阅读说明：本技术 生物传感器用片材 (Sheet for biosensor ) 是由 吉冈良真 于 2018-01-26 设计创作，主要内容包括：生物传感器用片材具备用于贴附于生物体表面的压敏粘接层、和被配置于压敏粘接层的探针,探针具有露出压敏粘接层的露出区域。(The biosensor sheet includes a pressure-sensitive adhesive layer for attachment to a surface of a living body, and a probe disposed on the pressure-sensitive adhesive layer, the probe having an exposed region where the pressure-sensitive adhesive layer is exposed.)

1. A biosensor sheet, comprising:

A pressure-sensitive adhesive layer for attachment to a surface of a living body; and

A probe disposed on the pressure-sensitive adhesive layer,

The probe has an exposed region where the pressure-sensitive adhesive layer is exposed.

2. The sheet for biosensor according to claim 1, wherein said probe has a thin layer shape.

3. The biosensor sheet according to claim 1, wherein the exposed region comprises a plurality of holes arranged at intervals.

4. The biosensor sheet according to claim 3, wherein the probe has a frame portion partitioning the plurality of holes.

5. The biosensor sheet according to claim 4, wherein the frame portion has a lattice shape.

6. The biosensor sheet according to claim 4,

The frame strip portion includes:

A plurality of 1 st frame portions extending in a direction orthogonal to a thickness direction of the pressure-sensitive adhesive layer at intervals and in parallel with each other; and

And the 2 nd frame strip parts bridge the 1 st frame strip parts adjacent to each other in the 1 st frame strip parts.

7. the biosensor sheet according to claim 6, wherein the 1 st frame portions extend in a 1 st direction orthogonal to the thickness direction,

The plurality of 2 nd frame strip portions extend in a 2 nd direction intersecting both the thickness direction and the 1 st direction so as to be spaced apart from each other and intersect the plurality of 1 st frame strip portions,

The dimension of each of the 1 st frame strip portions in the 2 nd direction is 5: 95-50: 50 of the dimension of each of the plurality of holes in the 2 nd direction,

The dimension of each of the plurality of 2 nd frame strip portions in the 1 st direction is 5: 95-50: 50 that of each of the plurality of holes in the 1 st direction.

8. The biosensor sheet according to claim 7, wherein the dimension in the 2 nd direction of each of the 1 st frame strip portions and the dimension in the 1 st direction of each of the 2 nd frame strip portions are 10 μm or more and 500 μm or less,

The dimension of each of the plurality of holes in the 1 st direction and the dimension of each of the plurality of holes in the 2 nd direction are 50 μm or more and 1000 μm or less, respectively.

Technical Field

The present invention relates to a sheet for biosensors.

Background

In the past, biosensors that are attached to the skin of a person or the like to detect a biological signal have been known.

For example, a biocompatible polymer substrate including a data acquisition member, a viscous polymer layer, a disc-shaped electrode disposed on the polymer layer, and a wiring for connecting the data acquisition member and the electrode has been proposed (see, for example, patent document 1).

In such a biocompatible polymer substrate, the polymer layer is attached to the skin of a human, the electrodes detect a biological signal, for example, a voltage signal from the myocardium, and the data acquisition unit receives and records the voltage signal from the myocardium.

Disclosure of Invention

Problems to be solved by the invention

However, in the biocompatible polymer substrate described in patent document 1, since the electrode 51 has a disc shape as shown in fig. 2B, when the polymer layer is attached to the skin 33 of a person and the electrode 51 is in contact with the skin 33, the electrode 51 may not follow fine irregularities of the skin 33. In this case, due to the fine irregularities, a gap 34 is generated between the electrode 51 and the surface of the skin 33. Therefore, there is a limit to the biocompatible polymer substrate described in patent document 1 in improving the accuracy of detecting a biological signal.

Accordingly, the present invention provides a biosensor sheet that allows a probe to follow fine irregularities on the surface of a living body.

means for solving the problems

the present invention [1] includes a biosensor sheet comprising a pressure-sensitive adhesive layer for attachment to a surface of a living body, and a probe disposed on the pressure-sensitive adhesive layer, wherein the probe has an exposed region where the pressure-sensitive adhesive layer is exposed.

With this configuration, since the probe has the exposed region where the pressure-sensitive adhesive layer is exposed, when the pressure-sensitive adhesive layer is attached to the surface of the living body and one surface of the probe is brought into contact with the surface of the living body, the probe can be bent so as to follow the surface of the living body through the exposed region, and the probe can follow the fine irregularities on the surface of the living body. Therefore, the biosensor provided with the sheet for biosensor can improve the accuracy of detecting a biological signal.

The invention [2] comprises the biosensor sheet according to [1], wherein the probe has a thin-layer shape.

With this configuration, since the probe has a thin-layer shape, the wearing feeling of the user can be reduced when the sheet for biosensor is attached to the surface of the living body.

The invention [3] includes the biosensor sheet according to [1] or [2], wherein the exposed region includes a plurality of holes arranged at intervals.

With this configuration, since the exposed region includes the plurality of holes arranged at intervals, flexibility can be imparted to the probe and the rigidity of the probe can be ensured.

The present invention [4] includes the biosensor sheet according to [3], wherein the probe includes a frame portion that partitions the plurality of holes.

with this configuration, since the plurality of holes are partitioned by the frame bar portion, the plurality of holes can be regularly arranged, and flexibility can be reliably provided to the probe. Therefore, the probe can reliably follow the fine unevenness on the surface of the living body.

The invention [5] includes the biosensor sheet according to [4], wherein the frame portion has a lattice shape.

With this configuration, since the plurality of holes are partitioned by the frame bar portion having the lattice shape, the plurality of holes can be uniformly arranged in a well-balanced manner in the entire probe. Therefore, the entire probe can be made to reliably follow the fine irregularities on the surface of the living body.

The present invention [6] includes the biosensor sheet according to [4] or [5], wherein the frame portion includes: a plurality of 1 st frame portions extending in a direction orthogonal to the thickness direction of the pressure-sensitive adhesive layer at intervals and in parallel to each other; and a plurality of 2 nd frame strip portions, wherein the plurality of 2 nd frame strip portions bridge mutually adjacent 1 st frame strip portions among the plurality of 1 st frame strip portions.

With this configuration, since the plurality of holes are partitioned by the plurality of 1 st frame segments parallel to each other at intervals and the plurality of 2 nd frame segments bridging the adjacent 1 st frame segments, flexibility can be imparted to the probe while rigidity is maintained by the 2 nd frame segments. Even if a part of the frame portion is broken, the 1 st frame portion is bridged by the 2 nd frame portion, so that conduction can be secured, and there is an advantage that the biosensor having the biosensor sheet retains the sensor function.

The present invention [7] includes the biosensor sheet according to [6], wherein the plurality of 1 st frame strip portions extend in a 1 st direction orthogonal to the thickness direction, the plurality of 2 nd frame strip portions extend in a 2 nd direction intersecting both the thickness direction and the 1 st direction at intervals from each other and intersecting the plurality of 1 st frame strip portions, the dimension in the 2 nd direction of each of the plurality of 1 st frame strip portions, i.e., the dimension in the 2 nd direction of each of the plurality of holes, is 5:95 to 50:50, and the dimension in the 1 st direction of each of the plurality of 2 nd frame strip portions, i.e., the dimension in the 1 st direction of each of the plurality of holes, is 5:95 to 50: 50.

With this configuration, the dimension in the 2 nd direction of each of the 1 st frame portions, i.e., the dimension in the 2 nd direction of each of the holes, is within the above-described range, and the dimension in the 1 st direction of each of the 2 nd frame portions, i.e., the dimension in the 1 st direction of each of the holes, is within the above-described range, so that the ratio of the area of the frame portions to the area of the holes can be ensured in a well-balanced manner, and the probe can be made to follow the fine irregularities on the surface of the living body more reliably.

The present invention [8] includes the biosensor sheet according to [7], wherein the dimension in the 2 nd direction of each of the plurality of 1 st frame strip portions and the dimension in the 1 st direction of each of the plurality of 2 nd frame strip portions are each 10 μm or more and 500 μm or less, and the dimension in the 1 st direction of each of the plurality of holes and the dimension in the 2 nd direction of each of the plurality of holes are each 50 μm or more and 1000 μm or less.

With this configuration, the dimension in the 2 nd direction of each 1 st frame portion and the dimension in the 1 st direction of each 2 nd frame portion are within the above-described ranges, and the dimension in the 1 st direction of each hole and the dimension in the 2 nd direction of each hole are within the above-described ranges, so that the ratio of the area of the frame portion to the area of the hole can be ensured with further good balance.

ADVANTAGEOUS EFFECTS OF INVENTION

The biosensor sheet of the present invention enables the probe to follow fine irregularities on the surface of a living body.

Drawings

Fig. 1 is a plan view of a biosensor laminate as one embodiment of the biosensor sheet of the present invention shown in fig. 1.

FIG. 2A is a sectional view taken along line A-A of the layered body for a biosensor shown in FIG. 1. Fig. 2B is an explanatory view of the prior art, showing a manner in which the probe has a plate shape.

Fig. 3A to 3D are process views showing the production process of the biosensor laminate shown in fig. 1, in which fig. 3A shows a step of preparing a base material and a wiring layer, fig. 3B shows a step of bonding a pressure-sensitive adhesive layer to a base material, fig. 3C shows a step of forming a through hole and inserting a probe member, and fig. 3D shows a step of forming a connecting portion.

FIG. 4 is a perspective view of a probe-containing sheet as viewed from below, showing a state in which a part of the 2 nd peel-off sheet is cut away.

FIG. 5 is a perspective view illustrating a process of manufacturing a probe member.

FIG. 6A to FIG. 6C are plan views of modified examples of the probe, in which FIG. 6A shows a mode in which a plurality of holes have a circular shape, FIG. 6B shows a mode in which a frame portion has a honeycomb shape, and FIG. 6C shows a mode in which a frame portion has a meandering (Japanese: thousand bird) shape.

Fig. 7A and 7B are plan views of modifications of the probe, where fig. 7A shows a mode in which the probe has a star-shaped frame portion, and fig. 7B shows a mode in which the probe has a circular frame portion.

Fig. 8A to 8C are plan views of modifications of the probe, where fig. 8A shows a mode in which the frame portions have a lattice shape in which a plurality of 1 st frame portions are not parallel to each other and a plurality of 2 nd frame portions are not parallel to each other, fig. 8B shows a mode in which the frame portions have a lattice shape in which a plurality of 1 st frame portions and a plurality of 2 nd frame portions intersect at an angle of less than 90 °, and fig. 8C shows a mode in which the frame portions have a lattice shape in which a plurality of 1 st frame portions and a plurality of 2 nd frame portions are wavy.

Fig. 9A and 9B are plan views of modifications of the probe, where fig. 9A shows a mode in which a plurality of holes communicate with each other to form an exposed region, and fig. 9B shows a mode in which the exposed region has a groove having a substantially U-shape in plan view.

FIG. 10 is a cross-sectional view of a modification (mode in which probes are arranged on the lower adhesive surface) of an embodiment of a layered body for biosensors.

Fig. 11 is a graph showing the results of resistance measurement in each of examples and comparative examples.

Detailed Description

< one embodiment >

1. Schematic structure of layered body for biosensor

A biosensor laminate 1 as one embodiment of the biosensor sheet according to the present invention will be described with reference to fig. 1 to 5.

In fig. 1, the left-right direction of the drawing is the longitudinal direction (1 st direction) of the biosensor laminate 1. The right side of the drawing is one side in the longitudinal direction (the 1 st direction side), and the left side of the drawing is the other side in the longitudinal direction (the 1 st direction side).

In fig. 1, the top-bottom direction of the drawing is the short-side direction of the biosensor stack 1 (the direction orthogonal to the long-side direction, the width direction, and the 2 nd direction orthogonal to (intersecting with) the 1 st direction). The upper side of the drawing sheet is one side in the short direction (one side in the width direction, one side in the 2 nd direction), and the lower side of the drawing sheet is the other side in the short direction (the other side in the width direction, the other side in the 2 nd direction).

In fig. 1, the paper thickness direction is the up-down direction of the biosensor laminate 1 (thickness direction, 3 rd direction orthogonal to the 1 st direction and the 2 nd direction). The front side of the drawing is the upper side (one side in the thickness direction, the 3 rd direction side), and the back side of the drawing is the lower side (the other side in the thickness direction, the 3 rd direction side).

the directions are according to the directional arrows shown in the figures.

The directions of the biosensor laminate 1 and the attached electrocardiograph 30 (described later) during the production and the use are not intended to be limited by the definitions of these directions.

As shown in fig. 1 to 2A, the biosensor laminate 1 has a substantially flat plate shape extending in the longitudinal direction. The layered body for biosensor 1 includes: a pressure-sensitive adhesive layer 2 for attachment to a surface of a living body, a base material 3 disposed on an upper surface of the pressure-sensitive adhesive layer 2, a wiring layer 4 disposed on the base material 3, a probe 5 disposed on the pressure-sensitive adhesive layer 2, and a connecting portion 6 for electrically connecting the wiring layer 4 and the probe 5. In fig. 1, the pressure-sensitive adhesive layer 2 and the base material 3 overlapping the probe 5 in the vertical direction are omitted for convenience.

The pressure-sensitive adhesive layer 2 forms the lower surface of the stack 1 for biosensors. The pressure-sensitive adhesive layer 2 is a layer for imparting pressure-sensitive adhesiveness to the lower surface of the laminate 1 for biosensor in order to attach the lower surface of the laminate 1 for biosensor to a surface of a living body (such as the skin 33). The pressure-sensitive adhesive layer 2 forms the outer shape of the layered body for biosensor 1. The pressure-sensitive adhesive layer 2 has, for example, a flat plate shape extending in the longitudinal direction. Specifically, the pressure-sensitive adhesive layer 2 may have a strip shape extending in the longitudinal direction, and a shape in which the longitudinal center portion expands outward in both the short-side directions. In the pressure-sensitive adhesive layer 2, both edges in the short side direction of the long side direction central portion are positioned on both outer sides in the short side direction with respect to both edges in the short side direction other than the long side direction central portion.

The pressure sensitive adhesive layer 2 has an adhesive upper surface 8 and an adhesive lower surface 9. The adhesive upper surface 8 is a flat surface. The lower adhesive surfaces 9 are disposed opposite to each other with a space therebetween below the upper adhesive surface 8.

The pressure-sensitive adhesive layer 2 has adhesive openings 11 at both ends in the longitudinal direction. Each of the 2 bonding openings 11 has a substantially annular shape in a plan view. The adhesive opening 11 penetrates the pressure-sensitive adhesive layer 2 in the thickness direction. The bonding opening 11 is filled with the connection portion 6.

The bonding lower surface 9 inside the bonding opening 11 has a bonding groove 10 corresponding to the probe 5 (described later). The adhesion groove 10 is open to the lower side.

The material of the pressure-sensitive adhesive layer 2 is not particularly limited, and may be, for example, a material having pressure-sensitive adhesiveness, and preferably a material having biocompatibility. Such a material includes an acrylic pressure-sensitive adhesive, a silicone pressure-sensitive adhesive, and the like, and preferably includes an acrylic pressure-sensitive adhesive. Examples of the acrylic pressure-sensitive adhesive include acrylic pressure-sensitive adhesives containing an acrylic polymer as a main component, which are described in jp 2003-a 342541.

The thickness of the pressure-sensitive adhesive layer 2 is, for example, 10 μm or more, preferably 20 μm or more, and is, for example, less than 100 μm, preferably 50 μm or less, in terms of the distance between the upper and lower adhesive surfaces 8 and 9 in the region other than the adhesive groove 10.

The substrate 3 forms the upper surface of the biosensor laminate 1. The base material 3 and the pressure-sensitive adhesive layer 2 together form the outer shape of the layered body for biosensor 1. The shape of the base material 3 in plan view is the same as the shape of the pressure-sensitive adhesive layer 2 in plan view. The base material 3 is disposed on the entire upper surface of the pressure-sensitive adhesive layer 2 (excluding the region where the connection portion 6 is provided). The base material 3 is a support layer for supporting the pressure-sensitive adhesive layer 2. The substrate 3 has a flat plate shape extending in the longitudinal direction.

The substrate 3 has a substrate lower surface 12 and a substrate upper surface 13. The lower substrate surface 12 is a flat surface.

The base material lower surface 12 is in contact with the adhesive upper surface 8 of the pressure-sensitive adhesive layer 2 (pressure-sensitive adhesion).

The substrate upper surface 13 is disposed opposite to the substrate lower surface 12 with a space therebetween. The base material upper surface 13 has a base material groove 14 corresponding to the wiring layer 4. The base material groove 14 has the same pattern shape as the wiring layer 4 in a plan view. The base material groove 14 is open to the upper side.

The base material 3 has a base material opening 15 corresponding to the bonding opening 11. The base material opening 15 communicates with the bonding opening 11 in the thickness direction. The base material opening 15 has a substantially annular shape having the same shape and the same size as those of the bonding opening 11 in a plan view.

The material of the base material 3 has elasticity, for example. The material of the base material 3 has, for example, an insulating layer. Examples of such a material include resins. Examples of the resin include thermoplastic resins such as polyurethane resins, silicone resins, acrylic resins, polystyrene resins, vinyl chloride resins, and polyester resins.

The material of the substrate 3 is preferably a polyurethane resin from the viewpoint of ensuring more excellent stretchability and moisture permeability.

The thickness of the base material 3 is, for example, 1 μm or more, preferably 5 μm or more, and is, for example, 300 μm or less, preferably 10 μm or less, in terms of the distance between the base material lower surface 12 and the base material upper surface 13 in the region other than the base material groove 14.

The wiring layer 4 is buried in the base material groove 14. Specifically, the wiring layer 4 is embedded in the upper portion of the base material 3 so as to be exposed from the base material upper surface 13 of the base material 3. The wiring layer 4 has an upper surface and a lower surface which are arranged at an interval from each other, and a side surface which connects peripheral end edges thereof. All of the lower surface and all of the side surfaces are in contact with the base material 3. The upper surface is exposed from the substrate upper surface 13 (excluding the substrate groove 14). The upper surface of the wiring layer 4 forms the upper surface of the biosensor laminate 1 together with the substrate upper surface 13.

As shown in fig. 1, the wiring layer 4 has a wiring pattern for connecting the connection portion 6 to an electronic component 31 (described later) and a battery 32 (described later). Specifically, the wiring layer 4 is provided with the 1 st wiring pattern 41 and the 2 nd wiring pattern 42 independently.

The first wiring pattern 41 is disposed on one side in the longitudinal direction of the substrate 3. The 1 st wiring pattern 41 includes a 1 st wiring 16A and a 1 st terminal 17A and a 2 nd terminal 17B connected thereto.

the first wiring pattern 41 has a substantially T-shape in a plan view. Specifically, the 1 st wiring 16A of the 1 st wiring pattern 41 extends from one end in the longitudinal direction of the substrate 3 (the connection portion 6 located at one end in the longitudinal direction of the substrate 3) to the other side in the longitudinal direction, branches at the central portion in the longitudinal direction of the substrate 3, and extends to both outer sides in the short direction. In order to improve the stretchability of the biosensor laminate 1, the 1 st wire 16A may be formed in a wavy shape.

The 1 st terminal 17A and the 2 nd terminal 17B are respectively disposed at both ends in the short direction in the central part in the long direction of the base 3. The 1 st terminal 17A and the 2 nd terminal 17B each have a substantially rectangular shape (land shape) in a plan view. The 1 st terminal 17A and the 2 nd terminal 17B are connected to both ends of the 1 st wiring 16A extending along both outer sides in the short direction at the center in the long direction of the base 3.

The 2 nd wiring pattern 42 is provided at an interval on the other side in the longitudinal direction of the 1 st wiring pattern 41. The 2 nd wiring pattern 42 includes the 2 nd wiring 16B and the 3 rd terminal 17C and the 4 th terminal 17D connected thereto.

The 2 nd wiring pattern 42 has a substantially T-shape in a plan view. Specifically, the 2 nd wiring 16B of the 2 nd wiring pattern 42 extends from the other end portion in the longitudinal direction of the substrate 3 (the connection portion 6 located at the other end portion in the longitudinal direction of the substrate 3) to one side in the longitudinal direction, branches at the central portion in the longitudinal direction of the substrate 3, and extends to both outer sides in the short direction. In order to improve the stretchability of the biosensor laminate 1, the 2 nd wiring 16B may be formed in a wavy shape.

The 3 rd terminal 17C and the 4 th terminal 17D are disposed at both ends in the short direction in the central part in the long direction of the base 3, respectively. The 3 rd terminal 17C and the 4 th terminal 17D each have a substantially rectangular shape (pad shape) in a plan view. The 3 rd terminal 17C and the 4 th terminal 17D are connected to both ends of the 2 nd wiring 16B extending along both outer sides in the short direction at the center in the long direction of the base 3.

Examples of the material of the wiring layer 4 include conductors such as copper, nickel, gold, and alloys thereof, and copper is preferable.

The thickness of the wiring layer 4 is, for example, 0.1 μm or more, preferably 1 μm or more, for example, 100 μm or less, preferably 10 μm or less.

As shown in fig. 2A, the probe 5 is an electrode which comes into contact with a living body surface when the pressure-sensitive adhesive layer 2 is attached to the living body surface and senses an electric signal, temperature, vibration, sweat, metabolite, or the like from the living body. In the present embodiment, the probe 5 has a thin-layer shape, and is disposed on the pressure-sensitive adhesive layer 2 so that a probe lower surface 20, which is one surface, is exposed inside the adhesive opening 11 and a probe upper surface 21, which is one example of the other surface, is embedded in the pressure-sensitive adhesive layer 2. Specifically, the probe 5 is embedded in the adhesive groove 10 in the pressure-sensitive adhesive layer 2 inside the adhesive opening 11.

The probe 5 has an exposed region 57 where the pressure-sensitive adhesive layer 2 is exposed, as described in detail later. In the present embodiment, the exposed region 57 includes a plurality of holes 52 arranged at intervals from each other, and the probe 5 has a substantially mesh shape. The probe 5 includes a probe lower surface 20, a probe upper surface 21 disposed opposite to the probe lower surface 20 with a gap therebetween, and a side surface connecting peripheral end edges of the probe lower surface 20 and the probe upper surface 21.

The probe lower surface 20 is exposed from the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2. The probe lower surface 20 is coplanar with the adhesive lower surface 9. The probe lower surface 20 and the adhesive lower surface 9 together form the lower surface of the stack 1 for biosensors. The probe upper surface 21 and the side surfaces are covered with the pressure-sensitive adhesive layer 2.

As shown in fig. 5, the outermost surface of the side surfaces of the probe 5 is an outer side surface 22. The outer side surface 22 forms an imaginary circle passing through the outer side surface 22 in a plan view.

Examples of the material of the probe 5 include materials (specifically, conductors) exemplified in the wiring layer 4.

The outer dimensions of the probe 5 are set so that an imaginary circle passing through the outer surface 22 overlaps the inner peripheral surface of the bonding opening 11 in plan view.

The thickness of the probe 5 is, for example, 0.1 μm or more, preferably 1 μm or more, for example, less than 100 μm, preferably 10 μm or less.

The connecting portion 6 is provided so as to correspond to the base material opening 15 and the bonding opening 11, and has the same shape as these. The connection portion 6 penetrates (passes) the base material 3 and the pressure-sensitive adhesive layer 2 in the thickness direction (vertical direction), and is filled in the base material opening portion 15 and the adhesive opening portion 11. The connecting portion 6 has a ring shape in a plan view along the outer surface 22 of the probe 5. Specifically, the connecting portion 6 has a substantially cylindrical shape (along an imaginary circle passing through the outer surface 22) with its axis extending in the thickness direction.

As shown in fig. 2A, the inner surface of the connection portion 6 contacts the outer surface 22 of the probe 5. The connection portion 6 is pressure-sensitive bonded to the pressure-sensitive adhesive layer 2 outside the adhesive opening portion 11 and the pressure-sensitive adhesive layer 2 inside the adhesive opening portion 11.

The upper surface of the connecting portion 6 is coplanar with the substrate upper surface 13. The lower surface of the connecting portion 6 is coplanar with the lower adhesive surface 9.

As shown in fig. 1, of the 2 connection portions 6, the connection portion 6 located on one side in the longitudinal direction is connected at its upper end portion to one longitudinal-direction end edge of the 1 st wiring 16A located on one side in the longitudinal direction. The connecting portion 6 on the other longitudinal side is connected at its upper end portion to the other longitudinal end edge of the 2 nd wiring 16B on the other longitudinal side.

Thereby, the connection portion 6 electrically connects the wiring layer 4 and the probe 5.

Examples of the material of the connecting portion 6 include, for example, a metal, a conductive resin (including a conductive polymer), and the like, and preferably include a conductive resin and the like.

The thickness (vertical length) of the connecting portion 6 is the same as the total thickness of the base material 3 and the pressure-sensitive adhesive layer 2. The length of the connecting portion 6 in the radial direction (half of the value obtained by subtracting the inner diameter from the outer diameter) is, for example, 1 μm or more, preferably 100 μm or more, for example 1000 μm or less, preferably 500 μm or less.

2. Detailed description of the probes

Next, the probe 5 will be described in detail with reference to fig. 1.

As shown in fig. 1, the probe 5 includes an exposed region 57 including the plurality of holes 52 arranged at intervals, and a frame bar portion 53 partitioning the plurality of holes 52. The frame strips 53 are configured in a mesh shape.

In the present embodiment, the frame strip portion 53 has a lattice shape, and integrally includes a plurality of 1 st frame strip portions 54 and a plurality of 2 nd frame strip portions 55.

Each of the 1 st frame strip portions 54 has a substantially rod shape extending over the entire longitudinal direction of the probe 5. The plurality of 1 st frame strip portions 54 are arranged in parallel with a space therebetween in the short-side direction. That is, the plurality of 1 st frame strip portions 54 extend in the direction orthogonal to the thickness direction of the pressure-sensitive adhesive layer 2 at intervals and in parallel with each other.

The plurality of 2 nd frame strip portions 55 bridge the 1 st frame strip portions 54 adjacent to each other in the plurality of 1 st frame strip portions 54. The plurality of 2 nd frame bar portions 55 each have a substantially bar shape extending over the entire short-side direction of the probe 5, and are orthogonal (cross) to the plurality of 1 st frame bar portions 54. The plurality of 1 st frame strip portions 54 and the plurality of 2 nd frame strip portions 55 are connected to each other at portions where they intersect (cross) each other.

The plurality of 2 nd frame bar portions 55 are arranged in parallel with a space therebetween in the longitudinal direction. That is, the plurality of 2 nd frame portions 55 extend in the short side direction (2 nd direction) orthogonal to both the thickness direction and the long side direction (1 st direction) of the pressure-sensitive adhesive layer 2 so as to be parallel to each other with a space therebetween and orthogonal to (cross) the plurality of 1 st frame portions 54.

The dimension in the short side direction of each of the plurality of 1 st frame strip portions 54 (the width of each 1 st frame strip portion 54) and the dimension in the long side direction of each of the plurality of 2 nd frame strip portions 55 (the width of each 2 nd frame strip portion 55) are, for example, 10 μm or more, preferably 20 μm or more, more preferably 50 μm or more, for example, 500 μm or less, preferably 300 μm or less, and more preferably 100 μm or less, respectively.

The dimension in the short side direction of each 1 st frame portion 54 and the dimension in the long side direction of each 2 nd frame portion 55 are preferably the same.

The exposed region 57 is a portion of a region surrounded by an imaginary line (see description of the area of the probe 5) to be described later, where the adhesive lower surface 9 is exposed, and includes a plurality of holes 52.

The plurality of holes 52 give flexibility to the probe 5 so that the probe 5 can follow fine irregularities on the surface of the living body. The plurality of holes 52 are partitioned by the frame bar portions 53 and arranged at intervals. The plurality of holes 52 include a plurality of rows of the plurality of holes 52 arranged at intervals (2 nd frame part 55) in the longitudinal direction so as to be spaced apart from each other in the short-side direction (1 st frame part 54).

The plurality of holes 52 expose the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2 from the lower side, respectively. The plurality of holes 52 are each partitioned into a space surrounded by the 1 st frame strip portions 54 adjacent to each other among the plurality of 1 st frame strip portions 54 and the 2 nd frame strip portions 55 intersecting the 1 st frame strip portions 54 and adjacent to each other. Each hole 52 penetrates the probe 5 in the thickness direction.

In the present embodiment, each hole 52 has a rectangular shape in a plan view, more specifically, a square shape in a plan view. Each hole 52 is filled with the pressure-sensitive adhesive layer 2.

The dimension of each hole 52 in the longitudinal direction and the dimension of each hole 52 in the short direction are, for example, 50 μm or more, preferably 200 μm or more, more preferably 300 μm or more, particularly preferably 400 μm or more, for example, 1000 μm or less, preferably 900 μm or less, respectively.

The dimension in the short side direction of each 1 st frame strip portion 54, i.e., the dimension in the short side direction of each hole 52, is, for example, 5:95 to 50:50, preferably 5:95 to 40:60, and more preferably 5:95 to 20: 80. The dimension in the longitudinal direction of each 2 nd frame portion 55, i.e., the dimension in the longitudinal direction of each hole 52, is, for example, 5:95 to 50:50, preferably 5:95 to 40:60, and more preferably 5:95 to 20: 80.

When the dimension in the short side direction of each 1 st frame portion 54, the dimension in the short side direction of each hole 52, and the dimension in the long side direction of each 2 nd frame portion 55, the dimension in the long side direction of each hole 52 are within the above-described ranges, the ratio of the area of the frame portion 53 to the area of the hole 52 can be secured with good balance, and the probe 5 can be made to follow the fine irregularities on the surface of the living body more reliably.

The number of the holes 52 in the probe 5 is, for example, 50 or more, preferably 100 or more, for example, 500,000 or less, preferably 50,000 or less.

The area of the probe 5 is, for example, 0.5cm²Above, preferably 1cm²Above, e.g. 10cm²Hereinafter, preferably 5cm²The following.

The area of the probe 5 is: the area of a region surrounded by a virtual line connecting the outermost portions of the cut surface when the probe 5 is cut on a virtual plane orthogonal to the thickness direction of the probe 5 by the shortest distance.

For example, as shown in fig. 7A, when the outermost part of the tangent plane has a plurality of vertices, the area of the probe 5 is the area of the region surrounded by the virtual line 56A connecting the vertices at the shortest distance.

As shown in fig. 7B, when all the outermost portions of the cut surface are lines, a virtual line 56A connecting the outermost portions of the cut surface at the shortest distance coincides with the line 56B, and the area of the probe 5 is the area of the region surrounded by the line 56B.

As shown in fig. 9B, when the outermost portion of the tangent plane includes a plurality of vertices and lines, the area of the probe 5 is the area of the region surrounded by the virtual line 56A and the line 56B connecting the vertices at the shortest distance.

The sum of the areas of the exposed regions 57 (including the plurality of holes 52) is, for example, 50% or more, preferably 80% or more, for example, 95% or less, relative to the area of the probe 5.

When the total area of the exposed regions 57 with respect to the area of the probes 5 is equal to or greater than the lower limit, the area of the holes 52 that allow moisture to pass therethrough can be sufficiently ensured, and the load on the living body can be suppressed when the layered body for biosensor 1 is attached to the living body. When the total area of the exposed regions 57 with respect to the area of the probe 5 is equal to or less than the upper limit, the signal receiving capability of the probe 5 can be sufficiently ensured.

3. Method for producing laminate for biosensor

Next, a method for manufacturing the multilayer body for biosensor 1 will be described with reference to fig. 3A to 5.

As shown in fig. 3A to 3C, in this method, for example, first, the laminate 28 and the probe member 18 are prepared separately.

The laminate 28 includes the pressure-sensitive adhesive layer 2, the base 3 disposed on the upper surface of the pressure-sensitive adhesive layer 2, and the wiring layer 4 disposed on the base 3.

The pressure-sensitive adhesive layer 2, the substrate 3, and the wiring layer 4 in the laminate 28 have the same configurations as those of the pressure-sensitive adhesive layer 2, the substrate 3, and the wiring layer 4 described above, respectively.

In order to prepare the laminate 28, for example, after the base material 3 on which the wiring layer 4 is disposed is prepared, the pressure-sensitive adhesive layer 2 is disposed on the base material lower surface 12 of the base material 3.

The substrate 3 on which the wiring layer 4 is disposed can be prepared such that the wiring layer 4 is embedded in the substrate groove 14, for example, by the methods described in japanese patent laid-open nos. 2017-22236 and 2017-22237.

Next, in order to dispose the pressure-sensitive adhesive layer 2 on the lower surface 12 of the base material, for example, first, a coating liquid containing a material of the pressure-sensitive adhesive layer 2 is prepared, next, the coating liquid is applied to the upper surface of the 1 st release sheet 19, and then, drying is performed by heating. Thereby, the pressure-sensitive adhesive layer 2 is disposed on the upper surface of the 1 st release sheet 19. The 1 st release sheet 19 has, for example, a substantially flat plate shape extending in the longitudinal direction.

Examples of the material of the 1 st release sheet 19 include resins such as polyethylene terephthalate.

Then, the pressure-sensitive adhesive layer 2 and the substrate 3 are bonded together, for example, by a laminator or the like. Specifically, the adhesive upper surface 8 of the pressure-sensitive adhesive layer 2 is brought into contact with the base material lower surface 12 of the base material 3.

At this time, the base material 3 and the pressure-sensitive adhesive layer 2 do not have the base material opening 15 and the adhesive opening 11, respectively.

Thus, the laminate 28 supported by the 1 st release sheet 19 can be prepared.

As shown in fig. 3C and 5, a probe member 18 is prepared.

The probe member 18 includes a pressure-sensitive adhesive layer 2, a base material 3 disposed on the upper surface of the pressure-sensitive adhesive layer 2, and a thin-layer probe 5 disposed on the pressure-sensitive adhesive layer 2 such that a probe lower surface 20 is exposed and a probe upper surface 21 is embedded in the pressure-sensitive adhesive layer 2.

The pressure-sensitive adhesive layer 2, the substrate 3, and the probes 5 in the probe member 18 have the same configurations as those of the pressure-sensitive adhesive layer 2, the substrate 3, and the probes 5 described above, respectively.

To prepare the probe member 18, first, as shown in fig. 4, a sheet 26 containing the probes is prepared.

The probe-containing sheet 26 includes the pressure-sensitive adhesive layer 2, the probe pattern 25 embedded in the pressure-sensitive adhesive layer 2, and the base material 3 disposed on the bonding upper surface 8 of the pressure-sensitive adhesive layer 2.

The probe pattern 25 has the same pattern shape as the probe 5, and the material of the probe pattern 25 is the same as the material of the probe 5. The probe pattern 25 has a plane area larger than an imaginary circle passing through the outer side surface 22 of the probe 5.

The probe-containing sheet 26 can be prepared, for example, according to the methods described in japanese patent application laid-open nos. 2017-22236 and 2017-22237.

Specifically, although not shown, a seed layer made of copper is formed on the upper surface of a peeling layer made of stainless steel, and then a photoresist is laminated on the entire upper surface of the seed layer. Next, the photoresist is exposed and developed, and the photoresist is formed into a reverse pattern of the probe pattern 25. Next, a probe pattern 25 is formed on the upper surface of the seed layer by electrolytic plating, and then, the photoresist is removed. Then, a coating liquid containing a material of the pressure-sensitive adhesive layer 2 is applied so as to cover the probe pattern 25, and cured to form the pressure-sensitive adhesive layer 2. Next, the substrate 3 is bonded to the upper surface of the pressure-sensitive adhesive layer 2, for example, by a laminator or the like. Then, the peeling layer is peeled off from the lower surface of the seed layer, and then, the seed layer is removed. Then, if necessary, the 2 nd release sheet 29 is attached to the lower surface of the pressure-sensitive adhesive layer 2. The 2 nd release sheet 29 has the same configuration as the 1 st release sheet 19 described above.

Thereby, the sheet 26 containing the probe can be prepared.

Next, as shown in fig. 5, a cutting line 27 is formed in a substantially circular shape in a plan view on the probe pattern 25, the pressure-sensitive adhesive layer 2, and the base material 3. The cutting line 27 may be formed by blanking, for example. The cutting line 27 divides the probe pattern 25, the pressure-sensitive adhesive layer 2, and the base material 3 into the inside and the outside of the cutting line 27, but the cutting line 27 is not formed on the 2 nd release sheet 29. The dimension of the cutting line 27 is the same as the inner diameter of the bonding opening 11 and the base material opening 15. That is, the cutting line 27 coincides with an imaginary circle passing through the outer side surface 22.

By forming the cutting line 27, the probe member 18 can be formed.

In the probe member 18, the outer side surface 22 of the probe 5 is coplanar with the outer side surface of the pressure-sensitive adhesive layer 2. In the probe member 18, the outer surface 22 is exposed radially outward from the outer surface of the pressure-sensitive adhesive layer 2.

Next, as shown by the arrow in fig. 5, the probe member 18 is lifted from the 2 nd release sheet 29. Specifically, the lower adhesive surface 9 and the lower probe surface 20 of the probe member 18 are peeled off from the 2 nd release sheet 29.

In this manner, the probe member 18 can be prepared.

The thickness (dimension in the vertical direction) of the probe member 18 is equal to or greater than the thickness (dimension in the vertical direction) of the laminate 28, and is preferably the same as the thickness of the laminate 28.

Next, as shown in fig. 3C, the through-hole 23 is formed in the stacked body 28.

the through-hole 23 vertically penetrates the stacked body 28. The through-hole 23 is a hole (through-hole) having a substantially circular shape in plan view, which is partitioned by an outer peripheral surface partitioning the base material opening portion 15 and an outer peripheral surface partitioning the bonding opening portion 11. In addition, the through hole 23 is adjacent to the 1 st wiring 16A (or the 2 nd wiring 16B) of the wiring layer 4. The through-hole 23 opens to the upper side. On the other hand, the lower end of the through hole 23 is closed by the 1 st release sheet 19.

The inner diameter of the through hole 23 is larger than the outer diameter of the probe member 18. The through opening 23 has the following dimensions: when the probe member 18 is disposed in the through-hole 23, a gap 100 is formed between the inner surface 23A of the through-hole 23 and the peripheral surface 18A of the probe member 18.

For example, the laminated body 28 is punched out and half-etched to form the through-hole 23.

Next, as shown by the arrows in fig. 3C, the probe member 18 is fitted into the through-hole 23 so as to form the gap 100.

The gap 100 is formed by positioning the pressure-sensitive adhesive layer 2, the base material 3, and the probes 5 of the probe member 18 and the pressure-sensitive adhesive layer 2 and the base material 3 around the through-hole 23 at positions spaced apart from each other in the radial direction of the probe member 18. The gap 100 is adjacent to the wiring layer 4 (the 1 st wiring 16A or the 2 nd wiring 16B) and the outer side surface 22 of the probe 5.

Then, as shown in fig. 3D, a connection portion 6 electrically connecting the wiring layer 4 and the probe 5 is formed in the gap 100.

When the material of the connecting portion 6 is a conductive resin composition, the conductive resin composition is injected (or coated) into the gap 100. Then, the conductive resin composition is heated and cured as necessary.

Thus, the layered product for biosensor 1 can be produced.

The biosensor laminate 1 includes, but is preferably formed of, only the pressure-sensitive adhesive layer 2, the base 3, the wiring layer 4, the probes 5, the connecting portions 6, and the 1 st release sheet 19. As shown in fig. 2A, the biosensor laminate 1 may be formed of only the pressure-sensitive adhesive layer 2, the base material 3, the wiring layer 4, the probes 5, and the connecting portions 6 without the 1 st release sheet 19.

The biosensor laminate 1 is a device that can be distributed alone and is industrially used. Specifically, the biosensor laminate 1 can be separately circulated from the electronic device 31 and the battery 32 (see the imaginary line in fig. 1) described below. That is, the layered product 1 for biosensor is a member for manufacturing the attached electrocardiograph 30 without mounting the electronic component 31 and the battery 32.

Next, a method of manufacturing the attached electrocardiograph 30 and a method of using the attached electrocardiograph 30, which are examples of the biosensor, will be described using the layered body 1 for a biosensor.

As shown in fig. 1 and 2A, in order to manufacture the attached electrocardiograph recording instrument 30, for example, first, a layered body 1 for biosensor, an electronic device 31, and a battery 32 are prepared.

Examples of the electronic device 31 include an analog front end, a microcomputer, and a memory for processing and storing an electric signal from a living body acquired by the probe 5; and a communication IC, a transmitter, and the like for converting the electric signal into an electric wave, and wirelessly transmitting it to an external receiver. The electronic device 31 may have a part or all of them. The electronic component 31 has 2 terminals (not shown) or 2 or more terminals (not shown) provided on the lower surface thereof.

The battery 32 has 2 terminals (not shown) provided on the lower surface thereof.

Next, 2 terminals of the electronic device 31 are electrically connected to the 1 st terminal 17A and the 3 rd terminal 17C. Further, 2 terminals of the battery 32 are electrically connected to the 2 nd terminal 17B and the 4 th terminal 17D.

In this way, the attached electrocardiograph 30 including the layered body 1 for biosensor, and the electronic device 31 and the battery 32 mounted thereon was manufactured.

In order to use the sticking type electrocardiograph 30, first, the 1 st release sheet 19 (see the arrow and the imaginary line in fig. 3D) is peeled off from the pressure-sensitive adhesive layer 2 and the probe 5.

As shown by the phantom line of fig. 2A, next, the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2 is brought into contact with, for example, the skin 33 of a human body. Specifically, the pressure-sensitive adhesive layer 2 is pressure-sensitive adhered to the surface of the skin 33.

In this way, the probe lower surface 20 of the probe 5 is brought into contact with the surface of the skin 33 by pressure-sensitive adhesion (attachment) of the adhesive lower surface 9 to the skin 33. At this time, the probe 5 is bent so as to follow the skin 33 through each of the plurality of holes 52, and follows the fine unevenness of the skin 33.

Next, the probe 5 senses the activity potential of the heart as an electrical signal, and the electrical signal sensed by the probe 5 is input to the electronic device 31 via the connection portion 6 and the wiring layer 4. The electronic device 31 processes the electric signal based on the electric power supplied from the battery 32 and stores the processed electric signal as information. Further, the electric signal is converted into an electric wave as necessary, and the electric wave is wirelessly transmitted to an external receiver.

In the layered body for biosensor 1, as shown in fig. 2A, the probe 5 has an exposed region 57 including a plurality of holes 52 arranged at intervals.

Therefore, when the pressure-sensitive adhesive layer 2 is attached to the skin 33 and the probe lower surface 20 of the probe 5 is brought into contact with the surface of the skin 33, the probe 5 can be bent so as to follow the surface of the skin 33 based on the exposed region 57 (each of the plurality of holes 52), and the probe 5 can follow the fine unevenness of the surface of the skin 33.

As a result, in the attached electrocardiograph 30 including the layered body 1 for biosensor, the accuracy of detecting a biological signal can be improved.

In addition, the probe 5 has a thin layer shape. Therefore, when the layered body for a biosensor 1 is attached to the surface of a living body, the wearing sensation of the user can be reduced.

In addition, the plurality of holes 52 are partitioned by the frame bar portions 53. Therefore, flexibility can be imparted to the probe 5 while the plurality of holes 52 are regularly arranged. As a result, the probe 5 can reliably follow the fine irregularities on the surface of the living body.

In addition, the frame strip portion 53 has a lattice shape. Therefore, the plurality of holes 52 can be uniformly arranged in a well-balanced manner in the entire probe 5. As a result, the entire probe 5 can reliably follow the fine irregularities on the surface of the living body.

The plurality of holes 52 are partitioned by a plurality of 1 st frame strip portions 54 which are parallel to each other at intervals, and a plurality of 2 nd frame strip portions 55 which bridge the adjacent 1 st frame strip portions 54. Therefore, flexibility can be imparted to the probe 5, and rigidity can be maintained by the 2 nd frame portion 55.

The dimension in the 2 nd direction of each 1 st frame strip portion 54, i.e., the dimension in the 2 nd direction of each hole 52, is within the above-described range, and the dimension in the 1 st direction of each 2 nd frame strip portion 55, i.e., the dimension in the 1 st direction of each hole 52, is within the above-described range. Therefore, the ratio of the area of the frame portion 53 to the area of the hole 52 can be ensured with good balance, and the probe 5 can be made to follow the fine irregularities on the surface of the skin 33 more reliably.

The dimension in the short side direction of each 1 st frame portion 54 and the dimension in the long side direction of each 2 nd frame portion 55 are in the above ranges, and the dimension in the long side direction of each hole 52 and the dimension in the short side direction of each hole 52 are in the above ranges. Therefore, the ratio of the area of the frame portion 53 to the area of the hole 52 can be ensured with further good balance.

< modification example >

In the following modifications, the same members and steps as those of the above-described embodiment are denoted by the same reference numerals, and detailed description thereof is omitted. Further, the respective modifications can be combined as appropriate. Each of the modified examples can provide the same operational advantages as the one embodiment unless otherwise specified.

As shown in fig. 1 and 5, in one embodiment, an imaginary line passing through the outer side surface 22 is a circular shape, but the shape is not particularly limited, and for example, although not shown, a rectangular shape may be used.

In one embodiment, the plurality of holes 52 are partitioned by the frame bar portions 53 in the probe 5, but the probe 5 may not have the frame bar portions 53 and may have a plurality of holes 52.

For example, as shown in fig. 6A, a plurality of holes 52 may be formed in the plate-shaped probe 5.

The shape of the plurality of holes 52 is not particularly limited, and may have a substantially circular shape in a plan view, for example.

In one embodiment, the frame bar portions 53 have a lattice shape, but the shape of the frame bar portions 53 is not particularly limited. For example, the frame portion 53 may have a honeycomb shape as shown in fig. 6B, or may have a meandering shape as shown in fig. 6C.

As shown in fig. 6B, when the frame portion 53 has a honeycomb shape, each of the plurality of 1 st frame portions 54 extends in the longitudinal direction so as to form a stepped step, and the plurality of 1 st frame portions 54 are arranged in parallel with each other at intervals in the short-side direction. In addition, the plurality of 2 nd frame strip portions 55 bridge the 1 st frame strip portions 54 adjacent to each other in the plurality of 1 st frame strip portions 54. In fig. 6B, for convenience, the 1 st frame strip portions 54 are indicated by thick lines. The plurality of holes 52 are partitioned by the plurality of 1 st frame portions 54 and the plurality of 2 nd frame portions 55, and have a substantially hexagonal shape in a plan view.

As shown in fig. 6C, when the frame strip portion 53 has a meandering shape, each of the plurality of 1 st frame strip portions 54 linearly extends in the longitudinal direction, and the plurality of 1 st frame strip portions 54 are arranged in parallel with each other at intervals in the short-side direction. The plurality of 2 nd frame portions 55 bridge the 1 st frame portions 54 adjacent to each other in the plurality of 1 st frame portions 54 at different positions in the longitudinal direction so as not to be continuous in the short direction. The plurality of holes 52 are partitioned by the plurality of 1 st frame strip portions 54 and the plurality of 2 nd frame strip portions 55, and have a substantially rectangular shape in a plan view.

In addition, the shape of the probe 5 is not particularly limited. For example, as shown in fig. 7A, the probe 5 may have a star shape. The frame bar portion 53 of the probe 5 includes a frame portion 59 having a hollow star shape (specifically, a pentagram shape), and a plurality of bridge portions 60 arranged in the frame portion 59. Each of the plurality of bridge portions 60 has a substantially rod shape extending in the surface direction of the probe 5. The plurality of bridging portions 60 bridge opposing portions of the inner surface of the frame portion 59 so as to partition the plurality of holes 52 inside the frame portion 59.

The shape of the frame portion 59 is not particularly limited. For example, as shown in fig. 7B, the frame portion 53 may include a frame portion 59 having an annular shape, a plurality of 1 st frame bar portions 54, and a plurality of 2 nd frame bar portions 55. The frame portion 59 surrounds the plurality of 1 st frame portions 54 and the plurality of 2 nd frame portions 55, and is continuous with the end portions thereof.

in one embodiment, the plurality of 1 st frame portions 54 are arranged in parallel with each other, and the plurality of 2 nd frame portions 55 are arranged in parallel with each other, but the invention is not limited thereto. For example, as shown in fig. 8A, each of the plurality of 1 st frame elements 54 is inclined at an angle of less than ± 45 ° with respect to the longitudinal direction, and the plurality of 1 st frame elements 54 are arranged so as not to be parallel to each other at intervals in the short-side direction. The plurality of 2 nd frame portions 55 are each inclined at an angle of less than ± 45 ° with respect to the short-side direction, and the plurality of 2 nd frame portions 55 are arranged so as not to be parallel to each other at intervals in the long-side direction.

In one embodiment, the plurality of 1 st frame strip portions 54 are orthogonal to the plurality of 2 nd frame strip portions 55, but as shown in fig. 8B, the plurality of 1 st frame strip portions 54 and the plurality of 2 nd frame strip portions 55 may intersect at an angle of less than 90 ℃ (or an angle of more than 90 ℃). The plurality of holes 52 are partitioned by the plurality of 1 st frame portions 54 and the plurality of 2 nd frame portions 55, and have a substantially rhombic shape in a plan view.

In one embodiment, the plurality of 1 st frame portions 54 and the plurality of 2 nd frame portions 55 each extend linearly, but the shapes thereof are not particularly limited. As shown in fig. 8C, each of the plurality of 1 st frame strip portions 54 and the plurality of 2 nd frame strip portions 55 may have a wavy shape. In the embodiment shown in fig. 8A to 8C, the frame bar portion 53 has a lattice shape.

In one embodiment, the exposed region 57 includes a plurality of holes 52, but the exposed region 57 is not particularly limited as long as the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2 can be exposed.

For example, as shown in fig. 9A, the exposed region 57 may be formed by a plurality of holes 52 communicating with each other. In this case, for example, each of the 2 nd frame bar portions 55 has a notch portion 58 so as to communicate with the holes 52 adjacent to each other in the longitudinal direction. The notch 58 is formed by cutting out a part of each 2 nd frame strip portion 55. Further, although not shown, each of the 1 st frame strip portions 54 may have a cutout portion so as to communicate the holes 52 adjacent to each other in the short side direction.

as shown in fig. 9B, the exposed region 57 may include a groove 63 that is open to one side in the predetermined direction and has a substantially U-shape in a plan view. In this case, the frame strip portion 53 includes a plurality of grooves 63, a plurality of 1 st frame strip portions 61 extending in the predetermined direction, and a 2 nd frame strip portion 62 connecting the other end portions of the plurality of 1 st frame strip portions 61 in the predetermined direction.

Specifically, the 1 st frame strip portions 61 extend in the longitudinal direction at intervals in the lateral direction and are parallel to each other. The dimensions of the plurality of 1 st frame strip portions 61 in the longitudinal direction may be the same or different from each other. In fig. 9B, the plurality of 1 st frame portions 61 are different in dimension in the longitudinal direction from each other, and the plurality of 1 st frame portions 61 are arranged as follows: the longest 1 st frame portion 61 among the 1 st frame portions 61 is arranged at the center in the short side direction, and the length of the 1 st frame portion 61 is gradually shortened as it approaches to the outside in the short side direction.

The 2 nd frame portion 62 connects the other end portions in the longitudinal direction of the plurality of 1 st frame portions 61. The 2 nd frame portion 62 has a shape of a substantially circular arc in plan view that is open to one side in the longitudinal direction.

Each groove 63 is partitioned into a space surrounded by the 1 st frame strip portion 61 adjacent to each other among the plurality of 1 st frame strip portions 61 and the 2 nd frame strip portion 62 connecting the 1 st frame strip portions 61. Each groove 63 has a substantially U-shape in plan view, which is open to one side in the longitudinal direction.

In one embodiment, as shown in fig. 2A, the probe 5 is embedded in the pressure-sensitive adhesive layer 2, but is not particularly limited as long as it is disposed on the pressure-sensitive adhesive layer 2. For example, as shown in fig. 10, the probe 5 may be disposed on the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2. In this case, the probe upper surface 21 of the probe 5 is in contact with the lower surface of the connection portion 6, and the probe 5 and the connection portion 6 are electrically connected.

In one embodiment, the biosensor laminate 1 is exemplified as an example of the biosensor sheet of the present invention, but the biosensor sheet of the present invention includes a probe member 18 having a pressure-sensitive adhesive layer 2 and probes 5, and a probe-containing sheet 26 having a pressure-sensitive adhesive layer 2 and probe patterns 25 (an example of probes). The biosensor sheet of the present invention may be provided with the pressure-sensitive adhesive layer 2 and the probes 5, and may not include the substrate 3.

In one embodiment, the attached electrocardiograph 30 is exemplified as an example of the biosensor, but examples thereof include devices that sense a biological signal and monitor the state of a living body, and specifically include an attached electroencephalograph, an attached sphygmomanometer, an attached pulsimeter, an attached electromyograph, an attached thermometer, and an attached accelerometer. These may be independent devices, or a plurality of them may be combined in 1 device.

The living body includes a human body and living organisms other than a human body, and is preferably a human body.