;

FIG. 4 is a schematic structural diagram of a dried blood spot quality detection device, a dried blood spot card transfer tray, and a calibration card and quality control card placement device according to an embodiment of the present invention;

FIG. 5 is a schematic diagram of the internal structure of the dried blood spot quality detection apparatus according to an embodiment of the present invention;

fig. 6 is a schematic structural diagram of a dried blood spot card with a hole punched or a poor blood sampling in an embodiment of the present invention.

Wherein, 1-carrying rod; 2-non-punched dried blood spot card placing carrier; 3-a first mechanical arm; 4-dry blood spot quality detection device; 5-dry blood spot card transfer tray; 6-code spraying instrument; 7-electric appliance cabinet; 8-first and second robotic arm X motion rails; 9-a second mechanical arm; 10-first and second robotic arm X motion motors; 11-a calibration card and a quality control card placing device; 12-a machine switch; 13-completing the dried blood spot card placing carrier with punching or poor blood sampling; 14-a punch; 201-a carrier tray; 202-blood spot card placing rack; 203-right adjusting plate; 204-carrier floor, 205-front adjustment plate; 301-suction cup; 302-robotic arm Z motion system; 303-mechanical arm Y moving slide rail; 304-Y motion motor; 305-a suction cup mounting plate; 401-lower camera housing; 402-upper camera housing; 501-card tray; 502-card gripping jaws; 503-tray rail mounting blocks; 504-tray motion floor; 505-a tray guide; 506-linear bearings; 1101-a card clamping block; 1102-calibration card; 1103-scaling card baffle.

Detailed Description

The invention relates to a full-automatic punching instrument for a dry blood spot card and an operation method thereof.

The following description of the embodiments of the present invention will be made with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.