阅读说明：本技术 治疗痰热壅肺证的儿童成人共用中药制剂及其制备方法 (Children and adults common traditional Chinese medicine preparation for treating phlegm-heat obstructing lung and preparation method thereof ) 是由 刘丽宏 赵铁良 曹锐 刘河 权红 吕亚丽 于 2019-10-10 设计创作，主要内容包括：本发明公开了一种治疗痰热壅肺证的儿童成人共用中药制剂,包括：麻黄3-40份,石膏3-20份,连翘2-15份,板蓝根2-15份,苦杏仁3-20份,枇杷叶3-20份,紫苏子2-15份,百部0-20份,桑皮0-20份；其制备方法主要通过水蒸气蒸馏和煎煮,得到相应的中药制剂；本发明药物组方配方合理,各组分协同作用,相辅相成能疗效好；在保证疗效的同时,使得儿童和成人均能使用,且不造成其它的不良影响；同时其制备方法简单,具有广阔的市场前景。(The invention discloses a common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung, which comprises the following components: 3-40 parts of ephedra, 3-20 parts of gypsum, 2-15 parts of fructus forsythiae, 2-15 parts of radix isatidis, 3-20 parts of bitter almond, 3-20 parts of loquat leaf, 2-15 parts of perilla fruit, 0-20 parts of radix stemonae and 0-20 parts of mulberry bark; the preparation method comprises distilling with water vapor and decocting to obtain corresponding Chinese medicinal preparation; the medicine has reasonable formula, and the components have synergistic effect and good curative effect; the medicine can be used by both children and adults without causing other adverse effects while ensuring the curative effect; meanwhile, the preparation method is simple and has wide market prospect.)

1. The common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung is characterized by comprising the following raw materials in parts by weight:

3-40 parts of ephedra, 3-20 parts of gypsum, 2-15 parts of fructus forsythiae, 2-15 parts of isatis root, 3-20 parts of bitter almond, 3-20 parts of loquat leaf and 2-15 parts of perilla fruit.

2. The common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung syndrome as claimed in claim 1, further comprising 0-20 parts by weight of radix stemonae.

3. The common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung syndrome as claimed in claim 1, further comprising 0-20 parts by weight of mulberry bark.

4. The common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung as claimed in claim 1, wherein the specific raw materials in parts by weight are ephedra 3 parts, gypsum 20 parts, forsythia 15 parts, isatis root 15 parts, bitter apricot kernel 10 parts, loquat leaf 15 parts, and perilla fruit 10 parts.

5. The method for preparing the common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung according to any one of claims 1 to 4, which is characterized by comprising the following steps:

step one, performing steam distillation on the ephedra and the bitter apricot kernel in parts by weight, and collecting distillate and dregs for later use;

step two, mixing the dregs obtained in the step one with other components in parts by weight for decoction, adding 10 times of water for the first time of 1.5 hours and 8 times of water for the second time of 1 hour, combining the decoction, filtering by a 80-mesh sieve, performing ultrafiltration by an alcohol precipitation method or an ultrafiltration column with molecular weight cut-off of 5000-;

and step three, processing the extracting solution obtained in the step two to obtain a mixture, granules, tablets, capsules, soft capsules or pellets of the extracting solution.

6. The method of claim 5, wherein the ephedra herb and bitter apricot are soaked in water at room temperature for 2 hours before the steam distillation.

7. The method for preparing a common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung as claimed in claim 5, wherein the method for distilling water vapor in the first step comprises:

s1, pulverizing the ephedra and bitter apricot in parts by weight by using an ultrafine pulverizer to obtain powder with the mesh number of 200-300 meshes;

s2, coating the powder with a 0.2 micron microfiltration membrane, and soaking the powder in the immersion liquid for 10 hours at the temperature of 35 ℃ to obtain primary immersion liquid and wet mixed powder; wherein, the primary immersion liquid is prepared from the following components in percentage by weight: ethanol volume ratio 5: 1 is obtained by proportional allocation;

s3, performing steam distillation on the primary extract and the mixed powder in the S2 to obtain distillate.

8. The application of the traditional Chinese medicine preparation for treating phlegm-heat obstructing lung of children and adults according to any one of claims 1 to 7, wherein the traditional Chinese medicine preparation is applied to preparing the medicine for treating phlegm-heat obstructing lung with symptoms of flushed face and fever, pharyngalgia, hoarseness, cough, shortness of breath and excessive, yellow and thick phlegm.

Technical Field

The invention relates to the field of traditional Chinese medicine preparations. More specifically, the invention relates to a common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung and a preparation method thereof.

Background

The pattern of phlegm-heat obstructing the lung refers to the condition of lung meridian excess-heat caused by the lung failing to disperse and descend due to the intermingled phlegm-heat obstructing the lung, which is also called the pattern of phlegm-heat obstructing the lung. The clinical manifestations are cough, yellow and thick sputum, chest distress, dyspnea with coarse sputum, even flaring of nasal wings, wheezing of phlegm in the throat, dysphoria, fever, thirst, cough, pus, bloody and smelly sputum, chest pain, constipation, scanty and dark urine, red tongue with yellow and greasy coating, and smooth and rapid pulse.

The existing treatment method is that the formulas of children and adults are separated, and in the existing formula, the children adopt roasted ephedra, gypsum, bitter apricot seeds, pepperweed seeds and the like; adults adopt semen lepidii, honey ephedra, bulbus fritillariae cirrhosae, bitter apricot seeds, trichosanthes peel and the like, the types of traditional Chinese medicine formulas of the adults are too many, the medicine effect is too complex and not suitable for children, the formula effect of the children is too weak, and the treatment effect of the adults after use is not good, so that on the basis of the prior art, the formula needs to be improved, and a traditional Chinese medicine formula which can be used by both the adults and the children and has a good effect is optimized.

Disclosure of Invention

An object of the present invention is to solve at least the above problems and to provide at least the advantages described later.

The invention also aims to provide a common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung and a preparation method thereof, wherein the formula of the medicine is reasonable, and the components have synergistic effect and good curative effect; the prescription can be used by both children and adults while ensuring the curative effect; meanwhile, the preparation method is simple and has wide market prospect.

In order to achieve the purposes and other advantages, the invention provides a common traditional Chinese medicine preparation for children and adults for treating phlegm-heat obstructing lung, which comprises the following raw materials in parts by weight:

3-40 parts of ephedra, 3-20 parts of gypsum, 2-15 parts of fructus forsythiae, 2-15 parts of isatis root, 3-20 parts of bitter almond, 3-20 parts of loquat leaf and 2-15 parts of perilla fruit.

Preferably, 0 to 20 parts of stemona root by weight is also included.

Preferably, the mulberry fruit juice also comprises 0 to 20 parts of mulberry bark by weight.

Preferably, the raw materials in parts by weight are 3 parts of ephedra herb, 20 parts of gypsum, 15 parts of forsythia, 15 parts of isatis root, 10 parts of bitter apricot seed, 15 parts of loquat leaf and 10 parts of perilla fruit.

The preparation method of the children and adults common traditional Chinese medicine preparation for treating phlegm-heat obstructing lung syndrome comprises the following specific steps:

step one, performing steam distillation on the ephedra and the bitter apricot kernel in parts by weight, and collecting distillate and dregs for later use;

step two, decocting the dregs obtained in the step one and other components according to the parts by weight, adding 10 times of water for 1.5 hours for the first time and 8 times of water for 1 hour for the second time, merging decoction, filtering by a 80-mesh sieve, performing ultrafiltration by an alcohol precipitation method or an ultrafiltration column with molecular weight cut-off of 5000-20000, concentrating the filtrate to a relative density of 1.05-1.35, adding the distillate obtained in the step one, and mixing to obtain an extracting solution;

and step three, processing the extracting solution obtained in the step two to obtain a mixture, granules, tablets, capsules, soft capsules or pellets of the extracting solution.

Preferably, the ephedra and bitter apricot are soaked in water at normal temperature for 2 hours before steam distillation.

Preferably, the steam distillation method in the first step is specifically as follows:

s1, pulverizing the ephedra and bitter apricot in parts by weight by using an ultrafine pulverizer to obtain powder with the mesh number of 200-300 meshes;

s2, coating the powder with a 0.2 micron microfiltration membrane, and soaking the powder in the immersion liquid for 10 hours at the temperature of 35 ℃ to obtain primary immersion liquid and wet mixed powder; wherein, the primary immersion liquid is prepared from the following components in percentage by weight: ethanol volume ratio 5: 1 is obtained by proportional allocation;

s3, performing steam distillation on the primary extract and the mixed powder in the S2 to obtain distillate.

The application of the traditional Chinese medicine preparation for treating the phlegm-heat obstructing lung syndrome of children and adults is to prepare the medicine for treating the phlegm-heat obstructing lung syndrome with symptoms of flushed face and fever, sore throat, hoarseness, cough, shortness of breath and excessive, yellow and thick phlegm.

The invention at least comprises the following beneficial effects:

the medicine composition has reasonable formula, and the components have synergistic effect and supplement each other.

Ma Huang is pungent and warm in property and mild in nature, and enters lung meridian mainly, so it is indicated for exterior syndrome due to exterior syndrome obstruction of exterior, whether it is cold or heat, deficiency or excess.

Gypsum, Gypsum Fibrosum, being pungent and cold, can directly clear away the interior heat, clear away the lung-heat and relieve dyspnea, thus ensuring the right of descending and regulating; forsythia fruit relieves the accumulated heat of meridians; radix Isatidis is cold in nature and bitter in taste, and has effects of clearing heat, removing toxic substance, and cooling blood; the composition is used as a ministerial drug.

The bitter apricot kernel is bitter and descending, assists the ephedra herb to relieve asthma, and the ephedra herb ascends and disperses, so the bitter apricot kernel which can lower lung qi and disperse wind-cold is taken as an adjuvant drug, and the bitter apricot kernel, together with the ephedra herb, can disperse and descend, can strengthen the effect of relieving depression and asthma; pi Pa Ye processed with honey can strengthen the action of moistening lung to arrest cough, and is mostly indicated for dryness of lung, lung yin deficiency, cough with little phlegm, etc.

Perilla seed, fructus Perillae purges qi, clears phlegm, moistens lung, and widens the intestine. It is indicated for cough, dyspnea with phlegm and qi stagnation.

The six medicinal materials are mutually matched and supplemented, so that the thoroughfare of the conventional phlegm-clearing and lung-moistening prescription is weakened, the medicinal effect of the prescription is mild and long-lasting, and the prescription is suitable for adults and children;

radix Stemonae is sweet, bitter and warm in nature, enters lung meridian, and is mainly used for moistening lung, descending qi and relieving cough; mulberry bark, cortex mori is cold in nature and can purge lung fire and water and gas in the lung to relieve asthma, enter lung channel to clear and reduce lung gas, treat cough and asthma due to lung heat and regulate water passage to induce diuresis;

on the basis, the addition of the radix stemonae and the mulberry bark can also increase the dissolution rate of other traditional Chinese medicine active ingredients from the physical property, so that the drug effect of the product is further enhanced;

the traditional Chinese medicine before steam distillation is treated by adopting a low-temperature heating and soaking method, so that the extraction rate of each effective component in the traditional Chinese medicine is higher.

Pharmacological experiments prove that the medicine formula of the invention accords with the traditional Chinese medicine principle and the pathological characteristics of patients with upper respiratory tract infection, acute tracheitis, acute attack of chronic tracheitis or secondary lung infection, has the effects of clearing lung, reducing phlegm and relieving cough, and is used for treating diseases such as children phlegm-heat obstructing lung.

Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.

Detailed Description

The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.

The pharmacology of the main traditional Chinese medicine raw materials used by the invention is as follows:

herba ephedrae: pungent and warm with mild nature. Ma Huang is indicated for exterior syndrome due to exterior syndrome obstruction of muscle, whether cold or heat, deficiency or excess, because it enters lung meridian mainly and is the key herb for relieving exterior syndrome.

Gypsum: gypsum, Gypsum Fibrosum, with pungent and cold natures, can directly clear interior heat, clear lung-heat and relieve dyspnea, thus having the right to descend and regulate the function.

Fructus forsythiae: clear heat accumulated in meridians.

Radix isatidis: is cold in nature and bitter in taste, and has the effects of clearing heat, removing toxic substances and cooling blood.

Bitter apricot seeds: bitter flavor can descend, assist Ma Huang to relieve dyspnea, and Ma Huang ascends and disperses, so it is combined with lung qi-descending and wind-cold-dispersing apricot kernel as an adjuvant drug, which, together with Ma Huang, can disperse and descend to enhance the actions of resolving stagnation and relieving dyspnea.

Loquat leaf: stir-baked with honey can strengthen the action of moistening lung to arrest cough, and it is usually indicated for dryness of lung, or lung yin deficiency, cough with little phlegm, etc.

Perilla seed: descend qi, clear phlegm, moisten lung and widen intestine. It is indicated for cough, dyspnea with phlegm and qi stagnation.

< example 1>

A traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung comprises the following components in parts by weight: 3 parts of ephedra, 20 parts of gypsum, 15 parts of fructus forsythiae, 15 parts of radix isatidis, 10 parts of bitter almond, 15 parts of loquat leaf and 10 parts of perilla fruit.

The preparation method of the traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung syndrome comprises the following steps:

step one, carrying out steam distillation on the ephedra and the bitter apricot kernel in parts by weight to obtain distillate and dregs, and collecting the distillate for later use;

step two, mixing the dregs obtained by steam distillation with the rest medicinal materials in parts by weight to obtain medicinal materials to be decocted, adding water in an amount which is 10 times of the total weight of the medicinal materials to be decocted for decoction, wherein the first decoction time is 1.5 hours, filtering to obtain first filtrate and filter residue after decoction, continuously adding water in an amount which is 8 times of the amount of the medicinal materials to be decocted to the filter residue, decocting for 1 hour, and filtering to obtain second filtrate; wherein, before the first decoction, the gypsum needs to be decocted for 0.5 hour;

step three, combining the first filtrate and the second filtrate, and filtering through a 80-mesh sieve to obtain an extracting solution;

step four, adopting an ultrafiltration column ultrafiltration method with molecular weight cutoff of 5000-.

< example 2>

A traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung comprises the following components in parts by weight: 3 parts of ephedra, 20 parts of gypsum, 15 parts of fructus forsythiae, 15 parts of radix isatidis, 10 parts of bitter almond, 15 parts of loquat leaf, 10 parts of perilla fruit, 4 parts of radix stemonae and 4 parts of mulberry bark.

The preparation method of the traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung syndrome comprises the following steps:

step one, carrying out steam distillation on the ephedra and the bitter apricot kernel in parts by weight to obtain distillate and dregs, and collecting the distillate for later use;

step two, mixing the dregs obtained by steam distillation with the rest medicinal materials in parts by weight to obtain medicinal materials to be decocted, adding water in an amount which is 10 times of the total weight of the medicinal materials to be decocted for decoction, wherein the first decoction time is 1.5 hours, filtering to obtain first filtrate and filter residue after decoction, continuously adding water in an amount which is 8 times of the amount of the medicinal materials to be decocted to the filter residue, decocting for 1 hour, and filtering to obtain second filtrate; wherein, before the first decoction, the gypsum needs to be decocted for 0.5 hour;

step three, combining the first filtrate and the second filtrate, and filtering through a 80-mesh sieve to obtain an extracting solution;

step four, adopting an ultrafiltration column ultrafiltration method with molecular weight cut-off of 5000-.

< example 3>

A traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung comprises the following components in parts by weight: 40 parts of ephedra, 3 parts of gypsum, 2 parts of fructus forsythiae, 2 parts of radix isatidis, 20 parts of bitter almond, 20 parts of loquat leaf, 15 parts of perilla fruit, 20 parts of radix stemonae and 20 parts of mulberry bark.

The preparation method of the traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung syndrome comprises the following steps:

step one, carrying out steam distillation on the ephedra and the bitter apricot kernel in parts by weight to obtain distillate and dregs, and collecting the distillate for later use;

step two, mixing the dregs obtained by steam distillation with the rest medicinal materials in parts by weight to obtain medicinal materials to be decocted, adding water in an amount which is 10 times of the total weight of the medicinal materials to be decocted for decoction, wherein the first decoction time is 1.5 hours, filtering to obtain first filtrate and filter residue after decoction, continuously adding water in an amount which is 8 times of the amount of the medicinal materials to be decocted to the filter residue, decocting for 1 hour, and filtering to obtain second filtrate; wherein, before the first decoction, the gypsum needs to be decocted for 0.5 hour;

step three, combining the first filtrate and the second filtrate, and filtering through a 80-mesh sieve to obtain an extracting solution;

step four, adopting an ultrafiltration column ultrafiltration method with molecular weight cut-off of 5000-.

< example 4>

A traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung comprises the following components in parts by weight: 3 parts of ephedra, 20 parts of gypsum, 15 parts of fructus forsythiae, 15 parts of radix isatidis, 10 parts of bitter almond, 15 parts of loquat leaf, 10 parts of perilla fruit, 20 parts of radix stemonae and 20 parts of mulberry bark.

A method for preparing a traditional Chinese medicine preparation for treating phlegm-heat obstructing lung of children, which is the same as the preparation method in example 2 to obtain the traditional Chinese medicine preparation oral liquid.

< example 5>

A traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung comprises the following components in parts by weight: 20 parts of ephedra, 13 parts of gypsum, 10 parts of fructus forsythiae, 10 parts of radix isatidis, 12 parts of bitter almond, 12 parts of loquat leaf, 8 parts of perilla fruit, 4 parts of radix stemonae and 4 parts of mulberry bark.

A preparation method of a traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung is the same as the preparation method of example 1, and the traditional Chinese medicine preparation oral liquid is obtained.

< example 6>

A traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung comprises the following components in parts by weight: 3 parts of ephedra, 20 parts of gypsum, 15 parts of fructus forsythiae, 15 parts of radix isatidis, 10 parts of bitter almond, 15 parts of loquat leaf, 10 parts of perilla fruit, 20 parts of radix stemonae and 20 parts of mulberry bark.

The preparation method of the traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung syndrome comprises the following steps:

step one, carrying out steam distillation on the ephedra and the bitter apricot kernel in parts by weight to obtain distillate and dregs, and collecting the distillate for later use;

the steam distillation method comprises the following specific steps:

s1, pulverizing the ephedra and bitter apricot in parts by weight by using an ultrafine pulverizer to obtain powder with the mesh number of 200-300 meshes;

s2, coating the powder with a 0.2 micron microfiltration membrane, and soaking the powder in the immersion liquid for 10 hours at the temperature of 35 ℃ to obtain primary immersion liquid and wet mixed powder; wherein, the primary immersion liquid is prepared from the following components in percentage by weight: ethanol volume ratio 5: 1 is obtained by proportional allocation;

s3, carrying out steam distillation on the primary extract and the mixed powder in the S2 to obtain distillate;

step two, mixing the decoction dregs obtained by steam distillation with other residual medicinal materials in parts by weight to obtain medicinal materials to be decocted, adding water in an amount which is 10 times of the total weight of the medicinal materials to be decocted for decoction, wherein the first decoction time is 1.5 hours, filtering to obtain first filtrate and filter residue after decoction, continuously adding water in an amount which is 8 times of the amount of the medicinal materials to be decocted to the filter residue, decocting for 1 hour, and filtering to obtain second filtrate; wherein, before the first decoction, the gypsum needs to be decocted for 0.5 hour;

step three, combining the first filtrate and the second filtrate, and filtering through a 80-mesh sieve to obtain an extracting solution;

step four, refining the extracting solution in the step three by adopting an alcohol precipitation method, then concentrating the extracting solution until the relative density is 1.22(60 ℃), adding the steam distillate, and concentrating the mixture to obtain a traditional Chinese medicine preparation;

and step five, adding a proper amount of dextrin into the traditional Chinese medicine preparation, metering according to 0.2-0.3 g/granule, and preparing into a capsule preparation according to a capsule processing and preparing method.

< example 7>

A traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung comprises the following components in parts by weight: 3 parts of ephedra, 20 parts of gypsum, 15 parts of fructus forsythiae, 15 parts of radix isatidis, 10 parts of bitter almond, 15 parts of loquat leaf, 10 parts of perilla fruit, 4 parts of radix stemonae and 4 parts of mulberry bark.

The preparation method of the traditional Chinese medicine preparation for treating children phlegm-heat obstructing lung syndrome comprises the following steps:

step one, carrying out steam distillation on the ephedra and the bitter apricot kernel in parts by weight to obtain distillate and dregs, and collecting the distillate for later use;

the steam distillation method comprises the following specific steps:

s1, pulverizing the ephedra and bitter apricot in parts by weight by using an ultrafine pulverizer to obtain powder with the mesh number of 200-300 meshes;

s2, coating the powder with a 0.2 micron microfiltration membrane, and soaking the powder in the immersion liquid for 10 hours at the temperature of 35 ℃ to obtain primary immersion liquid and wet mixed powder; wherein, the primary immersion liquid is prepared from the following components in percentage by weight: ethanol volume ratio 5: 1 is obtained by proportional allocation;

s3, carrying out steam distillation on the primary extract and the mixed powder in the S2 to obtain distillate;

step two, mixing the dregs obtained by steam distillation with the rest medicinal materials in parts by weight to obtain medicinal materials to be decocted, adding water in an amount which is 10 times of the total weight of the medicinal materials to be decocted for decoction, wherein the first decoction time is 1.5 hours, filtering to obtain first filtrate and filter residue after decoction, continuously adding water in an amount which is 8 times of the amount of the medicinal materials to be decocted to the filter residue, decocting for 1 hour, and filtering to obtain second filtrate; wherein, before the first decoction, the gypsum needs to be decocted for 0.5 hour;

step three, combining the first filtrate and the second filtrate, and filtering through a 80-mesh sieve to obtain an extracting solution;

step four, adopting an alcohol precipitation method to refine the extracting solution in the step three, then concentrating the extracting solution until the relative density is 1.35(60 ℃), adding the steam distillate, and concentrating the mixture to obtain a traditional Chinese medicine preparation;

and step five, concentrating the traditional Chinese medicine preparation to prepare liquid medicine, mixing the liquid medicine with a soft capsule material mainly comprising gelatin, respectively flowing out at different speeds from the outer layer and the inner layer of the double-layer dripper, wrapping the quantitative liquid medicine with quantitative glue solution, dripping into cooling liquid immiscible with the glue solution, forming a spherical shape under the action of surface tension, gradually cooling and solidifying to form the soft capsule.

Wherein, for the embodiment 1-2, the concentrated solution can be made into any one of granules, tablets, capsules and pellet preparations besides the oral liquid, and the embodiment 3-5 can also be changed according to the requirements, and the corresponding preparation method specifically comprises the following steps:

(1) the preparation method of the granules comprises the following steps: drying the concentrated solution, adding appropriate amount of cyclodextrin and 85% ethanol, granulating, drying, and grading to obtain granule.

(2) The preparation method of the tablet comprises the following steps: drying the concentrated solution, pulverizing, adding appropriate amount of adjuvants, metering according to 0.2-0.3 g/tablet, and making into round or other tablet according to tablet processing method.

(3) The preparation method of the capsule in the capsule comprises the following steps: drying the concentrated solution, pulverizing, adding appropriate amount of adjuvants, metering according to 0.2-0.3 g/granule, and making into capsule according to capsule processing and preparation method.

(4) The preparation method of the soft capsule comprises the following steps: preparing the concentrated solution into medicinal liquid, mixing with soft capsule wall material mainly containing gelatin, respectively flowing out at different speeds at the outer layer and inner layer of the double-layer dripper, wrapping the medicinal liquid with quantitative glue solution, dripping into coolant immiscible with the glue solution, forming into spherical shape due to surface tension, gradually cooling, and solidifying to obtain soft capsule.

(5) The preparation method of the pellet comprises the following steps: drying the concentrated solution, pulverizing, adding adjuvant powder, mixing, adding binder to obtain soft material, sieving, granulating, rolling in coating pan to obtain pellet, and coating to obtain pellet.

The prescription is different from children and adults in use method, and takes oral liquid as an example;

for children:

the using method comprises the following steps: is administered orally.

5ml of the medicine is taken once every 6-12 months, and 2 times a day; 5ml for 1-3 years old once, 3 times a day; 10ml for 3-6 years old once, 2 times a day; 10ml for 6-14 years old once, 3 times a day; it is forbidden for children less than 6 months and people allergic to the product.

For adults:

the using method comprises the following steps: is administered orally.

10-20ml each time, 3 times a day, and 7 days as a treatment course; it is forbidden for patients allergic to this herb.

The formula protected by the invention is put on record by Beijing drug administration.

Examples of the experiments

Firstly, detecting the medicine components

The dry basis contents of amygdalin, forsythin, goitrin, and rosmarinic acid in the chinese medicinal preparations prepared in example 1, example 2, and example 5 were measured, and the results are shown in table 1 below:

TABLE 1

Group of	Amygdalin	Forsythiaside	Root of Daoyinchun	Rosmarinic acid
					Example 1	0.21mg/g	0.22mg/g	0.31mg/g	0.18mg/g
Example 2	0.18mg/g	0.19mg/g	0.26mg/g	0.12mg/g
					Example 4	0.18mg/g	0.20mg/g	0.26mg/g	0.13mg/g
Example 7	0.21mg/g	0.21mg/g	0.28mg/g	0.14mg/g

The components shown in Table 1 are from different medicinal materials, wherein amygdalin is from semen Armeniacae amarum, phillyrin is from fructus forsythiae, goitrin is from radix Isatidis, and rosmarinic acid is from fructus Perillae;