阅读说明：本技术 一种化学药物自动溶出度测试装置 (Automatic dissolution rate testing device for chemical drugs ) 是由 杨怀瑾 孙琍 施翼麟 沈爱琴 谢韬 王露 孙晓晶 于 2019-08-30 设计创作，主要内容包括：本发明公开了一种化学药物自动溶出度测试装置,它包含底座(1),该底座(1)整体为上顶部设置有开口的长方体的盒状结构,所述底座(1)的上顶面处设置有测试装置,所述底座(1)的内部设置有驱动测试装置作往复运动的驱动装置；所述测试装置包含一块可以贴合底座(1)上顶面处水平移动的第一座板(2),该第一座板(2)的上顶面处水平设置有第二座板(3)。本发明结构简单,操作方便,通过将溶出杯整体摆动的方式有效的避免了各个溶出杯在测量过程中的数据误差,提高了检测数值的准确程度。(the invention discloses an automatic dissolution testing device for chemical drugs, which comprises a base (1), wherein the base (1) is integrally of a cuboid box-shaped structure, the upper top of the base is provided with an opening, a testing device is arranged on the upper top surface of the base (1), and a driving device for driving the testing device to do reciprocating motion is arranged in the base (1); the testing device comprises a first base plate (2) which can be attached to the upper top surface of the base (1) and can move horizontally, and a second base plate (3) is horizontally arranged on the upper top surface of the first base plate (2). The invention has simple structure and convenient operation, effectively avoids data errors of various dissolution cups in the measuring process by swinging the dissolution cups integrally, and improves the accuracy of the detected numerical value.)

1. The automatic dissolution rate testing device for the chemical drugs is characterized by comprising a base (1), wherein the base (1) is integrally of a cuboid box-shaped structure, the upper top of the base is provided with an opening, a testing device is arranged on the upper top surface of the base (1), and a driving device for driving the testing device to do reciprocating motion is arranged inside the base (1);

the testing device comprises a first seat plate (2) which can be attached to the upper top surface of a base (1) and can move horizontally, a second seat plate (3) is horizontally arranged at the upper top surface of the first seat plate (2), four corners of the lower bottom surface of the second seat plate (3) are fixedly connected with the upper top surface of the first seat plate (2) into a whole through horizontal adjusting bolts (4), a dissolution cup mounting frame (5) is horizontally arranged at the upper top surface of the second seat plate (3), the four corners of the dissolution cup mounting frame (5) are respectively welded and fixed with the second seat plate (3) into a whole through pillars (6), a plurality of dissolution cup mounting holes (51) which are arranged at equal intervals are formed in the upper top surface of the dissolution cup mounting frame (5), and dissolution cups (52) are embedded into each dissolution cup mounting hole (51);

The driving device comprises a mounting seat (7), a first rotating shaft (8) and a second rotating shaft (9) which can be connected and matched with the mounting seat in a rotating manner are respectively mounted at two ends of the inner side face of the mounting seat (7), a first driving gear (10) and a positioning sleeve (11) which is in clearance sliding fit with the first rotating shaft (8) or the second rotating shaft (9) are respectively fixedly mounted on the first rotating shaft (8) and the second rotating shaft (9) from outside to inside in sequence, the two first driving gears (10) are mutually meshed and matched, a key groove (111) is radially formed in the inner wall of the positioning sleeve (11), a key (112) corresponding to the key groove (111) extends out of the first rotating shaft (8) and the second rotating shaft (9) in the radial direction respectively, the end part of the first rotating shaft (8) penetrates through the mounting seat (7) and is fixedly connected with a driven gear (12) into a whole, a driving motor (13) is mounted on the outer side, the output shaft end of the driving motor (13) penetrates through the base (1) and is fixedly connected with a driving gear, and the driving gear is meshed and matched with the driven gear (12);

the inner wall of the base (1) is provided with two third rotating shafts (14) which can be in rotating connection and matching with the base, the two third rotating shafts (14) respectively axially correspond to the first rotating shaft (8) and the second rotating shaft (9), two ends of each third rotating shaft (14) are respectively and fixedly provided with a second driving gear (15) and a first end face saw gear ring (16), a rack (17) which can be in meshing matching with the two second driving gears (15) is arranged above the two second driving gears (15), and the end part of the positioning sleeve (11) is axially fixed with a second end face saw gear ring (18) which is in meshing matching with the first end face saw gear ring (16);

the rack (17) is fixedly welded in the middle of the lower bottom surface of the first seat plate (2);

and a clutch device is arranged between the first rotating shaft (8) and the second rotating shaft (9).

2. the automatic dissolution testing device of chemical drugs according to claim 1, wherein the clutch device comprises a positioning shaft rod (19) fixedly installed at the bottom of the base (1), the positioning shaft rod (19) is located between the first rotating shaft (8) and the second rotating shaft (9), a positioning sleeve (20) and a first clutch rod (21) which can be rotatably connected and matched with the positioning shaft rod (19) are sleeved on the top of the positioning shaft rod (19), wherein the first clutch rod (21) is located above the positioning sleeve (20), connecting rods (22) are respectively and radially welded and fixed on two sides of the bottom of the positioning sleeve (20), a clamping seat (23) which can be rotatably connected and matched with the connecting rods (22) is arranged below the connecting rods (22), an n-shaped groove (24) is formed below the clamping seat (23), and a slot (25) which can be inserted into the n-shaped groove (24) with clearance is radially formed on the positioning sleeve (11), a positioning rod (26) radially extends outwards from one side of the top of the positioning sleeve (20), the end part of the positioning rod (26) extends out of the base (1) through a first pin shaft (27), and the first pin shaft (27) is vertically and fixedly arranged on the positioning rod (26);

The end part of one end of the first clutch lever (21) opposite to the positioning shaft lever (19) and the middle part of the second clutch lever (28) are welded into a T-shaped structure, a second shaft pin (29) is welded and fixed at the middle part of the second clutch lever (28), the second shaft pin (29) and the first shaft pin (27) are connected into a whole through a spring (30), both ends of the second clutch lever (28) are respectively provided with a deflector rod (31), the two deflector rods (31) are respectively and fixedly arranged at the end part of the second clutch lever (28) in a vertically staggered way, both ends of the rack (17) are respectively and horizontally welded with a shifting sheet (32), the plane of the shifting sheet (32) is of a right-angled triangle structure, the lower bottom edge of the plectrum (32) is welded and fixed on the outer side surface of the rack (17), the inclined edge of the shifting piece (32) faces to the adjacent shifting rod (31), and two ends of the base (1) are respectively provided with a groove (33) for the shifting piece (32) to pass through in a clearance way.

3. the automatic dissolution testing device for chemical drugs according to claim 1, wherein sliding rails (34) parallel to the rack (17) are respectively fixedly installed at two sides of the first seat plate (2), and a sliding groove (35) capable of sliding fit with the sliding rails (34) in a clearance manner is formed at the upper top surface of the base (1).

4. The automatic dissolution testing device for chemical drugs according to claim 1, wherein one side of the middle part of the base (1) is provided with a positioning chute (36) which is in clearance sliding fit with the positioning rod (26), two lug seats (37) are fixedly welded below the positioning chute (36), a fourth rotating shaft (38) which is in rotating connection and fit with the two lug seats (37) is arranged between the two lug seats (37), and the middle part of the fourth rotating shaft (38) is welded with a clutch fork (39) which is integrally in a V shape;

When the V-shaped clutch shifting fork (39) rotates to be attached to the outer side face of the base (1) and the opening is upward, the end part of the positioning rod (26) is just positioned at the bottom of the V-shaped clutch shifting fork (39);

one end of the fourth rotating shaft (38) extends out of the ear seat (37) and is fixedly connected with the handle rod (40) into a whole.

Technical Field

The invention relates to the technical field related to chemical drug detection equipment, in particular to an automatic dissolution rate testing device for a chemical drug.

background

automatic dissolution testing machines, commonly known as dissolution machines, are an ideal choice for those formulations requiring different types of media for automatic dissolution testing. It is commonly used to simulate changes in pH in vivo, and the apparatus is particularly useful for testing sustained release and sustained release formulations, simulating changes in the gastrointestinal tract in vivo. The dissolution instrument can run for several days (normal 3-12 days) under the unattended condition, and the dissolution instrument of Agilent BIO-DIS type and the dissolution instrument of riggtek brand which are widely used for comparing color and in the field have partial difference on the specific operation structure, but are realized by adopting the stirring shaft matched with the stirring blades on the dissolution mixing structure which mainly simulates the gastrointestinal tract of a human body;

in order to improve the accuracy of a sample, a large number of test tests in batches are usually carried out, the average value of each batch is finally taken as a final dissolution numerical value, in order to improve the test efficiency, a plurality of stirring shafts and corresponding motors are usually configured on each dissolution instrument, and it is known that even though a certain rotation speed difference exists among motors of the same model, the difference of the rotation speed differences within one hour is not obvious, but the gradually accumulated rotation speed difference in a continuous test environment for 3-12 days often causes great numerical difference of dissolution in each dissolution cup, and the integral test accuracy and the contrast effect are directly influenced;

and before the operation, the levelness, the verticality of the stirring shaft, the coaxiality of the dissolution cup and the stirring shaft and the swinging of the stirring shaft are required to be adjusted and corrected, so that the test error is avoided to the maximum extent, and the whole operation process is very troublesome.

disclosure of Invention

The invention aims to provide a chemical drug automatic dissolution testing device which can effectively solve the problems in the background technology.

in order to solve the problems existing in the background technology, the device comprises a base 1, wherein the base 1 is integrally of a cuboid box-shaped structure, the upper top of the base 1 is provided with an opening, a testing device is arranged on the upper top surface of the base 1, and a driving device for driving the testing device to do reciprocating motion is arranged in the base 1;

The testing device comprises a first seat plate 2 which can be attached to the upper top surface of a base 1 and move horizontally, a second seat plate 3 is horizontally arranged at the upper top surface of the first seat plate 2, four corners of the lower bottom surface of the second seat plate 3 are fixedly connected with the upper top surface of the first seat plate 2 into a whole through horizontal adjusting bolts 4, a dissolution cup mounting frame 5 is horizontally arranged at the upper top surface of the second seat plate 3, four corners of the dissolution cup mounting frame 5 are respectively welded and fixed with the second seat plate 3 into a whole through supporting columns 6, a plurality of dissolution cup mounting holes 51 which are arranged at equal intervals are formed in the upper top surface of the dissolution cup mounting frame 5, and a dissolution cup 52 is embedded in each dissolution cup mounting hole 51;

the driving device comprises a mounting seat 7, a first rotating shaft 8 and a second rotating shaft 9 which can be rotatably connected and matched with the mounting seat 7 are respectively arranged at two ends of the inner side surface of the mounting seat 7, a first driving gear 10 and a positioning sleeve 11 which is in clearance sliding fit with the first rotating shaft 8 or the second rotating shaft 9 are respectively fixedly arranged on the first rotating shaft 8 and the second rotating shaft 9 from outside to inside in sequence, the two first driving gears 10 are mutually meshed and matched, a key groove 111 is radially arranged on the inner wall of the positioning sleeve 11, keys 112 corresponding to the key groove 111 are respectively radially extended out from the first rotating shaft 8 and the second rotating shaft 9, the end part of the first rotating shaft 8 penetrates through the mounting seat 7 to be fixedly connected with a driven gear 12 into a whole, a driving motor 13 is arranged at the outer side of the base 1, and the output shaft end of the driving motor 13 penetrates through the base 1 to be fixedly connected with the, the driving gear is meshed with the driven gear 12;

Two third rotating shafts 14 which can be in rotating connection and matching with the base 1 are installed on the inner wall of the base 1, the two third rotating shafts 14 respectively correspond to the first rotating shaft 8 and the second rotating shaft 9 in the axial direction, a second driving gear 15 and a first end face sawing tooth ring 16 are respectively and fixedly installed at two ends of each third rotating shaft 14, a rack 17 which can be in meshing matching with the two second driving gears 15 is arranged above the two second driving gears 15, and a second end face sawing tooth ring 18 which is in meshing matching with the first end face sawing tooth ring 16 is axially fixed at the end part of the positioning sleeve 11;

the rack 17 is fixedly welded in the middle of the lower bottom surface of the first seat plate 2;

And a clutch device is arranged between the first rotating shaft 8 and the second rotating shaft 9.

The clutch device comprises a positioning shaft rod 19 fixedly arranged at the lower bottom surface of the base 1, the positioning shaft rod 19 is positioned between the first rotating shaft 8 and the second rotating shaft 9, the top of the positioning shaft rod 19 is sleeved with a positioning sleeve 20 and a first clutch rod 21 which can be in rotary connection and matching with the positioning shaft rod, wherein the first clutch lever 21 is positioned above the positioning sleeve 20, the connecting rods 22 are respectively fixed on two sides of the bottom of the positioning sleeve 20 in a radial welding manner, a clamping seat 23 which can be rotationally connected and matched with the connecting rod 22 is arranged below the connecting rod 22, an n-shaped groove 24 is arranged below the clamping seat 23, a slot 25 for inserting the n-shaped slot 24 in a clearance is radially arranged on the positioning sleeve 11, a positioning rod 26 radially extends out from one side of the top of the positioning sleeve 20, the end of the positioning rod 26 extends out of the base 1 through a first pin shaft 27, and the first pin shaft 27 is vertically and fixedly installed on the positioning rod 26;

The end part of one end of the first clutch lever 21 opposite to the positioning shaft lever 19 is welded with the middle part of the second clutch lever 28 to form a T-shaped structure, the middle part of the second clutch lever 28 is fixedly welded with a second shaft pin 29, the second shaft pin 29 and the first shaft pin 27 are connected into a whole through a spring 30, two ends of the second clutch lever 28 are respectively provided with a shift lever 31, the two shift levers 31 are respectively and fixedly installed at the end part of the second clutch lever 28 in a vertically staggered manner, two ends of the rack 17 are respectively and horizontally welded with a shift sheet 32, the plane of the shift sheet 32 is of a right-angled triangle structure, the lower bottom edge of the shift sheet 32 is fixedly welded at the outer side surface of the rack 17, the bevel edge of the shift sheet 32 faces to the adjacent shift lever 31, and two ends of the base 1 are respectively provided with a groove 33 for the shift sheet 32.

The two sides of the first seat plate 2 are respectively and fixedly provided with a sliding rail 34 which is parallel to the rack 17, and the upper top surface of the base 1 is provided with a sliding groove 35 which is in clearance sliding fit with the sliding rail 34.

A positioning chute 36 which can be in clearance sliding fit with the positioning rod 26 is formed in one side of the middle of the base 1, two lug seats 37 are fixedly welded below the positioning chute 36, a fourth rotating shaft 38 which is in rotating connection and fit with the two lug seats 37 is arranged between the two lug seats 37, and a clutch shifting fork 39 which is integrally in a V shape is welded in the middle of the fourth rotating shaft 38;

when the V-shaped clutch shifting fork 39 rotates to be attached to the outer side surface of the base 1 and the opening is upward, the end part of the positioning rod 26 is just positioned at the bottom of the V-shaped clutch shifting fork 39;

one end of the fourth shaft 38 extends out of the ear seat 37 and is fixedly connected with the handle bar 40 into a whole.

Due to the adoption of the technical scheme, the invention has the following beneficial effects: simple structure, convenient operation, through will dissolving out the effectual data error of each cup in the measurement process of having avoided of the whole wobbling mode of cup, improved the degree of accuracy that detects numerical value.

Drawings

In order to more clearly illustrate the present invention, embodiments will be briefly described below with reference to the accompanying drawings.

FIG. 1 is a schematic diagram of the overall structure of the present invention;

FIG. 2 is a schematic view showing a structure of a driving device portion according to the present invention;

Fig. 3 is a plan view of the first and second rotating shafts in the present invention.

Detailed Description

In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the technical scheme in the embodiment of the invention will be clearly and completely described below with reference to the attached drawings in the embodiment of the invention.