阅读说明：本技术 复合季铵盐消毒剂及其制作方法 (Composite quaternary ammonium salt disinfectant and its preparation method ) 是由 李宇鑫 李晓东 侯彦秋 石立周 刘薇 李子航 于 2019-08-26 设计创作，主要内容包括：本发明提供了一种复合季铵盐消毒剂及其制作方法,以双辛烷基二甲基氯化铵、十二烷基二甲基苄基氯化铵、月桂基葡糖苷、冰乙酸、胍类消毒剂、表面活性剂、复合碘酸钾、壳聚糖盐酸盐、二溴海因、氢化超支化聚烯烃、莫西沙星、大蒜素、β-葡聚糖棕榈酸酯为原料制得的复合季铵盐消毒剂,能够有效抑制和杀灭金黄色葡萄球菌、大肠杆菌、白色念珠菌,能够提高复合季铵盐消毒剂的杀灭效率,使得复合季铵盐消毒剂具有高的杀灭持久性。另外,本发明用于对器材、器械尤其是医用器械的消毒,其对医用器械的消毒效果能达到目前医用器械消毒主流产品戊二醛类消毒产品的消毒效果,且不会对所消毒的对象产生损害,对环境无污染,对金属器皿等无腐蚀。(The invention provides a compound quaternary ammonium salt disinfectant and a preparation method thereof, the compound quaternary ammonium salt disinfectant is prepared by taking dioctyldimethylammonium chloride, dodecyl dimethyl benzyl ammonium chloride, lauryl glucoside, glacial acetic acid, guanidine disinfectant, surfactant, compound potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, garlicin and beta-glucan palmitate as raw materials, can effectively inhibit and kill staphylococcus aureus, escherichia coli and candida albicans, can improve the killing efficiency of the compound quaternary ammonium salt disinfectant, and has high killing durability. In addition, the invention is used for disinfecting equipment, instruments, particularly medical instruments, the disinfection effect of the invention on the medical instruments can reach the disinfection effect of the glutaraldehyde disinfection product which is the mainstream product for disinfecting the medical instruments at present, and the invention does not damage the disinfected objects, has no pollution to the environment and does not corrode metal utensils and the like.)

1. The compound quaternary ammonium salt disinfectant is characterized by comprising the following raw materials in parts by weight:

20-30 parts of dioctyldimethylammonium chloride, 10-20 parts of dodecyldimethylbenzylammonium chloride, 2-4 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-5 parts of guanidine disinfectant, 20-40 parts of surfactant, 7-10 parts of potassium iodate, 3-5 parts of chitosan hydrochloride, 1-2 parts of dibromohydantoin, 1-2 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2-3 parts of allicin, 1-2 parts of beta-glucan palmitate and 50-60 parts of distilled water.

2. The compound quaternary ammonium salt disinfectant as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight:

23-27 parts of dioctyldimethylammonium chloride, 15-20 parts of dodecyl dimethyl benzyl ammonium chloride, 2-3 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-4 parts of guanidine disinfectant, 25-35 parts of surfactant, 8-10 parts of potassium iodate complex, 4-5 parts of chitosan hydrochloride, 1.5-2 parts of dibromohydantoin, 1-1.5 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2.5-3 parts of allicin, 1-1.5 parts of beta-glucan palmitate and 50-55 parts of distilled water.

3. The compound quaternary ammonium salt disinfectant as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight:

25 parts of dioctyldimethylammonium chloride, 15 parts of dodecyl dimethylbenzyl ammonium chloride, 3 parts of lauryl glucoside, 1 part of glacial acetic acid, 4 parts of guanidine disinfectant, 30 parts of surfactant, 8 parts of composite potassium iodate, 4 parts of chitosan hydrochloride, 2 parts of dibromohydantoin, 1 part of hydrogenated hyperbranched polyolefin, 2 parts of moxifloxacin, 3 parts of allicin, 1.5 parts of beta-glucan palmitate and 50 parts of distilled water.

4. The compound quaternary ammonium salt disinfectant according to claim 1, wherein the guanidine disinfectant is polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine propionate or polyoxyalkyleneguanidine hydrochloride.

5. The compound quaternary ammonium salt disinfectant according to claim 1, wherein the compound iodine comprises potassium iodate, iodine and povidone-iodine.

6. The compound quaternary ammonium salt disinfectant as set forth in claim 1, wherein the surfactant is fatty alcohol polyvinyl chloride ether, alkylphenol polyoxyethylene ether or polyethylene glycol laurate.

7. The method for preparing the compound quaternary ammonium salt disinfectant according to claim 1, which is characterized by comprising the following steps:

a) adding a surfactant into water, and uniformly stirring;

b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;

c) adding lauryl glucoside, glacial acetic acid, guanidine disinfectants, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;

d) ultrafiltering the mixed solution obtained in the step c) by an ultrafiltration membrane to obtain the product.

8. The method of claim 7, wherein the nanofiltration membrane is a PVDF nanofiltration membrane.

9. The preparation method of claim 7, wherein the nanofiltration membrane has a molecular weight cut-off of 500-800D.

Technical Field

The invention belongs to the field of disinfectants, and particularly relates to a compound quaternary ammonium salt disinfectant and a preparation method thereof.

Background

Medical instruments are concerned with the health of patients, and have higher requirements on disinfection and sterilization of the instruments. The existing medical instrument disinfectant is generally required to have the following characteristics: 1. the disinfectant has no corrosion to equipment and can be used for a long time; 2. the disinfection effect is good, and germs on the apparatus can be killed quickly; 3. the medicine is non-toxic and pollution-free, and does not cause physical damage to patients; 4. the disinfectant can not cause harm to operators.

At present, representative products for strong sterilization in the domestic disinfection product market mainly comprise the following products: 1. chlorine disinfectant: such as 84, bleaching powder and the like, the main effective components are organic chlorine, and the disinfectant has broad-spectrum and high-efficiency sterilization, strong irritation and strong corrosivity, is easily influenced by organic matters, pollutes the environment and can generate toxic and side effects on a human body. 2. A phenolic disinfectant: such as phenol, lesu, etc., has good sterilizing effect, strong irritation, heavy smell, is easily influenced by organic matters, has pollution to water and environment, and can generate toxic and side effects on human bodies. 3. Aldehyde disinfectant: such as glutaraldehyde, has good disinfection effect on medical instruments, but also has corrosion effect on the disinfected products. In the face of the urgent need of new environment-friendly and efficient disinfection products in various social fields, researchers develop various new products, wherein quaternary ammonium salt disinfectants are one of the disinfectants which are greatly expected. At present, quaternary ammonium salt disinfection products in the domestic disinfection product market are mostly single-component preparations or simple 'quaternary ammonium salt + quaternary ammonium salt' so-called compound products, and the sterilization effect is poor.

Disclosure of Invention

The invention provides a compound quaternary ammonium salt disinfectant and a preparation method thereof, which can effectively inhibit and kill staphylococcus aureus, escherichia coli and candida albicans, and can improve the killing efficiency of the compound quaternary ammonium salt disinfectant.

The technical scheme of the invention is realized as follows:

a compound quaternary ammonium salt disinfectant comprises the following raw materials in parts by weight:

20-30 parts of dioctyldimethylammonium chloride, 10-20 parts of dodecyldimethylbenzylammonium chloride, 2-4 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-5 parts of guanidine disinfectant, 20-40 parts of surfactant, 7-10 parts of potassium iodate, 3-5 parts of chitosan hydrochloride, 1-2 parts of dibromohydantoin, 1-2 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2-3 parts of allicin, 1-2 parts of beta-glucan palmitate and 50-60 parts of distilled water.

Preferably, the feed comprises the following raw materials in parts by weight:

23-27 parts of dioctyldimethylammonium chloride, 15-20 parts of dodecyl dimethyl benzyl ammonium chloride, 2-3 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-4 parts of guanidine disinfectant, 25-35 parts of surfactant, 8-10 parts of potassium iodate complex, 4-5 parts of chitosan hydrochloride, 1.5-2 parts of dibromohydantoin, 1-1.5 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2.5-3 parts of allicin, 1-1.5 parts of beta-glucan palmitate and 50-55 parts of distilled water.

Preferably, the feed comprises the following raw materials in parts by weight:

25 parts of dioctyldimethylammonium chloride, 15 parts of dodecyl dimethylbenzyl ammonium chloride, 3 parts of lauryl glucoside, 1 part of glacial acetic acid, 4 parts of guanidine disinfectant, 30 parts of surfactant, 8 parts of composite potassium iodate, 4 parts of chitosan hydrochloride, 2 parts of dibromohydantoin, 1 part of hydrogenated hyperbranched polyolefin, 2 parts of moxifloxacin, 3 parts of allicin, 1.5 parts of beta-glucan palmitate and 50 parts of distilled water.

Preferably, the guanidine disinfectant is polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine propionate or polyoxyalkyleneguanidine hydrochloride.

Preferably, the complex iodine comprises potassium iodate, iodine and povidone iodine.

Preferably, the surfactant is fatty alcohol polyvinyl chloride ether, alkylphenol polyoxyethylene ether or polyethylene glycol laurate.

The invention also provides a preparation method of the compound quaternary ammonium salt disinfectant, which comprises the following steps:

a) adding a surfactant into water, and uniformly stirring;

b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;

c) adding lauryl glucoside, glacial acetic acid, guanidine disinfectants, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;

d) ultrafiltering the mixed solution obtained in the step c) by an ultrafiltration membrane to obtain the product.

Preferably, the nanofiltration membrane is a PVDF nanofiltration membrane.

Preferably, the molecular weight cut-off of the nanofiltration membrane is 500-800D.

The invention provides a compound quaternary ammonium salt disinfectant and a preparation method thereof, the compound quaternary ammonium salt disinfectant is prepared by taking dioctyldimethylammonium chloride, dodecyl dimethyl benzyl ammonium chloride, lauryl glucoside, glacial acetic acid, guanidine disinfectant, surfactant, compound potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, garlicin and beta-glucan palmitate as raw materials, can effectively inhibit and kill staphylococcus aureus, escherichia coli and candida albicans, can improve the killing efficiency of the compound quaternary ammonium salt disinfectant, and enables the compound quaternary ammonium salt disinfectant to have high killing durability. In addition, the invention is used for disinfecting equipment, instruments, particularly medical instruments, the disinfection effect of the invention on the medical instruments can reach the disinfection effect of the glutaraldehyde disinfection product which is the mainstream product for disinfecting the medical instruments at present, and the invention does not damage the disinfected objects, has no pollution to the environment and does not corrode metal utensils and the like.

Detailed Description

The invention provides a compound quaternary ammonium salt disinfectant, which comprises the following raw materials in parts by weight:

20-30 parts of dioctyldimethylammonium chloride, 10-20 parts of dodecyldimethylbenzylammonium chloride, 2-4 parts of lauryl glucoside, 1-2 parts of glacial acetic acid, 3-5 parts of guanidine disinfectant, 20-40 parts of surfactant, 7-10 parts of potassium iodate, 3-5 parts of chitosan hydrochloride, 1-2 parts of dibromohydantoin, 1-2 parts of hydrogenated hyperbranched polyolefin, 1-2 parts of moxifloxacin, 2-3 parts of allicin, 1-2 parts of beta-glucan palmitate and 50-60 parts of distilled water.

According to the invention, the compound quaternary ammonium salt disinfectant prepared by taking the dioctyldimethylammonium chloride, the dodecyldimethylbenzylammonium chloride, the lauryl glucoside, the glacial acetic acid, the guanidine disinfectant, the surfactant, the compound potassium iodate, the chitosan hydrochloride, the dibromohydantoin, the hydrogenated hyperbranched polyolefin, the moxifloxacin, the allicin and the beta-glucan palmitate as raw materials can effectively inhibit and kill staphylococcus aureus, escherichia coli and candida albicans, can improve the killing efficiency of the compound quaternary ammonium salt disinfectant, and enables the compound quaternary ammonium salt disinfectant to have high killing durability. In addition, the invention is used for disinfecting equipment, instruments, particularly medical instruments, the disinfection effect of the invention on the medical instruments can reach the disinfection effect of the glutaraldehyde disinfection product which is the mainstream product for disinfecting the medical instruments at present, and the invention does not damage the disinfected objects, has no pollution to the environment and does not corrode metal utensils and the like.

The dioctyl dimethyl ammonium chloride, dodecyl dimethyl benzyl ammonium chloride and guanidine disinfectant generate synergistic effect, so that the composite quaternary ammonium salt disinfectant has high bactericidal capacity.

In the embodiment of the invention, the weight part of the dioctyldimethylammonium chloride is 20-30 parts; in a preferred embodiment, the weight part of the dioctyldimethylammonium chloride is 23-27 parts; in other embodiments, the weight portion of dioctyldimethylammonium chloride is 25 parts.

In the embodiment of the invention, the weight part of the dodecyl dimethyl benzyl ammonium chloride is 10-20 parts; in a preferred embodiment, the weight part of the dodecyl dimethyl benzyl ammonium chloride is 15-20 parts; in other embodiments, the parts by weight of dodecyl dimethyl benzyl ammonium chloride is 15 parts.

In the embodiment of the invention, the weight part of lauryl glucoside is 2-4 parts; in a preferred embodiment, the weight part of lauryl glucoside is 2-3 parts; in other embodiments, the parts by weight of lauryl glucoside is 3 parts.

In the embodiment of the invention, the weight part of the glacial acetic acid is 1-2 parts; in a preferred embodiment, the weight part of the glacial acetic acid is 1-2 parts; in other embodiments, the parts by weight of glacial acetic acid is 1 part.

In the embodiment of the present invention, the guanidine disinfectant is polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine propionate or polyoxyalkyleneguanidine hydrochloride

In the embodiment of the invention, the guanidine disinfectant is 3-5 parts by weight; in a preferred embodiment, the guanidine disinfectant is 3-4 parts by weight; in other embodiments, the guanidine disinfectant is present in an amount of 4 parts by weight.

In the embodiment of the invention, the weight part of the surfactant is 20-40 parts; in a preferred embodiment, the weight part of the surfactant is 25-35 parts; in other embodiments, the weight fraction of surfactant is 30 parts.

In the embodiment of the invention, the surfactant is fatty alcohol polyvinyl chloride ether, alkylphenol polyoxyethylene ether or polyethylene glycol laurate. The surfactant can improve the cleaning and sterilizing effects of the compound quaternary ammonium salt disinfectant on medical instruments.

In the embodiment of the invention, the weight part of the composite potassium iodate is 7-10 parts; in a preferred embodiment, the weight part of the composite potassium iodate is 8-10 parts; in other embodiments, the weight portion of the potassium iodate complex is 8 parts.

Wherein the compound iodine comprises potassium iodate, iodine and povidone iodine; the mass ratio of the potassium iodate to the iodine to the povidone iodine is 1: (0.5-0.6): (2-3); the compound iodine can improve the sterilization effect of the compound quaternary ammonium salt disinfectant.

The chitosan hydrochloride and the beta-glucan palmitate can enable the compound quaternary ammonium salt disinfectant to be easy to form a film, and the compound quaternary ammonium salt disinfectant is beneficial to sterilizing medical supplies and improving the sterilization efficiency. In the embodiment of the invention, the weight part of the chitosan hydrochloride is 3-5 parts; in a preferred embodiment, the weight part of the chitosan hydrochloride is 3-4 parts; in other embodiments, the chitosan hydrochloride is 4 parts by weight.

In the embodiment of the invention, the weight part of the dibromohydantoin is 1-2 parts; in a preferred embodiment, the weight part of the dibromohydantoin is 1.5 to 2 parts; in other embodiments, the weight portion of dibromohydantoin is 2 parts.

The hydrogenated hyperbranched polyolefin can improve the killing stability of the compound quaternary ammonium salt disinfectant. In the embodiment of the invention, the weight part of the hydrogenated hyperbranched polyolefin is 1-2 parts; in a preferred embodiment, the weight part of the hydrogenated hyperbranched polyolefin is 1-1.5 parts; in other embodiments, the hydrogenated hyperbranched polyolefin is 1 part by weight.

The moxifloxacin increases the binding capacity of the compound quaternary ammonium salt disinfectant to bacteria and the penetrating power of cell membranes, and the antibacterial effect is strong and durable. In the embodiment of the invention, the weight part of the moxifloxacin is 1-2 parts; in a preferred embodiment, the weight part of the moxifloxacin is 1-2 parts; in other embodiments, the parts by weight of moxifloxacin is 2 parts.

In the embodiment of the invention, the weight part of the allicin is 2-3 parts; in a preferred embodiment, the weight part of the allicin is 2.5-3 parts; in other embodiments, the allicin is present in an amount of 3 parts by weight.

In the embodiment of the invention, the weight part of the beta-glucan palmitate is 1-2 parts; in a preferred embodiment, the weight part of the beta-glucan palmitate is 1-1.5 parts; in other embodiments, the weight fraction of β -glucan palmitate is 1.5 parts.

In the embodiment of the invention, the weight part of the distilled water is 50-60 parts; in a preferred embodiment, the weight part of the distilled water is 50-55 parts; in other embodiments, the distilled water is 50 parts by weight.

The invention also provides a preparation method of the compound quaternary ammonium salt disinfectant, which comprises the following steps:

a) adding a surfactant into water, and uniformly stirring;

b) adding dioctyl dimethyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride into the mixed solution obtained in the step a), and uniformly stirring;

c) adding lauryl glucoside, glacial acetic acid, guanidine disinfectants, composite potassium iodate, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin and beta-glucan palmitate into the mixed solution obtained in the step b), and uniformly mixing;

d) ultrafiltering the mixed solution obtained in the step c) by an ultrafiltration membrane to obtain the product.

Among them, dioctyldimethylammonium chloride, dodecyldimethylbenzylammonium chloride, lauryl glucoside, glacial acetic acid, guanidine disinfectant, surfactant, potassium iodate complex, chitosan hydrochloride, dibromohydantoin, hydrogenated hyperbranched polyolefin, moxifloxacin, allicin, beta-glucan palmitate, and distilled water are the same as above, and are not described again here.

In an embodiment of the invention, the nanofiltration membrane is a PVDF nanofiltration membrane. Wherein the cut-off molecular weight of the nanofiltration membrane is 500-800D

In order to further illustrate the present invention, the following examples are provided to describe the method for preparing high purity fructo-oligosaccharide from sucrose in detail, but they should not be construed as limiting the scope of the present invention.