阅读说明：本技术 一种快速获取目标神经治疗能量投送位点的物理标测装置 (Physical mapping device for rapidly acquiring target nerve treatment energy delivery site ) 是由 黄晶 马长生 肖灵 钱俊 郑小宇 容顺康 熊波 姚沅清 于 2019-09-24 设计创作，主要内容包括：本发明涉及一种快速获取目标神经治疗能量投送位点的物理标测装置,所述的物理标测系统包括振动声物理信号拾取系统、振动声物理信号显示系统以及振动声物理信号分析系统；振动声物理信号拾取系统用于拾取声波,并将该声波传递至振动声物理信号显示系统进行处理。其优点表现在：能够快速获取目标神经治疗能量投送位点,实现快速精准探测-消融一体化。(The invention relates to a physical mapping device for rapidly acquiring a target nerve treatment energy delivery site, wherein a physical mapping system comprises a vibration sound physical signal pickup system, a vibration sound physical signal display system and a vibration sound physical signal analysis system; the vibration sound physical signal pickup system is used for picking up sound waves and transmitting the sound waves to the vibration sound physical signal display system for processing. Its advantages are: the target nerve treatment energy delivery site can be rapidly obtained, and rapid and accurate detection-ablation integration is realized.)

1. A physical mapping device for rapidly acquiring a target nerve treatment energy delivery site is characterized in that a physical mapping system comprises a vibration sound physical signal pickup system, a vibration sound physical signal display system and a vibration sound physical signal analysis system; the vibration sound physical signal pickup system is used for picking up sound waves and transmitting the sound waves to the vibration sound physical signal display system for processing; the vibration sound physical signal display system comprises a preamplifier, a filter and a digital oscilloscope; the vibration sound physical signal pickup system is used for picking up echoes generated by different tissues after difference frequency focusing ultrasonic stimulation; the vibration sound physical signal display system is used for converting sound waves or echoes into digitized echo signals, transmitting the digitized echo signals to a preamplifier in the vibration sound physical signal display system, amplifying the echo signals, further transmitting the echo signals to a filter unit in the vibration sound physical signal display system, filtering clutter signals in the echo signals by the filter in a low-pass/high-pass or other mode, and finally transmitting the echo signals to a digital oscilloscope in the vibration sound physical signal display system for display; the vibration sound physical signal analysis system comprises a treatment planning unit, an ultrasonic image unit and a superposed image unit; the treatment planning unit and the superposed image unit are connected with a digital oscilloscope in the vibration sound physical signal display system and used for receiving the tissue echo signal on the digital oscilloscope.

The treatment planning unit is used for receiving echo signals on the digital oscilloscope, comparing the obtained echo signals with echo signals generated after differential frequency ultrasonic stimulation of various tissues preset in the treatment planning unit, performing gray scale type scanning to construct a hardness distribution diagram of a target area, displaying the distribution state of target nerves in the target area through the hardness diagram, displaying the hardness diagram in the form of a gray scale diagram, a three-dimensional histogram and a pseudo-color diagram, and visually displaying an ablation treatment plan;

The ultrasonic image unit comprises an ultrasonic image probe, and can also be a magnetic resonance coil, an electronic computer tomography scanning device and a nuclear medicine detector; the ultrasonic image probe is arranged in the difference frequency focusing ultrasonic transducer, can flexibly turn, and can perform two-dimensional and Doppler blood flow imaging when the difference frequency ultrasonic works;

The superposition image unit superposes and combines the gray-scale image, the three-dimensional histogram, the pseudo-color image and the Doppler blood flow imaging output by the ultrasonic image unit, which are output by the treatment planning unit, and is used for providing image support during ablation, searching a treatment target point and a scanning plane, and setting a treatment energy delivery site by utilizing the virtual focus of the treatment unit through the three-dimensional motion of the treatment unit.

2. The physical mapping device of claim 1, wherein the vibro-acoustic physical signal pick-up system is a hydrophone, and the hydrophone can adopt both a water tank signal pick-up mode and a body signal pick-up mode, and the water tank is paved with flexible sound-absorbing rubber to reduce the influence of surface reflection.

3. The physical mapping device of claim 1, wherein the physical mapping device is further equipped with an ultrasound signal generator, a difference frequency focused ultrasound transducer; the ultrasonic signal generator generates ultrasonic signals with a certain frequency difference, the ultrasonic signals are sent to the difference frequency focusing ultrasonic transducer, and two or more beams of difference frequency focusing ultrasonic waves with a certain frequency difference are generated by the difference frequency focusing ultrasonic transducer.

4. The physical mapping device of claim 3, wherein the difference frequency focused ultrasound transducer emits the difference frequency focused ultrasound with a frequency difference lower than 1% of a fundamental frequency.

5. The physical mapping device of claim 1, wherein the physical mapping device is further equipped with a physiological mapping system and a host computer; the physiological detection system comprises: the biological signal acquisition device is used for assisting the discrimination system; the biological signal acquisition device is used for acquiring and recording body physiological electric signals and sending the acquired body physiological signals to the auxiliary judgment system; the auxiliary judgment system is used for analyzing and judging the acquired body physiological signals, comparing the acquired body physiological signals with preset signals, judging the signals by an operator according to the signal analysis result, and sending the result to the main control computer to adjust the focused ultrasound treatment parameters in real time.

6. The physical mapping device of claim 5, wherein the bio-signal acquisition device comprises: an electrocardiogram analyzer, a multi-channel physiological recorder, a respiration monitor and/or electroencephalograph, a nerve potential analyzer, and a blood biochemical analyzer.

7. The physical mapping device according to claim 2, wherein after the physical mapping is completed, the physical mapping system superimposes the distribution state image of the target nerve in the target region provided by the image unit, the difference frequency focused ultrasound transducer re-emits two beams of difference frequency focused ultrasound with a certain frequency difference to act on the target nerve, and the biological signal acquisition device starts to record the physiological effect of the target nerve after the difference frequency stimulation, so as to obtain the evaluation result of the target nerve.

8. The physical mapping device according to claim 7, wherein the main control computer sends an ablation instruction according to the definition of the target nerve evaluation result, the instruction is transmitted to the ultrasonic signal generator, two groups of ultrasonic signals with the same frequency are generated and sent to the difference frequency focused ultrasonic transducer, a focused ultrasonic beam with the same frequency is sent out, and ultrasonic ablation is performed on the target nerve according to the composite image generated by the ultrasonic imaging unit and the superposition image unit.

Technical Field

The invention relates to the technical field of medical instruments, in particular to a physical mapping device for detecting and ablating a target nerve treatment energy delivery site.

Background

In recent years, with the development of non-invasive ultrasound systems, it is a mainstream research direction to use ultrasound systems to generate mechanical stimulation to nerves, and detect the reaction of nerve activity through mechanical stimulation, so as to find a target point for disease treatment.

at present, the closest prior art regarding the treatment of ultrasound is that the applicant has already applied for patentability: the specification of the dual-frequency focusing ultrasound system (CN102793890B) describes "diagnosis and treatment of a lesion by combining mechanical stimulation and tissue ablation by dual-frequency focusing ultrasound". However, although the detection and ablation can be integrated in this solution, the integration of the detection and ablation cannot be realized quickly and accurately, that is, when the delivery site of a certain site is detected, the site can not be ablated and treated quickly. The reason is that the technical scheme is applied to physiological mapping and can only be used for detecting the surface nerves, and the delivery site cannot be accurately found for the target nerves in the body and at depth, namely, only one target region where the target nerves are located is possibly detected, so that the integration of detection and ablation cannot be rapidly and accurately realized. Wherein "target nerve" and "target area" are defined, and the target area: specific body tissues containing the "target nerve" include, for example: in hypertension treatment, the target region refers to the perirenal artery tissue containing the renal sympathetic nerves, which refers to the renal sympathetic nerves as well as: in the process of analgesic treatment of cancer pain, the target region refers to deep tissue including abdominal cavity and visceral ganglion, and the target nerve refers to abdominal ganglion

In view of the above, there is a need for a physical mapping device capable of rapidly acquiring a target nerve treatment energy delivery site and rapidly and precisely detecting and ablating the target nerve treatment energy delivery site, and no report about such a physical mapping device is found at present.

Disclosure of Invention

The invention aims to provide a physical mapping device which can quickly acquire a target nerve treatment energy delivery site and can quickly and accurately detect and ablate.

In order to achieve the purpose, the invention adopts the technical scheme that:

A physical mapping device for rapidly acquiring a target nerve treatment energy delivery site comprises a vibration sound physical signal pickup system, a vibration sound physical signal display system and a vibration sound physical signal analysis system; the vibration sound physical signal pickup system is used for picking up sound waves and transmitting the sound waves to the vibration sound physical signal display system for processing; the vibration sound physical signal display system comprises a preamplifier, a filter and a digital oscilloscope; the vibration sound physical signal pickup system is used for picking up echoes generated by different tissues after difference frequency focusing ultrasonic stimulation; the vibration sound physical signal display system is used for converting sound waves or echoes into digitized echo signals, transmitting the digitized echo signals to a preamplifier in the vibration sound physical signal display system, amplifying the echo signals, further transmitting the echo signals to a filter unit in the vibration sound physical signal display system, filtering clutter signals in the echo signals by the filter in a low-pass/high-pass or other mode, and finally transmitting the echo signals to a digital oscilloscope in the vibration sound physical signal display system for display; the vibration sound physical signal analysis system comprises a treatment planning unit, an ultrasonic image unit and a superposed image unit; the treatment planning unit and the superposed image unit are connected with a digital oscilloscope in the vibration sound physical signal display system and used for receiving the tissue echo signal on the digital oscilloscope.

the treatment planning unit is used for receiving echo signals on the digital oscilloscope, comparing the obtained echo signals with echo signals generated after differential frequency ultrasonic stimulation of various tissues preset in the treatment planning unit, performing gray scale type scanning to construct a hardness distribution diagram of a target area, displaying the distribution state of target nerves in the target area through the hardness diagram, displaying the hardness diagram in the form of a gray scale diagram, a three-dimensional histogram and a pseudo-color diagram, and visually displaying an ablation treatment plan;

The ultrasonic image unit comprises an ultrasonic image probe, and can also be a magnetic resonance coil, an electronic computer tomography scanning device and a nuclear medicine detector; the ultrasonic image probe is arranged in the difference frequency focusing ultrasonic transducer, can flexibly turn, and can perform two-dimensional and Doppler blood flow imaging when the difference frequency ultrasonic works;

The superposition image unit superposes and combines the gray-scale image, the three-dimensional histogram, the pseudo-color image and the Doppler blood flow imaging output by the ultrasonic image unit, which are output by the treatment planning unit, and is used for providing image support during ablation, searching a treatment target point and a scanning plane, and setting a treatment energy delivery site by utilizing the virtual focus of the treatment unit through the three-dimensional motion of the treatment unit.

As a preferable technical scheme, the vibration sound physical signal pickup system is a hydrophone, the hydrophone can adopt two pickup modes of a water tank signal and a body signal, the water tank is used for reducing the influence of surface reflection, and flexible sound absorption rubber is paved on the water surface.

As a preferred technical solution, the physical mapping device is further equipped with an ultrasonic signal generator, a difference frequency focusing ultrasonic transducer; the ultrasonic signal generator generates ultrasonic signals with a certain frequency difference, the ultrasonic signals are sent to the difference frequency focusing ultrasonic transducer, and two or more beams of difference frequency focusing ultrasonic waves with a certain frequency difference are generated by the difference frequency focusing ultrasonic transducer.

As a preferred technical solution, the difference frequency focused ultrasound transducer emits the difference frequency focused ultrasound with a certain frequency difference, and the frequency difference is lower than 1% of the fundamental frequency.

As a preferred technical solution, the physical mapping device is further equipped with a physiological mapping system and a main control computer; the physiological detection system comprises: the biological signal acquisition device is used for assisting the discrimination system; the biological signal acquisition device is used for acquiring and recording body physiological electric signals and sending the acquired body physiological signals to the auxiliary judgment system; the auxiliary judgment system is used for analyzing and judging the acquired body physiological signals, comparing the acquired body physiological signals with preset signals, judging the signals by an operator according to the signal analysis result, and sending the result to the main control computer to adjust the focused ultrasound treatment parameters in real time.

As a preferred technical solution, the biological signal collecting apparatus includes: an electrocardiogram analyzer, a multi-channel physiological recorder, a respiration monitor and/or electroencephalograph, a nerve potential analyzer, and a blood biochemical analyzer.

As a preferred technical solution, after the physical mapping device completes the physical mapping, the physical mapping system superimposes the distribution state image of the target nerve in the target region provided by the image unit, the difference frequency focused ultrasound transducer emits two bundles of difference frequency focused ultrasound with a certain frequency difference again to act on the target nerve portion, and the biological signal acquisition device starts to record the physiological effect formed after the difference frequency stimulation of the target nerve, so as to obtain the target nerve evaluation result.

As a preferred technical solution, the main control computer sends out an ablation instruction by defining the target nerve evaluation result, the instruction is transmitted to the ultrasonic signal generator, two groups of ultrasonic signals with the same frequency are generated and sent to the difference frequency focused ultrasonic transducer, a focused ultrasonic beam with the same frequency is sent out, and ultrasonic ablation is performed on the target nerve according to a composite image generated by the ultrasonic image unit and the superposition image unit.

The invention has the advantages that:

1. The invention relates to a physical mapping device for rapidly acquiring a target nerve treatment energy delivery site, which forms a focus on a deep part of an organism by high-frequency focused ultrasound, creates a physical/physiological property double mapping positioning method on a deep tissue of the organism by using a difference frequency confocal ultrasound interference principle, forms a 'tapping' force by generating mechanical stress of low-frequency vibration sound at the focus and forms a deep nerve stimulation stress principle, guides focused ultrasound energy treatment and a curative effect verification system method, and provides wide application prospects for mapping, regulating, ablating treatment and the like of excitable tissues of the organism.

2. The characteristic that external focused ultrasound is used for non-invasively delivering energy to the deep part of a tissue is utilized, the low-frequency component force is generated by using the ultrasonic difference frequency principle and is used for nerve mapping, and the detection function is skillfully developed under the condition that the main framework of the system is basically maintained. And because the detection and the therapeutic intervention are in the same focus, the accuracy of the therapeutic target is ensured while the system structure is greatly simplified.

3. The physical mapping system adopts a 'tapping' mode to obtain the intensity of vibration sound, and in addition, the part to be tapped is in a mechanical environment with mechanical force, and tapping is carried out through low-frequency vibration, and the design mode can obtain obvious vibration sound intensity.

4. The physical mapping system firstly carries out fast mapping to find the position or the relative position of the detection surface where the target nerve is located, then carries out accurate mapping on the detection surface through the physical mapping system, the interval time between the physical mapping and the physiological mapping is short, the physical mapping can be used for prescanning, the stimulation response is confirmed, the energy can be released immediately for treatment, and the realization of integrated treatment of detection and ablation is facilitated.

5. The physical mapping system takes stress generated by low-frequency vibration generated by the acoustic signal generator as a mapping source, and then taps the tissue of a focus by the stress generated by a difference frequency signal in the difference frequency vibration. The mapping source is carried out in vitro, good acoustic coupling can be realized without any electrode or catheter entering the body, and noninvasive treatment of deep target tissues can be realized; the mode of beating is favorable to comprehensive accurate physical information who obtains the degree of depth tissue.

6. The three-dimensional motion scanning system is arranged, and when physical detection is carried out, the focused ultrasonic transducer is controlled to carry out three-dimensional arbitrary surface motion relative to a target area, and arbitrary three-dimensional scanning can be carried out on a part to be detected, so that the physical mapping system can obtain a hardness distribution map with more comprehensive physical information, and a detection surface can be accurately obtained. When physiological detection is carried out, the focus is not limited by an anatomical structure, and two-dimensional or three-dimensional scanning can be carried out at any point of the solid tissue, so that the same focus is realized during mapping and ablation treatment. However, in the conventional physiological detection, due to the absence of a three-dimensional motion scanning system, the stimulation of the physiological detection in the blood vessel is limited by space, and the physiological detection cannot be detected if the nerve is far away from the blood vessel.

7. the physical mapping device for rapidly acquiring the target nerve treatment energy delivery site can rapidly acquire the target nerve treatment energy delivery site and can rapidly and accurately realize detection-ablation integration.

Drawings

Fig. 1 is a block diagram of a physical mapping device for rapidly acquiring a targeted neuro-therapeutic energy delivery site in accordance with the present invention.

Fig. 2 is a schematic flow diagram of a physical mapping device for rapidly acquiring a targeted neuro-therapeutic energy delivery site in accordance with the present invention.

Fig. 3 is a schematic diagram of a structure of a physical mapping system.

fig. 4 is a block diagram of a structure of a physiological mapping system.

Detailed Description

The following detailed description of the present invention will be made with reference to the accompanying drawings.

The reference numerals and components referred to in the drawings are as follows:

1. Main control computer 2. ultrasonic signal generator

3. Three-dimensional motion scanning system 4. difference frequency focusing ultrasonic transducer

5. Degassing water circulation system 6. physical mapping system

61. Vibro-acoustic physical signal pickup system 62 vibro-acoustic physical signal display system

621. Preamplifier 622 filter

623. Digital oscilloscope 63 vibration sound physical signal analysis system

631. Treatment planning unit 632 ultrasound imaging unit

633. Superimposed image unit 7. physiological mapping system

71. Multichannel physiological recorder 72 auxiliary discrimination system