阅读说明：本技术 一种多方位抗皱多肽精华液及其制备方法 (Multidirectional anti-wrinkle polypeptide essence and preparation method thereof ) 是由 张立萍 方一泓 张丽娜 吴长机 于 2019-10-30 设计创作，主要内容包括：本发明公开了一种多方位抗皱多肽精华液及其制备方法,本发明通过复配多种多肽,辅以多种植物提取物,从而预防表情纹、促进胶原蛋白生成以及修缮真皮组织等多方位进行抗皱；同时本发明采用冷配方式制备精华液,避免了因反应温度不当而导致活性物质失活。(The invention discloses a multi-azimuth anti-wrinkle polypeptide essence and a preparation method thereof, and the multi-azimuth anti-wrinkle polypeptide essence is prepared by compounding a plurality of polypeptides and assisting a plurality of plant extracts, so that expression lines are prevented, collagen generation is promoted, dermal tissues are repaired, and the like, and multi-azimuth anti-wrinkle is carried out; meanwhile, the essence is prepared in a cold mixing mode, so that the inactivation of active substances caused by improper reaction temperature is avoided.)

1. The multidirectional anti-wrinkle polypeptide essence is characterized by comprising the following raw materials in parts by weight:

10-32 parts of polypeptide mixed liquor;

50-75 parts of aloe extract;

5.2-13.5 parts of a moisturizing soothing agent;

0.5-1 part of dendrobium stem extract;

0.05-0.1 part of sophora flavescens root extract;

0.2-0.5 part of Ningxia wolfberry fruit extract;

0.1-0.4 parts of echinacea purpurea extract;

1-3 parts of 1, 3-propylene glycol;

0.5-1.5 parts of saccharide isomer;

1-5 parts of 1, 2-pentanediol;

0.2-0.7 part of creatinine HCl;

0.1-1 part of arginine;

The polypeptide mixed solution comprises acetyl octapeptide-3, acetyl hexapeptide-8, palmitoyl pentapeptide-4 and dipeptide diaminobutyrylbenzylamide diacetate.

2. The multi-aspect anti-wrinkle polypeptide essence according to claim 1, wherein: the mass ratio of the acetyl octapeptide-3, the acetyl hexapeptide-8, the palmitoyl pentapeptide-4 and the dipeptide diaminobutyrylbenzylamide diacetate is 3-8:3-10:3-10: 1-4.

3. The multi-azimuth anti-wrinkle polypeptide essence according to claim 1 or 2, wherein: also comprises 0.3 to 0.8 weight portion of preservative; the preservative is a mixed extract compounded by artemisia capillaris flower extract and clove flower extract.

4. the multi-aspect anti-wrinkle polypeptide essence according to claim 3, wherein: the weight ratio of the artemisia capillaris flower extract to the clove flower extract is 1: 0.5-0.8.

5. The multi-aspect anti-wrinkle polypeptide essence of claim 4, wherein: the moisturizing and soothing agent comprises 3-5 parts of erythritol, 1-4 parts of dihydroavenyl anthranilic acid and 1.2-4.5 parts of a mixed extract compounded by trehalose, an ophiopogon root extract and a prickly pear stem extract.

6. The multi-aspect anti-wrinkle polypeptide essence of claim 5, wherein: the weight ratio of the trehalose to the radix ophiopogonis extract to the prickly pear stem extract is 0.5-1.5: 0.4-1.5: 0.3-1.5.

7. the multi-aspect anti-wrinkle polypeptide essence of claim 6, wherein: also comprises 0.1 to 1 weight part of acrylic acid (ester)/C12 to 22 alkanol methacrylate copolymer.

8. The multi-azimuth anti-wrinkle polypeptide essence according to claim 7, which is prepared from the following raw materials in parts by weight: 63.45 parts of aloe extract, 4 parts of 1, 2-pentanediol, 36 parts of acetyl octapeptide, 85 parts of acetyl hexapeptide, 44 parts of palmitoyl pentapeptide, 2 parts of dipeptide diaminobutyryl benzylamide diacetate, 3 parts of erythritol, 0.2 part of carnitine HCl, 0.5 part of dendrobium stem extract, 0.1 part of sophora flavescens ait root extract, 0.3 part of lycium barbarum fruit extract, 0.2 part of echinacea purpurea extract, 1.5 parts of 1, 3-propanediol, 0.8 part of saccharide isomer, 0.5 part of trehalose, 0.7 part of ophiopogon root extract, 1 part of opuntia ficus-indica stem extract, 3 parts of dihydroavenoylaminobenzoic acid, 0.3 part of acrylic acid (ester)/C12-22 alkanol methacrylate copolymer, 0.3 part of arginine, 0.4 part of artemisia capillaris flower extract and 0.2 part of clove flower extract.

9. a preparation method of multi-azimuth anti-wrinkle polypeptide essence is characterized by comprising the following steps:

mixing Aloe extract, stem extract of herba Dendrobii, radix Sophorae Flavescentis extract, fructus Lycii extract of Ningxia and Echinacea purpurea extract at room temperature to obtain component A;

Mixing the polypeptide mixed solution, the moisturizing soothing agent and the saccharide isomerate at room temperature to obtain a component B;

And uniformly stirring and mixing the component A and the component B, adding 1, 3-propylene glycol, 1, 2-pentanediol, sarcosine HCl, a preservative, an acrylic acid (ester)/C12-22 alkanol methacrylate copolymer and arginine, and uniformly mixing to obtain the anti-wrinkle polypeptide essence.

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to a multi-aspect anti-wrinkle polypeptide essence and a preparation method thereof.

background

Skin aging is a continuous and gradual physiological process which directly affects the appearance and function of skin, and wrinkles are a sign of the appearance of skin aging and are called as 'annual rings of life'. With the improvement of the life quality of people, the anti-aging, wrinkle removal and rejuvenation become topics concerned by consumers.

the human body is a living body with rich emotion, the expression is used as an image body language, the psychological state of the human body is not represented at all times, the facial muscles are inevitably dragged when the expression is displayed, and the skin is temporarily wrinkled and folded along with the contraction of the facial muscles. The long-term continuous action is easy to cause dynamic expression lines. Meanwhile, with the age, the collagen and elastin fibers in the dermal tissue are damaged due to the decline of the metabolic capability of the skin and the influence of exogenous factors, so that the integrity of the dermal tissue structure is damaged, an irreversible static line is formed, and the dynamic line is very easy to convert into the static line. Both the dynamic warp and the static grain show the aging traces of years out of the world, which is not accepted by beauty-loving women.

The product with wrinkle resistance is declared to be full of line on the market, however, many products adopt high molecular polymer analogues, such as choline ethylene glycol polyphosphate acrylate/acrylic acid (ester), cross-linked polymer-like sodium-2, specially treated sodium hyaluronate and the like, and only have the instant effect of covering wrinkles and forming a false effect; or the efficacy raw materials are used for resisting wrinkles in a single way, and the effect of resisting wrinkles cannot be good, so that a multi-direction anti-wrinkle product from inside to outside is particularly important.

Disclosure of Invention

In order to solve the problems, the invention provides a multi-azimuth anti-wrinkle polypeptide essence and a preparation method thereof, and the primary purpose of the invention is to prevent expression wrinkles, promote collagen generation, repair dermal tissues and the like from multi-azimuth anti-wrinkle by compounding a plurality of polypeptides and assisting a plurality of plant extracts; meanwhile, the essence is prepared in a cold mixing mode, so that the inactivation of active substances caused by improper reaction temperature is avoided.

The invention is realized by the following technical scheme:

A multi-directional anti-wrinkle polypeptide essence is composed of the following raw materials in parts by weight:

the polypeptide mixed solution comprises acetyl octapeptide-3, acetyl hexapeptide-8, palmitoyl pentapeptide-4 and dipeptide diaminobutyrylbenzylamide diacetate.

Furthermore, the mass ratio of the acetyl octapeptide-3 to the acetyl hexapeptide-8 to the palmitoyl pentapeptide-4 to the dipeptide diaminobutyrylbenzylamide diacetate is 3-8:3-10:3-10: 1-4.

Further, 0.3 to 0.8 weight portion of preservative is also included; the preservative is a mixed extract compounded by artemisia capillaris flower extract and clove flower extract.

Further, the weight ratio of the artemisia capillaris flower extract to the clove flower extract is 1: 0.5-0.8.

Further, the moisturizing and soothing agent comprises 3-5 parts of erythritol, 1-4 parts of dihydroavenyl anthranilic acid and 1.2-4.5 parts of a mixed extract compounded by trehalose, a radix ophiopogonis extract and a prickly pear stem extract.

Further, the weight ratio of the trehalose to the radix ophiopogonis extract to the prickly pear stem extract is 0.5-1.5: 0.4-1.5: 0.3-1.5.

Further, the acrylic acid/C12-22 alkanol methacrylate copolymer also comprises 0.1-1 weight part of acrylic acid (ester)/acrylic acid (ester).

further, the multi-aspect anti-wrinkle polypeptide essence consists of the following raw materials in parts by weight: 63.45 parts of aloe extract, 4 parts of 1, 2-pentanediol, 36 parts of acetyl octapeptide, 85 parts of acetyl hexapeptide, 44 parts of palmitoyl pentapeptide, 2 parts of dipeptide diaminobutyryl benzylamide diacetate, 3 parts of erythritol, 0.2 part of carnitine HCl, 0.5 part of dendrobium stem extract, 0.1 part of sophora flavescens ait root extract, 0.3 part of lycium barbarum fruit extract, 0.2 part of echinacea purpurea extract, 1.5 parts of 1, 3-propanediol, 0.8 part of saccharide isomer, 0.5 part of trehalose, 0.7 part of ophiopogon root extract, 1 part of opuntia ficus-indica stem extract, 3 parts of dihydroavenoylaminobenzoic acid, 0.3 part of acrylic acid (ester)/C12-22 alkanol methacrylate copolymer, 0.3 part of arginine, 0.4 part of artemisia capillaris flower extract and 0.2 part of clove flower extract.

The invention also comprises a preparation method of the multi-aspect anti-wrinkle polypeptide essence, which comprises the following steps:

(1) mixing Aloe extract, stem extract of herba Dendrobii, radix Sophorae Flavescentis extract, fructus Lycii extract of Ningxia and Echinacea purpurea extract at room temperature to obtain component A;

(2) Mixing the polypeptide mixed solution, the moisturizing soothing agent and the saccharide isomerate at room temperature to obtain a component B;

(3) And uniformly stirring and mixing the component A and the component B, adding 1, 3-propylene glycol, 1, 2-pentanediol, sarcosine HCl, a preservative, an acrylic acid (ester)/C12-22 alkanol methacrylate copolymer and arginine, and uniformly mixing to obtain the anti-wrinkle polypeptide essence.

the invention has the beneficial effects that:

1. The compound skin care composition is compounded with a plurality of polypeptides and a plurality of plant extracts, so that the compound skin care composition can effectively prevent and inhibit dynamic expression lines in a synergistic manner, promote the synthesis of collagen, elastin and glycosaminoglycan per se, remodel healthy and compact skin structure, repair deep moisture and water of static lines formed by damaged dermal tissue structures caused by internal and external factors, promote aquaporin, promote skin microcirculation and repair skin barriers. Meanwhile, the aloe vera leaf juice replaces production water, more active substances are added, the effects of relieving and resisting inflammation are achieved, the clove and the artemisia capillaris are ground, a natural plant anticorrosion environment is built, damage of the preservative to the skin is reduced, and the aloe vera leaf juice is suitable for sensitive skin.

2. The compound preparation is compounded with a plurality of polypeptides and a plurality of plant extracts, so that the compound preparation is synergistic, dynamic expression lines are effectively prevented and inhibited, the synthesis of collagen, elastin and glycosaminoglycan per se is promoted, healthy and compact skin structures are remodeled, static lines formed by damaged dermal tissue structures caused by internal and external factors are repaired, the generation of wrinkles is prevented from the source by acetyl hexapeptide-8, acetyl octapeptide-3 and dipeptide diaminobutyryl benzylamide diacetate, the release of neurotransmitters can be effectively blocked by the acetyl hexapeptide-8 and the acetyl octapeptide-3, the muscle contraction is reduced, and the generation of dynamic lines is prevented and inhibited; the dipeptide diaminobutyrylbenzylamide diacetate inhibits the combination of neurotransmitters and receptors, thereby effectively relaxing muscles and preventing and inhibiting dynamic wrinkle formation; the palmitoyl pentapeptide-4 and various plant extracts have synergistic effect to repair damaged skin, so that wrinkles are improved; palmitoyl pentapeptide-4 can promote the synthesis of collagen, elastin and glycosaminoglycan in types I, III and IV, rebuild a dermal tissue structure to be full, effectively improve static wrinkles, inhibit the conversion of dynamic lines to static lines, promote the synthesis of collagen, elastin and glycosaminoglycan in types I, III and IV, and strengthen the dermal tissue structure, and the addition of extracts such as dendrobium stem extract, sophora flavescens root extract, lycium barbarum fruit extract, echinacea purpurea extract and the like promotes the expression of aquaporin AQP3 in cells, replenishes fluid to generate body fluid, deeply replenishes water, smoothes fine lines and scurf caused by drying, and further improves wrinkles; in addition, the plant extract can promote the absorption of the polypeptide mixture, thereby improving the function of each functional substance, improving wrinkles in multiple directions, durably nourishing and moistening the skin, creating a good moisturizing effect, and meanwhile, the plant extract can also clear free radicals, relieve and moisten the skin and enable the skin to be moisturized and permeable.

3. The radix ophiopogonis extract and the twisted cactus stem extract can strengthen the adhesion and fixation between the upper cuticle layer and a protective film (trehalose forms the protective film), promote the recombination and formation of a skin barrier and promote the recombination and formation of the skin barrier, the radix ophiopogonis extract and the twisted cactus stem extract are active ingredients containing polyfructose, and the tubers contain mucus which can gather water, so that the water replenishing and moisturizing function is strong; the trehalose is slowly released from the protective film, so that the skin can be sustainably and mildly moistened, and the dendrobium stem extract can improve the moisture content of the skin and improve the expression of aquaporin AQP 3; the addition of erythritol in the humectant can reduce the sticky feeling caused by the radix ophiopogonis extract, the prickly pear stem extract and trehalose; the formed double protective film can lock various trace elements and amino acids rich in the Ningxia wolfberry fruit, so as to prevent nutrient loss; the trehalose, the radix ophiopogonis extract, the twisted cactus stem extract and the dihydrooat acyl anthranilic acid are compounded, so that the skin is effectively calmed, inflammation is eliminated, itching is relieved, redness and swelling are relieved, and the effects of skin passivation and skin immunity and tolerance improvement are achieved.

4. The artemisia capillaris flower extract and the clove flower extract are compounded, and the vacuum pump bottle is adopted for physical corrosion prevention, so that the heating risk of the traditional preservative or the polyol popular in the market instead of the traditional preservative is completely eliminated.

Drawings

FIG. 1 is a bar graph of fibroblast viability versus product;

FIG. 2 is a visual effect diagram of the nasolabial sulcus of volunteer 1;

FIG. 3 is a visual effect diagram of the nasolabial sulcus of volunteer 2;

FIG. 4 is a visual effect diagram of the nasolabial sulcus of the volunteer 3;

FIG. 5 is a diagram of the visual effect of the volunteer 4 around the eyes;

Fig. 6 is a diagram of the visual effect of 5 volunteers around the eyes.

Detailed Description

In order to better understand the present invention, the following examples are further described, which are only used to explain the present invention and do not limit the present invention.

The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art, and the raw materials used are commercially available products.

Trehalose, radix Ophiopogonis extract, radix Opuntiae Dillenii stem extract, and radix Sophorae Flavescentis extract are from vast Sen Biotech limited of Beijing Oriental; erythritol and sarcosine HCl are from france stadama; linlan Runlu is from vast forest Biotech, Inc., Beijing Oriental; erythritol and carnosine HCl are derived from Smadama acetyl octapeptide-3, acetyl hexapeptide-8, palmitoyl pentapeptide-4, dipeptide diaminobutyrylbenzylamide diacetate from Dongguan Hua Industrial Co., Ltd